Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1

Alzheimer's and Dementia

Volumn 13, Issue 6, 2017, Pages 689-700

  Cronin, Peter ^a   McCarthy, Michael J ^b,c   Lim, Andrew S P ^d   Salmon, David P ^a   Galasko, Douglas ^a   Masliah, Eliezer ^a,c   De Jager, Philip L ^e   Bennett, David A ^f   Desplats, Paula ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; BMAL1; Brain; Circadian clock; Circadian rhythms; DNA methylation; Epigenetics; Fibroblasts; Methylation cycles; Neurodegeneration

Indexed keywords

TRANSCRIPTION FACTOR ARNTL; ARNTL PROTEIN, HUMAN;

AGING; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; CIRCADIAN RHYTHM; COGNITIVE DEFECT; CONTROLLED STUDY; DNA METHYLATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIGENETIC REPRESSION; FIBROBLAST CULTURE; FRONTAL CORTEX; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; CASE CONTROL STUDY; CELL CULTURE; FEMALE; FIBROBLAST; FRONTAL LOBE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETICS; MALE; METABOLISM; PHYSIOLOGY; VERY ELDERLY;

AGED, 80 AND OVER; ALZHEIMER DISEASE; ARNTL TRANSCRIPTION FACTORS; CASE-CONTROL STUDIES; CELLS, CULTURED; CIRCADIAN RHYTHM; DNA METHYLATION; FEMALE; FIBROBLASTS; FRONTAL LOBE; GENE EXPRESSION; HUMANS; MALE; TRANSCRIPTION, GENETIC;

EID: 85012873703     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2016.10.003     Document Type: Article

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