Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice

International Journal of Molecular Sciences

Volumn 14, Issue 12, 2013, Pages 24380-24398

  Cao, Yunshan ^a,b   Tao, Lichan ^a,b   Shen, Shutong ^a,b   Xiao, Junjie ^a,c   Wu, Hang ^a   Li, Beibei ^a   Wu, Xiangqi ^a,b   Luo, Wen ^b   Xiao, Qi ^b   Hu, Xiaoshan ^b   Liu, Hailang ^a   Nie, Junwei ^b   Lu, Shuangshuang ^b   Yuan, Baiyin ^b   Han, Zhonglin ^a   Xiao, Bo ^d   Yang, Zhongzhou ^b   Li, Xinli ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c SHANGHAI UNIVERSITY   (China)

^d SICHUAN UNIVERSITY   (China)

Author keywords

ER; Heart growth; Infant heart failure; MTORC1; Rheb1

Indexed keywords

3 OXOACID COENZYME A TRANSFERASE; ACETYL COENZYME A CARBOXYLASE; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CARNITINE PALMITOYLTRANSFERASE I; CASPASE 12; CASPASE 3; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MALONYL COENZYME A DECARBOXYLASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MYOSIN HEAVY CHAIN BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN DISULFIDE ISOMERASE; PROTEIN KINASE B; RHEB PROTEIN; RHEB1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; ENDOPLASMIC RETICULUM STRESS; ENERGY METABOLISM; ENZYME ACTIVITY; GENE DELETION; GENE EXPRESSION; GENETIC REGULATION; HEART ARRHYTHMIA; HEART DEVELOPMENT; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HEART RATE; HEART WEIGHT; HOMEOSTASIS; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MOUSE; NICK END LABELING; NONHUMAN; PERINATAL PERIOD; PREMATURITY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ARRHYTHMIAS, CARDIAC; CELLS, CULTURED; ENDOPLASMIC RETICULUM; HEART; HEART FAILURE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOMERIC GTP-BINDING PROTEINS; MYOCYTES, CARDIAC; NEUROPEPTIDES; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE;

EID: 84890380098     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141224380     Document Type: Article

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