CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia

Journal of Experimental Medicine

Volumn 214, Issue 2, 2017, Pages 359-380

  Riether, Carsten ^a   Schürch, Christian M ^a   Bührer, Elias D ^a   Hinterbrandner, Magdalena ^a   Huguenin, Anne Laure ^a   Hoepner, Sabine ^a   Zlobec, Inti ^a   Pabst, Thomas ^a   Radpour, Ramin ^a   Ochsenbein, Adrian F ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BIRC5 PROTEIN; CCND1 PROTEIN; CD27 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD70 ANTIGEN; CD8 ANTIGEN; LEF PROTEIN; METHYLCELLULOSE; MUSASHI PROTEIN; MYC PROTEIN; NCK INTERACTING KINASE; PROTEIN; PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; VASCULOTROPIN; CD70 PROTEIN, HUMAN; GERMINAL CENTER KINASES; MONOCLONAL ANTIBODY; PROTEIN SERINE THREONINE KINASE; PSMD2 PROTEIN, HUMAN;

ACUTE MYELOID LEUKEMIA; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASYMMETRIC CELL DIVISION; CANCER PROGNOSIS; CANCER SURVIVAL; CELL ACTIVATION; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL FATE; CELL GROWTH; CELL POPULATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; COLONY FORMATION; COLONY FORMING UNIT; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; IN VIVO STUDY; MAJOR CLINICAL STUDY; MIDDLE AGED; MOUSE; NONHUMAN; OVERALL SURVIVAL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL; STEM CELL SELF-RENEWAL; TUMOR XENOGRAFT; U-937 CELL LINE; UPREGULATION; WNT SIGNALING PATHWAY; XENOTRANSPLANTATION; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; BLAST CRISIS; BLOOD; GENETICS; LEUKEMIA, MYELOID, ACUTE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

AGED; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD27; ANTIGENS, CD70; BLAST CRISIS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 2; TUMOR CELLS, CULTURED; WNT SIGNALING PATHWAY;

EID: 85012240335     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20152008     Document Type: Article

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