Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease

Cell Reports

Volumn 18, Issue 6, 2017, Pages 1484-1498

  Rodriguez Muela, Natalia ^a,b   Litterman, Nadia K ^a,b   Norabuena, Erika M ^a,b   Mull, Jesse L ^a,b   Galazo, Maria José ^a,b   Sun, Chicheng ^a,b   Ng, Shi Yan ^a,b   Makhortova, Nina R ^a,b   White, Andrew ^a   Lynes, Maureen M ^a,b   Chung, Wendy K ^d   Davidow, Lance S ^a,b   Macklis, Jeffrey D ^a,b,c   Rubin, Lee L ^a,b  

^a Harvard University   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

^c HARVARD UNIVERSITY   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

amyotrophic lateral sclerosis; cell death; cell heterogeneity; protein degradation; single cell analysis; spinal muscular atrophy; survival of motor neuron; therapeutics

Indexed keywords

SURVIVAL MOTOR NEURON PROTEIN; UBIQUITIN PROTEIN LIGASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; DEGRADATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEK293 CELL LINE; HISTOLOGY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROMUSCULAR DISEASE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RNA SPLICING; SPINAL CORD; ANIMAL; DISEASE MODEL; METABOLISM; MOTONEURON; PROCEDURES; SINGLE CELL ANALYSIS; SPINAL MUSCULAR ATROPHY;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MICE; MOTOR NEURONS; MUSCULAR ATROPHY, SPINAL; NEUROMUSCULAR DISEASES; SINGLE-CELL ANALYSIS; SMN COMPLEX PROTEINS; SPINAL CORD;

EID: 85011860419     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.01.035     Document Type: Article

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