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Volumn 34, Issue 3, 2013, Pages 1381-1389

Glycyrrhiza polysaccharide induces apoptosis and inhibits proliferation of human hepatocellular carcinoma cells by blocking PI3K/AKT signal pathway

Author keywords

Glycyrrhiza polysaccharide; Human hepatocellular carcinoma cell; P53 PI3K AKT

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; GLYCYRRHIZA POLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT MEDICINAL PRODUCT; PROTEIN KINASE B; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 84878716826     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0746-7     Document Type: Article
Times cited : (35)

References (20)
  • 1
    • 4444321828 scopus 로고    scopus 로고
    • Effects of mushroom and herb polysaccharides on cellular and humoral immune responses of Eimeria tenella-infected chickens
    • 15285503 1:CAS:528:DC%2BD2cXmt1Oktrc%3D
    • Guo FC, Kwakkel RP, Williams BA, Parmentier HK, Li WK, Yang ZQ, et al. Effects of mushroom and herb polysaccharides on cellular and humoral immune responses of Eimeria tenella-infected chickens. Poult Sci. 2004;83:1124-32.
    • (2004) Poult Sci , vol.83 , pp. 1124-1132
    • Guo, F.C.1    Kwakkel, R.P.2    Williams, B.A.3    Parmentier, H.K.4    Li, W.K.5    Yang, Z.Q.6    Verstegen, M.W.7
  • 2
    • 0025670629 scopus 로고
    • Immunopotentiating effect of traditional Chinese drugs - Ginsenoside and glycyrrhiza polysaccharide
    • 2293226 1:STN:280:DyaK3M7ls1Kntg%3D%3D
    • Yang G, Yu Y. Immunopotentiating effect of traditional Chinese drugs - ginsenoside and glycyrrhiza polysaccharide. Proc Chin Acad Med Sci Peking Union Med Coll. 1990;5:188-93.
    • (1990) Proc Chin Acad Med Sci Peking Union Med Coll , vol.5 , pp. 188-193
    • Yang, G.1    Yu, Y.2
  • 3
    • 0031792611 scopus 로고    scopus 로고
    • Activation of macrophages by crude polysaccharide fractions obtained from shoots of Glycyrrhiza glabra and hairy roots of Glycyrrhiza uralensis in vitro
    • 9821821 10.1248/bpb.21.1110 1:CAS:528:DyaK1cXntVSlu7Y%3D
    • Nose M, Terawaki K, Oguri K, Ogihara Y, Yoshimatsu K, Shimomura K. Activation of macrophages by crude polysaccharide fractions obtained from shoots of Glycyrrhiza glabra and hairy roots of Glycyrrhiza uralensis in vitro. Biol Pharm Bull. 1998;21:1110-2.
    • (1998) Biol Pharm Bull , vol.21 , pp. 1110-1112
    • Nose, M.1    Terawaki, K.2    Oguri, K.3    Ogihara, Y.4    Yoshimatsu, K.5    Shimomura, K.6
  • 4
    • 0031414682 scopus 로고    scopus 로고
    • Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular
    • 9568540 10.1016/S0192-0561(97)00076-3 1:CAS:528:DyaK1cXjs1KhsLo%3D
    • Yoshida Y, Wang MQ, Liu JN, Shan BE, Yamashita U. Immunomodulating activity of Chinese medicinal herbs and Oldenlandia diffusa in particular. Int J Immunopharmacol. 1997;19:359-70.
    • (1997) Int J Immunopharmacol , vol.19 , pp. 359-370
    • Yoshida, Y.1    Wang, M.Q.2    Liu, J.N.3    Shan, B.E.4    Yamashita, U.5
  • 5
    • 68849125227 scopus 로고    scopus 로고
    • Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa
    • 19607905 10.1016/j.jep.2009.07.009 1:CAS:528:DC%2BD1MXhtVensLvE
    • Wittschier N, Faller G, Hensel A. Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa. J Ethnopharmacol. 2009;125:218-23.
    • (2009) J Ethnopharmacol , vol.125 , pp. 218-223
    • Wittschier, N.1    Faller, G.2    Hensel, A.3
  • 6
    • 0026732028 scopus 로고
    • Core structure of glycyrrhizan GA, the main polysaccharide from the stolon of Glycyrrhiza glabra var. glandulifera; Anti-complementary and alkaline phosphatase-inducing activities of the polysaccharide and its degradation products
    • 10.1248/cpb.40.2487 1:CAS:528:DyaK3sXptlyjsQ%3D%3D
    • Takada K, Tomoda M, Shimizu N. Core structure of glycyrrhizan GA, the main polysaccharide from the stolon of Glycyrrhiza glabra var. glandulifera; anti-complementary and alkaline phosphatase-inducing activities of the polysaccharide and its degradation products. Chem Pharm Bull (Tokyo). 1992;40:2487-90.
    • (1992) Chem Pharm Bull (Tokyo) , vol.40 , pp. 2487-2490
    • Takada, K.1    Tomoda, M.2    Shimizu, N.3
  • 7
    • 0029035488 scopus 로고
    • Isolation of a previously unidentified polysaccharide (MAR-10) from Hyssop officinalis that exhibits strong activity against human immunodeficiency virus type 1
    • 7741735 10.1006/bbrc.1995.1639 1:CAS:528:DyaK2MXlsF2mtr0%3D
    • Gollapudi S, Sharma HA, Aggarwal S, Byers LD, Ensley HE, Gupta S. Isolation of a previously unidentified polysaccharide (MAR-10) from Hyssop officinalis that exhibits strong activity against human immunodeficiency virus type 1. Biochem Biophys Res Commun. 1995;210:145-51.
    • (1995) Biochem Biophys Res Commun , vol.210 , pp. 145-151
    • Gollapudi, S.1    Sharma, H.A.2    Aggarwal, S.3    Byers, L.D.4    Ensley, H.E.5    Gupta, S.6
  • 8
    • 0242660522 scopus 로고    scopus 로고
    • Inhibitory effects of hyssop (Hyssopus officinalis) extracts on intestinal alpha-glucosidase activity and postprandial hyperglycemia
    • 10.3177/jnsv.49.346 1:CAS:528:DC%2BD3sXptVyhuro%3D
    • Miyazaki H, Matsuura H, Yanagiya C, Mizutani J, Tsuji M, Ishihara C. Inhibitory effects of hyssop (Hyssopus officinalis) extracts on intestinal alpha-glucosidase activity and postprandial hyperglycemia. J Nutr Sci Vitaminol (Tokyo). 2003;49:346-9.
    • (2003) J Nutr Sci Vitaminol (Tokyo) , vol.49 , pp. 346-349
    • Miyazaki, H.1    Matsuura, H.2    Yanagiya, C.3    Mizutani, J.4    Tsuji, M.5    Ishihara, C.6
  • 9
    • 0034043914 scopus 로고    scopus 로고
    • Immunomodulation and anti-cancer activity of polysaccharide-protein complexes
    • 10702635 10.2174/0929867003374705 1:CAS:528:DC%2BD3cXjvFCmtLY%3D
    • Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000;7:715-29.
    • (2000) Curr Med Chem , vol.7 , pp. 715-729
    • Ooi, V.E.1    Liu, F.2
  • 11
    • 84862642815 scopus 로고    scopus 로고
    • Antitumor and immunostimulatory activity of a polysaccharide-protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice
    • Zhao H, Li Y, Wang Y, Zhang J, Ouyang X, Peng R, et al. Antitumor and immunostimulatory activity of a polysaccharide-protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice. Food Chem Toxicol. 2012;8:2648-55.
    • (2012) Food Chem Toxicol , vol.8 , pp. 2648-2655
    • Zhao, H.1    Li, Y.2    Wang, Y.3    Zhang, J.4    Ouyang, X.5    Peng, R.6    Yang, J.7
  • 12
    • 77952287178 scopus 로고    scopus 로고
    • Novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway
    • 20092988 10.1016/j.phymed.2009.12.014 1:CAS:528:DC%2BC3cXpsVyhu7g%3D
    • Cao W, Li XQ, Wang X, Fan HT, Zhang XN, Hou Y, et al. novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. Phytomedicine. 2010;17:598-605.
    • (2010) Phytomedicine , vol.17 , pp. 598-605
    • Cao, W.1    Li, X.Q.2    Wang, X.3    Fan, H.T.4    Zhang, X.N.5    Hou, Y.6    Liu, S.B.7    Mei, Q.B.A.8
  • 13
    • 0030435781 scopus 로고    scopus 로고
    • Experimental and epidemiological evidence of the cancer-preventive effects of Panax ginseng C.A. Meyer
    • 9110579 10.1111/j.1753-4887.1996.tb03822.x 1:STN:280:DyaK2s3msVOktg%3D%3D
    • Yun TK. Experimental and epidemiological evidence of the cancer-preventive effects of Panax ginseng C.A. Meyer. Nutr Rev. 1996;54:S71-81.
    • (1996) Nutr Rev , vol.54 , pp. 71-81
    • Yun, T.K.1
  • 14
    • 85027937822 scopus 로고    scopus 로고
    • Dynamics of antitumor resistance after cyclophosphamide injection
    • 22803147 10.1007/s10517-012-1589-8 1:CAS:528:DC%2BC38XlslWrtLw%3D
    • Terpinskaya TI. Dynamics of antitumor resistance after cyclophosphamide injection. Bull Exp Biol Med. 2012;152:613-4.
    • (2012) Bull Exp Biol Med , vol.152 , pp. 613-614
    • Terpinskaya, T.I.1
  • 15
    • 0030612749 scopus 로고    scopus 로고
    • JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis
    • 9247146 10.1016/S0014-5793(97)00669-8 1:CAS:528:DyaK2sXktlCqtLY%3D
    • Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett. 1997;411:77-82.
    • (1997) FEBS Lett , vol.411 , pp. 77-82
    • Salvioli, S.1    Ardizzoni, A.2    Franceschi, C.3    Cossarizza, A.4
  • 16
    • 34347230544 scopus 로고    scopus 로고
    • Sulforhodamine B colorimetric assay for cytotoxicity screening
    • 17406391 10.1038/nprot.2006.179 1:CAS:528:DC%2BD28XhtFOitL3O
    • Vichai V, Kirtikara K. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc. 2006;1:1112-6.
    • (2006) Nat Protoc , vol.1 , pp. 1112-1116
    • Vichai, V.1    Kirtikara, K.2
  • 17
    • 34447117003 scopus 로고    scopus 로고
    • Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    • 17616664 10.1158/0008-5472.CAN-06-4607 1:CAS:528:DC%2BD2sXnsVyqsbo%3D
    • Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, et al. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res. 2007;67:6092-9.
    • (2007) Cancer Res , vol.67 , pp. 6092-6099
    • Gramantieri, L.1    Ferracin, M.2    Fornari, F.3    Veronese, A.4    Sabbioni, S.5    Liu, C.G.6
  • 18
    • 0033582526 scopus 로고    scopus 로고
    • Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
    • 9988752 10.1074/jbc.274.8.5053 1:CAS:528:DyaK1MXhsFSlsbo%3D
    • Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR, Cohen GM. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem. 1999;274:5053-60.
    • (1999) J Biol Chem , vol.274 , pp. 5053-5060
    • Sun, X.M.1    MacFarlane, M.2    Zhuang, J.3    Wolf, B.B.4    Green, D.R.5    Cohen, G.M.6
  • 19
    • 84878711914 scopus 로고    scopus 로고
    • Study on chemistry and pharmacology of glycyrrhiza polysaccharide
    • (natural sciences edition)
    • Chen-feng J, Wei J, Xiao-jing W. Study on chemistry and pharmacology of glycyrrhiza polysaccharide. Journal of Harbin University of Commerce (natural sciences edition). 2004; 20.
    • (2004) Journal of Harbin University of Commerce , vol.20
    • Chen-Feng, J.1    Wei, J.2    Xiao-Jing, W.3
  • 20
    • 77956627711 scopus 로고    scopus 로고
    • The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    • 20639898 10.1038/onc.2010.236 1:CAS:528:DC%2BC3cXovFCnt7c%3D
    • Whittaker S, Marais R, Zhu AX. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene. 2010;29:4989-5005.
    • (2010) Oncogene , vol.29 , pp. 4989-5005
    • Whittaker, S.1    Marais, R.2    Zhu, A.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.