Paradoxical effects of Rapamycin on experimental house dust mite-induced asthma

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Fredriksson, Karin ^a   Fielhaber, Jill A ^b   Lam, Jonathan K ^a   Yao, Xianglan ^a   Meyer, Katharine S ^a   Keeran, Karen J ^a   Zywicke, Gayle J ^a   Qu, Xuan ^a   Yu, Zu Xi ^a   Moss, Joel ^a   Kristof, Arnold S ^b   Levine, Stewart J ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN; S6 KINASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; ASTHMA; CELL HYPERPLASIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATOPHAGOIDES; DISEASE SEVERITY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GOBLET CELL; GOBLET CELL HYPERPLASIA; HOUSE DUST MITE INDUCED ASTHMA; MOUSE; NONHUMAN; PARADOXICAL DRUG REACTION; PATHOGENESIS; PROTEIN PHOSPHORYLATION; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; TH2 CELL; TREATMENT DURATION; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECT; GENETICS; IMMUNOLOGY; INFLAMMATION; LUNG; LUNG LAVAGE; METABOLISM; PHOSPHORYLATION; PYROGLYPHIDAE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MAMMALIA; MURINAE; MUS; PYROGLYPHIDAE;

ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; FEMALE; INFLAMMATION; LUNG; MICE; MICE, INBRED BALB C; PHOSPHORYLATION; PYROGLYPHIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84861463599     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033984     Document Type: Article

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