-
1
-
-
52949140814
-
Making insulin-deficient type 1 diabetic rodents thrive without insulin
-
Yu X, Park BH, Wang MY, Wang ZV, Unger RH. Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci U S A. 2008;105(37):14070-14075.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, Issue.37
, pp. 14070-14075
-
-
Yu, X.1
Park, B.H.2
Wang, M.Y.3
Wang, Z.V.4
Unger, R.H.5
-
2
-
-
78049271280
-
Leptin therapy improves insulindeficient type 1 diabetes by CNS-dependent mechanisms in mice
-
Fujikawa T, Chuang JC, Sakata I, Ramadori G, Coppari R. Leptin therapy improves insulindeficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc Natl Acad Sci U S A. 2010;107(40):17391-17396.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, Issue.40
, pp. 17391-17396
-
-
Fujikawa, T.1
Chuang, J.C.2
Sakata, I.3
Ramadori, G.4
Coppari, R.5
-
3
-
-
18344374382
-
Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats
-
Hidaka S, et al. Chronic central leptin infusion restores hyperglycemia independent of food intake and insulin level in streptozotocin-induced diabetic rats. FASEB J. 2002;16(6):509-518.
-
(2002)
FASEB J.
, vol.16
, Issue.6
, pp. 509-518
-
-
Hidaka, S.1
-
4
-
-
0036084101
-
Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats
-
Lin CY, Higginbotham DA, Judd RL, White BD. Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2002;282(5):E1084-E1091.
-
(2002)
Am J Physiol Endocrinol Metab.
, vol.282
, Issue.5
, pp. E1084-E1091
-
-
Lin, C.Y.1
Higginbotham, D.A.2
Judd, R.L.3
White, B.D.4
-
5
-
-
84883483789
-
Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin
-
Fujikawa T, et al. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab. 2013;18(3):431-444.
-
(2013)
Cell Metab.
, vol.18
, Issue.3
, pp. 431-444
-
-
Fujikawa, T.1
-
6
-
-
84883172997
-
Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia
-
Meek TH, et al. Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia. Endocrinology. 2013;154(9):3067-3076.
-
(2013)
Endocrinology.
, vol.154
, Issue.9
, pp. 3067-3076
-
-
Meek, T.H.1
-
7
-
-
0033037727
-
Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat
-
Chinookoswong N, Wang JL, Shi ZQ. Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes. 1999;48(7):1487-1492.
-
(1999)
Diabetes.
, vol.48
, Issue.7
, pp. 1487-1492
-
-
Chinookoswong, N.1
Wang, J.L.2
Shi, Z.Q.3
-
8
-
-
77950373635
-
Leptin therapy in insulin-deficient type i diabetes
-
Wang MY, et al. Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci U S A. 2010;107(11):4813-4819.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, Issue.11
, pp. 4813-4819
-
-
Wang, M.Y.1
-
9
-
-
38149012112
-
Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: The effect of long-term leptin therapy
-
Park JY, et al. Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: The effect of long-term leptin therapy. J Clin Endocrinol Metab. 2008;93(1):26-31.
-
(2008)
J Clin Endocrinol Metab.
, vol.93
, Issue.1
, pp. 26-31
-
-
Park, J.Y.1
-
10
-
-
84962169651
-
Euglycemia restoration by central leptin in type 1 diabetes requires STAT3 signaling but not fast-acting neurotransmitter release
-
Xu Y, Chang JT, Myers MG, Xu Y, Tong Q. Euglycemia restoration by central leptin in type 1 diabetes requires STAT3 signaling but not fast-acting neurotransmitter release. Diabetes. 2016;65(4):1040-1049.
-
(2016)
Diabetes.
, vol.65
, Issue.4
, pp. 1040-1049
-
-
Xu, Y.1
Chang, J.T.2
Myers, M.G.3
Xu, Y.4
Tong, Q.5
-
11
-
-
84861819258
-
Malonyl-CoA: The regulator of fatty acid synthesis and oxidation
-
Foster DW. Malonyl-CoA: The regulator of fatty acid synthesis and oxidation. J Clin Invest. 2012;122(6):1958-1959.
-
(2012)
J Clin Invest.
, vol.122
, Issue.6
, pp. 1958-1959
-
-
Foster, D.W.1
-
12
-
-
84904000735
-
Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis
-
Perry RJ, et al. Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nat Med. 2014;20(7):759-763.
-
(2014)
Nat Med.
, vol.20
, Issue.7
, pp. 759-763
-
-
Perry, R.J.1
-
13
-
-
84948843974
-
Evidence against hypothalamic-pituitary-adrenal axis suppression in the antidiabetic action of leptin
-
Morton GJ, Meek TH, Matsen ME, Schwartz MW. Evidence against hypothalamic-pituitary-adrenal axis suppression in the antidiabetic action of leptin. J Clin Invest. 2015;125(12):4587-4591.
-
(2015)
J Clin Invest.
, vol.125
, Issue.12
, pp. 4587-4591
-
-
Morton, G.J.1
Meek, T.H.2
Matsen, M.E.3
Schwartz, M.W.4
-
14
-
-
84887995002
-
Development of small-molecule inhibitors targeting adipose triglyceride lipase
-
Mayer N, et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat Chem Biol. 2013;9(12):785-787.
-
(2013)
Nat Chem Biol.
, vol.9
, Issue.12
, pp. 785-787
-
-
Mayer, N.1
-
15
-
-
84922709227
-
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
-
Perry RJ, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 2015;160(4):745-758.
-
(2015)
Cell.
, vol.160
, Issue.4
, pp. 745-758
-
-
Perry, R.J.1
-
16
-
-
0017738601
-
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
-
McGarry JD, Mannaerts GP, Foster DW. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis. J Clin Invest. 1977;60(1):265-270.
-
(1977)
J Clin Invest.
, vol.60
, Issue.1
, pp. 265-270
-
-
McGarry, J.D.1
Mannaerts, G.P.2
Foster, D.W.3
-
17
-
-
84928790920
-
FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitaryadrenal axis
-
Perry RJ, Lee S, Ma L, Zhang D, Schlessinger J, Shulman GI. FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitaryadrenal axis. Nat Commun. 2015;6:6980.
-
(2015)
Nat Commun.
, vol.6
, pp. 6980
-
-
Perry, R.J.1
Lee, S.2
Ma, L.3
Zhang, D.4
Schlessinger, J.5
Shulman, G.I.6
-
18
-
-
0036114844
-
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
-
Petersen KF, et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest. 2002;109(10):1345-1350.
-
(2002)
J Clin Invest.
, vol.109
, Issue.10
, pp. 1345-1350
-
-
Petersen, K.F.1
-
19
-
-
84907386500
-
Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease
-
Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med. 2014;371(12):1131-1141.
-
(2014)
N Engl J Med.
, vol.371
, Issue.12
, pp. 1131-1141
-
-
Shulman, G.I.1
-
20
-
-
84956666350
-
The pathogenesis of insulin resistance: Integrating signaling pathways and substrate flux
-
Samuel VT, Shulman GI. The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. J Clin Invest. 2016;126(1):12-22.
-
(2016)
J Clin Invest.
, vol.126
, Issue.1
, pp. 12-22
-
-
Samuel, V.T.1
Shulman, G.I.2
-
21
-
-
84994613956
-
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
-
Petersen MC, et al. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J Clin Invest. 2016;126(11):4361-4371.
-
(2016)
J Clin Invest.
, vol.126
, Issue.11
, pp. 4361-4371
-
-
Petersen, M.C.1
-
22
-
-
84946200022
-
Metabolism: Light on leptin link to lipolysis
-
Ruud J, Brüning JC. Metabolism: Light on leptin link to lipolysis. Nature. 2015;527(7576):43-44.
-
(2015)
Nature.
, vol.527
, Issue.7576
, pp. 43-44
-
-
Ruud, J.1
Brüning, J.C.2
-
23
-
-
80052297054
-
Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats
-
Cummings BP, et al. Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats. Proc Natl Acad Sci U S A. 2011;108(35):14670-14675.
-
(2011)
Proc Natl Acad Sci U S A.
, vol.108
, Issue.35
, pp. 14670-14675
-
-
Cummings, B.P.1
-
24
-
-
79959421553
-
Leptin therapy reverses hyperglycemia in mice with streptozotocininduced diabetes, independent of hepatic leptin signaling
-
Denroche HC, et al. Leptin therapy reverses hyperglycemia in mice with streptozotocininduced diabetes, independent of hepatic leptin signaling. Diabetes. 2011;60(5):1414-1423.
-
(2011)
Diabetes.
, vol.60
, Issue.5
, pp. 1414-1423
-
-
Denroche, H.C.1
-
25
-
-
84924061396
-
Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes
-
Kim GH, Szabo A, King EM, Ayala J, Ayala JE, Altarejos JY. Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes. Mol Metab. 2015;4(3):227-236.
-
(2015)
Mol Metab.
, vol.4
, Issue.3
, pp. 227-236
-
-
Kim, G.H.1
Szabo, A.2
King, E.M.3
Ayala, J.4
Ayala, J.E.5
Altarejos, J.Y.6
-
26
-
-
0023571397
-
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
-
Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest. 1987;80(4):1037-1044.
-
(1987)
J Clin Invest.
, vol.80
, Issue.4
, pp. 1037-1044
-
-
Rossetti, L.1
Shulman, G.I.2
Zawalich, W.3
DeFronzo, R.A.4
-
27
-
-
0023275573
-
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
-
Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest. 1987;79(5):1510-1515.
-
(1987)
J Clin Invest.
, vol.79
, Issue.5
, pp. 1510-1515
-
-
Rossetti, L.1
Smith, D.2
Shulman, G.I.3
Papachristou, D.4
DeFronzo, R.A.5
-
28
-
-
0023638757
-
Sample site selection for tracer studies applying a unidirectional circulatory approach
-
Layman DK, Wolfe RR. Sample site selection for tracer studies applying a unidirectional circulatory approach. Am J Physiol. 1987;253(2 Pt 1):E173-E178.
-
(1987)
Am J Physiol.
, vol.253
, Issue.2
, pp. E173-E178
-
-
Layman, D.K.1
Wolfe, R.R.2
-
29
-
-
0026666355
-
On the determination of turnover in vivo with tracers
-
Katz J. On the determination of turnover in vivo with tracers. Am J Physiol. 1992; 263(3 Pt 1):E417-E424.
-
(1992)
Am J Physiol.
, vol.263
, Issue.3
, pp. E417-E424
-
-
Katz, J.1
-
30
-
-
0019498959
-
The determination of lactate turnover in vivo with 3H-and 14C-labelled lactate
-
Katz J, Okajima F, Chenoweth M, Dunn A. The determination of lactate turnover in vivo with 3H-and 14C-labelled lactate. The significance of sites of tracer administration and sampling. Biochem J. 1981;194(2):513-524.
-
(1981)
The Significance of Sites of Tracer Administration and Sampling. Biochem J.
, vol.194
, Issue.2
, pp. 513-524
-
-
Katz, J.1
Okajima, F.2
Chenoweth, M.3
Dunn, A.4
-
31
-
-
33845261493
-
A rapid method of total lipid extraction and purification
-
Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37(8):911-917.
-
(1959)
Can J Biochem Physiol.
, vol.37
, Issue.8
, pp. 911-917
-
-
Bligh, E.G.1
Dyer, W.J.2
-
32
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem. 2002;277(52):50230-50236.
-
(2002)
J Biol Chem.
, vol.277
, Issue.52
, pp. 50230-50236
-
-
Yu, C.1
|