The Alzheimer's disease-associated R47H variant of TREM2 has an altered glycosylation pattern and protein stability

Frontiers in Neuroscience

Volumn 10, Issue JAN, 2017, Pages

  Park, Ji Seon ^a   Ji, In Jung ^b,c   Kim, Dong Hou ^a   An, Hyun Joo ^b,c   Yoon, Seung Yong ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Asia Glycomics Reference Site   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

Alzheimer's disease; Glycosylation; Nasu Hakola disease; Trafficking; TREM2

Indexed keywords

GLYCAN; KIFUNENSINE; MONENSIN; PROTEIN VARIANT; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HALF LIFE TIME; LIGAND BINDING; MASS SPECTROMETRY; MOLECULAR PATHOLOGY; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN TRANSPORT; SOLUBILITY; TRANS GOLGI NETWORK; TREM2 GENE; UPREGULATION; WILD TYPE;

EID: 85011891026     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2016.00618     Document Type: Article

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