-
1
-
-
0033037727
-
Leptin restores euglycemia and Normalizes glucose turnover in insulin-deficient diabetes in the rat
-
Chinookoswong N, Wang JL, Shi ZQ Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes 1999; 48:1487-1492
-
(1999)
Diabetes
, vol.48
, pp. 1487-1492
-
-
Chinookoswong, N.1
Wang, J.L.2
Shi, Z.Q.3
-
2
-
-
30044447631
-
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
-
Morton GJ, Gelling RW, Niswender K.D., Morrison CD, Rhodes CJ, Schwartz MW. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab 2005; 2:411-420
-
(2005)
Cell Metab
, vol.2
, pp. 411-420
-
-
Morton, G.J.1
Gelling, R.W.2
Niswender, K.D.3
Morrison, C.D.4
Rhodes, C.J.5
Schwartz, M.W.6
-
3
-
-
0030847432
-
Acute stimulation of glucose metabolism in mice by leptin treatment
-
Kamohara S, Burcelin R, Halaas J.L., Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 1997; 389: 374-377
-
(1997)
Nature
, vol.389
, pp. 374-377
-
-
Kamohara, S.1
Burcelin, R.2
Halaas, J.L.3
Friedman, J.M.4
Charron, M.J.5
-
4
-
-
77950373635
-
Leptin therapy in insulin-deficient type I diabetes
-
Wang MY, Chen L, Clark G.O., et al. Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci USA 2010; 107:4813-4819
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 4813-4819
-
-
Wang, M.Y.1
Chen, L.2
Clark, G.O.3
-
5
-
-
52949140814
-
Making insulin-deficient type 1 diabetic rodents thrive without insulin
-
Yu X, Park BH, Wang M.Y., Wang ZV, Unger RH. Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci USA 2008; 105: 14070-14075
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14070-14075
-
-
Yu, X.1
Park, B.H.2
Wang, M.Y.3
Wang, Z.V.4
Unger, R.H.5
-
6
-
-
79551600048
-
Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
-
Lee Y, Wang MY, Du X.Q., Charron MJ, Unger RH. Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Diabetes 2011; 60: 391-397
-
(2011)
Diabetes
, vol.60
, pp. 391-397
-
-
Lee, Y.1
Wang, M.Y.2
Du, X.Q.3
Charron, M.J.4
Unger, R.H.5
-
7
-
-
84904000735
-
Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis
-
Perry RJ, Zhang XM, Zhang D, et al Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Nat Med 2014; 20:759-763
-
(2014)
Nat Med
, vol.20
, pp. 759-763
-
-
Perry, R.J.1
Zhang, X.M.2
Zhang, D.3
-
8
-
-
78049271280
-
Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
-
Fujikawa T, Chuang JC, Sakata I, Ramadori G., Coppari R. Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc Natl Acad Sci USA 2010; 107:17391-17396
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 17391-17396
-
-
Fujikawa, T.1
Chuang, J.C.2
Sakata, I.3
Ramadori, G.4
Coppari, R.5
-
9
-
-
79959421553
-
Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling
-
Denroche HC, Levi J, Wideman R.D., et al. Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. Diabetes 2011; 60:1414-1423
-
(2011)
Diabetes
, vol.60
, pp. 1414-1423
-
-
Denroche, H.C.1
Levi, J.2
Wideman, R.D.3
-
10
-
-
0034776770
-
Selective deletion of leptin receptor in neurons leads to obesity
-
Cohen P, Zhao C, Cai X., et al. Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest 2001; 108:1113-1121
-
(2001)
J Clin Invest
, vol.108
, pp. 1113-1121
-
-
Cohen, P.1
Zhao, C.2
Cai, X.3
-
11
-
-
0029739970
-
Identification of targets of leptin action in rat hypothalamus
-
Schwartz MW, Seeley RJ, Campfield L.A., Burn P., Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996; 98:1101-1106
-
(1996)
J Clin Invest
, vol.98
, pp. 1101-1106
-
-
Schwartz, M.W.1
Seeley, R.J.2
Campfield, L.A.3
Burn, P.4
Baskin, D.G.5
-
13
-
-
58749086043
-
The geometry of leptin action in the brain: More complicated than a simple ARC
-
Myers MG J.r., Münzberg H, Leinninger G.M., Leshan RL. The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab 2009; 9:117-123
-
(2009)
Cell Metab
, vol.9
, pp. 117-123
-
-
Myers, M.G.1
Münzberg, H.2
Leinninger, G.M.3
Leshan, R.L.4
-
14
-
-
33845911799
-
Distributed neural control of energy balance: Contributions from hindbrain and hypothalamus
-
Grill HJ. Distributed neural control of energy balance: contributions from hindbrain and hypothalamus. Obesity (Silver Spring) 2006; 14(Suppl. 5): 216S-221S
-
(2006)
Obesity (Silver Spring)
, vol.14
, pp. 216S-221S
-
-
Grill, H.J.1
-
15
-
-
33748541108
-
Leptin regulation of the mesoaccumbens dopamine pathway
-
Fulton S, Pissios P, Manchon R.P., et al. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 2006; 51:811-822
-
(2006)
Neuron
, vol.51
, pp. 811-822
-
-
Fulton, S.1
Pissios, P.2
Manchon, R.P.3
-
16
-
-
79955595479
-
Leptin does not directly affect CNS serotonin neurons to influence appetite
-
Lam DD, Leinninger GM, Louis G.W., et al. Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metab 2011; 13:584-591
-
(2011)
Cell Metab
, vol.13
, pp. 584-591
-
-
Lam, D.D.1
Leinninger, G.M.2
Louis, G.W.3
-
17
-
-
79960190012
-
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
-
Vong L, Ye C, Yang Z., Choi B, Chua S Jr, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 2011; 71:142-154
-
(2011)
Neuron
, vol.71
, pp. 142-154
-
-
Vong, L.1
Ye, C.2
Yang, Z.3
Choi, B.4
Chua, S.5
Lowell, B.B.6
-
18
-
-
84860341475
-
Role of GABA release from leptin receptor-expressing neurons in body weight regulation
-
Xu Y, O'Brien WG 3rd, Lee CC, Myers MG Jr, Tong Q. Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology 2012; 153:2223-2233
-
(2012)
Endocrinology
, vol.153
, pp. 2223-2233
-
-
Xu, Y.1
O'Brien, W.G.2
Lee, C.C.3
Myers, M.G.4
Tong, Q.5
-
19
-
-
84877677436
-
Glutamate release mediates leptin action on energy expenditure
-
Xu Y, Kim ER, Zhao R, Myers MG Jr, Munzberg H, Tong Q. Glutamate release mediates leptin action on energy expenditure. Mol Metab 2013; 2: 109-115
-
(2013)
Mol Metab
, vol.2
, pp. 109-115
-
-
Xu, Y.1
Kim, E.R.2
Zhao, R.3
Myers, M.G.4
Munzberg, H.5
Tong, Q.6
-
20
-
-
84883483789
-
Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin
-
Fujikawa T, Berglund ED, Patel V.R., et al. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab 2013; 18: 431-444
-
(2013)
Cell Metab
, vol.18
, pp. 431-444
-
-
Fujikawa, T.1
Berglund, E.D.2
Patel, V.R.3
-
21
-
-
84883172997
-
Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to Normalize diabetic hyperglycemia
-
Meek TH, Matsen ME, Dorfman M.D., et al. Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia. Endocrinology 2013; 154:3067-3076
-
(2013)
Endocrinology
, vol.154
, pp. 3067-3076
-
-
Meek, T.H.1
Matsen, M.E.2
Dorfman, M.D.3
-
22
-
-
34247616021
-
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
-
Tong Q, Ye C, McCrimmon R.J., et al. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 2007; 5:383-393
-
(2007)
Cell Metab
, vol.5
, pp. 383-393
-
-
Tong, Q.1
Ye, C.2
McCrimmon, R.J.3
-
23
-
-
72249092928
-
Recent advances in understanding leptin signaling and leptin resistance
-
Morris DL, Rui L. Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 2009; 297:E1247-E1259
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
, pp. E1247-E1259
-
-
Morris, D.L.1
Rui, L.2
-
24
-
-
77951153669
-
Insufficiency of janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions
-
Robertson S, Ishida-Takahashi R, Tawara I., et al. Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes 2010; 59:782-790
-
(2010)
Diabetes
, vol.59
, pp. 782-790
-
-
Robertson, S.1
Ishida-Takahashi, R.2
Tawara, I.3
-
25
-
-
0037456304
-
STAT3 signalling is required for leptin regulation of energy balance but not reproduction
-
Bates SH, Stearns WH, Dundon T.A., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003; 421: 856-859
-
(2003)
Nature
, vol.421
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
-
26
-
-
84876561914
-
BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production
-
Meek TH, Wisse BE, Thaler J.P., et al. BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production. Diabetes 2013; 62:1512-1518
-
(2013)
Diabetes
, vol.62
, pp. 1512-1518
-
-
Meek, T.H.1
Wisse, B.E.2
Thaler, J.P.3
-
27
-
-
84887447664
-
FGF19 action in the brain induces insulin-independent glucose lowering
-
Morton GJ, Matsen ME, Bracy D.P., et al. FGF19 action in the brain induces insulin-independent glucose lowering. J Clin Invest 2013; 123: 4799-4808
-
(2013)
J Clin Invest
, vol.123
, pp. 4799-4808
-
-
Morton, G.J.1
Matsen, M.E.2
Bracy, D.P.3
-
28
-
-
84924061396
-
Leptin recruits creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulindeficient diabetes
-
Kim GH, Szabo A, King E.M., Ayala J., Ayala JE, Altarejos JY. Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulindeficient diabetes. Mol Metab 2015; 4:227-236
-
(2015)
Mol Metab
, vol.4
, pp. 227-236
-
-
Kim, G.H.1
Szabo, A.2
King, E.M.3
Ayala, J.4
Ayala, J.E.5
Altarejos, J.Y.6
-
29
-
-
33646429180
-
A shared vesicular carrier allows synaptic corelease of GABA and glycine
-
Wojcik SM, Katsurabayashi S, Guillemin I., et al. A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron 2006; 50:575-587
-
(2006)
Neuron
, vol.50
, pp. 575-587
-
-
Wojcik, S.M.1
Katsurabayashi, S.2
Guillemin, I.3
-
30
-
-
0842324775
-
VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
-
Fremeau RT J.r., Voglmaier S, Seal R.P., Edwards RH. VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate. Trends Neurosci 2004; 27:98-103
-
(2004)
Trends Neurosci
, vol.27
, pp. 98-103
-
-
Fremeau, R.T.1
Voglmaier, S.2
Seal, R.P.3
Edwards, R.H.4
-
31
-
-
77951528099
-
Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamineregulated transcript neurons of the extended central amygdala
-
Leshan RL, Opland DM, Louis G.W., et al. Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamineregulated transcript neurons of the extended central amygdala. J Neurosci 2010; 30:5713-5723
-
(2010)
J Neurosci
, vol.30
, pp. 5713-5723
-
-
Leshan, R.L.1
Opland, D.M.2
Louis, G.W.3
-
32
-
-
50249120768
-
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
-
Tong Q, Ye CP, Jones J.E., Elmquist JK, Lowell BB. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci 2008; 11:998-1000
-
(2008)
Nat Neurosci
, vol.11
, pp. 998-1000
-
-
Tong, Q.1
Ye, C.P.2
Jones, J.E.3
Elmquist, J.K.4
Lowell, B.B.5
-
33
-
-
73949140059
-
A robust and high-throughput cre reporting and characterization system for the whole mouse brain
-
Madisen L, Zwingman TA, Sunkin S.M., et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci 2010; 13:133-140
-
(2010)
Nat Neurosci
, vol.13
, pp. 133-140
-
-
Madisen, L.1
Zwingman, T.A.2
Sunkin, S.M.3
-
34
-
-
35648968069
-
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms
-
Gong Y, Ishida-Takahashi R, Villanueva E.C., Fingar DC, Münzberg H, Myers MG Jr. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem 2007; 282:31019-31027
-
(2007)
J Biol Chem
, vol.282
, pp. 31019-31027
-
-
Gong, Y.1
Ishida-Takahashi, R.2
Villanueva, E.C.3
Fingar, D.C.4
Münzberg, H.5
Myers, M.G.6
-
35
-
-
84889659070
-
Glutamate mediates the function of melanocortin receptor 4 on sim1 neurons in body weight regulation
-
Xu Y, Wu Z, Sun H., et al. Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation. Cell Metab 2013; 18: 860-870
-
(2013)
Cell Metab
, vol.18
, pp. 860-870
-
-
Xu, Y.1
Wu, Z.2
Sun, H.3
-
36
-
-
84926507971
-
Limma powers differential expression analyses for RNA-sequencing and microarray studies
-
Ritchie ME, Phipson B, Wu D., et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 2015; 43:e47
-
(2015)
Nucleic Acids Res
, vol.43
, pp. e47
-
-
Ritchie, M.E.1
Phipson, B.2
Wu, D.3
-
37
-
-
28744458859
-
Bioconductor: Open software development for computational biology and bioinformatics
-
Gentleman RC, Carey VJ, Bates D.M., et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004; 5: R80
-
(2004)
Genome Biol
, vol.5
, pp. R80
-
-
Gentleman, R.C.1
Carey, V.J.2
Bates, D.M.3
-
38
-
-
84869058775
-
Leptin action via LepR-b tyr1077 contributes to the control of energy balance and female reproduction
-
Patterson CM, Villanueva EC, Greenwald-Yarnell M, et al. Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction. Mol Metab 2012; 1:61-69
-
(2012)
Mol Metab
, vol.1
, pp. 61-69
-
-
Patterson, C.M.1
Villanueva, E.C.2
Greenwald-Yarnell, M.3
-
39
-
-
70349761735
-
Empirical bayes estimates for large-scale prediction problems
-
Efron B. Empirical Bayes estimates for large-scale prediction problems. J Am Stat Assoc 2009; 104:1015-1028
-
(2009)
J Am Stat Assoc
, vol.104
, pp. 1015-1028
-
-
Efron, B.1
-
40
-
-
84908032144
-
Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes
-
Meek TH, Matsen ME, Damian V, Cubelo A., Chua SC Jr, Morton GJ. Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes. Endocrinology 2014; 155:4157-4167
-
(2014)
Endocrinology
, vol.155
, pp. 4157-4167
-
-
Meek, T.H.1
Matsen, M.E.2
Damian, V.3
Cubelo, A.4
Chua, S.C.5
Morton, G.J.6
-
41
-
-
84901281450
-
Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions
-
Gonçalves G.H., Li W, Garcia A.V., Figueiredo MS, Bjørbæk C. Hypothalamic agouti-related peptide neurons and the central melanocortin system are crucial mediators of leptin's antidiabetic actions. Cell Reports 2014; 7:1093-1103
-
(2014)
Cell Reports
, vol.7
, pp. 1093-1103
-
-
Gonçalves, G.H.1
Li, W.2
Garcia, A.V.3
Figueiredo, M.S.4
Bjørbæk, C.5
-
42
-
-
17844389670
-
The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity
-
Coppari R, Ichinose M, Lee C.E., et al. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab 2005; 1:63-72
-
(2005)
Cell Metab
, vol.1
, pp. 63-72
-
-
Coppari, R.1
Ichinose, M.2
Lee, C.E.3
-
43
-
-
79551555006
-
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
-
Rossi J, Balthasar N, Olson D., et al. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab 2011; 13:195-204
-
(2011)
Cell Metab
, vol.13
, pp. 195-204
-
-
Rossi, J.1
Balthasar, N.2
Olson, D.3
-
44
-
-
80755168891
-
Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice
-
Thorel F, Damond N, Chera S., et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. Diabetes 2011; 60:2872-2882
-
(2011)
Diabetes
, vol.60
, pp. 2872-2882
-
-
Thorel, F.1
Damond, N.2
Chera, S.3
-
45
-
-
84948843974
-
Evidence against hypothalamic-pituitary-adrenal axis suppression in the antidiabetic action of leptin
-
Morton GJ, Meek TH, Matsen M.E., Schwartz MW. Evidence against hypothalamic-pituitary-adrenal axis suppression in the antidiabetic action of leptin. J Clin Invest 2015; 2015:4587-4591
-
(2015)
J Clin Invest
, vol.2015
, pp. 4587-4591
-
-
Morton, G.J.1
Meek, T.H.2
Matsen, M.E.3
Schwartz, M.W.4
-
46
-
-
79551582075
-
Glucagon as a critical factor in the pathology of diabetes
-
Edgerton DS, Cherrington AD Glucagon as a critical factor in the pathology of diabetes. Diabetes 2011; 60:377-380
-
(2011)
Diabetes
, vol.60
, pp. 377-380
-
-
Edgerton, D.S.1
Cherrington, A.D.2
-
47
-
-
0041938628
-
Effects of leptin on melaninconcentrating hormone expression in the brain of lean and obese lep(ob)/Lep(ob) mice
-
Huang Q, Viale A, Picard F., Nahon J, Richard D. Effects of leptin on melaninconcentrating hormone expression in the brain of lean and obese Lep(ob)/Lep(ob) mice. Neuroendocrinology 1999; 69:145-153
-
(1999)
Neuroendocrinology
, vol.69
, pp. 145-153
-
-
Huang, Q.1
Viale, A.2
Picard, F.3
Nahon, J.4
Richard, D.5
-
48
-
-
0032492893
-
Hypothalamic CART is a new anorectic peptide regulated by leptin
-
Kristensen P, Judge ME, Thim L, et al Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998; 393:72-76
-
(1998)
Nature
, vol.393
, pp. 72-76
-
-
Kristensen, P.1
Judge, M.E.2
Thim, L.3
-
49
-
-
84923332677
-
Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses
-
Bonnavion P, Jackson AC, Carter M.E., de Lecea L. Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses. Nat Commun 2015; 6:6266
-
(2015)
Nat Commun
, vol.6
, pp. 6266
-
-
Bonnavion, P.1
Jackson, A.C.2
Carter, M.E.3
De Lecea, L.4
-
50
-
-
0033711946
-
Down-regulated STAT3 messenger ribonucleic acid and STAT3 protein in the hypothalamic arcuate nucleus of the obese leptin-deficient (ob/ob) mouse
-
Håkansson-Ovesjö ML, Collin M, Meister B. Down-regulated STAT3 messenger ribonucleic acid and STAT3 protein in the hypothalamic arcuate nucleus of the obese leptin-deficient (ob/ob) mouse. Endocrinology 2000; 141:3946-3955
-
(2000)
Endocrinology
, vol.141
, pp. 3946-3955
-
-
Håkansson-Ovesjö, M.L.1
Collin, M.2
Meister, B.3
|