Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans

Annals of Neurology

Volumn 78, Issue 2, 2015, Pages 317-322

  Wang, Joshua L ^a   Lim, Andrew S ^a,b   Chiang, Wei Yin ^c,d   Hsieh, Wan Hsin ^c,d   Lo, Men Tzung ^c,d   Schneider, Julie A ^e   Buchman, Aron S ^e   Bennett, David A ^e   Hu, Kun ^a,c,d   Saper, Clifford B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VASOACTIVE INTESTINAL POLYPEPTIDE;

ACTIMETRY; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN TISSUE; CELL COUNT; CIRCADIAN RHYTHM; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIGHT DARK CYCLE; LOCOMOTION; LONGITUDINAL STUDY; MALE; MAMMILLARY BODY; MOTOR ACTIVITY; NERVE CELL; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEASONAL VARIATION; SENESCENCE; SUPRACHIASMATIC NUCLEUS; SUPRAOPTIC NUCLEUS; VERY ELDERLY; WAVEFORM; CASE CONTROL STUDY; CYTOLOGY; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACTIGRAPHY; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; CELL COUNT; CIRCADIAN RHYTHM; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR ACTIVITY; NEURONS; SUPRACHIASMATIC NUCLEUS; VASOACTIVE INTESTINAL PEPTIDE;

EID: 84937726145     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24432     Document Type: Article

References (22)

1. Saper CB,. The central circadian timing system. Curr Opin Neurobiol 2013; 23: 747-751.
2. An S, Harang R, Meeker K, et al., A neuropeptide speeds circadian entrainment by reducing intercellular synchrony. Proc Natl Acad Sci U S A 2013; 110: E4355-E4361.
3. Yamaguchi Y, Suzuki T, Mizoro Y, et al., Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag. Science 2013; 342: 85-90.
4. Abrahamson EE, Moore RY,. Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections. Brain Res 2001; 916: 172-191.
5. Kondratova AA, Kondratov RV,. The circadian clock and pathology of the ageing brain. Nat Rev Neurosci 2012; 13: 325-335.
6. Zhou J-N, Hofman MA, Swaab DF,. VIP neurons in the human SCN in relation to sex, age, and Alzheimer's disease. Neurobiol Aging 1995; 16: 571-576.
7. Swaab DFF, Fliers E, Partiman TSS,. The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia. Brain Res 1985; 342: 37-44.
8. Bennett DA, Schneider JA, Buchman AS, et al., Overview and findings from the rush Memory and Aging Project. Curr Alzheimer Res 2012; 9: 646-663.
9. Lim ASP, Ellison BA, Wang JL, et al., Sleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimer's disease. Brain 2014; 137 (pt 10): 2847-2861.
10. Bennett DA, Schneider JA, Arvanitakis Z, et al., Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 2006; 66: 1837-1844.
11. Huang NE, Shen Z, Long SR, Wu MLC, Shih HH, Zheng QN, Yen NC, Tung CC, Liu HH,. The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time analysis. Proc Roy Soc London, Series A-Mathematical Physical and Engineering Sciences 1998; 454: 903-995.
12. Chou TC, Scammell TE, Gooley JJ, et al., Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci 2003; 23: 10691-10702.
13. Sokolove PG, Bushell WN,. The chi square periodogram: its utility for analysis of circadian rhythms. J Theor Biol 1978; 72: 131-160.
14. Hatfield CF, Herbert J, van Someren EJW, et al., Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia. Brain 2004; 127 (pt 5): 1061-1074.
15. Harper DG, Volicer L, Stopa EG, et al., Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. Am J Geriatr Psychiatry 2005; 13: 359-368.
16. Harper DG, Stopa EG, Kuo-Leblanc V, et al., Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain 2008; 131 (pt 6): 1609-1617.
17. Liu RY, Zhou JN, Hoogendijk WJ, et al., Decreased vasopressin gene expression in the biological clock of Alzheimer disease patients with and without depression. J Neuropathol Exp Neurol 2000; 59: 314-322.
18. Pollak CP, Perlick D,. Sleep problems and institutionalization of the elderly. J Geriatr Psychiatry Neurol 1991; 4: 204-210.
19. Chen CP, Eastwood SL, Hope T, et al., Immunocytochemical study of the dorsal and median raphe nuclei in patients with Alzheimer's disease prospectively assessed for behavioural changes. Neuropathol Appl Neurobiol 2000; 26: 347-355.
20. Morin LP,. Serotonin and the regulation of mammalian circadian rhythmicity. Ann Med 1999; 31: 12-33.
21. Satlin A, Volicer L, Ross V, et al., Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer's disease. Am J Psychiatry 1992; 149: 1028-1032.
22. Lovell BB, Ancoli-Israel S, Gevirtz R,. Effect of bright light treatment on agitated behavior in institutionalized elderly subjects. Psychiatry Res 1995; 57: 7-12.