ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

Nature Communications

Volumn 6, Issue , 2015, Pages

  Sun, Shuying ^a,b   Ling, Shuo Chien ^a,b,c   Qiu, Jinsong ^b   Albuquerque, Claudio P ^a,b   Zhou, Yu ^b   Tokunaga, Seiya ^a   Li, Hairi ^b   Qiu, Haiyan ^d   Bui, Anh ^a   Yeo, Gene W ^a,b   Huang, Eric J ^d   Eggan, Kevin ^e   Zhou, Huilin ^a,b   Fu, Xiang Dong ^b   Lagier Tourenne, Clotilde ^a,f   Cleveland, Don W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Harvard University   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEAR RNA; SURVIVAL MOTOR NEURON PROTEIN; AMINO ACID; MUTANT PROTEIN; PROTEIN BINDING; RNA BINDING PROTEIN FUS; RNA PRECURSOR;

MUTATION; NERVOUS SYSTEM DISORDER; NEUROLOGY; PROTEIN; RNA;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST; FUS TLS GENE; GAIN OF FUNCTION MUTATION; GENE INTERACTION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MOUSE; MUTATOR GENE; NONHUMAN; RNA ANALYSIS; RNA PROCESSING; RNA SPLICING; SPINAL MUSCULAR ATROPHY; STEADY STATE; TRANSGENIC MOUSE; AFFINITY CHROMATOGRAPHY; ALTERNATIVE RNA SPLICING; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GENETICS; HELA CELL LINE; ISOTOPE LABELING; METABOLISM; MUTATION; PATHOLOGY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TERTIARY STRUCTURE; PROTEOMICS; SPINAL CORD;

ALTERNATIVE SPLICING; AMINO ACID MOTIFS; AMINO ACIDS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CHROMATOGRAPHY, AFFINITY; FIBROBLASTS; HELA CELLS; HUMANS; ISOTOPE LABELING; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MUTANT PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN INTERACTION MAPS; PROTEIN STRUCTURE, TERTIARY; PROTEOMICS; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; RNA PRECURSORS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA-BINDING PROTEIN FUS; SMN COMPLEX PROTEINS; SPINAL CORD;

EID: 84923088131     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7171     Document Type: Article

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