메뉴 건너뛰기




Volumn 10, Issue 1, 2017, Pages 1-11

Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma

Author keywords

CART cocktail immunotherapy; CD133; Cholangiocarcinoma; EGFR

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIBIOTIC AGENT; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CA 19-9 ANTIGEN; CD133 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; ETANERCEPT; IMMUNOGLOBULIN; INTERLEUKIN 6; METHYLPREDNISOLONE; NIVOLUMAB; PACLITAXEL; TUMOR NECROSIS FACTOR; EGFR PROTEIN, HUMAN;

EID: 85008425546     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-016-0378-7     Document Type: Article
Times cited : (189)

References (38)
  • 1
    • 84902786936 scopus 로고    scopus 로고
    • Cholangiocarcinoma
    • Nataliya R, Gores GJ. Cholangiocarcinoma. Lancet. 2014;383:2168-79.
    • (2014) Lancet , vol.383 , pp. 2168-2179
    • Nataliya, R.1    Gores, G.J.2
  • 3
    • 84878056257 scopus 로고    scopus 로고
    • Advances in the management of biliary tract cancers
    • 23416860 3713630
    • Ciombor KK, Goff LW. Advances in the management of biliary tract cancers. Clin Adv Hematol Oncol. 2013;11(1):28-34.
    • (2013) Clin Adv Hematol Oncol , vol.11 , Issue.1 , pp. 28-34
    • Ciombor, K.K.1    Goff, L.W.2
  • 4
    • 84939219427 scopus 로고    scopus 로고
    • Targeted therapy in biliary tract cancers
    • 26266637 4534500
    • Merla A, Liu KG, Rajdev L. Targeted therapy in biliary tract cancers. Curr Treat Options Oncol. 2015;16(10):48.
    • (2015) Curr Treat Options Oncol , vol.16 , Issue.10 , pp. 48
    • Merla, A.1    Liu, K.G.2    Rajdev, L.3
  • 5
    • 84942549617 scopus 로고    scopus 로고
    • Recent advances for the treatment of pancreatic and biliary tract cancer after first-line treatment failure
    • 1:CAS:528:DC%2BC2MXhslCmsbzO 26325474
    • Onesti CE, Romiti A, Roberto M, Falcone R, Marchetti P. Recent advances for the treatment of pancreatic and biliary tract cancer after first-line treatment failure. Expert Rev Anticancer Ther. 2015;15(10):1183-98.
    • (2015) Expert Rev Anticancer Ther , vol.15 , Issue.10 , pp. 1183-1198
    • Onesti, C.E.1    Romiti, A.2    Roberto, M.3    Falcone, R.4    Marchetti, P.5
  • 6
    • 84941758827 scopus 로고    scopus 로고
    • Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia
    • 26451310 4590028
    • Dai H, Zhang W, Li X, Han Q, Guo Y, Zhang Y, et al. Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia. Oncoimmunology. 2015;4(11):e1027469.
    • (2015) Oncoimmunology , vol.4 , Issue.11 , pp. e1027469
    • Dai, H.1    Zhang, W.2    Li, X.3    Han, Q.4    Guo, Y.5    Zhang, Y.6
  • 7
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • 1:CAS:528:DC%2BC3sXmsFKgtLo%3D 23527958 4058440
    • Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med. 2013;368:1509-18.
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3    Aplenc, R.4    Porter, D.L.5    Rheingold, S.R.6
  • 8
    • 84876005284 scopus 로고    scopus 로고
    • CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy refractory acute lymphoblastic leukemia
    • 23515080 3742551
    • Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, Cowell LG, et al. CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy refractory acute lymphoblastic leukemia. Sci Transl Med. 2013;5(177):177ra38.
    • (2013) Sci Transl Med , vol.5 , Issue.177 , pp. 177ra38
    • Brentjens, R.J.1    Davila, M.L.2    Riviere, I.3    Park, J.4    Wang, X.5    Cowell, L.G.6
  • 9
    • 84890827981 scopus 로고    scopus 로고
    • Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
    • 1:CAS:528:DC%2BC3sXhvFOqsr7P 24055823 3862276
    • Kochenderfer JN, Dudley ME, Carpenter RO, Kassim SH, Rose JJ, Telford WG, et al. Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood. 2013;122:4129-39.
    • (2013) Blood , vol.122 , pp. 4129-4139
    • Kochenderfer, J.N.1    Dudley, M.E.2    Carpenter, R.O.3    Kassim, S.H.4    Rose, J.J.5    Telford, W.G.6
  • 10
    • 84979268324 scopus 로고    scopus 로고
    • Chimeric antigen receptors modified T-cells for cancer therapy
    • djv439
    • Dai H, Wang Y, Lu X, Han W. Chimeric antigen receptors modified T-cells for cancer therapy. J Natl Cancer Inst. 2016; 108(7). doi: 10.1093/jnci/djv439.
    • (2016) J Natl Cancer Inst , vol.108 , Issue.7
    • Dai, H.1    Wang, Y.2    Han, W.3
  • 11
    • 84967145937 scopus 로고    scopus 로고
    • Making better chimeric antigen receptors for adoptive T-cell therapy
    • 1:CAS:528:DC%2BC28XmsFeqs7s%3D 27084741
    • Maus MV, June CH. Making better chimeric antigen receptors for adoptive T-cell therapy. Clin Cancer Res. 2016;22(8):1875-84.
    • (2016) Clin Cancer Res , vol.22 , Issue.8 , pp. 1875-1884
    • Maus, M.V.1    June, C.H.2
  • 12
    • 84903537674 scopus 로고    scopus 로고
    • Gemcitabine and oxaliplatin with or without cetuximab in advanced biliary-tract cancer (BINGO): a randomised, open-label, non-comparative phase 2 trial
    • 1:CAS:528:DC%2BC2cXosFamsLo%3D 24852116
    • Malka D, Cervera P, Foulon S, Trarbach T, de la Fouchardière C, Boucher E, et al. Gemcitabine and oxaliplatin with or without cetuximab in advanced biliary-tract cancer (BINGO): a randomised, open-label, non-comparative phase 2 trial. Lancet Oncol. 2014;15(8):819-28.
    • (2014) Lancet Oncol , vol.15 , Issue.8 , pp. 819-828
    • Malka, D.1    Cervera, P.2    Foulon, S.3    Trarbach, T.4    De la Fouchardière, C.5    Boucher, E.6
  • 13
    • 84960326834 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer
    • 1:CAS:528:DC%2BC28XksVygsb4%3D 26968708
    • Feng K, Guo Y, Dai H, Wang Y, Li X, Jia H, et al. Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer. Sci China Life Sci. 2016;59(5):468-79.
    • (2016) Sci China Life Sci , vol.59 , Issue.5 , pp. 468-479
    • Feng, K.1    Guo, Y.2    Dai, H.3    Wang, Y.4    Li, X.5    Jia, H.6
  • 14
    • 84961942167 scopus 로고    scopus 로고
    • Chemotherapy targeting cancer stem cells
    • 1:CAS:528:DC%2BC28Xpsleiu7s%3D 26045975 4449424
    • Liu H, Lv L, Yang K. Chemotherapy targeting cancer stem cells. Am J Cancer Res. 2015;5(3):880-93.
    • (2015) Am J Cancer Res , vol.5 , Issue.3 , pp. 880-893
    • Liu, H.1    Lv, L.2    Yang, K.3
  • 15
    • 84945278283 scopus 로고    scopus 로고
    • Tumor microenvironment versus cancer stem cells in cholangiocarcinoma: synergistic effects?
    • 1:CAS:528:DC%2BC2MXhsFamt7rI 26357947
    • Romano M, De Francesco F, Gringeri E, Giordano A, Ferraro GA, Di Domenico M, et al. Tumor microenvironment versus cancer stem cells in cholangiocarcinoma: synergistic effects? J Cell Physiol. 2016;231(4):768-76.
    • (2016) J Cell Physiol , vol.231 , Issue.4 , pp. 768-776
    • Romano, M.1    De Francesco, F.2    Gringeri, E.3    Giordano, A.4    Ferraro, G.A.5    Di Domenico, M.6
  • 16
    • 84971260415 scopus 로고    scopus 로고
    • CD133, Selectively targeting the root of cancer. Toxins.
    • Schmohl JU, Vallera DA. CD133, Selectively targeting the root of cancer. Toxins. 2016;8(6). doi:10.3390/toxins8060165..
    • (2016) , vol.8 , Issue.6
    • Schmohl, J.U.1    Vallera, D.A.2
  • 17
    • 79961243719 scopus 로고    scopus 로고
    • Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia
    • 1:CAS:528:DC%2BC3MXjvVCltbg%3D 21385372 3226283
    • McGinley L, McMahon J, Strappe P, Barry F, Murphy M, O’Toole D, et al. Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia. Stem Cell Res Ther. 2011;2(2):12.
    • (2011) Stem Cell Res Ther , vol.2 , Issue.2 , pp. 12
    • McGinley, L.1    McMahon, J.2    Strappe, P.3    Barry, F.4    Murphy, M.5    O’Toole, D.6
  • 18
    • 84940881287 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
    • 26333935
    • Porter DL, Hwang WT, Frey NV, Lacey SF, Shaw PA, Loren AW, et al. Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Sci Transl Med. 2015;7(303):303ra139.
    • (2015) Sci Transl Med , vol.7 , Issue.303 , pp. 303ra139
    • Porter, D.L.1    Hwang, W.T.2    Frey, N.V.3    Lacey, S.F.4    Shaw, P.A.5    Loren, A.W.6
  • 19
    • 82955207691 scopus 로고    scopus 로고
    • Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
    • 1:CAS:528:DC%2BC3MXhs1ansb3O 21984804 3234664
    • Louis CU, Savoldo B, Dotti G, Pule M, Yvon E, Myers GD, et al. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood. 2011;118(23):6050-6.
    • (2011) Blood , vol.118 , Issue.23 , pp. 6050-6056
    • Louis, C.U.1    Savoldo, B.2    Dotti, G.3    Pule, M.4    Yvon, E.5    Myers, G.D.6
  • 20
    • 84974555520 scopus 로고    scopus 로고
    • CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients
    • 27111235 4887159
    • Turtle CJ, Hanafi LA, Berger C, Gooley TA, Cherian S, Hudecek M, et al. CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients. J Clin Invest. 2016;126(6):2123-38.
    • (2016) J Clin Invest , vol.126 , Issue.6 , pp. 2123-2138
    • Turtle, C.J.1    Hanafi, L.A.2    Berger, C.3    Gooley, T.A.4    Cherian, S.5    Hudecek, M.6
  • 21
    • 84923197176 scopus 로고    scopus 로고
    • Immune escape mechanisms as a guide for cancer immunotherapy
    • 1:CAS:528:DC%2BC2MXislGhtb4%3D 25501578
    • Beatty GL, Gladney WL. Immune escape mechanisms as a guide for cancer immunotherapy. Clin Cancer Res. 2015;21(4):687-92.
    • (2015) Clin Cancer Res , vol.21 , Issue.4 , pp. 687-692
    • Beatty, G.L.1    Gladney, W.L.2
  • 22
    • 84959529731 scopus 로고    scopus 로고
    • PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations
    • Zou W, Wolchok JD, Chen L. PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations. Sci Transl Med. 2016;8(328):328rv324.
    • (2016) Sci Transl Med , vol.8 , Issue.328 , pp. 328rv324
    • Zou, W.1    Wolchok, J.D.2    Chen, L.3
  • 23
    • 84905993539 scopus 로고    scopus 로고
    • Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors
    • 1:CAS:528:DC%2BC2cXhtlCltrzO 24919573 4134701
    • Moon EK, Wang LC, Dolfi DV, Wilson CB, Ranganathan R, Sun J, et al. Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors. Clin Cancer Res. 2014;20(16):4262-73.
    • (2014) Clin Cancer Res , vol.20 , Issue.16 , pp. 4262-4273
    • Moon, E.K.1    Wang, L.C.2    Dolfi, D.V.3    Wilson, C.B.4    Ranganathan, R.5    Sun, J.6
  • 24
    • 84857702419 scopus 로고    scopus 로고
    • Molecular pathways: hypoxia response in immune cells fighting or promoting cancer
    • 1:CAS:528:DC%2BC38Xjt1Wltr8%3D 22205687
    • Palazon A, Aragones J, Morales-Kastresana A, de Landazuri MO, Melero I. Molecular pathways: hypoxia response in immune cells fighting or promoting cancer. Clin Cancer Res. 2012;18(5):1207-13.
    • (2012) Clin Cancer Res , vol.18 , Issue.5 , pp. 1207-1213
    • Palazon, A.1    Aragones, J.2    Morales-Kastresana, A.3    De Landazuri, M.O.4    Melero, I.5
  • 25
    • 84960158712 scopus 로고    scopus 로고
    • Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?
    • 1:CAS:528:DC%2BC28Xkt1CktLY%3D 26951040
    • Bernstein MB, Krishnan S, Hodge JW, Chang JY. Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach? Nat Rev Clin Oncol. 2016;13(8):516-24.
    • (2016) Nat Rev Clin Oncol , vol.13 , Issue.8 , pp. 516-524
    • Bernstein, M.B.1    Krishnan, S.2    Hodge, J.W.3    Chang, J.Y.4
  • 26
    • 84922021366 scopus 로고    scopus 로고
    • Immune-priming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy
    • 1:CAS:528:DC%2BC2MXhs12ktbs%3D 25616204
    • Shahabi V, Postow MA, Tuck D, Wolchok JD. Immune-priming of the tumor microenvironment by radiotherapy: rationale for combination with immunotherapy to improve anticancer efficacy. Am J Clin Oncol. 2015;38(1):90-7.
    • (2015) Am J Clin Oncol , vol.38 , Issue.1 , pp. 90-97
    • Shahabi, V.1    Postow, M.A.2    Tuck, D.3    Wolchok, J.D.4
  • 27
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • 1:CAS:528:DC%2BC38XktFOgurw%3D 22397654 3345206
    • Postow MA, Callahan MK, Barker CA, Yamada Y, Yuan J, Kitano S, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366(10):925-31.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3    Yamada, Y.4    Yuan, J.5    Kitano, S.6
  • 28
    • 84937525789 scopus 로고    scopus 로고
    • Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumors: a proof-of-principle trial
    • 1:CAS:528:DC%2BC2MXhtVKhtb3F 26095785
    • Golden EB, Chhabra A, Chachoua A, Adams S, Donach M, Fenton-Kerimian M, et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumors: a proof-of-principle trial. Lancet Oncol. 2015;16(7):795-803.
    • (2015) Lancet Oncol , vol.16 , Issue.7 , pp. 795-803
    • Golden, E.B.1    Chhabra, A.2    Chachoua, A.3    Adams, S.4    Donach, M.5    Fenton-Kerimian, M.6
  • 29
    • 84904609350 scopus 로고    scopus 로고
    • Blockade of PD-1 immunosuppression boosts CAR T-cell therapy
    • 24353912 3862687
    • John LB, Kershaw MH, Darcy PK. Blockade of PD-1 immunosuppression boosts CAR T-cell therapy. Oncoimmunology. 2013;2(10):e26286.
    • (2013) Oncoimmunology , vol.2 , Issue.10 , pp. e26286
    • John, L.B.1    Kershaw, M.H.2    Darcy, P.K.3
  • 30
    • 84963621254 scopus 로고    scopus 로고
    • Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
    • 1:CAS:528:DC%2BC28XmtVOrurc%3D 27079802
    • Topalian SL, Taube JM, Anders RA, Pardoll DM. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer. 2016;16(5):275-87.
    • (2016) Nat Rev Cancer , vol.16 , Issue.5 , pp. 275-287
    • Topalian, S.L.1    Taube, J.M.2    Anders, R.A.3    Pardoll, D.M.4
  • 31
    • 84872185005 scopus 로고    scopus 로고
    • Recent advances in cancer stem cell research for cholangiocarcinoma
    • 22907641
    • Kokuryo T, Yokoyama Y, Nagino M. Recent advances in cancer stem cell research for cholangiocarcinoma. J Hepatobiliary Pancreat Sci. 2012;19(6):606-13.
    • (2012) J Hepatobiliary Pancreat Sci , vol.19 , Issue.6 , pp. 606-613
    • Kokuryo, T.1    Yokoyama, Y.2    Nagino, M.3
  • 33
    • 84861737097 scopus 로고    scopus 로고
    • Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy
    • 22387005
    • Shien K, Toyooka S, Ichimura K, Soh J, Furukawa M, Maki Y, et al. Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy. Lung Cancer. 2012;77(1):162-7.
    • (2012) Lung Cancer , vol.77 , Issue.1 , pp. 162-167
    • Shien, K.1    Toyooka, S.2    Ichimura, K.3    Soh, J.4    Furukawa, M.5    Maki, Y.6
  • 34
    • 84883866836 scopus 로고    scopus 로고
    • Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells
    • 23926201
    • Cameron BJ, Gerry AB, Dukes J, Harper JV, Kannan V, Bianchi FC, et al. Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells. Sci Transl Med. 2013;5(197):197ra103.
    • (2013) Sci Transl Med , vol.5 , Issue.197 , pp. 197ra103
    • Cameron, B.J.1    Gerry, A.B.2    Dukes, J.3    Harper, J.V.4    Kannan, V.5    Bianchi, F.C.6
  • 35
    • 84896335556 scopus 로고    scopus 로고
    • Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
    • 24553386 4684949
    • Davila ML, Riviere I, Wang X, Bartido S, Park J, Curran K, et al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med. 2014;6(224):224ra25.
    • (2014) Sci Transl Med , vol.6 , Issue.224 , pp. 224ra25
    • Davila, M.L.1    Riviere, I.2    Wang, X.3    Bartido, S.4    Park, J.5    Curran, K.6
  • 36
    • 84977477922 scopus 로고    scopus 로고
    • Toxicities of chimeric antigen receptor T cells: recognition and management
    • 1:CAS:528:DC%2BC28Xhs1entL%2FE 27207799
    • Brudno JN, Kochenderfer JN. Toxicities of chimeric antigen receptor T cells: recognition and management. Blood. 2016;127(26):3321-30.
    • (2016) Blood , vol.127 , Issue.26 , pp. 3321-3330
    • Brudno, J.N.1    Kochenderfer, J.N.2
  • 37
    • 84942907010 scopus 로고    scopus 로고
    • Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent antitumor activity
    • 1:CAS:528:DC%2BC2MXhsVWqtLnK 26330164 4624228
    • Caruso HG, Hurton LV, Najjar A, Rushworth D, Ang S, Olivares S, et al. Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent antitumor activity. Cancer Res. 2015;75(17):3505-18.
    • (2015) Cancer Res , vol.75 , Issue.17 , pp. 3505-3518
    • Caruso, H.G.1    Hurton, L.V.2    Najjar, A.3    Rushworth, D.4    Ang, S.5    Olivares, S.6
  • 38
    • 84978886867 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for the treatment of solid tumors: defining the challenges and next steps
    • 1:CAS:528:DC%2BC28XhtFSnsbvF 27373504
    • Beatty GL, O’Hara M. Chimeric antigen receptor-modified T cells for the treatment of solid tumors: defining the challenges and next steps. Pharmacol Ther. 2016;166:30-9.
    • (2016) Pharmacol Ther , vol.166 , pp. 30-39
    • Beatty, G.L.1    O’Hara, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.