Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Li, Kai ^a   Zhang, Yue ^a   Liang, Kang Yan ^a   Xu, Song ^a   Zhou, Xue Juan ^a   Tan, Kang ^a   Lin, Jun ^a   Bai, Xiao Chun ^a   Yang, Cui Lan ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; OVALBUMIN; PROTEIN BINDING; RHEB PROTEIN; RHEB PROTEIN, MOUSE;

ANIMAL; ASTHMA; BONE MARROW CELL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; DISEASE MODEL; GENE DELETION; GENETICS; HYPERSENSITIVITY; IMMUNOLOGY; MACROPHAGE; MACROPHAGE ACTIVATION; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

ALLERGENS; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; GENE DELETION; HYPERSENSITIVITY; MACROPHAGE ACTIVATION; MACROPHAGES; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MICE; MICE, INBRED C57BL; MYELOID CELLS; OVALBUMIN; PROTEIN BINDING; RAS HOMOLOG ENRICHED IN BRAIN PROTEIN; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS;

EID: 85013768516     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep42655     Document Type: Article

References (45)

1. Umetsu, D. T., McIntire, J. J., Akbari, O., Macaubas, C., DeKruyff, R. H. Asthma: an epidemic of dysregulated immunity. Nat Immunol 3, 715-720, doi: 10. 1038/ni0802-715 (2002).
2. Park, H. J., et al. Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol 9, 261-267, doi: 10. 1016/j. intimp. 2008. 10. 021 (2009).
3. Contoli, M., et al. Th2 cytokines impair innate immune responses to rhinovirus in respiratory epithelial cells. Allergy 70, 910-920, doi: 10. 1111/all. 12627 (2015).
4. Nair, M. G., Cochrane, D. W., Allen, J. E. Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro. Immunology Letters 85, 173-180, doi: 10. 1016/s0165-2478(02)00225-0 (2003).
5. Nair, M. G., et al. Chitinase and Fizz Family Members Are a Generalized Feature of Nematode Infection with Selective Upregulation of Ym1 and Fizz1 by Antigen-Presenting Cells. Infection and Immunity 73, 385-394, doi: 10. 1128/iai. 73. 1. 385-394. 2005 (2004).
6. Martinez, F. O., et al. Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences. Blood 121, e57-69, doi: 10. 1182/blood-2012-06-436212 (2013).
7. Gordon, S., Martinez, F. O. Alternative activation of macrophages: mechanism and functions. Immunity 32, 593-604, doi: 10. 1016/j. immuni. 2010. 05. 007 (2010).
8. Moreira, A. P., Hogaboam, C. M. Macrophages in allergic asthma: fine-tuning their pro-and anti-inflammatory actions for disease resolution. J Interferon Cytokine Res 31, 485-491, doi: 10. 1089/jir. 2011. 0027 (2011).
9. Pappas, K., Papaioannou, A. I., Kostikas, K., Tzanakis, N. The role of macrophages in obstructive airways disease: chronic obstructive pulmonary disease and asthma. Cytokine 64, 613-625, doi: 10. 1016/j. cyto. 2013. 09. 010 (2013).
10. Liu, Y. C., Zou, X. B., Chai, Y. F., Yao, Y. M. Macrophage polarization in inflammatory diseases. Int J Biol Sci 10, 520-529, doi: 10. 7150/ijbs. 8879 (2014).
11. Laplante, M., Sabatini, D. M. mTOR signaling at a glance. J Cell Sci 122, 3589-3594, doi: 10. 1242/jcs. 051011 (2009).
12. Chen, W., et al. Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2-mTOR Pathway. Cancer Research 72, 1363-1372, doi: 10. 1158/0008-5472. can-11-2684 (2012).
13. Pan, H., O'Brien, T. F., Zhang, P., Zhong, X. P. The role of tuberous sclerosis complex 1 in regulating innate immunity. J Immunol 188, 3658-3666, doi: 10. 4049/jimmunol. 1102187 (2012).
14. Orlova, K. A., Crino, P. B. The tuberous sclerosis complex. Ann N Y Acad Sci 1184, 87-105, doi: 10. 1111/j. 1749-6632. 2009. 05117. x (2010).
15. Huang, J., Manning, B. D. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 412, 179-190, doi: 10. 1042/BJ20080281 (2008).
16. Zhu, L., et al. TSC1 controls macrophage polarization to prevent inflammatory disease. Nat Commun 5, 4696, doi: 10. 1038/ncomms5696 (2014).
17. Stocker, H., et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 5, 559-565, doi: 10. 1038/ncb995 (2003).
18. Goorden, S. M., et al. Rheb is essential for murine development. Mol Cell Biol 31, 1672-1678, doi: 10. 1128/MCB. 00985-10 (2011).
19. Groenewoud, M. J., Zwartkruis, F. J. Rheb and mammalian target of rapamycin in mitochondrial homoeostasis. Open Biol 3, 130185, doi: 10. 1098/rsob. 130185 (2013).
20. Heard, J. J., Fong, V., Bathaie, S. Z., Tamanoi, F. Recent progress in the study of the Rheb family GTPases. Cell Signal 26, 1950-1957, doi: 10. 1016/j. cellsig. 2014. 05. 011 (2014).
21. Avruch, J., et al. Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Biochem Soc Trans 37, 223-226, doi: 10. 1042/BST0370223 (2009).
22. Bai, X., et al. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 318, 977-980, doi: 10. 1126/science. 1147379 (2007).
23. Sun, Y., et al. Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proc Natl Acad Sci USA 105, 8286-8291, doi: 10. 1073/pnas. 0712268105 (2008).
24. Manning, B. D., Cantley, L. C. Rheb fills a GAP between TSC and TOR. Trends Biochem Sci 28, 573-576, doi: 10. 1016/j. tibs. 2003. 09. 003 (2003).
25. Gould, H. J., Sutton, B. J. IgE in allergy and asthma today. Nature reviews. Immunology 8, 205-217, doi: 10. 1038/nri2273 (2008).
26. Ma, L., et al. ANP/NPRA signaling preferentially mediates Th2 responses in favor of pathological processes during the course of acute allergic asthma. Int J Clin Exp Med 8, 5121-5128 (2015).
27. Fujitani, Y., Trifilieff, A. In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. Am J Respir Crit Care Med 167, 193-198, doi: 10. 1164/rccm. 200205-455OC (2003).
28. Fredriksson, K., et al. Paradoxical effects of rapamycin on experimental house dust mite-induced asthma. PLoS One 7, e33984, doi: 10. 1371/journal. pone. 0033984 (2012).
29. Tigani, B., Hannon, J. P., Schaeublin, E., Mazzoni, L., Fozard, J. R. Effects of immunomodulators on airways hyperresponsiveness to adenosine induced in actively sensitised Brown Norway rats by exposure to allergen. Naunyn Schmiedebergs Arch Pharmacol 368, 17-25, doi: 10. 1007/s00210-003-0767-7 (2003).
30. Murray, P. J., Wynn, T. A. Obstacles and opportunities for understanding macrophage polarization. J Leukoc Biol 89, 557-563, doi: 10. 1189/jlb. 0710409 (2011).
31. Martinez, F. O., Gordon, S., Locati, M., Mantovani, A. Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression. The Journal of Immunology 177, 7303-7311, doi: 10. 4049/jimmunol. 177. 10. 7303 (2006).
32. Yang, M., Kumar, R. K., Hansbro, P. M., Foster, P. S. Emerging roles of pulmonary macrophages in driving the development of severe asthma. J Leukoc Biol 91, 557-569, doi: 10. 1189/jlb. 0711357 (2012).
33. Mantovani, A., et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25, 677-686, doi: 10. 1016/j. it. 2004. 09. 015 (2004).
34. Mantovani, A. From phagocyte diversity and activation to probiotics: back to Metchnikoff. Eur J Immunol 38, 3269-3273, doi: 10. 1002/eji. 200838918 (2008).
35. Stein, M., Keshav, S., Harris, N., Gordon, S. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 176, 287-292 (1992).
36. Kim, E. Y., et al. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med 14, 633-640, doi: 10. 1165/rcmb. 2009-0016OC (2008).
37. Melgert, B. N., et al. Macrophages. American Journal of Respiratory Cell and Molecular Biology 42, 595-603, doi: 10. 1165/rcmb. 2009-0016OC (2010).
38. Hume, D. A. Macrophages as APC and the Dendritic Cell Myth. The Journal of Immunology 181, 5829-5835, doi: 10. 4049/jimmunol. 181. 9. 5829 (2008).
39. Goleva, E., et al. Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages. J Allergy Clin Immunol 122, 550-559 e553, doi: 10. 1016/j. jaci. 2008. 07. 007 (2008).
40. Cao, Y., et al. Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice. Int J Mol Sci 14, 24380-24398, doi: 10. 3390/ijms141224380 (2013).
41. Powell, J. D., Delgoffe, G. M. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity 33, 301-311, doi: 10. 1016/j. immuni. 2010. 09. 002 (2010).
42. Kumar, R., Herbert, C., Foster, P. The "Classical" Ovalbumin Challenge Model of Asthma in Mice. Current Drug Targets 9, 485-494, doi: 10. 2174/138945008784533561 (2008).
43. Li, Y. J., et al. The effects of oxidative stress induced by prolonged low-dose diesel exhaust particle exposure on the generation of allergic airway inflammation differ between BALB/c and C57BL/6 mice. Immunopharmacol Immunotoxicol 31, 230-237, doi: 10. 1080/08923970802383316 (2009).
44. Kurakula, K., et al. Nuclear Receptor Nur77 Attenuates Airway Inflammation in Mice by Suppressing NF-kappaB Activity in Lung Epithelial Cells. J Immunol 195, 1388-1398, doi: 10. 4049/jimmunol. 1401714 (2015).
45. Hamilton, T. A., Zhao, C., Pavicic, P. G. Jr., Datta, S. Myeloid colony-stimulating factors as regulators of macrophage polarization. Front Immunol 5, 554, doi: 10. 3389/fimmu. 2014. 00554 (2014).