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Volumn 66, Issue 8, 2017, Pages 969-977

Dendritic cell rehab: new strategies to unleash therapeutic immunity in ovarian cancer

Author keywords

Dendritic cells; Immunosuppression; Immunotherapy; Ovarian cancer; Regulatory myeloid suppressor cells; Tumor microenvironment

Indexed keywords

CD40 ANTIGEN; DENDRITIC CELL VACCINE; NANOPARTICLE; TOLL LIKE RECEPTOR; CANCER VACCINE;

EID: 85013124311     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-017-1958-2     Document Type: Review
Times cited : (21)

References (56)
  • 3
    • 84979781044 scopus 로고    scopus 로고
    • Management of relapsed ovarian cancer: a review
    • PID: 27516935
    • Giornelli GH (2016) Management of relapsed ovarian cancer: a review. SpringerPlus 5(1):1197
    • (2016) SpringerPlus , vol.5 , Issue.1 , pp. 1197
    • Giornelli, G.H.1
  • 4
    • 0037448353 scopus 로고    scopus 로고
    • Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    • COI: 1:CAS:528:DC%2BD3sXksVehug%3D%3D, PID: 12529460
    • Zhang L et al (2003) Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 348(3):203–213
    • (2003) N Engl J Med , vol.348 , Issue.3 , pp. 203-213
    • Zhang, L.1
  • 5
    • 68049118835 scopus 로고    scopus 로고
    • CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion
    • COI: 1:CAS:528:DC%2BD1MXpt1Cgu74%3D, PID: 19602595
    • Nesbeth Y et al (2009) CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion. Cancer Res 69(15):6331–6338
    • (2009) Cancer Res , vol.69 , Issue.15 , pp. 6331-6338
    • Nesbeth, Y.1
  • 6
    • 77954723327 scopus 로고    scopus 로고
    • CD4 + T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells
    • COI: 1:CAS:528:DC%2BC3cXls1Wju7o%3D, PID: 20400704
    • Nesbeth YC et al (2010) CD4 + T cells elicit host immune responses to MHC class II-negative ovarian cancer through CCL5 secretion and CD40-mediated licensing of dendritic cells. J Immunol 184(10):5654–5662
    • (2010) J Immunol , vol.184 , Issue.10 , pp. 5654-5662
    • Nesbeth, Y.C.1
  • 7
    • 4644345036 scopus 로고    scopus 로고
    • Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A
    • COI: 1:CAS:528:DC%2BD2cXntFSktL4%3D, PID: 15334073
    • Conejo-Garcia JR et al (2004) Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat Med 10(9):950–958
    • (2004) Nat Med , vol.10 , Issue.9 , pp. 950-958
    • Conejo-Garcia, J.R.1
  • 8
    • 28644447974 scopus 로고    scopus 로고
    • Regulatory T cells in ovarian cancer: biology and therapeutic potential
    • COI: 1:CAS:528:DC%2BD28XosVyntA%3D%3D, PID: 16305662
    • Barnett B et al (2005) Regulatory T cells in ovarian cancer: biology and therapeutic potential. Am J Reprod Immunol 54(6):369–377
    • (2005) Am J Reprod Immunol , vol.54 , Issue.6 , pp. 369-377
    • Barnett, B.1
  • 9
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • COI: 1:CAS:528:DC%2BD3sXjtlamtLc%3D, PID: 12704383
    • Curiel TJ et al (2003) Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 9(5):562–567
    • (2003) Nat Med , vol.9 , Issue.5 , pp. 562-567
    • Curiel, T.J.1
  • 10
    • 54749135372 scopus 로고    scopus 로고
    • Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity
    • COI: 1:CAS:528:DC%2BD1cXhtFWltb3M, PID: 18768667
    • Huarte E et al (2008) Depletion of dendritic cells delays ovarian cancer progression by boosting antitumor immunity. Cancer Res 68(18):7684–7691
    • (2008) Cancer Res , vol.68 , Issue.18 , pp. 7684-7691
    • Huarte, E.1
  • 11
    • 68849112640 scopus 로고    scopus 로고
    • Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity
    • COI: 1:CAS:528:DC%2BD1MXpsFClurc%3D, PID: 19620771
    • Cubillos-Ruiz JR et al (2009) Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest 119(8):2231–2244
    • (2009) J Clin Invest , vol.119 , Issue.8 , pp. 2231-2244
    • Cubillos-Ruiz, J.R.1
  • 12
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC38XksVegtrw%3D, PID: 22437870
    • Pardoll DM (2012) The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12(4):252–264
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 13
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
    • COI: 1:CAS:528:DC%2BC2MXmsVWqsbc%3D, PID: 25860605
    • Sharma P, Allison JP (2015) Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell 161(2):205–214
    • (2015) Cell , vol.161 , Issue.2 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 14
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • COI: 1:CAS:528:DC%2BD28XhtVCiurrK, PID: 16946036
    • Morgan RA et al (2006) Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314(5796):126–129
    • (2006) Science , vol.314 , Issue.5796 , pp. 126-129
    • Morgan, R.A.1
  • 15
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • COI: 1:CAS:528:DC%2BD38XotFSntbY%3D, PID: 12242449
    • Dudley ME et al (2002) Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298(5594):850–854
    • (2002) Science , vol.298 , Issue.5594 , pp. 850-854
    • Dudley, M.E.1
  • 16
    • 84951126341 scopus 로고    scopus 로고
    • Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer
    • COI: 1:CAS:528:DC%2BC28Xht1SqtbvE, PID: 26351349
    • Hamanishi J et al (2015) Safety and antitumor activity of anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer. J Clin Oncol 33(34):4015–4022
    • (2015) J Clin Oncol , vol.33 , Issue.34 , pp. 4015-4022
    • Hamanishi, J.1
  • 17
    • 33750699642 scopus 로고    scopus 로고
    • A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
    • COI: 1:CAS:528:DC%2BD28XhtFWhsbnL, PID: 17062687
    • Kershaw MH et al (2006) A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin Cancer Res 12(20 Pt 1):6106–6115
    • (2006) Clin Cancer Res , vol.12 , Issue.20 , pp. 6106-6115
    • Kershaw, M.H.1
  • 18
    • 84874625308 scopus 로고    scopus 로고
    • Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer
    • PID: 23482679
    • Kandalaft LE et al (2013) Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer. Oncoimmunology 2(1):e22664
    • (2013) Oncoimmunology , vol.2 , Issue.1
    • Kandalaft, L.E.1
  • 19
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • COI: 1:CAS:528:DC%2BC3cXhtlyhsrw%3D, PID: 20133564
    • Geissmann F et al (2010) Development of monocytes, macrophages, and dendritic cells. Science 327(5966):656–661
    • (2010) Science , vol.327 , Issue.5966 , pp. 656-661
    • Geissmann, F.1
  • 20
    • 84900461408 scopus 로고    scopus 로고
    • Development and function of dendritic cell subsets
    • COI: 1:CAS:528:DC%2BC2cXosV2kt7k%3D, PID: 24837101
    • Mildner A, Jung S (2014) Development and function of dendritic cell subsets. Immunity 40(5):642–656
    • (2014) Immunity , vol.40 , Issue.5 , pp. 642-656
    • Mildner, A.1    Jung, S.2
  • 21
    • 84859181084 scopus 로고    scopus 로고
    • Demand-adapted regulation of early hematopoiesis in infection and inflammation
    • COI: 1:CAS:528:DC%2BC38Xlt1Okur8%3D, PID: 22246037
    • Takizawa H, Boettcher S, Manz MG (2012) Demand-adapted regulation of early hematopoiesis in infection and inflammation. Blood 119(13):2991–3002
    • (2012) Blood , vol.119 , Issue.13 , pp. 2991-3002
    • Takizawa, H.1    Boettcher, S.2    Manz, M.G.3
  • 22
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • COI: 1:CAS:528:DC%2BC38XksVensrs%3D, PID: 22437938
    • Gabrilovich DI, Ostrand-Rosenberg S, Bronte V (2012) Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 12(4):253–268
    • (2012) Nat Rev Immunol , vol.12 , Issue.4 , pp. 253-268
    • Gabrilovich, D.I.1    Ostrand-Rosenberg, S.2    Bronte, V.3
  • 23
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: linking inflammation and cancer
    • COI: 1:CAS:528:DC%2BD1MXjvFOjtrg%3D, PID: 19342621
    • Ostrand-Rosenberg S, Sinha P (2009) Myeloid-derived suppressor cells: linking inflammation and cancer. J Immunol 182(8):4499–4506
    • (2009) J Immunol , vol.182 , Issue.8 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 24
    • 84975775438 scopus 로고    scopus 로고
    • State-of-the-art of regulatory dendritic cells in cancer
    • COI: 1:CAS:528:DC%2BC28XntVOlsr4%3D, PID: 27118338
    • Conejo-Garcia JR, Rutkowski MR, Cubillos-Ruiz JR (2016) State-of-the-art of regulatory dendritic cells in cancer. Pharmacol Ther 164:97–104
    • (2016) Pharmacol Ther , vol.164 , pp. 97-104
    • Conejo-Garcia, J.R.1    Rutkowski, M.R.2    Cubillos-Ruiz, J.R.3
  • 25
    • 70349750194 scopus 로고    scopus 로고
    • In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells
    • COI: 1:CAS:528:DC%2BD1MXhtFaku7rJ, PID: 19738057
    • Scarlett UK et al (2009) In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer Res 69(18):7329–7337
    • (2009) Cancer Res , vol.69 , Issue.18 , pp. 7329-7337
    • Scarlett, U.K.1
  • 26
    • 84858793263 scopus 로고    scopus 로고
    • Ovarian cancer progression is controlled by phenotypic changes in dendritic cells
    • COI: 1:CAS:528:DC%2BC38XktFOnsL0%3D, PID: 22351930
    • Scarlett UK et al (2012) Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. J Exp Med 209(3):495–506
    • (2012) J Exp Med , vol.209 , Issue.3 , pp. 495-506
    • Scarlett, U.K.1
  • 27
    • 70350055199 scopus 로고    scopus 로고
    • an emerging key player in the mammalian immune system
    • COI: 1:CAS:528:DC%2BD1MXhsVSks7rI, PID: 19764983
    • Munder M, Arginase (2009) an emerging key player in the mammalian immune system. Br J Pharmacol 158(3):638–651
    • (2009) Br J Pharmacol , vol.158 , Issue.3 , pp. 638-651
    • Munder, M.1    Arginase2
  • 28
    • 79851504402 scopus 로고    scopus 로고
    • CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells
    • PID: 21113407
    • Cubillos-Ruiz JR et al (2010) CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells. Oncotarget 1(5):329–338
    • (2010) Oncotarget , vol.1 , Issue.5 , pp. 329-338
    • Cubillos-Ruiz, J.R.1
  • 29
    • 84990857337 scopus 로고    scopus 로고
    • The roles of microRNAs related with progression and metastasis in human cancers
    • Liu HT, Gao P (2016) The roles of microRNAs related with progression and metastasis in human cancers. Tumor Biol 37(12):15383–15397. doi:10.1007/s13277-016-5436-9
    • (2016) Tumor Biol , vol.37 , Issue.12 , pp. 15385-15397
    • Liu, H.T.1    Gao, P.2
  • 30
    • 34247584465 scopus 로고    scopus 로고
    • Requirement of bic/microRNA-155 for normal immune function
    • COI: 1:CAS:528:DC%2BD2sXksFeksbg%3D, PID: 17463290
    • Rodriguez A et al (2007) Requirement of bic/microRNA-155 for normal immune function. Science 316(5824):608–611
    • (2007) Science , vol.316 , Issue.5824 , pp. 608-611
    • Rodriguez, A.1
  • 31
    • 84859386994 scopus 로고    scopus 로고
    • Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer
    • COI: 1:CAS:528:DC%2BC38XkvVelsLg%3D, PID: 22307839
    • Cubillos-Ruiz JR et al (2012) Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer. Cancer Res 72(7):1683–1693
    • (2012) Cancer Res , vol.72 , Issue.7 , pp. 1683-1693
    • Cubillos-Ruiz, J.R.1
  • 32
    • 84884478648 scopus 로고    scopus 로고
    • A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice
    • COI: 1:CAS:528:DC%2BC3sXhtFejsb7P, PID: 23487026
    • Zonari E et al (2013) A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice. Blood 122(2):243–252
    • (2013) Blood , vol.122 , Issue.2 , pp. 243-252
    • Zonari, E.1
  • 33
    • 84959123285 scopus 로고    scopus 로고
    • Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells
    • COI: 1:CAS:528:DC%2BC28XisFOht7g%3D, PID: 26876172
    • Tesone AJ et al (2016) Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells. Cell Rep 14(7):1774–1786
    • (2016) Cell Rep , vol.14 , Issue.7 , pp. 1774-1786
    • Tesone, A.J.1
  • 34
    • 84931569761 scopus 로고    scopus 로고
    • ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis
    • COI: 1:CAS:528:DC%2BC2MXhtVeiu77J, PID: 26073941
    • Cubillos-Ruiz JR et al (2015) ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell 161(7):1527–1538
    • (2015) Cell , vol.161 , Issue.7 , pp. 1527-1538
    • Cubillos-Ruiz, J.R.1
  • 35
    • 84883387793 scopus 로고    scopus 로고
    • Targeting the unfolded protein response in disease
    • COI: 1:CAS:528:DC%2BC3sXhtlCgt7jL, PID: 23989796
    • Hetz C, Chevet E, Harding HP (2013) Targeting the unfolded protein response in disease. Nat Rev Drug Discov 12(9):703–719
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.9 , pp. 703-719
    • Hetz, C.1    Chevet, E.2    Harding, H.P.3
  • 36
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    • COI: 1:CAS:528:DC%2BD38XjtlKlsg%3D%3D, PID: 11779464
    • Yoshida H et al (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107(7):881–891
    • (2001) Cell , vol.107 , Issue.7 , pp. 881-891
    • Yoshida, H.1
  • 37
    • 0142059951 scopus 로고    scopus 로고
    • XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    • COI: 1:CAS:528:DC%2BD3sXosFOgsLY%3D, PID: 14559994
    • Lee AH, Iwakoshi NN, Glimcher LH (2003) XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23(21):7448–7459
    • (2003) Mol Cell Biol , vol.23 , Issue.21 , pp. 7448-7459
    • Lee, A.H.1    Iwakoshi, N.N.2    Glimcher, L.H.3
  • 38
    • 84902158446 scopus 로고    scopus 로고
    • Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival
    • COI: 1:CAS:528:DC%2BC2cXpvFahsrw%3D, PID: 24812669
    • Tang CH et al (2014) Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest 124(6):2585–2598
    • (2014) J Clin Invest , vol.124 , Issue.6 , pp. 2585-2598
    • Tang, C.H.1
  • 39
    • 84897541350 scopus 로고    scopus 로고
    • XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway
    • COI: 1:CAS:528:DC%2BC2cXlsFOqtLY%3D, PID: 24670641
    • Chen X et al (2014) XBP1 promotes triple-negative breast cancer by controlling the HIF1alpha pathway. Nature 508(7494):103–107
    • (2014) Nature , vol.508 , Issue.7494 , pp. 103-107
    • Chen, X.1
  • 40
    • 77957288028 scopus 로고    scopus 로고
    • Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma
    • COI: 1:CAS:528:DC%2BC3cXhtFaqu7%2FI, PID: 20702765
    • Auf G et al (2010) Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma. Proc Natl Acad Sci USA 107(35):15553–15558
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.35 , pp. 15553-15558
    • Auf, G.1
  • 41
    • 84876407251 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma
    • COI: 1:CAS:528:DC%2BC3sXlsVeqtLw%3D, PID: 23412101
    • Dalton LE et al (2013) The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma. Br J Cancer 108(6):1340–1347
    • (2013) Br J Cancer , vol.108 , Issue.6 , pp. 1340-1347
    • Dalton, L.E.1
  • 42
    • 43949090166 scopus 로고    scopus 로고
    • Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer
    • COI: 1:CAS:528:DC%2BD1cXmtlant7g%3D, PID: 18386815
    • Davies MP et al (2008) Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer. Int J Cancer 123(1):85–88
    • (2008) Int J Cancer , vol.123 , Issue.1 , pp. 85-88
    • Davies, M.P.1
  • 43
    • 84873729773 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival
    • COI: 1:CAS:528:DC%2BC3sXhsFyrsg%3D%3D, PID: 23200913
    • Matsuo K et al (2013) The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol Oncol 128(3):552–559
    • (2013) Gynecol Oncol , vol.128 , Issue.3 , pp. 552-559
    • Matsuo, K.1
  • 44
    • 77955344402 scopus 로고    scopus 로고
    • Lipid accumulation and dendritic cell dysfunction in cancer
    • COI: 1:CAS:528:DC%2BC3cXos1aisLc%3D, PID: 20622859
    • Herber DL et al (2010) Lipid accumulation and dendritic cell dysfunction in cancer. Nat Med 16(8):880–886
    • (2010) Nat Med , vol.16 , Issue.8 , pp. 880-886
    • Herber, D.L.1
  • 45
    • 85025478245 scopus 로고    scopus 로고
    • Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients
    • PID: 28417112
    • Condamine T et al (2016) Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients. Sci Immunol 1(2):aaf8943
    • (2016) Sci Immunol , vol.1 , Issue.2 , pp. aaf8943
    • Condamine, T.1
  • 46
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
    • COI: 1:CAS:528:DyaK1cXjs1Kmtbw%3D, PID: 9624005
    • Schoenberger SP et al (1998) T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions. Nature 393(6684):480–483
    • (1998) Nature , vol.393 , Issue.6684 , pp. 480-483
    • Schoenberger, S.P.1
  • 47
    • 0032482356 scopus 로고    scopus 로고
    • Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    • COI: 1:CAS:528:DyaK1cXjs1Kmtro%3D, PID: 9624004
    • Bennett SR et al (1998) Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393(6684):478–480
    • (1998) Nature , vol.393 , Issue.6684 , pp. 478-480
    • Bennett, S.R.1
  • 48
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • COI: 1:CAS:528:DC%2BC3MXjs1CgtLY%3D, PID: 21436454
    • Beatty GL et al (2011) CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331(6024):1612–1616
    • (2011) Science , vol.331 , Issue.6024 , pp. 1612-1616
    • Beatty, G.L.1
  • 49
    • 84877792257 scopus 로고    scopus 로고
    • CD40 immunotherapy for pancreatic cancer
    • COI: 1:CAS:528:DC%2BC3sXmslamsbo%3D, PID: 23589109
    • Vonderheide RH et al (2013) CD40 immunotherapy for pancreatic cancer. Cancer Immunol Immunother 62(5):949–954
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.5 , pp. 949-954
    • Vonderheide, R.H.1
  • 50
    • 84995615046 scopus 로고    scopus 로고
    • T cell cancer therapy requires CD40-CD40L activation of tumor necrosis factor and inducible nitric-oxide-synthase-producing dendritic cells
    • COI: 1:CAS:528:DC%2BC28XhsFWitrnL, PID: 27622331
    • Marigo I et al (2016) T cell cancer therapy requires CD40-CD40L activation of tumor necrosis factor and inducible nitric-oxide-synthase-producing dendritic cells. Cancer Cell 30(3):377–390
    • (2016) Cancer Cell , vol.30 , Issue.3 , pp. 377-390
    • Marigo, I.1
  • 51
    • 84888086049 scopus 로고    scopus 로고
    • A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
    • COI: 1:CAS:528:DC%2BC3sXhslyku7nJ, PID: 23983255
    • Beatty GL et al (2013) A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. Clin Cancer Res 19(22):6286–6295
    • (2013) Clin Cancer Res , vol.19 , Issue.22 , pp. 6286-6295
    • Beatty, G.L.1
  • 52
    • 78650138274 scopus 로고    scopus 로고
    • A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma
    • COI: 1:CAS:528:DC%2BC3cXht1WhsL7F, PID: 20615924
    • Rosenfeld MR et al (2010) A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma. Neuro Oncol 12(10):1071–1077
    • (2010) Neuro Oncol , vol.12 , Issue.10 , pp. 1071-1077
    • Rosenfeld, M.R.1
  • 53
    • 68949208465 scopus 로고    scopus 로고
    • Nanocarriers’ entry into the cell: relevance to drug delivery
    • COI: 1:CAS:528:DC%2BD1MXps1Cqsbs%3D, PID: 19499185
    • Hillaireau H, Couvreur P (2009) Nanocarriers’ entry into the cell: relevance to drug delivery. CMLS Cell Mol Life Sci 66(17):2873–2896
    • (2009) CMLS Cell Mol Life Sci , vol.66 , Issue.17 , pp. 2873-2896
    • Hillaireau, H.1    Couvreur, P.2
  • 54
    • 75649133158 scopus 로고    scopus 로고
    • Nanomolecular targeting of dendritic cells for ovarian cancer therapy
    • PID: 19852731
    • Cubillos-Ruiz JR, Fiering S, Conejo-Garcia JR (2009) Nanomolecular targeting of dendritic cells for ovarian cancer therapy. Future Oncol 5(8):1189–1192
    • (2009) Future Oncol , vol.5 , Issue.8 , pp. 1189-1192
    • Cubillos-Ruiz, J.R.1    Fiering, S.2    Conejo-Garcia, J.R.3
  • 55
    • 84879264708 scopus 로고    scopus 로고
    • ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
    • Gaj T, Gersbach CA, Barbas CF 3rd (2013) ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol. 31(7):397–405
    • (2013) Trends Biotechnol , vol.31 , Issue.7 , pp. 397-405
    • Gaj, T.1    Gersbach, C.A.2    Barbas, C.F.3
  • 56
    • 84912101598 scopus 로고    scopus 로고
    • CRISPR-Cas9 knockin mice for genome editing and cancer modeling
    • COI: 1:CAS:528:DC%2BC2cXhs1agsbbE, PID: 25263330
    • Platt RJ et al (2014) CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell 159(2):440–455
    • (2014) Cell , vol.159 , Issue.2 , pp. 440-455
    • Platt, R.J.1


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