Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions

Journal of Proteome Research

Volumn 14, Issue 1, 2015, Pages 434-446

  Allam, Heba ^d   Aoki, Kazuhiro ^a   Benigno, Benedict B ^c   McDonald, John F ^b,c   Mackintosh, Samuel G ^d   Tiemeyer, Michael ^a   Abbott, Karen L ^d  

^a UNIVERSITY OF GEORGIA   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c Ovarian Cancer Institute   (United States)

^d UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

biomarkers; bisecting N linked glycans; glycoproteins; human tissue; mass spectrometry; ovarian cancer

Indexed keywords

ACID CERAMIDASE; ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALPHA 2 MACROGLOBULIN; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; B LYMPHOCYTE RECEPTOR; BETA CATENIN; BETA1 INTEGRIN; CATHEPSIN D; CD147 ANTIGEN; CELL SURFACE PROTEIN; CLUSTERIN; COMPLEMENT COMPONENT C4B; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOGLIN; ENDOPLASMIC RETICULUM GOLGI INTERMEDIATE COMPARTMENT PROTEIN 53; EPIDERMAL GROWTH FACTOR RECEPTOR; EPITHELIAL CELL ADHESION MOLECULE; FIBRILLIN 1; LACTADHERIN; MEMBRANE METALLOENDOPEPTIDASE; MEMBRANE PROTEIN; NOTCH RECEPTOR; PLANT LECTIN; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; WNT PROTEIN; BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE; N ACETYLGLUCOSAMINYLTRANSFERASE; SMALL INTERFERING RNA; TUMOR MARKER;

ARTICLE; CANCER CELL; CANCER TISSUE; CELL ADHESION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GLYCOBIOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LENTIVIRINAE; OVARY CANCER; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVERSED PHASE LIQUID CHROMATOGRAPHY; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; GENETICS; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; OVARY TUMOR; PROCEDURES;

BIOMARKERS, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLYCOMICS; GLYCOSYLATION; HUMANS; MEMBRANE GLYCOPROTEINS; N-ACETYLGLUCOSAMINYLTRANSFERASES; OVARIAN NEOPLASMS; RNA, SMALL INTERFERING; TANDEM MASS SPECTROMETRY;

EID: 84920278040     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr501174p     Document Type: Article

References (34)

1. Bhaumik, M.; Seldin, M. F.; Stanley, P. Cloning and chromosomal mapping of the mouse Mgat3 gene encoding N-acetylglucosaminyltransferase III Gene 1995, 164 (2) 295-300
2. Koles, K. Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster Glycobiology 2007, 17 (12) 1388-1403
3. Abbott, K. L. Targeted glycoproteomic identification of biomarkers for human breast carcinoma J. Proteome Res. 2008, 7 (4) 1470-1480
4. Tabb, D. L.; Fernando, C. G.; Chambers, M. C. MyriMatch: highly accurate tandem mass spectral peptide identification by multivariate hypergeometric analysis J. Proteome Res. 2007, 6 (2) 654-661
5. Ma, Z. Q. IDPicker 2.0: Improved protein assembly with high discrimination peptide identification filtering J. Proteome Res. 2009, 8 (8) 3872-3881
6. Zhao, P. Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma J. Biol. Chem. 2012, 287 (30) 25230-25240
7. Abbott, K. L. Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer Proteomics 2008, 8 (16) 3210-3220
8. Abbott, K. L. Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis Proteomics 2010, 10 (3) 470-481
9. Anugraham, M. Specific glycosylation of membrane proteins in epithelial ovarian cancer cell lines: glycan structures reflect gene expression and DNA methylation status Mol. Cell. Proteomics 2014, 13, 2213-2232
10. Uhlen, M. Towards a knowledge-based Human Protein Atlas Nat. Biotechnol. 2010, 28 (12) 1248-1250
11. Wang, M. M. Notch signaling and Notch signaling modifiers Int. J. Biochem. Cell Biol. 2011, 43 (11) 1550-1562
12. Wesley, C. S. Notch and wingless regulate expression of cuticle patterning genes Mol. Cell. Biol. 1999, 19 (8) 5743-5758
13. Nehring, L. C. The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface J. Biol. Chem. 2005, 280 (21) 20349-20355
14. VanDussen, K. L. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells Development 2012, 139 (3) 488-497
15. Li, T. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals J. Neurosci. 2003, 23 (8) 3272-3277
16. Horiguchi, M.; Ota, M.; Rifkin, D. B. Matrix control of transforming growth factor-beta function J. Biochem. 2012, 152 (4) 321-329
17. Meurer, S. K. Overexpression of endoglin modulates TGF-beta1-signalling pathways in a novel immortalized mouse hepatic stellate cell line PLoS One 2013, 8 (2) e56116
18. Barbolina, M. V. Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein J. Biol. Chem. 2013, 288 (1) 141-151
19. Takahashi, T. alpha1,6fucosyltransferase is highly and specifically expressed in human ovarian serous adenocarcinomas Int. J. Cancer 2000, 88 (6) 914-919
20. Song, Y. The bisecting GlcNAc on N-glycans inhibits growth factor signaling and retards mammary tumor progression Cancer Res. 2010, 70 (8) 3361-3371
21. North, S. J. Glycomics profiling of Chinese hamster ovary cell glycosylation mutants reveals N-glycans of a novel size and complexity J. Biol. Chem. 2010, 285 (8) 5759-5775
22. Yang, X. Structures and biosynthesis of the N- and O-glycans of recombinant human oviduct-specific glycoprotein expressed in human embryonic kidney cells Carbohydr. Res. 2012, 358, 47-55
23. Cancer Genome Atlas Research, N. Integrated genomic analyses of ovarian carcinoma Nature 2011, 474 (7353) 609-615
24. Blasius, A. L. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation J. Immunol 2006, 177 (5) 3260-3265
25. Cai, D. Up-regulation of bone marrow stromal protein 2 (BST2) in breast cancer with bone metastasis BMC Cancer 2009, 9, 102
26. Tai, Y. T. Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function Blood 2012, 119 (9) 2074-2082
27. Jeong, J. A. Membrane proteomic analysis of human mesenchymal stromal cells during adipogenesis Proteomics 2007, 7 (22) 4181-4191
28. Bock, A. J. Endoglin (CD105) expression in ovarian serous carcinoma effusions is related to chemotherapy status Tumour Biol. 2011, 32 (3) 589-596
29. Henriksen, R. Expression and prognostic significance of TGF-beta isotypes, latent TGF-beta 1 binding protein, TGF-beta type I and type II receptors, and endoglin in normal ovary and ovarian neoplasms Lab. Invest. 1995, 73 (2) 213-220
30. Ziebarth, A. J. Endoglin (CD105) contributes to platinum resistance and is a target for tumor-specific therapy in epithelial ovarian cancer Clin. Cancer Res. 2013, 19 (1) 170-182
31. Chmelarova, M. Methylation analysis of tumour suppressor genes in ovarian cancer using MS-MLPA Folia Biol. (Prague, Czech Repub.) 2012, 58 (6) 246-250
32. Ghosh, S. Use of multicellular tumor spheroids to dissect endothelial cell-tumor cell interactions: a role for T-cadherin in tumor angiogenesis FEBS Lett. 2007, 581 (23) 4523-4528
33. Philippova, M. Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival Mol. Cell. Biol. 2008, 28 (12) 4004-4017
34. Lombardo, Y. Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo Proc. Natl. Acad. Sci. U. S. A. 2012, 109 (41) 16558-16563