메뉴 건너뛰기




Volumn 8, Issue , 2017, Pages

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; REGULATOR PROTEIN; THREE AMINO ACID LOOP EXTENSION HOMEOBOX TG INTERACTING FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; REPRESSOR PROTEIN; TG-INTERACTING FACTOR 2, MOUSE;

EID: 85012284089     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14127     Document Type: Article
Times cited : (39)

References (67)
  • 1
    • 71449125977 scopus 로고    scopus 로고
    • Forcing cells to change lineages
    • Graf, T. & Enver, T. Forcing cells to change lineages. Nature 3, 587-594 (2009).
    • (2009) Nature , vol.3 , pp. 587-594
    • Graf, T.1    Enver, T.2
  • 2
    • 78951478823 scopus 로고    scopus 로고
    • Dedifferentiation,transdifferentiation and reprogramming: Three routes to regeneration
    • Jopling, C., Boue, S. & Izpisua Belmonte, J. Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat. Rev. Mol. Cell Biol. 12, 79-89 (2011).
    • (2011) Nat. Rev.Mol. Cell Biol. , vol.12 , pp. 79-89
    • Jopling, C.1    Boue, S.2    Izpisua Belmonte, J.3
  • 3
    • 34247350842 scopus 로고    scopus 로고
    • Metaplasia and transdifferentiation: From pure biology to the clinic
    • Slack, J. M. Metaplasia and transdifferentiation: from pure biology to the clinic. Nat. Rev. Mol. Cell Biol. 8, 369-378 (2007).
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 369-378
    • Slack, J.M.1
  • 4
    • 80054726357 scopus 로고    scopus 로고
    • Direct lineage conversions: Unnatural but useful?
    • Vierbuchen, T. & Wernig, M. Direct lineage conversions: unnatural but useful? Nat. Biotechnol. 29, 892-907 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 892-907
    • Vierbuchen, T.1    Wernig, M.2
  • 5
    • 84923764176 scopus 로고    scopus 로고
    • Recent breakthroughs and futurechallenges in in vivo reprogramming for tissue repair
    • Heinrich, C., Spagnoli, F. & Berninger, B. Recent breakthroughs and future challenges in in vivo reprogramming for tissue repair. Nat. Cell Biol. 17, 204-211 (2015).
    • (2015) Nat. Cell Biol. , vol.17 , pp. 204-211
    • Heinrich, C.1    Spagnoli, F.2    Berninger, B.3
  • 6
    • 84880506680 scopus 로고    scopus 로고
    • Adult duct-lining cells can reprogram into beta-like cellsable to counter repeated cycles of toxin-induced diabetes
    • Al-Hasani, K. et al. Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes. Dev. Cell 26, 86-100 (2013).
    • (2013) Dev. Cell , vol.26 , pp. 86-100
    • Al-Hasani, K.1
  • 7
    • 84892173922 scopus 로고    scopus 로고
    • Transient cytokine treatment induces acinar cellreprogramming and regenerates functional beta cell mass in diabetic mice
    • Baeyens, L. et al. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat. Biotechnol. 32, 76-83 (2014).
    • (2014) Nat.Biotechnol. , vol.32 , pp. 76-83
    • Baeyens, L.1
  • 8
    • 0034608816 scopus 로고    scopus 로고
    • In vitro cultivation of human islets from expanded ductaltissue
    • Bonner-Weir, S. et al. In vitro cultivation of human islets from expanded ductal tissue. Proc. Natl Acad. Sci. USA 97, 7999-8004 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 7999-8004
    • Bonner-Weir, S.1
  • 9
    • 84874626174 scopus 로고    scopus 로고
    • Epigenomic plasticity enables human pancreatic alpha tobeta cell reprogramming
    • Bramswig, N. C. et al. Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming. J. Clin. Invest. 123, 1275-1284 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 1275-1284
    • Bramswig, N.C.1
  • 10
    • 84920744392 scopus 로고    scopus 로고
    • Diabetes recovery by age-dependent conversion of pancreaticd-cells into insulin producers
    • Chera, S. et al. Diabetes recovery by age-dependent conversion of pancreatic d-cells into insulin producers. Nature 514, 503-507 (2014).
    • (2014) Nature , vol.514 , pp. 503-507
    • Chera, S.1
  • 11
    • 79955430577 scopus 로고    scopus 로고
    • Suppression of Ptf1a activityinduces acinar-to-endocrine conversion
    • Hesselson, D., Anderson, R. M. & Stainier, D. Y. Suppression of Ptf1a activity induces acinar-to-endocrine conversion. Curr. Biol. 21, 712-717 (2011).
    • (2011) Curr. Biol. , vol.21 , pp. 712-717
    • Hesselson, D.1    Anderson, R.M.2    Stainier, D.Y.3
  • 12
    • 84888096421 scopus 로고    scopus 로고
    • Expansion and conversion of human pancreatic ductal cells intoinsulin-secreting endocrine cells
    • Lee, J. et al. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife 2, e00940 (2013).
    • (2013) Elife , vol.2
    • Lee, J.1
  • 13
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells afterextreme beta-cell loss
    • Thorel, F. et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464, 1149-1154 (2010).
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1
  • 14
    • 84860410786 scopus 로고    scopus 로고
    • Context-specific alpha-to-beta-cell reprogramming by forced Pdx1 expression
    • Yang, Y. P., Thorel, F., Boyer, D. F., Herrera, P. L. & Wright, C. V. Context-specific alpha-to-beta-cell reprogramming by forced Pdx1 expression. Genes Dev. 25, 1680-1685 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 1680-1685
    • Yang, Y.P.1    Thorel, F.2    Boyer, D.F.3    Herrera, P.L.4    Wright, C.V.5
  • 15
    • 53349178722 scopus 로고    scopus 로고
    • In vivoreprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455, 627-632 (2008).
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 16
    • 0037458120 scopus 로고    scopus 로고
    • Experimental conversion ofliver to pancreas
    • Horb, M. E., Shen, C. N., Tosh, D. & Slack, J. M. Experimental conversion of liver to pancreas. Curr. Biol. 13, 105-115 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 105-115
    • Horb, M.E.1    Shen, C.N.2    Tosh, D.3    Slack, J.M.4
  • 17
    • 84866550121 scopus 로고    scopus 로고
    • In vivoreprogramming of Sox9+ cells in the liver to insulin-secreting ducts
    • Banga, A., Akinci, E., Greder, L. V., Dutton, J. R. & Slack, J. M. In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts. Proc. Natl Acad. Sci. USA 109, 15336-15341 (2012).
    • (2012) Proc. NatlAcad. Sci. USA , vol.109 , pp. 15336-15341
    • Banga, A.1    Akinci, E.2    Greder, L.V.3    Dutton, J.R.4    Slack, J.M.5
  • 18
    • 0034068602 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces expressionof insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
    • Ferber, S. et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat. Med. 6, 568-572 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 568-572
    • Ferber, S.1
  • 19
    • 33846316025 scopus 로고    scopus 로고
    • Adenovirus transduction isrequired for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver
    • Wang, A. Y., Ehrhardt, A., Xu, H. & Kay, M. A. Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. Mol. Ther. 15, 255-263 (2007).
    • (2007) Mol. Ther. , vol.15 , pp. 255-263
    • Wang, A.Y.1    Ehrhardt, A.2    Xu, H.3    Kay, M.A.4
  • 20
    • 61749094740 scopus 로고    scopus 로고
    • Neurogenin3 is sufficient for transdetermination of hepaticprogenitor cells into neo-islets in vivo but not transdifferentiation ofhepatocytes
    • Yechoor, V. et al. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev. Cell 16, 358-373 (2009).
    • (2009) Dev. Cell , vol.16 , pp. 358-373
    • Yechoor, V.1
  • 21
    • 0141534119 scopus 로고    scopus 로고
    • PDX-1 in liver initiates endocrine and exocrine pancreasdifferentiation but causes dysmorphogenesis
    • Miyatsuka, T. et al. PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem. Biophys. Res. Commun. 310, 1017-1025 (2003).
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 1017-1025
    • Miyatsuka, T.1
  • 22
    • 84897030116 scopus 로고    scopus 로고
    • De novo formation of insulin-producing 'Neo-b Cell Islets'from intestinal crypts
    • Yi-Ju Chen, Y. et al. De novo formation of insulin-producing 'Neo-b Cell Islets' from intestinal crypts. Cell Rep. 6, 1046-1058 (2014).
    • (2014) Cell Rep. , vol.6 , pp. 1046-1058
    • Yi-Ju Chen, Y.1
  • 23
    • 77949878205 scopus 로고    scopus 로고
    • Cellular plasticity within the pancreas-lessons learnedfrom development
    • Puri, S. & Hebrok, M. Cellular plasticity within the pancreas-lessons learned from development. Dev. Cell 18, 342-356 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 342-356
    • Puri, S.1    Hebrok, M.2
  • 24
    • 57349112286 scopus 로고    scopus 로고
    • Generation and regeneration of cells of the liver andpancreas
    • Zaret, K. & Grompe, M. Generation and regeneration of cells of the liver and pancreas. Science 322, 1490-1494 (2008).
    • (2008) Science , vol.322 , pp. 1490-1494
    • Zaret, K.1    Grompe, M.2
  • 25
    • 84883633934 scopus 로고    scopus 로고
    • Mutually exclusive signaling signatures define thehepatic and pancreatic progenitor cell lineages divergence
    • Rodríguez-Seguel, E. et al. Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineages divergence. Genes Dev. 27, 1932-1946 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 1932-1946
    • Rodríguez-Seguel, E.1
  • 26
    • 76249102739 scopus 로고    scopus 로고
    • Organogenesis and development of theliver
    • Si-Tayeb, K., Lemaigre, F. & Duncan, S. Organogenesis and development of the liver. Dev. Cell 18, 175-189 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 175-189
    • Si-Tayeb, K.1    Lemaigre, F.2    Duncan, S.3
  • 27
    • 79956326274 scopus 로고    scopus 로고
    • Chromatin 'prepattern' and histone modifiers in a fate choice forliver and pancreas
    • Xu, C. R. et al. Chromatin 'prepattern' and histone modifiers in a fate choice for liver and pancreas. Science 332, 963-966 (2011).
    • (2011) Science , vol.332 , pp. 963-966
    • Xu, C.R.1
  • 28
    • 41649118494 scopus 로고    scopus 로고
    • The Gata5 target, TGIF2, defines thepancreatic region by modulating BMP signals within the endoderm
    • Spagnoli, F. M. & Brivanlou, A. H. The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm. Development 135, 451-461 (2008).
    • (2008) Development , vol.135 , pp. 451-461
    • Spagnoli, F.M.1    Brivanlou, A.H.2
  • 29
    • 84890859445 scopus 로고    scopus 로고
    • Glimpse into hox and tale regulation of celldifferentiation and reprogramming
    • Cerda-Esteban, N. & Spagnoli, F. Glimpse into hox and tale regulation of cell differentiation and reprogramming. Dev. Dyn. 243, 76-87 (2014).
    • (2014) Dev. Dyn. , vol.243 , pp. 76-87
    • Cerda-Esteban, N.1    Spagnoli, F.2
  • 30
    • 33644976371 scopus 로고    scopus 로고
    • Hox cofactors in vertebrate development
    • Moens, C. B. & Selleri, L. Hox cofactors in vertebrate development. Dev. Biol. 291, 193-206 (2006).
    • (2006) Dev. Biol. , vol.291 , pp. 193-206
    • Moens, C.B.1    Selleri, L.2
  • 31
    • 0035943703 scopus 로고    scopus 로고
    • TGIF2 interacts with histonedeacetylase 1 and represses transcription
    • Melhuish, T. A., Gallo, C. M. & Wotton, D. TGIF2 interacts with histone deacetylase 1 and represses transcription. J. Biol. Chem. 276, 32109-32114 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 32109-32114
    • Melhuish, T.A.1    Gallo, C.M.2    Wotton, D.3
  • 32
    • 33646883064 scopus 로고    scopus 로고
    • Embryonic fibroblasts from mice lacking Tgif weredefective in cell cycling
    • Mar, L. & Hoodless, P. A. Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling. Mol. Cell Biol. 26, 4302-4310 (2006).
    • (2006) Mol. Cell Biol. , vol.26 , pp. 4302-4310
    • Mar, L.1    Hoodless, P.A.2
  • 33
    • 73649117155 scopus 로고    scopus 로고
    • Tgif1 and Tgif2 regulate Nodal signaling and are required forgastrulation
    • Powers, S. et al. Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development 137, 249-259 (2010).
    • (2010) Development , vol.137 , pp. 249-259
    • Powers, S.1
  • 34
    • 0036544854 scopus 로고    scopus 로고
    • Pbx1 inactivation disrupts pancreas development and inIpf1-deficient mice promotes diabetes mellitus
    • Kim, S. et al. Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat. Genet. 30, 430-435 (2002).
    • (2002) Nat. Genet. , vol.30 , pp. 430-435
    • Kim, S.1
  • 35
    • 14844333138 scopus 로고    scopus 로고
    • Distinct populations of endoderm cells convergeto generate the embryonic liver bud and ventral foregut tissues
    • Tremblay, K. D. & Zaret, K. S. Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Dev. Biol. 280, 87-99 (2005).
    • (2005) Dev. Biol. , vol.280 , pp. 87-99
    • Tremblay, K.D.1    Zaret, K.S.2
  • 36
    • 84883049695 scopus 로고    scopus 로고
    • Molecular characterization of mutant mouse strains generatedfrom the EUCOMM/KOMP-CSD ES cell resource
    • Ryder, E. et al. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm. Genome 24, 286-294 (2013).
    • (2013) Mamm. Genome , vol.24 , pp. 286-294
    • Ryder, E.1
  • 37
    • 4043070783 scopus 로고    scopus 로고
    • Efficient gene modulation inmouse epiblast using a Sox2Cre transgenic mouse strain
    • Hayashi, S., Lewis, P., Pevny, L. & McMahon, A. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech. Dev. 119, S97-S101 (2002).
    • (2002) Mech. Dev. , vol.119 , pp. S97-S101
    • Hayashi, S.1    Lewis, P.2    Pevny, L.3    McMahon, A.4
  • 38
    • 84866701121 scopus 로고    scopus 로고
    • Dual lineage-specific expression of Sox17 during mouseembryogenesis
    • Choi, E. et al. Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells 30, 2297-2308 (2012).
    • (2012) Stem Cells , vol.30 , pp. 2297-2308
    • Choi, E.1
  • 39
    • 84888137330 scopus 로고    scopus 로고
    • TheSox17CreERT2 knock-in mouse line displays spatiotemporal activation of Crerecombinase in distinct Sox17 lineage progenitors
    • Engert, S., Burtscher, I., Kalali, B., Gerhard, M. & Lickert, H. The Sox17CreERT2 knock-in mouse line displays spatiotemporal activation of Cre recombinase in distinct Sox17 lineage progenitors. Genesis 51, 793-802 (2013).
    • (2013) Genesis , vol.51 , pp. 793-802
    • Engert, S.1    Burtscher, I.2    Kalali, B.3    Gerhard, M.4    Lickert, H.5
  • 40
    • 0036333279 scopus 로고    scopus 로고
    • Depletion of definitive gut endoderm in Sox17-nullmutant mice
    • Kanai-Azuma, M. et al. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development 129, 2367-2379 (2002).
    • (2002) Development , vol.129 , pp. 2367-2379
    • Kanai-Azuma, M.1
  • 41
    • 67650246360 scopus 로고    scopus 로고
    • Sox17 regulates organ lineage segregation of ventral foregutprogenitor cells
    • Spence, J. R. et al. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev. Cell 17, 62-74 (2009).
    • (2009) Dev. Cell , vol.17 , pp. 62-74
    • Spence, J.R.1
  • 42
    • 33750846133 scopus 로고    scopus 로고
    • Production of pancreatic hormone-expressing endocrinecells from human embryonic stem cells
    • D'Amour, K. et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 24, 1392-1401 (2006).
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1392-1401
    • D'Amour, K.1
  • 43
    • 79551580013 scopus 로고    scopus 로고
    • Stage-specific signaling through TGF-beta family membersand WNT regulates patterning and pancreatic specification of humanpluripotent stem cells
    • Nostro, M. et al. Stage-specific signaling through TGF-beta family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development 138, 861-871 (2011).
    • (2011) Development , vol.138 , pp. 861-871
    • Nostro, M.1
  • 44
    • 84881184980 scopus 로고    scopus 로고
    • Vascularized and functional human liver from an iPSC-derivedorgan bud transplant
    • Takebe, T. et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499, 481-484 (2013).
    • (2013) Nature , vol.499 , pp. 481-484
    • Takebe, T.1
  • 45
    • 0346368084 scopus 로고    scopus 로고
    • Origin of exocrine pancreatic cellsfrom nestin-positive precursors in developing mouse pancreas
    • Esni, F., Stoffers, D., Takeuchi, T. & Leach, S. Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech. Dev. 121, 15-25 (2004).
    • (2004) Mech. Dev. , vol.121 , pp. 15-25
    • Esni, F.1    Stoffers, D.2    Takeuchi, T.3    Leach, S.4
  • 46
    • 84920989984 scopus 로고    scopus 로고
    • Long-term culture of genome-stable bipotent stem cells fromadult human liver
    • Huch, M. et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 160, 2990312 (2015).
    • (2015) Cell , vol.160 , pp. 2990312
    • Huch, M.1
  • 48
    • 33749176466 scopus 로고    scopus 로고
    • Plasticity of hepatic cell differentiation:bipotential adult mouse liver clonal cell lines competent to differentiate in vitroand in vivo
    • Fougère-Deschatrette, C. et al. Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo. Stem Cells 24, 2098-2109 (2006).
    • (2006) Stem Cells , vol.24 , pp. 2098-2109
    • Fougère-Deschatrette, C.1
  • 49
    • 79958051227 scopus 로고    scopus 로고
    • Prospective isolation of a bipotential clonogenic liverprogenitor cell in adult mice
    • Dorrell, C. et al. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev. 25, 1193-1203 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 1193-1203
    • Dorrell, C.1
  • 50
    • 84885617460 scopus 로고    scopus 로고
    • Artificial three-dimensional niches deconstruct pancreasdevelopment in vitro
    • Greggio, C. et al. Artificial three-dimensional niches deconstruct pancreas development in vitro. Development 140, 4452-4462 (2013).
    • (2013) Development , vol.140 , pp. 4452-4462
    • Greggio, C.1
  • 51
    • 30544442260 scopus 로고    scopus 로고
    • Hexhomeobox gene controls the transition of the endoderm to a pseudostratified,cell emergent epithelium for liver bud development
    • Bort, R., Signore, M., Tremblay, K., Martinez Barbera, J. & Zaret, K. Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev. Biol. 290, 44-56 (2006).
    • (2006) Dev. Biol. , vol.290 , pp. 44-56
    • Bort, R.1    Signore, M.2    Tremblay, K.3    Martinez Barbera, J.4    Zaret, K.5
  • 52
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal toD7Mit189 on chromosome 7 determines early-onset NIDDM in nonobeseC57BL/6 (Akita) mutant mice
    • Yoshioka, M., Kayo, T., Ikeda, T. & Koizumi, A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46, 887-894 (1997).
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4
  • 53
    • 84876278823 scopus 로고    scopus 로고
    • Robust cellular reprogramming occurs spontaneously duringliver regeneration
    • Yanger, K. et al. Robust cellular reprogramming occurs spontaneously during liver regeneration. Genes Dev. 27, 719-724 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 719-724
    • Yanger, K.1
  • 54
    • 80053610191 scopus 로고    scopus 로고
    • Embryonic ductal plate cells give rise to cholangiocytes,periportal hepatocytes, and adult liver progenitor cells
    • Carpentier, R. et al. Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Gastroenterology 141, 1432-1438 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1432-1438
    • Carpentier, R.1
  • 55
    • 79951539242 scopus 로고    scopus 로고
    • Sox9+ ductal cells are multipotent progenitors throughoutdevelopment but do not produce new endocrine cells in the normal or injuredadult pancreas
    • Kopp, J. L. et al. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 138, 653-665 (2011).
    • (2011) Development , vol.138 , pp. 653-665
    • Kopp, J.L.1
  • 56
    • 84868007347 scopus 로고    scopus 로고
    • Activation of innate immunity is required for efficient nuclearreprogramming
    • Lee, J. et al. Activation of innate immunity is required for efficient nuclear reprogramming. Cell 151, 547-558 (2012).
    • (2012) Cell , vol.151 , pp. 547-558
    • Lee, J.1
  • 57
    • 84865277434 scopus 로고    scopus 로고
    • A Sox9/Fgf feed-forward loop maintains pancreatic organidentity
    • Seymour, P. A. et al. A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development 139, 3363-3372 (2012).
    • (2012) Development , vol.139 , pp. 3363-3372
    • Seymour, P.A.1
  • 58
    • 84928938629 scopus 로고    scopus 로고
    • TEAD and YAP regulate the enhancer network of humanembryonic pancreatic progenitors
    • Cebola, I. et al. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors. Nat. Cell Biol. 17, 615-626 (2015).
    • (2015) Nat. Cell Biol. , vol.17 , pp. 615-626
    • Cebola, I.1
  • 59
    • 79955391920 scopus 로고    scopus 로고
    • Direct in vivo cellular reprogramming involves transitionthrough discrete, non-pluripotent steps
    • Richard, J. P. et al. Direct in vivo cellular reprogramming involves transition through discrete, non-pluripotent steps. Development 138, 1483-1492 (2011).
    • (2011) Development , vol.138 , pp. 1483-1492
    • Richard, J.P.1
  • 60
    • 67650073154 scopus 로고    scopus 로고
    • Cells keep a memory of their tissue origin during axolotl limbregeneration
    • Kragl, M. et al. Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 460, 60-65 (2009).
    • (2009) Nature , vol.460 , pp. 60-65
    • Kragl, M.1
  • 61
    • 0027321548 scopus 로고
    • Derivationof completely cell culture-derived mice from early-passage embryonic stemcells
    • Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. & Roder, J. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl Acad. Sci. USA 90, 8424-8428 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 8424-8428
    • Nagy, A.1    Rossant, J.2    Nagy, R.3    Abramow-Newerly, W.4    Roder, J.5
  • 62
    • 84868294581 scopus 로고    scopus 로고
    • A system for ex vivo culturing of embryonic pancreas
    • Petzold, K. & Spagnoli, F. A system for ex vivo culturing of embryonic pancreas. J. Vis. Exp. 66, e3979 (2012).
    • (2012) J. Vis. Exp. , vol.66
    • Petzold, K.1    Spagnoli, F.2
  • 63
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool(REST) for group-wise comparison and statistical analysis of relative expressionresults in real-time PCR
    • Pfaffl, M. W., Horgan, G. W. & Dempfle, L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30, e36 (2002).
    • (2002) Nucleic Acids Res. , vol.30 , pp. e36
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 64
    • 65649118799 scopus 로고    scopus 로고
    • Foxa2 regulates polarity and epithelialization in theendoderm germ layer of the mouse embryo
    • Burtscher, I. & Lickert, H. Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo. Development 136, 1029-1038 (2009).
    • (2009) Development , vol.136 , pp. 1029-1038
    • Burtscher, I.1    Lickert, H.2
  • 66
    • 67849088720 scopus 로고    scopus 로고
    • GeneCodis: Interpreting gene lists throughenrichment analysis and integration of diverse biological information
    • Nogales-Cadenas, R. et al. GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information. Nucleic Acids Res. 37, W137-122 (2009).
    • (2009) NucleicAcids Res. , vol.37 , pp. W137-W1122
    • Nogales-Cadenas, R.1
  • 67
    • 84896703602 scopus 로고    scopus 로고
    • Mesenchymal stromal cells improve transplanted islet survivaland islet function in a syngeneic mouse model
    • Borg, D. et al. Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model. Diabetologia 57, 522-531 (2014).
    • (2014) Diabetologia , vol.57 , pp. 522-531
    • Borg, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.