Higher in vivo serotonin-1A binding in posttraumatic stress disorder: A pet study with [11C]WAY-100635

Depression and Anxiety

Volumn 30, Issue 3, 2013, Pages 197-206

  Sullivan, Gregory M ^a,b   Ogden, R Todd ^a,b,c   Huang, Yung Yu ^a,b   Oquendo, Maria A ^a,b   Mann, J John ^a,b   Parsey, Ramin V ^a,b  

^a College of Physicians and Surgeons ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c Columbia University School of Public Health ^*  (United States)

Author keywords

major depressive disorder; positron emission tomography; posttraumatic stress disorder (PTSD); serotonin 1A (5 HT1A); WAY100635

Indexed keywords

ANTIDEPRESSANT AGENT; BIOLOGICAL MARKER; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE C 11; RADIOLIGAND; SEROTONIN; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AMYGDALOID NUCLEUS; ANTERIOR CINGULATE; ARTERIAL BLOOD; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; DSM-IV; FEMALE; FOREBRAIN; GENOTYPE; HIPPOCAMPUS; HUMAN; IMAGING SYSTEM; IN VIVO STUDY; INSULA; MAJOR DEPRESSION; MALE; NEUROIMAGING; OCCIPITAL CORTEX; PARAHIPPOCAMPAL GYRUS; PARIETAL CORTEX; POSITRON EMISSION TOMOGRAPHY; POST HOC ANALYSIS; POSTERIOR CINGULATE; POSTTRAUMATIC STRESS DISORDER; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; RAPHE NUCLEUS; RECEPTOR UPREGULATION; SEROTONIN RELEASE; TEMPORAL CORTEX;

ADULT; AMYGDALA; BIOLOGICAL MARKERS; BRAIN STEM; CARBON RADIOISOTOPES; CEREBRAL CORTEX; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PYRIDINES; RECEPTOR, SEROTONIN, 5-HT1A; STRESS DISORDERS, POST-TRAUMATIC; UP-REGULATION;

EID: 84874948400     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22019     Document Type: Article

References (59)

1. Kessler RC,. Posttraumatic stress disorder: the burden to the individual and to society. J Clin Psychiatry 2000; 61 (Suppl 5): 4-12; discussion 13-4.
2. Phillips CJ, Leardmann CA, Gumbs GR, Smith B,. Risk factors for posttraumatic stress disorder among deployed US male marines. BMC Psychiatry 2010; 10: 52. Available at: http://www.biomedcentral.com/1471-244X/10/52.
3. Adamec R, Holmes A, Blundell J,. Vulnerability to lasting anxiogenic effects of brief exposure to predator stimuli: sex, serotonin and other factors-relevance to PTSD. Neurosci Biobehav Rev 2008; 32 (7): 1287-1292.
4. Holmes A,. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neurosci Biobehav Rev 2008; 32 (7): 1293-1314.
5. Lanfumey L, Mongeau R, Cohen-Salmon C, Hamon M,. Corticosteroid-serotonin interactions in the neurobiological mechanisms of stress-related disorders. Neurosci Biobehav Rev 2008; 32 (6): 1174-1184.
6. Klemenhagen KC, Gordon JA, David DJ, et al. Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Neuropsychopharmacology 2006; 31 (1): 101-111.
7. Menard J, Treit D,. The septum and the hippocampus differentially mediate anxiolytic effects of R(+)-8-OH-DPAT. Behav Pharmacol 1998; 9 (2): 93-101.
8. Lanzenberger RR, Mitterhauser M, Spindelegger C, et al. Reduced serotonin-1A receptor binding in social anxiety disorder. Biol Psychiatry 2007; 61 (9): 1081-1089.
9. Nash JR, Sargent PA, Rabiner EA, et al. Serotonin 5-HT1A receptor binding in people with panic disorder: positron emission tomography study. Br J Psychiatry 2008; 193 (3): 229-234.
10. Sullivan GM, Oquendo MA, Simpson N, et al. Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxiety. Biol Psychiatry 2005; 58 (12): 947-954.
11. Gross C, Zhuang X, Stark K, et al. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 2002; 416 (6879): 396-400.
12. Sullivan GM, Neria Y,. Pharmacotherapy in post-traumatic stress disorder: evidence from randomized controlled trials. Curr Opin Investig Drugs 2009; 10 (1): 35-45.
13. Gomes FV, Reis DG, Alves FH, et al. Cannabidiol injected into the bed nucleus of the stria terminalis reduces the expression of contextual fear conditioning via 5-HT1A receptors. J Psychopharmacol 2012; 26 (1): 104-113.
14. Schneier FR, Neria Y, Pavlicova M, et al. Combined prolonged exposure therapy and paroxetine for PTSD related to the World Trade Center attack: a randomized controlled trial. Am J Psychiatry 2012; 169 (1): 80-88.
15. Hirvonen J, Karlsson H, Kajander J, et al. Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635. Int J Neuropsychopharmacol 2008; 11 (4): 465-476.
16. Parsey RV, Ogden RT, Miller JM, et al. Higher serotonin 1A binding in a second major depression cohort: modeling and reference region considerations. Biol Psychiatry 2010; 68 (2): 170-178.
17. Shrestha S, Hirvonen J, Hines CS, et al. Serotonin-1A receptors in major depression quantified using PET: controversies, confounds, and recommendations. Neuroimage 2012; 59 (4): 3243-3251.
18. Bonne O, Bain E, Neumeister A, et al. No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder. Am J Psychiatry 2005; 162 (2): 383-385.
19. Carson RE, Wu Y, Lang L, et al. Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs. J Cereb Blood Flow Metab 2003; 23 (2): 249-260.
20. Parsey RV, Arango V, Olvet DM, et al. Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography. J Cereb Blood Flow Metab 2005; 25 (7): 785-793.
21. Sullivan GM, Ogden RT, Oquendo MA, et al. Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. Biol Psychiatry 2009; 66 (3): 223-230.
22. First MB, Spitzer RL, Gibbon M, Williams JBW,. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition. SCID-I/P, Version 2.0. New York: Biometrics Research, New York State Psychiatric Institute; 1994.
23. Beck AT, Ward CH, Mendelson M, et al. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4: 561-571.
24. Hamilton M,. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
25. Endicott J, Spitzer RL, Fleiss JL, Cohen J,. The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry 1976; 33 (6): 766-771.
26. Brown GL, Goodwin FK, Ballenger JC, et al. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1979; 1 (2): 131-139.
27. Parsey RV, Slifstein M, Hwang DR, et al. Validation and reproducibility of measurement of 5-HT1A receptor parameters with [carbonyl-11C]WAY-100635 in humans: comparison of arterial and reference tissue input functions. J Cereb Blood Flow Metab 2000; 20 (7): 1111-1133.
28. Parsey RV, Belanger MJ, Sullivan GM, et al. Biodistribution and radiation dosimetry of 11C-WAY100,635 in humans. J Nucl Med 2005; 46 (4): 614-619.
29. Jenkinson M, Smith S,. A global optimisation method for robust affine registration of brain images. Med Image Anal 2001; 5 (2): 143-156.
30. Smith SM,. Fast robust automated brain extraction. Hum Brain Mapp 2002; 17 (3): 143-155.
31. Ashburner J, Friston KJ,. Nonlinear spatial normalization using basis functions. Hum Brain Mapp 1999; 7 (4): 254-266.
32. Ashburner J, Friston KJ,. Unified segmentation. Neuroimage 2005; 26 (3): 839-851.
33. Duvernoy HM,. The Human Brain: Surface, Three-Dimensional Sectional Anatomy and MRI. Wien: Springer-Verlag; 1991.
34. Talairach J, Tournoux P,. Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging. Stuttgart: Thieme; 1988.
35. Kates WR, Abrams MT, Kaufmann WE, et al. Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatry Res 1997; 75 (1): 31-48.
36. Killany RJ, Moss MB, Nicholson T, et al. An interactive procedure for extracting features of the brain from magnetic resonance images: the lobes. Hum Brain Mapp 1997; 5: 355-363.
37. Innis RB, Cunningham VJ, Delforge J, et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab 2007; 27 (9): 1533-1539.
38. Parsey RV, Oquendo MA, Ogden RT, et al. Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biol Psychiatry 2006; 59 (2): 106-113.
39. Pinheiro JC, Bates DM, ebrary Inc. Mixed-Effects Models in S and S-PLUS. Statistics and Computing. New York: Springer; 2000.
40. Miller JM, Brennan KG, Ogden TR, et al. Elevated serotonin 1A binding in remitted major depressive disorder: evidence for a trait biological abnormality. Neuropsychopharmacology 2009; 34 (10): 2275-2284.
41. Parsey RV, Olvet DM, Oquendo MA, et al. Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study. Neuropsychopharmacology 2006; 31 (8): 1745-1749.
42. Ogden RT, Tarpey T,. Estimation in regression models with externally estimated parameters. Biostatistics 2006; 7 (1): 115-129.
43. Parsey RV, Oquendo MA, Simpson NR, et al. Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635. Brain Res 2002; 954 (2): 173-182.
44. Kessler RC, Sonnega A, Bromet E, et al. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 1995; 52 (12): 1048-1060.
45. Neria Y, Olfson M, Gameroff MJ, et al. The mental health consequences of disaster-related loss: findings from primary care one year after the 9/11 terrorist attacks. Psychiatry 2008; 71 (4): 339-348.
46. Oquendo MA, Echavarria G, Galfalvy HC, et al. Lower cortisol levels in depressed patients with comorbid post-traumatic stress disorder. Neuropsychopharmacology 2003; 28 (3): 591-598.
47. Vythilingam M, Gill JM, Luckenbaugh DA, et al. Low early morning plasma cortisol in posttraumatic stress disorder is associated with co-morbid depression but not with enhanced glucocorticoid feedback inhibition. Psychoneuroendocrinology 2010; 35 (3): 442-450.
48. Drevets WC, Thase ME, Moses-Kolko EL, et al. Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nucl Med Biol 2007; 34 (7): 865-877.
49. Shively CA, Friedman DP, Gage HD, et al. Behavioral depression and positron emission tomography-determined serotonin 1A receptor binding potential in cynomolgus monkeys. Arch Gen Psychiatry 2006; 63 (4): 396-403.
50. McCrory E, De Brito SA, Viding E,. Research review: the neurobiology and genetics of maltreatment and adversity. J Child Psychol Psychiatry 2010; 51 (10): 1079-1095.
51. Harvey BH, Naciti C, Brand L, Stein DJ,. Endocrine, cognitive and hippocampal/cortical 5HT 1A/2A receptor changes evoked by a time-dependent sensitisation (TDS) stress model in rats. Brain Res 2003; 983 (1-2): 97-107.
52. Vicentic A, Francis D, Moffett M, et al. Maternal separation alters serotonergic transporter densities and serotonergic 1A receptors in rat brain. Neuroscience 2006; 140 (1): 355-365.
53. Lambas-Senas L, Mnie-Filali O, Certin V, et al. Functional correlates for 5-HT(1A) receptors in maternally deprived rats displaying anxiety and depression-like behaviors. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33 (2): 262-268.
54. Lemonde S, Turecki G, Bakish D, et al. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 2003; 23 (25): 8788-8799.
55. Rauch SL, Shin LM, Phelps EA,. Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future. Biol Psychiatry 2006; 60 (4): 376-382.
56. Koseki H, Matsumoto M, Togashi H, et al. Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models. Synapse 2009; 63 (9): 805-813.
57. Milad MR, Orr SP, Lasko NB, et al. Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study. J Psychiatr Res 2008; 42 (7): 515-520.
58. Murrough JW, Huang Y, Hu J, et al. Reduced amygdala serotonin transporter binding in posttraumatic stress disorder. Biol Psychiatry 2011; 70 (11): 1033-1038.
59. Murrough JW, Czermak C, Henry S, et al. The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding. Arch Gen Psychiatry 2011; 68 (9): 892-900.