Accumulation of oxidized LDL in human semilunar valves correlates with coronary atherosclerosis

Cardiovascular Research

Volumn 45, Issue 4, 2000, Pages 874-882

  Mehrabi, Mohammad Reza ^a   Sinzinger, Helmut ^a   Ekmekcioglu, Cem ^a   Tamaddon, Forouzan ^a   Plesch, Karina ^a   Glogar, Helmut D ^a   Maurer, Gerald ^a   Stefenelli, Thomas ^a   Lang, Irene Martha ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Atherosclerosis; Cholesterol; Lipid metabolism; Lipoproteins; Valve (disease)

Indexed keywords

ANTIBODY; CD68 ANTIGEN; CELL ADHESION MOLECULE; CHOLESTEROL; CYTOKINE; ENZYME INHIBITOR; MACROPHAGE CHEMOTACTIC FACTOR; OXIDIZED LOW DENSITY LIPOPROTEIN; PLASMINOGEN ACTIVATOR; PLATELET DERIVED GROWTH FACTOR A;

ADULT; AGED; ARTICLE; ATHEROGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; MACROPHAGE; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN MODIFICATION; VALVULAR HEART DISEASE;

AGED; ANALYSIS OF VARIANCE; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; AORTIC VALVE; BIOLOGICAL MARKERS; CORONARY ARTERIOSCLEROSIS; CORONARY VESSELS; FEMALE; HEART FAILURE, CONGESTIVE; HEART TRANSPLANTATION; HEART VALVES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; OXIDATION-REDUCTION; PULMONARY VALVE;

EID: 0033954503     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(99)00389-2     Document Type: Article

References (36)

1. Thomas H.E. Jr., Kannel W.B., Dawber T.R., McNamara P.M. Cholesterol-phospholipid ratio in the prediction of coronary heart disease. N Engl J Med. 274:1966;701-705.
2. Castelli W.P. Lipids, risk factors and ischaemic heart disease. Atherosclerosis. 124:1996;1-9.
3. Cathcart M.K., Morel D.W., Chisolm G.M. Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. J Leukoc Biol. 38:1985;341-350.
4. Henriksen T., Mahoney E.M., Steinberg D. Enhanced macrophage degradation of biologically modified low density lipoprotein. Arteriosclerosis. 3:1983;149-159.
5. Morel D.W., DiCorleto P.E., Chisolm G.M. Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation. Arteriosclerosis. 4:1984;357-364.
6. Sparrow C.P., Parthasarathy S., Steinberg D. A macrophage receptor that recognizes low density lipoprotein but not acetylated low density lipoprotein. J Biol Chem. 264:1989;2599-2604.
7. Witztum J.L., Steinberg D. Role of oxidized low-density lipoprotein in atherogenesis. J Clin Invest. 88:1991;1785-1792.
8. Mehta A., Yang B., Khan S., Hendricks J.B., Stephen C., Mehta J.L. Oxidized low-density lipoproteins facilitate leukocyte adhesion to aortic intima without affecting endothelium-dependent relaxation: Role of P-selectin. Arterioscler Thromb Vasc Biol. 15:1995;2076-2083.
9. Liao L., Starzyk R.M., Granger D.N. Molecular determinants of oxidized low-density lipoprotein-induced leucocyte adhesion and microvascular dysfunction. Arterioscler Thromb Vasc Biol. 17:1997;437-444.
10. Minuz P., Lechi C., Gaino S., Bonapace S., Fontana L., Garbin U., Paluani F., Cominacini L., Zatti M., Lechi A. Oxidized LDL and reduction of the antiaggregating activity of nitric oxide derived from endothelial cells. Thromb Haemost. 74:1995;1175-1179.
11. El-Saadani M., Esterbauer H., El-Sayed M., Goher M., Nassar A.Y., Jürgens G. A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent. J Lipid Res. 30:1989;627-630.
12. Esterbauer H., Gebicki J., Puhl H., Jürgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic Biol Med. 13:1992;341-390.
13. Kugiyama K., Kerns S.A., Morrisett J.D., Roberts R., Henry P.D. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoprotein. Nature. 344:1990;160-162.
14. Watson A.D., Navab M., Hama S.Y., Sevanian A., Prescott S.M., Stafforini D.M., McIntyre T.M., Du B.W., Fogelman A.M., Berliner J.A. Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density-lipoprotein. J Clin Invest. 95:1995;774-782.
15. Nievelstein-Post P., Mottino G., Fogelman A., Frank J. An ultrastructural study of lipoprotein accumulation in cardiac valves of the rabbit. Arterioscler Thromb. 14:1994;1151-1161.
16. Zahor Z., Czabanova V. Experimental atherosclerosis of the heart valves in rats following a long-term atherogenic regimen. Atherosclerosis. 27:1977;49-57.
17. Walton K.W., Williamson N., Johnson A.G. The pathogenesis of atherosclerosis of the mitral and aortic valves. J Pathol. 101:1970;205-220.
18. Kim K.M., Huang S.N. Ultrastructural study of calcification of human aortic valve. Lab Invest. 25:1971;357-366.
19. Thubrikar M.J., Deck J.D., Aouad J., Chen J.M. Intramural stress as a causative factor in atherosclerotic lesions of the aortic valve. Atherosclerosis. 55:1985;299-311.
20. Simionescu N., Vasile E., Lupu F., Popescu G., Simionescu M. Prelesional events in atherogenesis: Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit. Am J Pathol. 123:1986;109-125.
21. Filip D.A., Nistor A., Bulla A., Radu A., Lupu F., Simionescu M. Cellular events in the development of valvular atherosclerotic lesions induced by experimental hypercholesterolemia. Atherosclerosis. 67:1987;199-214.
22. Lin S.L., Liu C.P., Chen C.Y., Ger L.P., Chiang H.A.T. The relation between thickened aortic valve and coronary artery disease. Chung Hua I Hsueh Tsa Chih (TaiPei). 60:1997;92-97.
23. Winvard P.G., Tatzber F., Esterbauer H., Kus M.L., Blake D.R., Morris C.J. Presence of foam cells containing oxidized low-density lipoprotein in the synovial membrane from patients with rheumatoid arthritis. Ann Rheum Dis. 52:1993;677-680.
24. Johnson F.B., Sinclair D.A., Guarente L. Molecular biology of aging. Cell. 96:1999;291-302.
25. Otto C.M., Lind B.K., Kitzman D.W., Gersh B.J., Siscovick D.S. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med. 341:1999;142-147.
26. Mohler E.R., Sheridan M.J., Nichols R., Harvey W.P., Waller B.F. Development and progression of aortic valve stenosis: atherosclerotic risk factors - a causal relationship? A clinical morphologic study. Cardiology. 14:1991;995-999.
27. Gotoh T., Kuroda T., Yamasawa M. Correlation between lipoprotein (a) and aortic valve sclerosis assessed by echocardiography (the JMS Cardiac Echo and Cohort Study). Am J Cardiol. 76:1995;928-932.
28. Aronow W.S., Schwartz K.S., Koenigsberg M. Correlation of serum lipids, calcium, and phosphorus, diabetes mellitus and history of systemic hypertension with presence or absence of calcified or thickened aortic cusps or root in elderly patients. Am J Cardiol. 59:1987;998-999.
29. Filip D.A., Radu A., Simionescu M. Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells. Circ Res. 59:1986;310-320.
30. Rosenhek R., Korschineck I., Mehrabi M., Huber K., Lang I.M. Increased fibrinolytic gene expression in the pulmonary artery. Circulation. 98 (abstract 314):1998;I63.
31. Martin T.R. Lung cytokines and ARDS: Roger S. Mitchell lecture. Chest. 116:1999;2s-8s.
32. Belov L., Meher Homji V., Putaswamy V., Miller R. Western blot analysis of bile or intestinal fluid from patients with septic shock or systemic inflammatory response syndrome, using antibodies to TNF-alpha, IL-1 alpha and IL-1 beta. Immunol Cell Biol. 77:1999;34-40.
33. Dibbs Z., Thornby J., White B.G., Mann D.L. Natural variability of circulating levels of cytokines and cytokine receptors in patients with heart failure: implications for clinical trials. J Am Coll Cardiol. 33:1999;1935-1942.
34. Bjorkerud B., Bjorkerud S. Contrary effects of lightly and strongly oxidized LDL with potent promotion of growth versus apoptosis on arterial smooth muscle cells, macrophages and fibroblasts. Arterioscler Thromb Vasc Biol. 16:1996;416-424.
35. Nishio E., Arimura S., Watanabe Y. Oxidized LDL induces apoptosis in cultured smooth muscle cells: a possible role for 7-ketocholesterol. Biochem Biophys Res Commun. 223:1996;413-418.
36. Jovinge S., Crisby M., Nilsson J. DNA fragmentation and ultrastructural changes in degenerating cells in atherosclerotic lesions and smooth muscle cells exposed to oxidised LDL in vitro. Arterioscler Thromb Vasc Biol. 17:1997;2225-2231.