Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 7, 2017, Pages 1631-1636

  Zeng, Qingchun ^a,b   Song, Rui ^a,b   Fullerton, David A ^a   Ao, Lihua ^a   Zhai, Yufeng ^a   Li, Suzhao ^c   Ballak, Dov B ^d   Cleveland, Joseph C ^a   Reece, T Brett ^a   McKinsey, Timothy A ^c   Xu, Dingli ^b   Dinarello, Charles A ^c,d   Meng, Xianzhong ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Calcification; Inflammation; Oxidized low density lipoprotein; Signal transduction; Toll like receptors

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 37; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXIDIZED LOW DENSITY LIPOPROTEIN; PAM 3CSK 4; RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 37; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE; RECOMBINANT PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA VALVE; AORTA VALVE DISEASE; AORTIC VALVE INTERSTITIAL CELL; ARTERIAL WALL THICKENING; ARTICLE; CALCIFIC AORTIC VALVE DISEASE; CALCIFICATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; LEYDIG CELL; LIPID DIET; LONG TERM EXPOSURE; MALE; MIDDLE AGED; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERAPY EFFECT; TREATMENT RESPONSE; AGED; ANIMAL; AORTIC VALVE; AORTIC VALVE STENOSIS; BONE DEVELOPMENT; C57BL MOUSE; CALCINOSIS; CELL CULTURE; DRUG EFFECT; FEMALE; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE;

AGED; ALKALINE PHOSPHATASE; ANIMALS; AORTIC VALVE; AORTIC VALVE STENOSIS; BONE MORPHOGENETIC PROTEIN 2; CALCINOSIS; CELLS, CULTURED; FEMALE; HUMANS; INTERLEUKINS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MIDDLE AGED; NF-KAPPA B; OSTEOGENESIS; RECOMBINANT PROTEINS;

EID: 85013078100     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1619667114     Document Type: Article

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