Liquiritigenin induces tumor cell death through mitogen-Activated protein kinase- (MPAKs-) mediated pathway in hepatocellular carcinoma cells

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Wang, Di ^a   Lu, Jiahui ^a   Liu, Yan ^a   Meng, Qingfan ^a   Xie, Jing ^a   Wang, Zhenzuo ^a   Teng, Lesheng ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; LACTATE DEHYDROGENASE; LIQUIRITIGENIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; FLAVANONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER SIZE; CARCINOMA CELL; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR XENOGRAFT; WEIGHT REDUCTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CARCINOMA, HEPATOCELLULAR; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; LIVER NEOPLASMS; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; FLAVANONES; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MICE; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 84897513399     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/965316     Document Type: Article

References (45)

1. Llovet J. M., Burroughs A., Bruix J., Hepatocellular carcinoma. The Lancet 2003 362 9399 1907 1917 2-s2.0-0141491273 10.1016/S0140-6736(03)14964-1 (Pubitemid 37518510)
2. Arii S., Yamaoka Y., Futagawa S., Inoue K., Kobayashi K., Kojiro M., Makuuchi M., Nakamura Y., Okita K., Yamada R., Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. Hepatology 2000 32 6 1224 1229 2-s2.0-0033646209
3. Wang N., Pan W., Zhu M., Zhang M., Hao X., Liang G., Feng Y., Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells. British Journal of Pharmacology 2011 164 2 731 742 2-s2.0-80052227790 10.1111/j.1476-5381.2011.01349.x
4. Hsu Y.-L., Kuo P.-L., Tzeng T.-F., Sung S.-C., Yen M.-H., Lin L.-T., Lin C.-C., Huang-lian-jie-du-tang, a traditional Chinese medicine prescription, induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo. Journal of Gastroenterology and Hepatology 2008 23 7 e290 e299 2-s2.0-47649092000 10.1111/j.1440-1746.2008.05390.x (Pubitemid 352019438)
5. Kim Y. W., Zhao R. J., Park S. J., Lee J. R., Cho I. J., Yang C. H., Kim S. G., Kim S. C., Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF- B-dependent iNOS and proinflammatory cytokines production. British Journal of Pharmacology 2008 154 1 165 173 2-s2.0-42949164997 10.1038/bjp.2008.79 (Pubitemid 351620405)
6. Shin Y.-W., Bae E.-A., Lee B., Seung H. L., Jeong A. K., Kim Y.-S., Kim D.-H., In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components. Planta Medica 2007 73 3 257 261 2-s2.0-34250372588 10.1055/s-2007-967126 (Pubitemid 46917478)
7. Jahromi M. A. F., Ray A. B., Chansouria J. P. N., Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium. Journal of Natural Products 1993 56 7 989 994 2-s2.0-0027234723 (Pubitemid 23222197)
8. Kim Y. W., Ki S. H., Lee J. R., Lee S. J., Kim C. W., Kim S. C., Kim S. G., Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine. Chemico-Biological Interactions 2006 161 2 125 138 2-s2.0-33646850088 10.1016/j.cbi.2006.03.008 (Pubitemid 43776630)
9. Liu Z.-L., Tanaka S., Horigome H., Hirano T., Oka K., Induction of apoptosis in human lung fibroblasts and peripheral lymphocytes in vitro by Shosaiko-to derived phenolic metabolites. Biological & pharmaceutical bulletin 2002 25 1 37 41 2-s2.0-0036369692
10. Zhang S.-P., Zhou Y.-J., Liu Y., Cai Y.-Q., Effect of liquiritigenin, a flavanone existed from Radix glycyrrhizae on pro-apoptotic in SMMC-7721 cells. Food and Chemical Toxicology 2009 47 4 693 701 2-s2.0-60849112240 10.1016/j.fct.2008.12.015
11. Zhou M., Higo H., Cai Y., Inhibition of hepatoma 22 tumor by liquiritigenin. Phytotherapy Research 2010 24 6 827 833 2-s2.0-77953243584 10.1002/ptr.3024
12. Wang D., Wong H. K., Feng Y. B., Liquiritigenin exhibits antitumour action in pituitary adenoma cells via Ras/ERKs and ROS-dependent mitochondrial signalling pathways. Journal of Pharmacy and Pharmacology 2013 66 3 408 417
13. Reed J. C., Dysregulation of apoptosis in cancer. Journal of Clinical Oncology 1999 17 9 2941 2953 2-s2.0-0032877668 (Pubitemid 29415256)
14. Kurokawa M., Kornbluth S., Caspases and kinases in a death grip. Cell 2009 138 5 838 854 2-s2.0-69449095860 10.1016/j.cell.2009.08.021
15. Wang Z.-W., Liu X.-L., Medium optimization for antifungal active substances production from a newly isolated Paenibacillus sp. using response surface methodology. Bioresource Technology 2008 99 17 8245 8251 2-s2.0-47749085920 10.1016/j.biortech.2008.03.039
16. Adams J. M., Cory S., The Bcl-2 protein family: arbiters of cell survival. Science 1998 281 5381 1322 1326 2-s2.0-0032575688 (Pubitemid 28406819)
17. Tsujimoto Y., Shimizu S., Role of the mitochondrial membrane permeability transition in cell death. Apoptosis 2007 12 5 835 840 2-s2.0-34247485841 10.1007/s10495-006-0525-7 (Pubitemid 46653286)
18. Simon H.-U., Haj-Yehia A., Levi-Schaffer F., Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000 5 5 415 418 2-s2.0-0034468736 10.1023/A:1009616228304 (Pubitemid 32162623)
19. Ricci J.-E., Gottlieb R. A., Green D. R., Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. The Journal of Cell Biology 2003 160 1 65 75 2-s2.0-0037421221 10.1083/jcb.200208089 (Pubitemid 36091717)
20. Pearson G., Robinson F., Gibson T. B., Xu B.-E., Karandikar M., Berman K., Cobb M. H., Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocrine Reviews 2001 22 2 153 183 2-s2.0-0034997845 10.1210/er.22.2.153 (Pubitemid 32458157)
21. Festa M., Capasso A., D'Acunto C. W., Masullo M., Rossi A. G., Pizza C., Piacente S., Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways. Journal of Natural Products 2011 74 12 2505 2513 2-s2.0-84855214883 10.1021/np200390x
22. Cheung E. C. C., Slack R. S., Emerging role for ERK as a key regulator of neuronal apoptosis. Science's STKE: Signal Transduction Knowledge Environment 2004 2004 251 PE45 2-s2.0-15244352198
23. Yang C. L. H., Chik S. C. C., Li J. C. B., Cheung B. K. W., Lau A. S. Y., Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages. Journal of Medicinal Chemistry 2009 52 21 6707 6715 2-s2.0-71049149246 10.1021/jm9006164
24. Zandbergen E., Haan R., Hijdra A., Systematic review of prediction of poor outcome in anoxic-ischaemic coma with biochemical markers of brain damage. Intensive Care Medicine 2001 27 10 1661 1667 2-s2.0-0034765530 10.1007/s001340101076 (Pubitemid 33027965)
25. + and acidic damage via autophagic pathway. Journal of Ethnopharmacology 2010 131 1 122 129 2-s2.0-77955332763 10.1016/j.jep.2010.06. 009
26. Suen D.-F., Norris K. L., Youle R. J., Mitochondrial dynamics and apoptosis. Genes and Development 2008 22 12 1577 1590 2-s2.0-45349094984 10.1101/gad.1658508 (Pubitemid 351846838)
27. Chao D. T., Korsmeyer S. J., BCL-2 family: regulators of cell death. Annual Review of Immunology 1998 16 395 419 2-s2.0-0031918223 10.1146/annurev.immunol.16.1.395 (Pubitemid 28183370)
28. Dizdaroglu M., Chemical determination of free radical-induced damage to DNA. Free Radical Biology and Medicine 1991 10 3-4 225 242 2-s2.0-0025973703 (Pubitemid 121003232)
29. Circu M. L., Aw T. Y., Reactive oxygen species, cellular redox systems, and apoptosis. Free Radical Biology and Medicine 2010 48 6 749 762 2-s2.0-76049083966 10.1016/j.freeradbiomed.2009.12.022
30. Liu C., Wang Y., Xie S., Zhou Y., Ren X., Li X., Cai Y., Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in heLa cells. Phytotherapy Research 2011 25 2 277 283 2-s2.0-79551669602 10.1002/ptr.3259
31. Raza H., John A., Benedict S., Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells. European Journal of Pharmacology 2011 668 1-2 15 24 2-s2.0-80052043989 10.1016/j.ejphar.2011.06.016
32. Choi A. Y., Choi J. H., Yoon H., Hwang K.-Y., Noh M. H., Choe W., Yoon K.-S., Ha J., Yeo E.-J., Kang I., Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells. European Journal of Pharmacology 2011 668 1-2 115 126 2-s2.0-80052056086 10.1016/j.ejphar.2011.06.047
33. Wu P.-P., Chung H.-W., Liu K.-C., Wu R. S.-C., Yang J.-S., Tang N.-Y., Lo C., Hsia T. E.-C., Yu C.-C., Chueh F. U.-S., Lin S.-S., Chung J.-G., Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways. International Journal of Oncology 2011 38 6 1605 1613 2-s2.0-79955833531 10.3892/ijo.2011.973
34. Chan S.-L., Yu V. C., Proteins of the Bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities. Clinical and Experimental Pharmacology and Physiology 2004 31 3 119 128 2-s2.0-1542616703 10.1111/j.1440-1681.2004.03975.x (Pubitemid 38338707)
35. Raisova M., Hossini A. M., Eberle J., Riebeling C., Wieder T., Sturm I., Daniel P. T., Orfanos C. E., Geilen C. C., The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis. Journal of Investigative Dermatology 2001 117 2 333 340 2-s2.0-0035720233 10.1046/j.0022-202X.2001.01409.x (Pubitemid 34205719)
36. El-Najjar N., Chatila M., Moukadem H., Vuorela H., Ocker M., Gandesiri M., Schneider-Stock R., Gali-Muhtasib H., Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. Apoptosis 2010 15 2 183 195 2-s2.0-77949263613 10.1007/s10495-009-0421-z
37. García-Fernández L. F., Losada A., Alcaide V., Álvarez A. M., Cuadrado A., González L., Nakayama K., Nakayama K. I., Fernández-Sousa J. M., Muñoz A., Sánchez-Puelles J. M., Aplidin ™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ Oncogene 2002 21 49 7533 7544 2-s2.0-3042781436 10.1038/sj.onc.1205972 (Pubitemid 35305581)
38. Zhang Z., Teruya K., Eto H., Shirahata S., Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ros-dependent JNK activation and mitochondria-mediated pathways. PLoS ONE 2011 6 11 2-s2.0-80855135589 10.1371/journal.pone.0027441 e27441
39. Krajarng A., Nakamura Y., Suksamrarn S., Watanapokasin R., α -mangostin induces apoptosis in human chondrosarcoma cells through downregulation of ERK/JNK and Akt signaling pathway. Journal of Agricultural and Food Chemistry 2011 59 10 5746 5754 2-s2.0-79957964309 10.1021/jf200620n
40. Tada K.-I., Kawahara K.-I., Matsushita S., Hashiguchi T., Maruyama I., Kanekura T., MK615, a Prunus mume Steb. Et Zucc ('Ume') Extract, Attenuates the Growth of A375 Melanoma Cells by Inhibiting the ERK1/2-Id-1 Pathway. Phytotherapy Research 2012 26 6 833 838 2-s2.0-80755130277 10.1002/ptr.3645
41. David Sweatt J., The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. Journal of Neurochemistry 2001 76 1 1 10 2-s2.0-0035166616 10.1046/j.1471-4159.2001.00054.x (Pubitemid 32044362)
42. Zhao S.-L., Hong J., Xie Z.-Q., Tang J.-T., Su W.-Y., Du W., Chen Y.-X., Lu R., Sun D.-F., Fang J.-Y., TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells. PLoS ONE 2011 6 8 2-s2.0-79961094819 10.1371/journal.pone.0023262 e23262
43. Boucher M. J., Morisset J., Vachon P. H., MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. Journal of Cellular Biochemistry 2000 79 3 355 369
44. Zhao Y., Shen S., Guo J., Chen H., Yu Greenblatt D., Kleeff J., Liao Q., Chen G., Friess H., Sing Leung P., Mitogen-activated protein kinases and chemoresistance in pancreatic cancer cells. Journal of Surgical Research 2006 136 2 325 335 2-s2.0-33750957951 10.1016/j.jss.2006.06.031 (Pubitemid 44737848)
45. Balmanno K., Cook S. J., Tumour cell survival signalling by the ERK1/2 pathway. Cell Death and Differentiation 2009 16 3 368 377 2-s2.0-60849112820 10.1038/cdd.2008.148