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Volumn 8, Issue 1, 2015, Pages

Bispecific antibodies and their applications

Author keywords

Bispecific antibody; BiTE; Cancer; Catumaxomab; Diagnosis; Formats

Indexed keywords

AMG 330; BAY 2010112; BISPECIFIC ANTIBODY; BLINATUMOMAB; CATUMAXOMAB; COVA 322; ERTUMAXOMAB; ES 414; FBTA 05; LY 3164530; MDX 447; MEDI 565; MGD 006; MGD 007; MGD 010; MM 111; MM 141; MOR 209; MSB 0010841; MT 111; MT 112; REGN 1979; RG 7716; RG 7802; RG 7813; RO 6895882; SOLITOMAB; TF 2; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANUCIZUMAB; ANTINEOPLASTIC AGENT;

EID: 84950989868     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-015-0227-0     Document Type: Review
Times cited : (232)

References (83)
  • 1
    • 84921352030 scopus 로고    scopus 로고
    • The therapeutic monoclonal antibody market
    • Ecker DM, Jones SD, Levine HL. The therapeutic monoclonal antibody market. mAbs. 2015;7(1):9-14.
    • (2015) MAbs. , vol.7 , Issue.1 , pp. 9-14
    • Ecker, D.M.1    Jones, S.D.2    Levine, H.L.3
  • 3
    • 84858257263 scopus 로고    scopus 로고
    • Dual targeting strategies with bispecific antibodies
    • Kontermann R. Dual targeting strategies with bispecific antibodies. mAbs. 2012;4(2):182-97.
    • (2012) MAbs. , vol.4 , Issue.2 , pp. 182-197
    • Kontermann, R.1
  • 4
    • 70349684791 scopus 로고    scopus 로고
    • Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
    • Regales L, Gong Y, Shen R, de Stanchina E, Vivanco I, Goel A, et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest. 2009;119(10):3000-10.
    • (2009) J Clin Invest , vol.119 , Issue.10 , pp. 3000-3010
    • Regales, L.1    Gong, Y.2    Shen, R.3    De Stanchina, E.4    Vivanco, I.5    Goel, A.6
  • 5
    • 84856808226 scopus 로고    scopus 로고
    • World bispecific antibody summit, September 27-28, 2011, boston, MA
    • Dhimolea E, Reichert JM. World bispecific antibody summit, September 27-28, 2011, Boston, MA. mAbs. 2012;4(1):4-13.
    • (2012) MAbs. , vol.4 , Issue.1 , pp. 4-13
    • Dhimolea, E.1    Reichert, J.M.2
  • 6
    • 84926348347 scopus 로고    scopus 로고
    • Alternative molecular formats and therapeutic applications for bispecific antibodies
    • Spiess C, Zhai Q, Carter PJ. Alternative molecular formats and therapeutic applications for bispecific antibodies. Mol Immunol. 2015;67(2):95-106.
    • (2015) Mol Immunol. , vol.67 , Issue.2 , pp. 95-106
    • Spiess, C.1    Zhai, Q.2    Carter, P.J.3
  • 7
    • 77951523463 scopus 로고    scopus 로고
    • Bispecific antibodies for cancer therapy
    • Chames P, Baty D. Bispecific antibodies for cancer therapy. mAbs. 2009;1(6):539-47.
    • (2009) MAbs. , vol.1 , Issue.6 , pp. 539-547
    • Chames, P.1    Baty, D.2
  • 9
    • 77956344338 scopus 로고    scopus 로고
    • Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM × anti-CD3) as a targeted cancer immunotherapy
    • Seimetz D, Lindhofer H, Bokemeyer C. Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM × anti-CD3) as a targeted cancer immunotherapy. Cancer Treat Rev. 2010;36(6):458-67.
    • (2010) Cancer Treat Rev. , vol.36 , Issue.6 , pp. 458-467
    • Seimetz, D.1    Lindhofer, H.2    Bokemeyer, C.3
  • 10
    • 84889850198 scopus 로고    scopus 로고
    • Knobs-intoholes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity
    • Shatz W, Chung S, Li B, Marshall B, Tejada M, Phung W, et al. Knobs-intoholes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity. mAbs. 2013;5(6):872-81.
    • (2013) MAbs. , vol.5 , Issue.6 , pp. 872-881
    • Shatz, W.1    Chung, S.2    Li, B.3    Marshall, B.4    Tejada, M.5    Phung, W.6
  • 12
    • 84897065464 scopus 로고    scopus 로고
    • Glycosylation analysis of an aggregated antibody produced by Chinese hamster ovary cells in bioreactor culture
    • Onitsuka M, Kawaguchi A, Asano R, Kumagai I, Honda K, Ohtake H, et al. Glycosylation analysis of an aggregated antibody produced by Chinese hamster ovary cells in bioreactor culture. J Biosci Bioeng. 2014;117(5):639-44.
    • (2014) J Biosci Bioeng. , vol.117 , Issue.5 , pp. 639-644
    • Onitsuka, M.1    Kawaguchi, A.2    Asano, R.3    Kumagai, I.4    Honda, K.5    Ohtake, H.6
  • 13
    • 79960592856 scopus 로고    scopus 로고
    • Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
    • Schaefer W, Regula JT, Bähner M, Schanzer J, Croasdale R, Dürr H, et al. Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies. Proc Natl Acad Sci. 2011;108(27):11187-92.
    • (2011) Proc Natl Acad Sci. , vol.108 , Issue.27 , pp. 11187-11192
    • Schaefer, W.1    Regula, J.T.2    Bähner, M.3    Schanzer, J.4    Croasdale, R.5    Dürr, H.6
  • 14
    • 84890667775 scopus 로고    scopus 로고
    • Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy
    • Kienast Y, Klein C, Scheuer W, Raemsch R, Lorenzon E, Bernicke D, et al. Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy. Clin Cancer Res. 2013;19(24):6730-40.
    • (2013) Clin Cancer Res. , vol.19 , Issue.24 , pp. 6730-6740
    • Kienast, Y.1    Klein, C.2    Scheuer, W.3    Raemsch, R.4    Lorenzon, E.5    Bernicke, D.6
  • 15
    • 84893859920 scopus 로고    scopus 로고
    • Generation of bispecific IgG antibodies by structure-based design of an orthogonal fab interface
    • Lewis SM, Wu X, Pustilnik A, Sereno A, Huang F, Rick HL, et al. Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat Biotechnol. 2014;32(2):191-8.
    • (2014) Nat Biotechnol. , vol.32 , Issue.2 , pp. 191-198
    • Lewis, S.M.1    Wu, X.2    Pustilnik, A.3    Sereno, A.4    Huang, F.5    Rick, H.L.6
  • 16
    • 77951520735 scopus 로고    scopus 로고
    • Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules
    • Wu C, Ying H, Bose S, Miller R, Medina L, Santora L, et al. Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules. mAbs. 2009;1(4):339-47.
    • (2009) MAbs. , vol.1 , Issue.4 , pp. 339-347
    • Wu, C.1    Ying, H.2    Bose, S.3    Miller, R.4    Medina, L.5    Santora, L.6
  • 17
    • 84988630132 scopus 로고    scopus 로고
    • TM) technology: A versatile, novel format for the next generation of dual-targeting biologics
    • Kontermann RE, editor. Berlin, Heidelberg: Springer Berlin Heidelberg
    • TM) technology: a versatile, novel format for the next generation of dual-targeting biologics. In: Kontermann RE, editor. Bispecific Antibodies. Berlin, Heidelberg: Springer Berlin Heidelberg; 2011. p. 171-85.
    • (2011) Bispecific Antibodies , pp. 171-185
    • Tarcsa, E.1    Fraunhofer, W.2    Ghayur, T.3    Salfeld, J.4    Gu, J.5
  • 18
    • 84878834722 scopus 로고    scopus 로고
    • Two-in-one antibodies with dual action fabs
    • Eigenbrot C, Fuh G. Two-in-one antibodies with dual action Fabs. Curr Opin Chem Biol. 2013;17(3):400-5.
    • (2013) Curr Opin Chem Biol. , vol.17 , Issue.3 , pp. 400-405
    • Eigenbrot, C.1    Fuh, G.2
  • 20
    • 84923247651 scopus 로고    scopus 로고
    • Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG
    • Fischer N, Elson G, Magistrelli G, Dheilly E, Fouque N, Laurendon A, et al. Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG. Nat Commun. 2015;6:6113.
    • (2015) Nat Commun. , vol.6 , pp. 6113
    • Fischer, N.1    Elson, G.2    Magistrelli, G.3    Dheilly, E.4    Fouque, N.5    Laurendon, A.6
  • 21
    • 0032801102 scopus 로고    scopus 로고
    • Di-, tri- and tetrameric single chain Fv antibody fragments against human CD19: Effect of valency on cell binding
    • Le Gall F, Kipriyanov SM, Moldenhauer G, Little M. Di-, tri- and tetrameric single chain Fv antibody fragments against human CD19: effect of valency on cell binding. FEBS Lett. 1999;453(1-2):164-8.
    • (1999) FEBS Lett. , vol.453 , Issue.1-2 , pp. 164-168
    • Le Gall, F.1    Kipriyanov, S.M.2    Moldenhauer, G.3    Little, M.4
  • 22
    • 79955970356 scopus 로고    scopus 로고
    • Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma
    • Moore PA, Zhang W, Rainey GJ, Burke S, Li H, Huang L, et al. Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma. Blood. 2011;117(17):4542-51.
    • (2011) Blood , vol.117 , Issue.17 , pp. 4542-4551
    • Moore, P.A.1    Zhang, W.2    Rainey, G.J.3    Burke, S.4    Li, H.5    Huang, L.6
  • 23
    • 84922391726 scopus 로고    scopus 로고
    • Bispecific antibodies rise again
    • Garber K. Bispecific antibodies rise again. Nat Rev Drug Discov. 2014;13(11):799-801.
    • (2014) Nat Rev Drug Discov. , vol.13 , Issue.11 , pp. 799-801
    • Garber, K.1
  • 25
    • 0035831483 scopus 로고    scopus 로고
    • Camel single-domain antibodies as modular building units in bispecific and bivalent antibody constructs
    • Conrath KE, Lauwereys M, Wyns L, Muyldermans S. Camel single-domain antibodies as modular building units in Bispecific and bivalent antibody constructs. J Biol Chem. 2001;276(10):7346-50.
    • (2001) J Biol Chem. , vol.276 , Issue.10 , pp. 7346-7350
    • Conrath, K.E.1    Lauwereys, M.2    Wyns, L.3    Muyldermans, S.4
  • 26
    • 37649020163 scopus 로고    scopus 로고
    • Multifunctional antibodies by the dock-and-lock method for improved cancer imaging and therapy by pretargeting
    • Goldenberg DM, Rossi EA, Sharkey RM, McBride WJ, Chang C-H. Multifunctional antibodies by the dock-and-lock method for improved cancer imaging and therapy by pretargeting. J Nucl Med. 2008;49(1):158-63.
    • (2008) J Nucl Med. , vol.49 , Issue.1 , pp. 158-163
    • Goldenberg, D.M.1    Rossi, E.A.2    Sharkey, R.M.3    McBride, W.J.4    Chang, C.-H.5
  • 27
    • 82755197856 scopus 로고    scopus 로고
    • Strategies for extended serum half-life of protein therapeutics
    • Kontermann RE. Strategies for extended serum half-life of protein therapeutics. Curr Opin Biotechnol. 2011;22(6):868-76.
    • (2011) Curr Opin Biotechnol. , vol.22 , Issue.6 , pp. 868-876
    • Kontermann, R.E.1
  • 28
    • 55749111387 scopus 로고    scopus 로고
    • The pharmacology of PEGylation: Balancing PD with PK to generate novel therapeutics
    • Fishburn CS. The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics. J Pharm Sci. 2008;97(10):4167-83.
    • (2008) J Pharm Sci. , vol.97 , Issue.10 , pp. 4167-4183
    • Fishburn, C.S.1
  • 30
    • 84926456239 scopus 로고    scopus 로고
    • AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells
    • Fan D, Li Z, Zhang X, Yang Y, Yuan X, Zhang X, et al. AntiCD3Fv fused to human interleukin-3 deletion variant redirected T cells against human acute myeloid leukemic stem cells. J Hematol Oncol. 2015;8(1):18.
    • (2015) J Hematol Oncol. , vol.8 , Issue.1 , pp. 18
    • Fan, D.1    Li, Z.2    Zhang, X.3    Yang, Y.4    Yuan, X.5    Zhang, X.6
  • 31
    • 84875955851 scopus 로고    scopus 로고
    • Redirection of T-cell effector functions for cancer therapy: Bispecific antibodies and chimeric antigen receptors
    • Satta A, Mezzanzanica D, Turatti F, Canevari S, Figini M. Redirection of T-cell effector functions for cancer therapy: bispecific antibodies and chimeric antigen receptors. Future Oncol. 2013;9(4):527-39.
    • (2013) Future Oncol. , vol.9 , Issue.4 , pp. 527-539
    • Satta, A.1    Mezzanzanica, D.2    Turatti, F.3    Canevari, S.4    Figini, M.5
  • 32
    • 84939464191 scopus 로고    scopus 로고
    • Clinical overview of anti-CD19 BiTE® and ex vivo data from anti-CD33 BiTE® as examples for retargeting T cells in hematologic malignancies
    • Zugmaier G, Klinger M, Schmidt M, Subklewe M. Clinical overview of anti-CD19 BiTE® and ex vivo data from anti-CD33 BiTE® as examples for retargeting T cells in hematologic malignancies. Mol Immunol. 2015;67(2):58-66.
    • (2015) Mol Immunol. , vol.67 , Issue.2 , pp. 58-66
    • Zugmaier, G.1    Klinger, M.2    Schmidt, M.3    Subklewe, M.4
  • 33
    • 0029063312 scopus 로고
    • Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a singlestep purification of bispecific antibodies
    • Lindhofer H, Mocikat R, Steipe B, Thierfelder S. Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a singlestep purification of bispecific antibodies. J Immunol. 1995;155(1):219-25.
    • (1995) J Immunol. , vol.155 , Issue.1 , pp. 219-225
    • Lindhofer, H.1    Mocikat, R.2    Steipe, B.3    Thierfelder, S.4
  • 35
    • 84909639757 scopus 로고    scopus 로고
    • Tumor-antigen-binding bispecific antibodies for cancer treatment
    • Weidle UH, Kontermann RE, Brinkmann U. Tumor-antigen-binding bispecific antibodies for cancer treatment. Semin Oncol. 2014;41(5):653-60.
    • (2014) Semin Oncol. , vol.41 , Issue.5 , pp. 653-660
    • Weidle, U.H.1    Kontermann, R.E.2    Brinkmann, U.3
  • 36
    • 66249126868 scopus 로고    scopus 로고
    • The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2
    • Jäger M, Schoberth A, Ruf P, Hess J, Lindhofer H. The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2. Cancer Res. 2009;69(10):4270-6.
    • (2009) Cancer Res. , vol.69 , Issue.10 , pp. 4270-4276
    • Jäger, M.1    Schoberth, A.2    Ruf, P.3    Hess, J.4    Lindhofer, H.5
  • 38
    • 47249143734 scopus 로고    scopus 로고
    • Bi20 (fBTA05), a novel trifunctional bispecific antibody (anti-CD20 × anti-CD3), mediates efficient killing of B-cell lymphoma cells even with very low CD20 expression levels
    • Stanglmaier M, Faltin M, Ruf P, Bodenhausen A, Schröder P, Lindhofer H. Bi20 (fBTA05), a novel trifunctional bispecific antibody (anti-CD20 × anti-CD3), mediates efficient killing of B-cell lymphoma cells even with very low CD20 expression levels. Int J Cancer. 2008;123(5):1181-9.
    • (2008) Int J Cancer , vol.123 , Issue.5 , pp. 1181-1189
    • Stanglmaier, M.1    Faltin, M.2    Ruf, P.3    Bodenhausen, A.4    Schröder, P.5    Lindhofer, H.6
  • 39
    • 84899473907 scopus 로고    scopus 로고
    • A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies
    • Breton CS, Nahimana A, Aubry D, Macoin J, Moretti P, Bertschinger M, et al. A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies. J Hematol Oncol. 2014;7(1):33.
    • (2014) J Hematol Oncol. , vol.7 , Issue.1 , pp. 33
    • Breton, C.S.1    Nahimana, A.2    Aubry, D.3    Macoin, J.4    Moretti, P.5    Bertschinger, M.6
  • 40
    • 84949188009 scopus 로고    scopus 로고
    • FDA approves first bispecific
    • Mullard A. FDA approves first bispecific. Nat Rev Drug Discov. 2014;14(1):7.
    • (2014) Nat Rev Drug Discov. , vol.14 , Issue.1 , pp. 7
    • Mullard, A.1
  • 42
    • 84938628792 scopus 로고    scopus 로고
    • Blinatumomab: A bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia
    • Wu J, Fu J, Zhang M, Liu D. Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia. J Hematol Oncol. 2015;8(1):111.
    • (2015) J Hematol Oncol. , vol.8 , Issue.1 , pp. 111
    • Wu, J.1    Fu, J.2    Zhang, M.3    Liu, D.4
  • 43
    • 84943302629 scopus 로고    scopus 로고
    • Increase of PD-L1 expressing B-precursor ALL cells in a patient resistant to the CD19/CD3-bispecific T cell engager antibody blinatumomab
    • Köhnke T, Krupka C, Tischer J, Knösel T, Subklewe M. Increase of PD-L1 expressing B-precursor ALL cells in a patient resistant to the CD19/CD3-bispecific T cell engager antibody blinatumomab. J Hematol Oncol. 2015;8(1):111.
    • (2015) J Hematol Oncol. , vol.8 , Issue.1 , pp. 111
    • Köhnke, T.1    Krupka, C.2    Tischer, J.3    Knösel, T.4    Subklewe, M.5
  • 44
    • 84938848237 scopus 로고    scopus 로고
    • Bispecific antibodies, nanoparticles and cells: Bringing the right cells to get the job done
    • Tang J, Shen D, Zhang J, Ligler FS, Cheng K. Bispecific antibodies, nanoparticles and cells: bringing the right cells to get the job done. Expert Opin Biol Ther. 2015;15(9):1251-5.
    • (2015) Expert Opin Biol Ther. , vol.15 , Issue.9 , pp. 1251-1255
    • Tang, J.1    Shen, D.2    Zhang, J.3    Ligler, F.S.4    Cheng, K.5
  • 45
    • 79955979077 scopus 로고    scopus 로고
    • DARTs take aim at BiTEs
    • Rader C. DARTs take aim at BiTEs. Blood. 2011;117(17):4403-4.
    • (2011) Blood , vol.117 , Issue.17 , pp. 4403-4404
    • Rader, C.1
  • 47
    • 84969371816 scopus 로고    scopus 로고
    • Abstract 669: Development of MGD007, a gpA33 x CD3 bi-specific DART for T-cell immunotherapy of metastatic colorectal cancer
    • Moore PA, Alderson R, Shah K, Yang Y, Burke S, Li H, et al. Abstract 669: development of MGD007, a gpA33 x CD3 bi-specific DART for T-cell immunotherapy of metastatic colorectal cancer. Cancer Res. 2014;74 Suppl 19:669.
    • (2014) Cancer Res. , vol.74 , pp. 669
    • Moore, P.A.1    Alderson, R.2    Shah, K.3    Yang, Y.4    Burke, S.5    Li, H.6
  • 49
    • 84938574282 scopus 로고    scopus 로고
    • AFM13: A first-in-class tetravalent bispecific anti-CD30/CD16A antibody for NK cell-mediated immunotherapy
    • Wu J, Fu J, Zhang M, Liu D. AFM13: a first-in-class tetravalent bispecific anti-CD30/CD16A antibody for NK cell-mediated immunotherapy. J Hematol Oncol. 2015;8(1):96.
    • (2015) J Hematol Oncol. , vol.8 , Issue.1 , pp. 96
    • Wu, J.1    Fu, J.2    Zhang, M.3    Liu, D.4
  • 50
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer. 2004;4(5):361-70.
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 51
    • 84859409756 scopus 로고    scopus 로고
    • Antitumor activity of a novel bispecific antibody that targets the Erbb2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3
    • McDonagh CF, Huhalov A, Harms BD, Adams S, Paragas V, Oyama S, et al. Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 Oncogenic unit and inhibits Heregulin-induced activation of ErbB3. Mol Cancer Ther. 2012;11(3):582-93.
    • (2012) Mol Cancer Ther. , vol.11 , Issue.3 , pp. 582-593
    • McDonagh, C.F.1    Huhalov, A.2    Harms, B.D.3    Adams, S.4    Paragas, V.5    Oyama, S.6
  • 52
    • 84894145210 scopus 로고    scopus 로고
    • MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors
    • Fitzgerald JB, Johnson BW, Baum J, Adams S, Iadevaia S, Tang J, et al. MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors. Mol Cancer Ther. 2014;13(2):410-25.
    • (2014) Mol Cancer Ther. , vol.13 , Issue.2 , pp. 410-425
    • Fitzgerald, J.B.1    Johnson, B.W.2    Baum, J.3    Adams, S.4    Iadevaia, S.5    Tang, J.6
  • 53
    • 84930536940 scopus 로고    scopus 로고
    • Duligotuzumab. Human anti-EGFR/anti-HER3 MAb, colorectal cancer therapy, head and neck cancer therapy
    • Cole P. Duligotuzumab. Human anti-EGFR/anti-HER3 MAb, colorectal cancer therapy, head and neck cancer therapy. Drugs Future. 2015;40(3):167.
    • (2015) Drugs Future. , vol.40 , Issue.3 , pp. 167
    • Cole, P.1
  • 54
    • 84920935911 scopus 로고    scopus 로고
    • Randomized phase II study of mehd7945a (mehd) vs cetuximab (cet) in > = 2nd-line recurrent/metastatic squamous cell carcinoma of the head & neck (rmscchn) progressive on/after platinum-based chemotherapy (ptct)
    • Fayette J, Wirth LJ, Oprean C, Hitt R, Udrea A, Jimeno A, et al. Randomized phase II study of Mehd7945a (mehd) vs cetuximab (cet) in > = 2nd-line recurrent/metastatic squamous cell carcinoma of the head & neck (rmscchn) progressive on/after platinum-based chemotherapy (ptct). Ann Oncol. 2014;25 suppl 4:iv340.
    • (2014) Ann Oncol. , vol.25 , pp. iv340
    • Fayette, J.1    Wirth, L.J.2    Oprean, C.3    Hitt, R.4    Udrea, A.5    Jimeno, A.6
  • 55
    • 84988542316 scopus 로고    scopus 로고
    • 989pdphase 1b study of MEHD7945A (mehd) plus cisplatin/Fluorouracil (cis/5fu) or carboplatin/Paclitaxel (carbo/Pac) for 1st-line treatment of Recurrent/Metastatic squamous cell carcinoma of head and neck (rmscchn)
    • Clement PM, Machiels JP, Wirth L, Specenier P, Seiwert T, Mardjuadi F, et al. 989pdphase 1b study of MEHD7945A (mehd) Plus Cisplatin/Fluorouracil (cis/5fu) or Carboplatin/Paclitaxel (carbo/Pac) for 1st-Line Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck (rmscchn). Ann Oncol. 2014;25(suppl 4):iv341-iv341.
    • (2014) Ann Oncol. , vol.25 , pp. iv341-iv341
    • Clement, P.M.1    Machiels, J.P.2    Wirth, L.3    Specenier, P.4    Seiwert, T.5    Mardjuadi, F.6
  • 56
    • 0036488496 scopus 로고    scopus 로고
    • Specialization of tumour vasculature
    • Ruoslahti E. Specialization of tumour vasculature. Nat Rev Cancer. 2002;2(2):83-90.
    • (2002) Nat Rev Cancer , vol.2 , Issue.2 , pp. 83-90
    • Ruoslahti, E.1
  • 57
    • 84923003376 scopus 로고    scopus 로고
    • Targeting the angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference
    • Biel NM, Siemann DW. Targeting the angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference. Cancer Lett. doi:10.1016/j.canlet.2014.09.035
    • Cancer Lett.
    • Biel, N.M.1    Siemann, D.W.2
  • 58
    • 84923331797 scopus 로고    scopus 로고
    • Cytokines as therapeutic targets in rheumatoid arthritis and other inflammatory diseases
    • Siebert S, Tsoukas A, Robertson J, McInnes I. Cytokines as therapeutic targets in rheumatoid arthritis and other inflammatory diseases. Pharmacol Rev. 2015;67(2):280-309.
    • (2015) Pharmacol Rev. , vol.67 , Issue.2 , pp. 280-309
    • Siebert, S.1    Tsoukas, A.2    Robertson, J.3    McInnes, I.4
  • 59
    • 84880269392 scopus 로고    scopus 로고
    • How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy
    • Schett G, Elewaut D, McInnes IB, Dayer J-M, Neurath MF. How cytokine networks fuel inflammation: toward a cytokine-based disease taxonomy. Nat Med. 2013;19(7):822-4.
    • (2013) Nat Med. , vol.19 , Issue.7 , pp. 822-824
    • Schett, G.1    Elewaut, D.2    McInnes, I.B.3    Dayer, J.-M.4    Neurath, M.F.5
  • 60
    • 84891847947 scopus 로고    scopus 로고
    • Targeting interleukin-6 in inflammatory autoimmune diseases and cancers
    • Yao X, Huang J, Zhong H, Shen N, Faggioni R, Fung M, et al. Targeting interleukin-6 in inflammatory autoimmune diseases and cancers. Pharmacol Ther. 2014;141(5):125-39.
    • (2014) Pharmacol Ther. , vol.141 , Issue.5 , pp. 125-139
    • Yao, X.1    Huang, J.2    Zhong, H.3    Shen, N.4    Faggioni, R.5    Fung, M.6
  • 61
    • 84880257603 scopus 로고    scopus 로고
    • How cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases
    • Baeten DLP, Kuchroo VK. How cytokine networks fuel inflammation: interleukin-17 and a tale of two autoimmune diseases. Nat Med. 2013;19(7):824-5.
    • (2013) Nat Med. , vol.19 , Issue.7 , pp. 824-825
    • Baeten, D.L.P.1    Kuchroo, V.K.2
  • 62
    • 84866555886 scopus 로고    scopus 로고
    • From IL-2 to IL-37: The expanding spectrum of anti-inflammatory cytokines
    • Banchereau J, Pascual V, O'Garra A. From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat Immunol. 2012;13(10):925-31.
    • (2012) Nat Immunol. , vol.13 , Issue.10 , pp. 925-931
    • Banchereau, J.1    Pascual, V.2    O'Garra, A.3
  • 63
    • 84881513403 scopus 로고    scopus 로고
    • Monoclonal antibody treatments for rheumatoid arthritis
    • Bossaller L, Rothe A. Monoclonal antibody treatments for rheumatoid arthritis. Expert Opin Biol Ther. 2013;13(9):1257-72.
    • (2013) Expert Opin Biol Ther. , vol.13 , Issue.9 , pp. 1257-1272
    • Bossaller, L.1    Rothe, A.2
  • 64
    • 84892716254 scopus 로고    scopus 로고
    • Small nanobody drugs win big backing from pharma
    • Williams SC. Small nanobody drugs win big backing from pharma. Nat Med. 2013;19(11):1355-6.
    • (2013) Nat Med. , vol.19 , Issue.11 , pp. 1355-1356
    • Williams, S.C.1
  • 67
    • 84903780105 scopus 로고    scopus 로고
    • InterMune and boehringer blaze trails for idiopathic pulmonary fibrosis drugs
    • Kingwell K. InterMune and Boehringer blaze trails for idiopathic pulmonary fibrosis drugs. Nat Rev Drug Discov. 2014;13(7):483-4.
    • (2014) Nat Rev Drug Discov. , vol.13 , Issue.7 , pp. 483-484
    • Kingwell, K.1
  • 69
    • 79957683054 scopus 로고    scopus 로고
    • Bispecific digoxigenin-binding antibodies for targeted payload delivery
    • Metz S, Haas AK, Daub K, Croasdale R, Stracke J, Lau W, et al. Bispecific digoxigenin-binding antibodies for targeted payload delivery. Proc Natl Acad Sci. 2011;108(20):8194-9.
    • (2011) Proc Natl Acad Sci. , vol.108 , Issue.20 , pp. 8194-8199
    • Metz, S.1    Haas, A.K.2    Daub, K.3    Croasdale, R.4    Stracke, J.5    Lau, W.6
  • 71
    • 84864539893 scopus 로고    scopus 로고
    • Phase I clinical study of the feasibility of pretargeted radioimmunotherapy (PT-RAIT) in patients with colorectal cancer (CRC): First results
    • Schoffelen R, Boerman O, Van Der GW, Van HC, Sharkey R, McBride W, et al. Phase I clinical study of the feasibility of pretargeted radioimmunotherapy (PT-RAIT) in patients with colorectal cancer (CRC): first results. J Nucl Med. 2011;52 suppl 1:358.
    • (2011) J Nucl Med. , vol.52 , pp. 358
    • Schoffelen, R.1    Boerman, O.2    Van Der, G.W.3    Van, H.C.4    Sharkey, R.5    McBride, W.6
  • 72
    • 84907982724 scopus 로고    scopus 로고
    • Engineering and pharmacology of blood-brain barrier-permeable bispecific antibodies
    • Stanimirovic D, Kemmerich K, Haqqani AS, Farrington GK: Engineering and pharmacology of blood-brain barrier-permeable bispecific antibodies. Adv Pharmacol. 2014;71:301-335.
    • (2014) Adv Pharmacol. , vol.71 , pp. 301-335
    • Stanimirovic, D.1    Kemmerich, K.2    Haqqani, A.S.3    Farrington, G.K.4
  • 73
    • 84878276906 scopus 로고    scopus 로고
    • Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier
    • Couch JA, Yu YJ, Zhang Y, Tarrant JM, Fuji RN, Meilandt WJ, et al. Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier. Sci Transl Med. 2013;5(183):183ra57.
    • (2013) Sci Transl Med. , vol.5 , Issue.183 , pp. 183ra57
    • Couch, J.A.1    Yu, Y.J.2    Zhang, Y.3    Tarrant, J.M.4    Fuji, R.N.5    Meilandt, W.J.6
  • 74
    • 79957452852 scopus 로고    scopus 로고
    • A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
    • Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y, et al. A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo. Sci Transl Med. 2011;3(84):84ra43.
    • (2011) Sci Transl Med. , vol.3 , Issue.84 , pp. 84ra43
    • Atwal, J.K.1    Chen, Y.2    Chiu, C.3    Mortensen, D.L.4    Meilandt, W.J.5    Liu, Y.6
  • 75
    • 84886099419 scopus 로고    scopus 로고
    • A tale of two specificities: Bispecific antibodies for therapeutic and diagnostic applications
    • Hannah Byrne PJC. A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications. Trends Biotechnol. 2013;31:11.
    • (2013) Trends Biotechnol. , vol.31 , pp. 11
    • Hannah Byrne, P.J.C.1
  • 76
    • 0020518331 scopus 로고
    • Hybrid hybridomas and their use in immunohistochemistry
    • Milstein C, Cuello AC. Hybrid hybridomas and their use in immunohistochemistry. Nature. 1983;305(5934):537-40.
    • (1983) Nature , vol.305 , Issue.5934 , pp. 537-540
    • Milstein, C.1    Cuello, A.C.2
  • 77
    • 0022998719 scopus 로고
    • Advantages of bispecific hybridomas in one-step immunocytochemistry and immunoassays
    • Suresh MR, Cuello AC, Milstein C. Advantages of bispecific hybridomas in one-step immunocytochemistry and immunoassays. Proc Natl Acad Sci. 1986;83(20):7989-93.
    • (1986) Proc Natl Acad Sci. , vol.83 , Issue.20 , pp. 7989-7993
    • Suresh, M.R.1    Cuello, A.C.2    Milstein, C.3
  • 79
    • 84925962821 scopus 로고    scopus 로고
    • Infectious diseases: Two-hit antibody tackles bacteria
    • Kingwell K. Infectious diseases: two-hit antibody tackles bacteria. Nat Rev Drug Discov. 2015;14(1):15.
    • (2015) Nat Rev Drug Discov. , vol.14 , Issue.1 , pp. 15
    • Kingwell, K.1
  • 80
    • 0025753131 scopus 로고
    • Bispecific antibodies that mediate killing of cells infected with human immunodeficiency virus of any strain
    • Berg J, Lötscher E, Steimer KS, Capon DJ, Baenziger J, Jäck HM, et al. Bispecific antibodies that mediate killing of cells infected with human immunodeficiency virus of any strain. Proc Natl Acad Sci. 1991;88(11):4723-7.
    • (1991) Proc Natl Acad Sci. , vol.88 , Issue.11 , pp. 4723-4727
    • Berg, J.1    Lötscher, E.2    Steimer, K.S.3    Capon, D.J.4    Baenziger, J.5    Jäck, H.M.6
  • 81
    • 0012870750 scopus 로고    scopus 로고
    • Generation and characterization of a novel tetravalent bispecific antibody that binds to hepatitis B virus surface antigens
    • Park SS, Ryu CJ, Kang YJ, Kashmiri SVS, Hong HJ. Generation and characterization of a novel tetravalent bispecific antibody that binds to hepatitis B virus surface antigens. Mol Immunol. 2000;37(18):1123-30.
    • (2000) Mol Immunol. , vol.37 , Issue.18 , pp. 1123-1130
    • Park, S.S.1    Ryu, C.J.2    Kang, Y.J.3    Kashmiri, S.V.S.4    Hong, H.J.5
  • 82
    • 0031572506 scopus 로고    scopus 로고
    • Bispecific monoclonal antibody complexes facilitate erythrocyte binding and liver clearance of a prototype particulate pathogen in a monkey model
    • Taylor RP, Martin EN, Reinagel ML, Nardin A, Craig M, Choice Q, et al. Bispecific monoclonal antibody complexes facilitate erythrocyte binding and liver clearance of a prototype particulate pathogen in a monkey model. J Immunol. 1997;159(8):4035-44.
    • (1997) J Immunol. , vol.159 , Issue.8 , pp. 4035-4044
    • Taylor, R.P.1    Martin, E.N.2    Reinagel, M.L.3    Nardin, A.4    Craig, M.5    Choice, Q.6
  • 83
    • 84942853133 scopus 로고    scopus 로고
    • Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patientderived B-ALL cells
    • Fan D, Li W, Yang Y, Zhang X, Zhang Q, Yan Y, et al. Redirection of CD4+ and CD8+ T lymphocytes via an anti-CD3 × anti-CD19 bi-specific antibody combined with cytosine arabinoside and the efficient lysis of patientderived B-ALL cells. J Hematol Oncol. 2015;8(1):108.
    • (2015) J Hematol Oncol. , vol.8 , Issue.1 , pp. 108
    • Fan, D.1    Li, W.2    Yang, Y.3    Zhang, X.4    Zhang, Q.5    Yan, Y.6


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