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Volumn 7, Issue , 2017, Pages

Therapeutic effects of Euphorbia Pekinensis and Glycyrrhiza glabra on Hepatocellular Carcinoma Ascites Partially Via Regulating the Frk-Arhgdib-Inpp5d-Avpr2-Aqp4 Signal Axis

Author keywords

[No Author keywords available]

Indexed keywords

AQP4 PROTEIN, MOUSE; AQUAPORIN 4; ARHGDIB PROTEIN, MOUSE; FRK PROTEIN, MOUSE; INPP5D PROTEIN, MOUSE; MINOR HISTOCOMPATIBILITY ANTIGEN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 5 PHOSPHATASE; PLANT EXTRACT; PROTEIN TYROSINE KINASE; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR 2; TUMOR MARKER; VASOPRESSIN RECEPTOR;

EID: 85011827070     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep41925     Document Type: Article
Times cited : (11)

References (51)
  • 1
    • 17744367799 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor KDR/Flk-1 is a major regulator of malignant ascites formation in the mouse hepatocellular carcinoma model
    • Yoshiji, H. et al. The vascular endothelial growth factor receptor KDR/Flk-1 is a major regulator of malignant ascites formation in the mouse hepatocellular carcinoma model. Hepatology 33, 841-7 (2001).
    • (2001) Hepatology , vol.33 , pp. 841-847
    • Yoshiji, H.1
  • 2
    • 34447298354 scopus 로고    scopus 로고
    • Pattern and prognostic factors in patients with malignant ascites: A retrospective study
    • Ayantunde, A. A. & Parsons, S. L. Pattern and prognostic factors in patients with malignant ascites: A retrospective study. Ann Oncol. 18, 945-9 (2007).
    • (2007) Ann Oncol. , vol.18 , pp. 945-949
    • Ayantunde, A.A.1    Parsons, S.L.2
  • 3
    • 0022475601 scopus 로고
    • Malignant ascites: Clinical and experimental observations
    • Garrison, R. N., Kaelin, L. D., Galloway, R. H. & Heuser, L. S. Malignant ascites: clinical and experimental observations. Ann Surg 203, 644-651 (1986).
    • (1986) Ann Surg , vol.203 , pp. 644-651
    • Garrison, R.N.1    Kaelin, L.D.2    Galloway, R.H.3    Heuser, L.S.4
  • 4
    • 84878642549 scopus 로고    scopus 로고
    • Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil
    • Jia, W., et al. Treatment of malignant ascites with a combination of chemotherapy drugs and intraperitoneal perfusion of verapamil. Cancer Chemother Pharmacol. 71, 1585-90 (2013).
    • (2013) Cancer Chemother Pharmacol. , vol.71 , pp. 1585-1590
    • Jia, W.1
  • 5
    • 70350616220 scopus 로고    scopus 로고
    • Management of ascites due to gastrointestinal malignancy
    • Saif, M. W., Siddiqui, I. A. & Sohail, M. A. Management of ascites due to gastrointestinal malignancy. Ann Saudi Med. 29, 369-77 (2009).
    • (2009) Ann Saudi Med. , vol.29 , pp. 369-377
    • Saif, M.W.1    Siddiqui, I.A.2    Sohail, M.A.3
  • 6
    • 0035842529 scopus 로고    scopus 로고
    • Malignant ascites: New concepts in pathophysiology, diagnosis, and management
    • Aslam, N. & Marino, C. R. Malignant ascites: new concepts in pathophysiology, diagnosis, and management. Intern Med. 161, 2733-7 (2001).
    • (2001) Intern Med. , vol.161 , pp. 2733-2737
    • Aslam, N.1    Marino, C.R.2
  • 7
    • 78650832745 scopus 로고    scopus 로고
    • Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae
    • Li, S., Zhang, B., Jiang, D., Wei, Y. & Zhang, N. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. BMC Bioinformatics 11, Suppl 11, S6 (2010).
    • (2010) BMC Bioinformatics , vol.11 , pp. S6
    • Li, S.1    Zhang, B.2    Jiang, D.3    Wei, Y.4    Zhang, N.5
  • 8
    • 85011873077 scopus 로고    scopus 로고
    • Clinical effect of integrated traditional Chinese and Western medicine therapy in treatment of cirrhotic ascites: A report of54cases
    • (In Chinese)
    • Luo, Y. H. Clinical effect of integrated traditional Chinese and Western medicine therapy in treatment of cirrhotic ascites: A report of54cases. Hunan Journal of Traditional Chinese Medicne 29, (In Chinese), 20-2 (2013).
    • (2013) Hunan Journal of Traditional Chinese Medicne , vol.29 , pp. 20-22
    • Luo, Y.H.1
  • 9
    • 85011873079 scopus 로고    scopus 로고
    • Clinical observations of the external application of Jidai formula and thermal therapy in the treatment of malignant ascites in 25 cases
    • He, N. Y. Clinical observations of the external application of Jidai formula and thermal therapy in the treatment of malignant ascites in 25 cases. Hebei Journal of Traditional Chinese Medicine 37, 190-1 (2015).
    • (2015) Hebei Journal of Traditional Chinese Medicine , vol.37 , pp. 190-191
    • He, N.Y.1
  • 10
    • 0034811428 scopus 로고    scopus 로고
    • Cytotoxicities and anti-herpes simplex virus activities of diterpenes isolated fromEuphorbiaspecies
    • Mucsi, I., Molnar, J., Hohmann, J. & Redei, D. Cytotoxicities and anti-herpes simplex virus activities of diterpenes isolated fromEuphorbiaspecies. Planta Med 67, 672-4 (2001).
    • (2001) Planta Med , vol.67 , pp. 672-674
    • Mucsi, I.1    Molnar, J.2    Hohmann, J.3    Redei, D.4
  • 11
    • 84878716826 scopus 로고    scopus 로고
    • Glycyrrhiza polysaccharide induces apoptosis and inhibits proliferation of human hepatocellular carcinoma cells by blocking PI3K/AKT signal pathway
    • Chen, J., Jin, X., Chen, J. & Liu, C. Glycyrrhiza polysaccharide induces apoptosis and inhibits proliferation of human hepatocellular carcinoma cells by blocking PI3K/AKT signal pathway. Tumour Biol. 34, 1381-9 (2013).
    • (2013) Tumour Biol. , vol.34 , pp. 1381-1389
    • Chen, J.1    Jin, X.2    Chen, J.3    Liu, C.4
  • 12
    • 84897513399 scopus 로고    scopus 로고
    • Liquiritigenin induces tumor cell death through mitogen-activated protein kinase-(mpaks-) mediated pathway in hepatocellular carcinoma cells
    • Wang, D. et al. Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase-(MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells. Biomed Res Int. 2014, 965316 (2014).
    • (2014) Biomed Res Int. , vol.2014 , pp. 965316
    • Wang, D.1
  • 13
    • 84901421076 scopus 로고    scopus 로고
    • Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-B and AP-1 activity in human liver cancer cells
    • Hsieh, M. J., Lin, C. W., Yang, S. F., Chen, M. K. & Chiou, H. L. Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-B and AP-1 activity in human liver cancer cells. Br J Pharmacol. 171, 3037-50 (2014).
    • (2014) Br J Pharmacol. , vol.171 , pp. 3037-3050
    • Hsieh, M.J.1    Lin, C.W.2    Yang, S.F.3    Chen, M.K.4    Chiou, H.L.5
  • 14
    • 85011911321 scopus 로고    scopus 로고
    • The treatment of Refractory ascites due to cirrhosis in 40 cases by the combination of multiple methods
    • (In Chinese)
    • Xia, J. Y. & Yan, T. C. The treatment of Refractory ascites due to cirrhosis in 40 cases by the combination of multiple methods. Heilongjiang Journal of Traditional Chinese Medicine 3, 29-30, (In Chinese) (1999).
    • (1999) Heilongjiang Journal of Traditional Chinese Medicine , vol.3 , pp. 29-30
    • Xia, J.Y.1    Yan, T.C.2
  • 15
    • 85011826342 scopus 로고    scopus 로고
    • The analysis of combinational rules and application characteristics of Chinese medicines Euphorbia with toxicity
    • (In Chinese)
    • Ye, L., Fan, X. S., Duan, J. A., Shang, E. X. & Guo, S. The analysis of combinational rules and application characteristics of Chinese medicines Euphorbia with toxicity. Information on Traditional Chinese Medicine 26, (In Chinese), 23-5 (2009).
    • (2009) Information on Traditional Chinese Medicine , vol.26 , pp. 23-25
    • Ye, L.1    Fan, X.S.2    Duan, J.A.3    Shang, E.X.4    Guo, S.5
  • 16
    • 33847777044 scopus 로고    scopus 로고
    • Molecular authentication of the traditional Chinese medicinal plant Euphorbia pekinensis
    • Xue, H. G., Zhou, S. D., He, X. J. & Yu, Y. Molecular authentication of the traditional Chinese medicinal plant Euphorbia pekinensis. Planta Med. 73, 91-3 (2007).
    • (2007) Planta Med. , vol.73 , pp. 91-93
    • Xue, H.G.1    Zhou, S.D.2    He, X.J.3    Yu, Y.4
  • 17
    • 33847377573 scopus 로고    scopus 로고
    • A robustness-based approach to systems oriented drug design
    • Kitano, H. A robustness-based approach to systems oriented drug design. Nat Rev Drug Discov. 6, 202-10 (2007).
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 202-210
    • Kitano, H.1
  • 18
    • 84971622002 scopus 로고    scopus 로고
    • Pathway of PPAR-gamma coactivators in thermogenesis: A pivotal traditional Chinese medicine-associated target for individualized treatment of rheumatoid arthritis
    • In press
    • Zhang, Y. et al. Pathway of PPAR-gamma coactivators in thermogenesis: A pivotal traditional Chinese medicine-associated target for individualized treatment of rheumatoid arthritis. Oncotarget. In press, doi: 10. 18632/oncotarget. 7419 (2016).
    • (2016) Oncotarget
    • Zhang, Y.1
  • 19
    • 84926335491 scopus 로고    scopus 로고
    • Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: Drug-target prediction, network analysis and experimental validation
    • Zhang, Y. et al. Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis and experimental validation. Sci Rep. 5, 9463 (2015).
    • (2015) Sci Rep. , vol.5 , pp. 9463
    • Zhang, Y.1
  • 20
    • 84876538277 scopus 로고    scopus 로고
    • A systems biology-based investigation into the pharmacological mechanisms of wu tou tang acting on rheumatoid arthritis by integrating network analysis
    • Zhang, Y. et al. A systems biology-based investigation into the pharmacological mechanisms of wu tou tang acting on rheumatoid arthritis by integrating network analysis. Evid Based Complement Alternat Med. 2013, 548498 (2013).
    • (2013) Evid Based Complement Alternat Med , vol.2013 , pp. 548498
    • Zhang, Y.1
  • 21
    • 84964755807 scopus 로고    scopus 로고
    • Revealing the effects of the herbal pair of euphorbia kansui and glycyrrhiza on hepatocellular carcinoma ascites with integrating network target analysis and experimental validation
    • Zhang, Y. et al. Revealing the Effects of the Herbal Pair of Euphorbia kansui and Glycyrrhiza on Hepatocellular Carcinoma Ascites with Integrating Network Target Analysis and Experimental Validation. Int J Biol Sci 12, 594-606 (2016).
    • (2016) Int J Biol Sci , vol.12 , pp. 594-606
    • Zhang, Y.1
  • 22
    • 84939814453 scopus 로고    scopus 로고
    • A systems biology perspective on the molecular mechanisms underlying the therapeutic effects of buyang huanwu decoction on ischemic stroke
    • Guo, Q. et al. A Systems Biology Perspective on the Molecular Mechanisms Underlying the Therapeutic Effects of Buyang Huanwu Decoction on Ischemic Stroke. Rejuvenation Res. 18, 313-25 (2015).
    • (2015) Rejuvenation Res , vol.18 , pp. 313-325
    • Guo, Q.1
  • 23
    • 84904913574 scopus 로고    scopus 로고
    • A systems biology-based approach to uncovering the molecular mechanisms underlying the effects of dragon's blood tablet in colitis, involving the integration of chemical analysis, ADME prediction, and network pharmacology
    • Xu, H. et al. A systems biology-based approach to uncovering the molecular mechanisms underlying the effects of dragon's blood tablet in colitis, involving the integration of chemical analysis, ADME prediction, and network pharmacology. PLoS One 9, e101432 (2014).
    • (2014) PLoS One , vol.9 , pp. e101432
    • Xu, H.1
  • 24
    • 84951022076 scopus 로고    scopus 로고
    • Identification of key active constituents of Buchang Naoxintong capsules with therapeutic effects against ischemic stroke by using an integrative pharmacology-based approach
    • Haiyu, X. et al. Identification of key active constituents of Buchang Naoxintong capsules with therapeutic effects against ischemic stroke by using an integrative pharmacology-based approach. Mol Biosyst. 12, 233-45 (2016).
    • (2016) Mol Biosyst. , vol.12 , pp. 233-245
    • Haiyu, X.1
  • 25
    • 84894678025 scopus 로고    scopus 로고
    • A systems biology-based investigation into the therapeutic effects of Gansui Banxia Tang on reversing the imbalanced network of hepatocellular carcinoma
    • Zhang, Y. et al. A systems biology-based investigation into the therapeutic effects of Gansui Banxia Tang on reversing the imbalanced network of hepatocellular carcinoma. Sci Rep. 4, 4154 (2014).
    • (2014) Sci Rep , vol.4 , pp. 4154
    • Zhang, Y.1
  • 26
    • 0036236310 scopus 로고    scopus 로고
    • Hepatoimmunology: A perspective
    • Mackay, I. R. Hepatoimmunology: A perspective. Immunol Cell Biol. 80, 36-44 (2002).
    • (2002) Immunol Cell Biol. , vol.80 , pp. 36-44
    • Mackay, I.R.1
  • 28
    • 85011904311 scopus 로고    scopus 로고
    • Urinary excretion of the water channel aquaporin 2 correlated with the pharmacological effect of tolvaptan in cirrhotic patients with ascites
    • In press
    • Nakanishi, H. et al. Urinary excretion of the water channel aquaporin 2 correlated with the pharmacological effect of tolvaptan in cirrhotic patients with ascites. J Gastroenterol. In press (2015).
    • (2015) J Gastroenterol
    • Nakanishi, H.1
  • 29
    • 0034537958 scopus 로고    scopus 로고
    • Renal water handling in mice with decompensated liver cirrhosis
    • Jonassen, T. E. et al. Renal water handling in mice with decompensated liver cirrhosis. Am J Physiol Renal Physiol. 279, F1101-9 (2000).
    • (2000) Am J Physiol Renal Physiol. , vol.279 , pp. F1101-F1109
    • Jonassen, T.E.1
  • 30
    • 0031819673 scopus 로고    scopus 로고
    • Decreased vasopressin-mediated renal water reabsorption in mice with compensated liver cirrhosis
    • Jonassen, T. E., Nielsen, S., Christensen, S. & Petersen, J. S. Decreased vasopressin-mediated renal water reabsorption in mice with compensated liver cirrhosis. Am J Physiol. 275, F216-25 (1998).
    • (1998) Am J Physiol. , vol.275 , pp. F216-F225
    • Jonassen, T.E.1    Nielsen, S.2    Christensen, S.3    Petersen, J.S.4
  • 31
    • 0028814505 scopus 로고
    • Increased gene expression of water channel in cirrhotic rat kidneys
    • Asahina, Y. et al. Increased gene expression of water channel in cirrhotic rat kidneys. Hepatology. 21, 169-73 (1995).
    • (1995) Hepatology. , vol.21 , pp. 169-173
    • Asahina, Y.1
  • 32
    • 84939893294 scopus 로고    scopus 로고
    • FRK inhibits migration and invasion of human glioma cells by promoting n-cadherin/-catenin complex formation
    • Shi, Q. et al. FRK Inhibits Migration and Invasion of Human Glioma Cells by Promoting N-cadherin/-catenin Complex Formation. J Mol Neurosci. 55, 32-41 (2015).
    • (2015) J Mol Neurosci. , vol.55 , pp. 32-41
    • Shi, Q.1
  • 33
    • 34047195741 scopus 로고    scopus 로고
    • Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter
    • Annerén, C., Welsh, M. & Jansson, L. Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter. Am J Physiol Endocrinol Metab. 292, E1183-90 (2007).
    • (2007) Am J Physiol Endocrinol Metab. , vol.292 , pp. E1183-E1190
    • Annerén, C.1    Welsh, M.2    Jansson, L.3
  • 34
    • 84874338100 scopus 로고    scopus 로고
    • In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma
    • Chen, J. S., Hung, W. S., Chan, H. H., Tsai, S. J. & Sun, H. S. In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics. 29, 420-7 (2013).
    • (2013) Bioinformatics. , vol.29 , pp. 420-427
    • Chen, J.S.1    Hung, W.S.2    Chan, H.H.3    Tsai, S.J.4    Sun, H.S.5
  • 35
    • 33745233810 scopus 로고    scopus 로고
    • D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness
    • Zhang, Y. & Zhang, B. D4-GDI, a Rho GTPase Regulator, Promotes Breast Cancer Cell Invasiveness. Cancer Res. 66, 5592-8 (2006).
    • (2006) Cancer Res , vol.66 , pp. 5592-5598
    • Zhang, Y.1    Zhang, B.2
  • 36
    • 52949124867 scopus 로고    scopus 로고
    • Altered cellular immunity in transgenic mice with T cell-specific expression of human D4-guanine diphosphatedissociation inhibitor (D4-GDI)
    • Kondoh, K. et al. Altered cellular immunity in transgenic mice with T cell-specific expression of human D4-guanine diphosphatedissociation inhibitor (D4-GDI). Int Immunol. 20, 1299-311 (2008).
    • (2008) Int Immunol. , vol.20 , pp. 1299-1311
    • Kondoh, K.1
  • 37
    • 84922264945 scopus 로고    scopus 로고
    • Rho GDP dissociation inhibitor beta promotes cell proliferation and invasion by modulating the AKT pathway in hepatocellular carcinoma
    • Fang, Y., Yi, J., Lizhi, L. & Qiucheng, C. Rho GDP dissociation inhibitor beta promotes cell proliferation and invasion by modulating the AKT pathway in hepatocellular carcinoma. DNA Cell Biol. 33, 781-6 (2014).
    • (2014) DNA Cell Biol. , vol.33 , pp. 781-786
    • Fang, Y.1    Yi, J.2    Lizhi, L.3    Qiucheng, C.4
  • 38
    • 34547402441 scopus 로고    scopus 로고
    • T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses
    • Tarasenko, T. et al. T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci USA 104, 11382-7 (2007).
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 11382-11387
    • Tarasenko, T.1
  • 39
    • 33847281336 scopus 로고    scopus 로고
    • Relationship between spleen tyrosine kinase and phosphatidylinositol 5sphatase expression and secretion from human basophils in the general population
    • MacGlashan, D. W., Jr. Relationship between spleen tyrosine kinase and phosphatidylinositol 5sphatase expression and secretion from human basophils in the general population. J Allergy Clin Immunol. 119, 626-33 (2007).
    • (2007) J Allergy Clin Immunol. , vol.119 , pp. 626-633
    • MacGlashan, D.W.1
  • 40
    • 38449111521 scopus 로고    scopus 로고
    • Significance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection
    • Sumie, S. et al. Significance of glucose intolerance and SHIP2 expression in hepatocellular carcinoma patients with HCV infection. Oncol Rep. 18, 545-52 (2007).
    • (2007) Oncol Rep. , vol.18 , pp. 545-552
    • Sumie, S.1
  • 42
    • 84887440981 scopus 로고    scopus 로고
    • Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia
    • Tamma, R. et al. Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia. Proc Natl Acad Sci USA 110, 18644-9 (2013).
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 18644-18649
    • Tamma, R.1
  • 43
    • 84903207850 scopus 로고    scopus 로고
    • Tolvaptan for the treatment of liver cirrhosis oedema
    • Sakaida, I. Tolvaptan for the treatment of liver cirrhosis oedema. Expert Rev Gastroenterol Hepatol. 8, 461-70 (2014).
    • (2014) Expert Rev Gastroenterol Hepatol. , vol.8 , pp. 461-470
    • Sakaida, I.1
  • 44
    • 84878020534 scopus 로고    scopus 로고
    • Satavaptan treatment for ascites in patients with cirrhosis: A meta-analysis of effect on hepatic encephalopathy development
    • Watson, H. et al. Satavaptan treatment for ascites in patients with cirrhosis: A meta-analysis of effect on hepatic encephalopathy development. Metab Brain Dis. 28, 301-5 (2013).
    • (2013) Metab Brain Dis. , vol.28 , pp. 301-305
    • Watson, H.1
  • 45
    • 84947215570 scopus 로고    scopus 로고
    • Control of the aquaporin-4 channel water permeability by structural dynamics of aromatic/arginine selectivity filter residues
    • Kitchen, P. & Conner, A. C. Control of the Aquaporin-4 Channel Water Permeability by Structural Dynamics of Aromatic/Arginine Selectivity Filter Residues. Biochemistry 54, 6753-5 (2015).
    • (2015) Biochemistry , vol.54 , pp. 6753-6755
    • Kitchen, P.1    Conner, A.C.2
  • 46
    • 77953122620 scopus 로고    scopus 로고
    • Role of aquaporin-4 in the development of brain oedema in liver failure
    • Wright, G. et al. Role of aquaporin-4 in the development of brain oedema in liver failure. J Hepatol. 53, 91-7 (2010).
    • (2010) J Hepatol. , vol.53 , pp. 91-97
    • Wright, G.1
  • 47
    • 84941051170 scopus 로고    scopus 로고
    • STRING v10: Protein-protein interaction networks, integrated over the tree of life
    • Szklarczyk, D. et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43, D447-52 (2015).
    • (2015) Nucleic Acids Res. , vol.43 , pp. D447-D452
    • Szklarczyk, D.1
  • 48
    • 33749223143 scopus 로고    scopus 로고
    • The kyoto encyclopedia of genes and genomes-KEGG
    • Wixon, J. & Kell, D. The Kyoto encyclopedia of genes and genomes-KEGG. Yeast. 17, 48-55 (2000).
    • (2000) Yeast. , vol.17 , pp. 48-55
    • Wixon, J.1    Kell, D.2
  • 49
    • 6344289257 scopus 로고    scopus 로고
    • Real-time quantitative PCR-based system for determining transgene copy number in transgenic animals
    • Ballester, M., Castelló, A., Ibáñez, E., Sánchez, A. & Folch, J. M. Real-time quantitative PCR-based system for determining transgene copy number in transgenic animals. Biotechniques 37, 610-3 (2004).
    • (2004) Biotechniques , vol.37 , pp. 610-613
    • Ballester, M.1    Castelló, A.2    Ibáñez, E.3    Sánchez, A.4    Folch, J.M.5
  • 50
    • 84886608491 scopus 로고    scopus 로고
    • Anti-angiogenic effect of triptolide in rheumatoid arthritis by targeting angiogenic cascade
    • Kong, X. et al. Anti-angiogenic effect of triptolide in rheumatoid arthritis by targeting angiogenic cascade. PLoS One 8, e77513 (2013).
    • (2013) PLoS One , vol.8 , pp. e77513
    • Kong, X.1
  • 51
    • 33845336176 scopus 로고    scopus 로고
    • Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice
    • Lin, N. et al. Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice. Biochem Pharmacol. 73, 136-46 (2007).
    • (2007) Biochem Pharmacol. , vol.73 , pp. 136-146
    • Lin, N.1


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