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Volumn 5, Issue 3, 2015, Pages 1741-1761

Extracellular vesicles from ovarian carcinoma cells display specific glycosignatures

Author keywords

Biomarkers; Extracellular vesicles; Galectin 3 binding protein; Glycosignatures; Glycosylation; Kifunensine; Ovarian cancer

Indexed keywords

CD63 ANTIGEN; CD81 ANTIGEN; CD82 ANTIGEN; CD9 ANTIGEN; CLATHRIN; CYTOSKELETON PROTEIN; ESCRT PROTEIN; GALECTIN 3; GLYCOPROTEIN; HEAT SHOCK PROTEIN; KIFUNENSINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NERVE CELL ADHESION MOLECULE L1; TETRASPANIN; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; WHEAT GERM AGGLUTININ; ALKALOID; LECTIN;

EID: 85012108394     PISSN: None     EISSN: 2218273X     Source Type: Journal    
DOI: 10.3390/biom5031741     Document Type: Article
Times cited : (65)

References (70)
  • 1
    • 84904704297 scopus 로고    scopus 로고
    • Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
    • Colombo, M.; Raposo, G.; Thery, C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 2014, 30, 255-289.
    • (2014) Annu. Rev. Cell Dev. Biol , vol.30 , pp. 255-289
    • Colombo, M.1    Raposo, G.2    Thery, C.3
  • 2
    • 84903512697 scopus 로고    scopus 로고
    • Extracellular vesicles: Emerging targets for cancer therapy
    • Vader, P.; Breakefield, X.O.; Wood, M.J. Extracellular vesicles: Emerging targets for cancer therapy. Trends Mol. Med. 2014, 20, 385-393.
    • (2014) Trends Mol. Med , vol.20 , pp. 385-393
    • Vader, P.1    Breakefield, X.O.2    Wood, M.J.3
  • 3
    • 84937248650 scopus 로고    scopus 로고
    • Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes
    • Taylor, D.D.; Shah, S. Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes. Methods 2015, doi:10.1016/j.ymeth.2015.02.019.
    • (2015) Methods
    • Taylor, D.D.1    Shah, S.2
  • 8
    • 84890458696 scopus 로고    scopus 로고
    • Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles
    • Colombo, M.; Moita, C.; van Niel, G.; Kowal, J.; Vigneron, J.; Benaroch, P.; Manel, N.; Moita, L.F.; Thery, C.; Raposo, G. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J. Cell Sci. 2013, 126, 5553-5565.
    • (2013) J. Cell Sci , vol.126 , pp. 5553-5565
    • Colombo, M.1    Moita, C.2    van Niel, G.3    Kowal, J.4    Vigneron, J.5    Benaroch, P.6    Manel, N.7    Moita, L.F.8    Thery, C.9    Raposo, G.10
  • 9
    • 0344708475 scopus 로고    scopus 로고
    • Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain
    • Hemler, M.E. Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu. Rev. Cell Dev. Biol. 2003, 19, 397-422.
    • (2003) Annu. Rev. Cell Dev. Biol , vol.19 , pp. 397-422
    • Hemler, M.E.1
  • 10
    • 0035945363 scopus 로고    scopus 로고
    • Specific tetraspanin functions
    • Hemler, M.E. Specific tetraspanin functions. J. Cell Biol. 2001, 155, 1103-1107.
    • (2001) J. Cell Biol , vol.155 , pp. 1103-1107
    • Hemler, M.E.1
  • 11
    • 0035207920 scopus 로고    scopus 로고
    • Complexes of tetraspanins with integrins: More than meets the eye
    • Berditchevski, F. Complexes of tetraspanins with integrins: More than meets the eye. J. Cell Sci. 2001, 114, 4143-4151.
    • (2001) J. Cell Sci , vol.114 , pp. 4143-4151
    • Berditchevski, F.1
  • 12
    • 84919468543 scopus 로고    scopus 로고
    • Tetraspanins in extracellular vesicle formation and function
    • Andreu, Z.; Yanez-Mo, M. Tetraspanins in extracellular vesicle formation and function. Front. Immunol. 2014, doi:10.3389/fimmu.2014.00442.
    • (2014) Front. Immunol
    • Andreu, Z.1    Yanez-Mo, M.2
  • 13
    • 67249110996 scopus 로고    scopus 로고
    • Multivesicular endosome biogenesis in the absence of ESCRTs
    • Stuffers, S.; Sem Wegner, C.; Stenmark, H.; Brech, A. Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic 2009, 10, 925-937.
    • (2009) Traffic , vol.10 , pp. 925-937
    • Stuffers, S.1    Sem Wegner, C.2    Stenmark, H.3    Brech, A.4
  • 15
    • 84886738545 scopus 로고    scopus 로고
    • Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies
    • Record, M.; Carayon, K.; Poirot, M.; Silvente-Poirot, S. Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Biochim. Biophys. Acta 2014, 1841, 108-120.
    • (2014) Biochim. Biophys. Acta , vol.1841 , pp. 108-120
    • Record, M.1    Carayon, K.2    Poirot, M.3    Silvente-Poirot, S.4
  • 17
    • 33947709328 scopus 로고    scopus 로고
    • Packaging of prions into exosomes is associated with a novel pathway of PrP processing
    • Vella, L.J.; Sharples, R.A.; Lawson, V.A.; Masters, C.L.; Cappai, R.; Hill, A.F. Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J. Pathol. 2007, 211, 582-590.
    • (2007) J. Pathol , vol.211 , pp. 582-590
    • Vella, L.J.1    Sharples, R.A.2    Lawson, V.A.3    Masters, C.L.4    Cappai, R.5    Hill, A.F.6
  • 18
    • 62649106103 scopus 로고    scopus 로고
    • HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin
    • Krishnamoorthy, L.; Bess, J.W., Jr.; Preston, A.B.; Nagashima, K.; Mahal, L.K. HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin. Nat. Chem. Biol. 2009, 5, 244-250.
    • (2009) Nat. Chem. Biol , vol.5 , pp. 244-250
    • Krishnamoorthy, L.1    Bess, J.W.2    Preston, A.B.3    Nagashima, K.4    Mahal, L.K.5
  • 20
    • 79953081976 scopus 로고    scopus 로고
    • Interaction and uptake of exosomes by ovarian cancer cells
    • Escrevente, C.; Keller, S.; Altevogt, P.; Costa, J. Interaction and uptake of exosomes by ovarian cancer cells. BMC Cancer 2011, 11, doi:10.1186/1471-2407-11-108.
    • (2011) BMC Cancer , vol.11
    • Escrevente, C.1    Keller, S.2    Altevogt, P.3    Costa, J.4
  • 23
    • 84928057135 scopus 로고    scopus 로고
    • Exosomes in bodily fluids are a highly stable resource of disease biomarkers
    • Boukouris, S.; Mathivanan, S. Exosomes in bodily fluids are a highly stable resource of disease biomarkers. Proteom. Clin. Appl. 2015, 9, 358-367.
    • (2015) Proteom. Clin. Appl , vol.9 , pp. 358-367
    • Boukouris, S.1    Mathivanan, S.2
  • 24
    • 84884585784 scopus 로고    scopus 로고
    • Exosomes: The future of biomarkers in medicine
    • Properzi, F.; Logozzi, M.; Fais, S. Exosomes: The future of biomarkers in medicine. Biomark. Med. 2013, 7, 769-778.
    • (2013) Biomark. Med , vol.7 , pp. 769-778
    • Properzi, F.1    Logozzi, M.2    Fais, S.3
  • 25
    • 84911455823 scopus 로고    scopus 로고
    • Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment
    • Liang, Y.; Eng, W.S.; Colquhoun, D.R.; Dinglasan, R.R.; Graham, D.R.; Mahal, L.K. Complex N-linked glycans serve as a determinant for exosome/microvesicle cargo recruitment. J. Biol. Chem. 2014, 289, 32526-32537.
    • (2014) J. Biol. Chem , vol.289 , pp. 32526-32537
    • Liang, Y.1    Eng, W.S.2    Colquhoun, D.R.3    Dinglasan, R.R.4    Graham, D.R.5    Mahal, L.K.6
  • 27
    • 0032536822 scopus 로고    scopus 로고
    • Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin
    • Sasaki, T.; Brakebusch, C.; Engel, J.; Timpl, R. Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin. EMBO J. 1998, 17, 1606-1613.
    • (1998) EMBO J , vol.17 , pp. 1606-1613
    • Sasaki, T.1    Brakebusch, C.2    Engel, J.3    Timpl, R.4
  • 28
    • 84863988112 scopus 로고    scopus 로고
    • Antibodies and Lectins in Glycan Analysis
    • 2nd ed.; Varki, A., Cummings, R.D., Esko, J.D., Freeze, H.H., Stanley, P., Bertozzi, C.R., Hart, G.W., Etzler, M.E., Eds.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, USA
    • Cummings, R.D.; Etzler, M.E. Antibodies and Lectins in Glycan Analysis. In Essentials of Glycobiology, 2nd ed.; Varki, A., Cummings, R.D., Esko, J.D., Freeze, H.H., Stanley, P., Bertozzi, C.R., Hart, G.W., Etzler, M.E., Eds.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, USA, 2009.
    • (2009) Essentials of Glycobiology
    • Cummings, R.D.1    Etzler, M.E.2
  • 29
    • 76649133774 scopus 로고    scopus 로고
    • Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis
    • Abbott, K.L.; Lim, J.M.; Wells, L.; Benigno, B.B.; McDonald, J.F.; Pierce, M. Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis. Proteomics 2010, 10, 470-481.
    • (2010) Proteomics , vol.10 , pp. 470-481
    • Abbott, K.L.1    Lim, J.M.2    Wells, L.3    Benigno, B.B.4    McDonald, J.F.5    Pierce, M.6
  • 30
    • 84920278040 scopus 로고    scopus 로고
    • Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions
    • Allam, H.; Aoki, K.; Benigno, B.B.; McDonald, J.F.; Mackintosh, S.G.; Tiemeyer, M.; Abbott, K.L. Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions. J. Proteome Res. 2015, 14, 434-446.
    • (2015) J. Proteome Res , vol.14 , pp. 434-446
    • Allam, H.1    Aoki, K.2    Benigno, B.B.3    McDonald, J.F.4    Mackintosh, S.G.5    Tiemeyer, M.6    Abbott, K.L.7
  • 31
    • 79551697660 scopus 로고    scopus 로고
    • N-Glycosylation of total cellular glycoproteins from the human ovarian carcinoma SKOV3 cell line and of recombinantly expressed human erythropoietin
    • Machado, E.; Kandzia, S.; Carilho, R.; Altevogt, P.; Conradt, H.S.; Costa, J. N-Glycosylation of total cellular glycoproteins from the human ovarian carcinoma SKOV3 cell line and of recombinantly expressed human erythropoietin. Glycobiology 2011, 21, 376-386.
    • (2011) Glycobiology , vol.21 , pp. 376-386
    • Machado, E.1    Kandzia, S.2    Carilho, R.3    Altevogt, P.4    Conradt, H.S.5    Costa, J.6
  • 32
    • 77449102731 scopus 로고    scopus 로고
    • Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages
    • Barres, C.; Blanc, L.; Bette-Bobillo, P.; Andre, S.; Mamoun, R.; Gabius, H.J.; Vidal, M. Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages. Blood 2010, 115, 696-705.
    • (2010) Blood , vol.115 , pp. 696-705
    • Barres, C.1    Blanc, L.2    Bette-Bobillo, P.3    Andre, S.4    Mamoun, R.5    Gabius, H.J.6    Vidal, M.7
  • 33
    • 79953729053 scopus 로고    scopus 로고
    • Co-purification of Mac-2 binding protein with galectin-3 and association with prostasomes in human semen
    • Block, A.S.; Saraswati, S.; Lichti, C.F.; Mahadevan, M.; Diekman, A.B. Co-purification of Mac-2 binding protein with galectin-3 and association with prostasomes in human semen. Prostate 2011, 71, 711-721.
    • (2011) Prostate , vol.71 , pp. 711-721
    • Block, A.S.1    Saraswati, S.2    Lichti, C.F.3    Mahadevan, M.4    Diekman, A.B.5
  • 34
    • 70350428098 scopus 로고    scopus 로고
    • The role of galectins in protein trafficking
    • Delacour, D.; Koch, A.; Jacob, R. The role of galectins in protein trafficking. Traffic 2009, 10, 1405-1413.
    • (2009) Traffic , vol.10 , pp. 1405-1413
    • Delacour, D.1    Koch, A.2    Jacob, R.3
  • 35
    • 84866351431 scopus 로고    scopus 로고
    • Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism
    • Mo, D.; Costa, S.A.; Ihrke, G.; Youker, R.T.; Pastor-Soler, N.; Hughey, R.P.; Weisz, O.A. Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. Mol. Biol. Cell 2012, 23, 3636-3646.
    • (2012) Mol. Biol. Cell , vol.23 , pp. 3636-3646
    • Mo, D.1    Costa, S.A.2    Ihrke, G.3    Youker, R.T.4    Pastor-Soler, N.5    Hughey, R.P.6    Weisz, O.A.7
  • 36
    • 82655181502 scopus 로고    scopus 로고
    • Mature N-linked glycans facilitate UT-A1 urea transporter lipid raft compartmentalization
    • Chen, G.; Howe, A.G.; Xu, G.; Frohlich, O.; Klein, J.D.; Sands, J.M. Mature N-linked glycans facilitate UT-A1 urea transporter lipid raft compartmentalization. FASEB J. 2011, 25, 4531-4539.
    • (2011) FASEB J , vol.25 , pp. 4531-4539
    • Chen, G.1    Howe, A.G.2    Xu, G.3    Frohlich, O.4    Klein, J.D.5    Sands, J.M.6
  • 38
    • 84896777949 scopus 로고    scopus 로고
    • The roles of extracellular vesicles in cancer biology: Toward the development of novel cancer biomarkers
    • Katsuda, T.; Kosaka, N.; Ochiya, T. The roles of extracellular vesicles in cancer biology: Toward the development of novel cancer biomarkers. Proteomics 2014, 14, 412-425.
    • (2014) Proteomics , vol.14 , pp. 412-425
    • Katsuda, T.1    Kosaka, N.2    Ochiya, T.3
  • 39
    • 33744799438 scopus 로고    scopus 로고
    • Mucin-type O-glycans in human colon and breast cancer: Glycodynamics and functions
    • Brockhausen, I. Mucin-type O-glycans in human colon and breast cancer: Glycodynamics and functions. EMBO Rep. 2006, 7, 599-604.
    • (2006) EMBO Rep , vol.7 , pp. 599-604
    • Brockhausen, I.1
  • 41
    • 84856637730 scopus 로고    scopus 로고
    • Differential glycomics of epithelial membrane glycoproteins from urinary exovesicles reveals shifts toward complex-type N-glycosylation in classical galactosemia
    • Staubach, S.; Schadewaldt, P.; Wendel, U.; Nohroudi, K.; Hanisch, F.G. Differential glycomics of epithelial membrane glycoproteins from urinary exovesicles reveals shifts toward complex-type N-glycosylation in classical galactosemia. J. Proteome Res. 2012, 11, 906-916.
    • (2012) J. Proteome Res , vol.11 , pp. 906-916
    • Staubach, S.1    Schadewaldt, P.2    Wendel, U.3    Nohroudi, K.4    Hanisch, F.G.5
  • 42
  • 47
    • 84866270576 scopus 로고    scopus 로고
    • Microvesicles: Novel biomarkers for neurological disorders
    • Colombo, E.; Borgiani, B.; Verderio, C.; Furlan, R. Microvesicles: Novel biomarkers for neurological disorders. Front. Physiol. 2012, doi:10.3389/fphys.2012.00063.
    • (2012) Front. Physiol
    • Colombo, E.1    Borgiani, B.2    Verderio, C.3    Furlan, R.4
  • 50
    • 84856707794 scopus 로고    scopus 로고
    • Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
    • Saman, S.; Kim, W.; Raya, M.; Visnick, Y.; Miro, S.; Jackson, B.; McKee, A.C.; Alvarez, V.E.; Lee, N.C.; Hall, G.F. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J. Biol. Chem. 2012, 287, 3842-3849.
    • (2012) J. Biol. Chem , vol.287 , pp. 3842-3849
    • Saman, S.1    Kim, W.2    Raya, M.3    Visnick, Y.4    Miro, S.5    Jackson, B.6    McKee, A.C.7    Alvarez, V.E.8    Lee, N.C.9    Hall, G.F.10
  • 52
    • 35448956015 scopus 로고    scopus 로고
    • Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis
    • Gomes, C.; Keller, S.; Altevogt, P.; Costa, J. Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis. Neurosci. Lett. 2007, 428, 43-46.
    • (2007) Neurosci. Lett , vol.428 , pp. 43-46
    • Gomes, C.1    Keller, S.2    Altevogt, P.3    Costa, J.4
  • 54
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H.; Ekstrom, K.; Bossios, A.; Sjostrand, M.; Lee, J.J.; Lotvall, J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007, 9, 654-659.
    • (2007) Nat. Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 55
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • Al-Nedawi, K.; Meehan, B.; Micallef, J.; Lhotak, V.; May, L.; Guha, A.; Rak, J. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 2008, 10, 619-624.
    • (2008) Nat. Cell Biol , vol.10 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3    Lhotak, V.4    May, L.5    Guha, A.6    Rak, J.7
  • 56
  • 57
    • 84903531999 scopus 로고    scopus 로고
    • The role of extracellular vesicles in the progression of neurodegenerative disease and cancer
    • Candelario, K.M.; Steindler, D.A. The role of extracellular vesicles in the progression of neurodegenerative disease and cancer. Trends Mol. Med. 2014, 20, 368-374.
    • (2014) Trends Mol. Med , vol.20 , pp. 368-374
    • Candelario, K.M.1    Steindler, D.A.2
  • 58
    • 84922762082 scopus 로고    scopus 로고
    • Exosomes: Vehicles of intercellular signaling, biomarkers, and vectors of cell therapy
    • Kourembanas, S. Exosomes: Vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu. Rev. Physiol. 2015, 77, 13-27.
    • (2015) Annu. Rev. Physiol , vol.77 , pp. 13-27
    • Kourembanas, S.1
  • 60
    • 84892653021 scopus 로고    scopus 로고
    • CD169 mediates the capture of exosomes in spleen and lymph node
    • Saunderson, S.C.; Dunn, A.C.; Crocker, P.R.; McLellan, A.D. CD169 mediates the capture of exosomes in spleen and lymph node. Blood 2014, 123, 208-216.
    • (2014) Blood , vol.123 , pp. 208-216
    • Saunderson, S.C.1    Dunn, A.C.2    Crocker, P.R.3    McLellan, A.D.4
  • 61
    • 84886387008 scopus 로고    scopus 로고
    • Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
    • Christianson, H.C.; Svensson, K.J.; van Kuppevelt, T.H.; Li, J.P.; Belting, M. Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity. Proc. Natl. Acad. Sci. USA 2013, 110, 17380-17385.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 17380-17385
    • Christianson, H.C.1    Svensson, K.J.2    van Kuppevelt, T.H.3    Li, J.P.4    Belting, M.5
  • 63
    • 33845677330 scopus 로고    scopus 로고
    • Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity
    • Hao, S.; Bai, O.; Li, F.; Yuan, J.; Laferte, S.; Xiang, J. Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity. Immunology 2007, 120, 90-102.
    • (2007) Immunology , vol.120 , pp. 90-102
    • Hao, S.1    Bai, O.2    Li, F.3    Yuan, J.4    Laferte, S.5    Xiang, J.6
  • 65
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • Alvarez-Erviti, L.; Seow, Y.; Yin, H.; Betts, C.; Lakhal, S.; Wood, M.J. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 2011, 29, 341-345.
    • (2011) Nat. Biotechnol , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.6
  • 69
    • 80053574021 scopus 로고    scopus 로고
    • Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain
    • Zhuang, X.; Xiang, X.; Grizzle, W.; Sun, D.; Zhang, S.; Axtell, R.C.; Ju, S.; Mu, J.; Zhang, L.; Steinman, L.; et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol. Ther. 2011, 19, 1769-1779.
    • (2011) Mol. Ther , vol.19 , pp. 1769-1779
    • Zhuang, X.1    Xiang, X.2    Grizzle, W.3    Sun, D.4    Zhang, S.5    Axtell, R.C.6    Ju, S.7    Mu, J.8    Zhang, L.9    Steinman, L.10


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