Advanced glycation end products regulate anabolic and catabolic activities via NLRP3-inflammasome activation in human nucleus pulposus cells

Journal of Cellular and Molecular Medicine

Volumn 21, Issue 7, 2017, Pages 1373-1387

  Song, Yu ^a   Wang, Yan ^b   Zhang, Yukun ^a   Geng, Wen ^c   Liu, Wei ^d   Gao, Yong ^a   Li, Shuai ^a   Wang, Kun ^a   Wu, Xinghuo ^a   Kang, Liang ^a   Yang, Cao ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CHINA UNIVERSITY OF GEOSCIENCES   (China)

^c CHINA MEDICAL UNIVERSITY   (China)

^d The First Hospital of Wuhan City   (China)

Author keywords

advanced glycation end products; calcium; human nucleus pulposus cells; IL 1 ; intervertebral disc degeneration; mitochondrial damage; NLRP3 inflammasome

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CALCIUM; COLLAGEN TYPE 2; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN METABOLITE; STROMELYSIN; MITOGEN ACTIVATED PROTEIN KINASE; MOK PROTEIN, HUMAN; TUMOR ANTIGEN;

ADULT; AGING; ARTICLE; ATTENUATION; CALCIUM MOBILIZATION; CELL DAMAGE; CELL ISOLATION; CLINICAL ARTICLE; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE MICROSCOPY; INFLAMMATION; INTERVERTEBRAL DISK DEGENERATION; MALE; MIDDLE AGED; MITOCHONDRION; NUCLEUS PULPOSUS; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; GENETICS; LOW BACK PAIN; METABOLISM; PATHOLOGY; SCOLIOSIS;

ANTIGENS, NEOPLASM; GLYCATION END PRODUCTS, ADVANCED; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTERVERTEBRAL DISC DEGENERATION; LOW BACK PAIN; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; NUCLEUS PULPOSUS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SCOLIOSIS;

EID: 85013392791     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.13067     Document Type: Article

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