ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis

Cellular Microbiology

Volumn 19, Issue 7, 2017, Pages

  Augenstreich, Jacques ^a   Arbues, Ainhoa ^a   Simeone, Roxane ^b   Haanappel, Evert ^a   Wegener, Alice ^a   Sayes, Fadel ^b   Le Chevalier, Fabien ^b   Chalut, Christian ^a   Malaga, Wladimir ^a   Guilhot, Christophe ^a   Brosch, Roland ^b   Astarie Dequeker, Catherine ^a  

^a UNIVERSITÉ PAUL SABATIER   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

ESX 1; macrophage; Mycobacterium; phagosomal membrane rupture; phthiocerol dimycocerosates; tuberculosis

Indexed keywords

BACTERIAL PROTEIN; ESX 1 PROTEIN; PHTHIOCEROL DIMYCOCEROSATE; UNCLASSIFIED DRUG; VIRULENCE FACTOR; BACTERIAL ANTIGEN; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; LIPID;

ACIDIFICATION; APOPTOSIS; ARTICLE; BIOASSAY; CELL DEATH; HOST CELL; HUMAN; HUMAN CELL; MACROPHAGE; MEMBRANE DAMAGE; MEMBRANE RUPTURE; MYCOBACTERIUM BOVIS BCG; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OUTER MEMBRANE; PHAGOCYTE; PHAGOSOME; PRIORITY JOURNAL; TYPE VII SECRETION SYSTEM; CELL MEMBRANE; METABOLISM; MICROBIOLOGY; MYCOBACTERIUM BOVIS; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; THP-1 CELL LINE; TUMOR CELL LINE;

ANTIGENS, BACTERIAL; APOPTOSIS; BACTERIAL PROTEINS; CELL LINE, TUMOR; CELL MEMBRANE; HUMANS; LIPIDS; MACROPHAGES; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOMES; THP-1 CELLS; VIRULENCE FACTORS;

EID: 85013339724     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/cmi.12726     Document Type: Article

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