메뉴 건너뛰기




Volumn 20, Issue 3, 2017, Pages 476-483

Neuronal activity modifies the chromatin accessibility landscape in the adult brain

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN C FOS; TRANSCRIPTION FACTOR AP 1; CHROMATIN;

EID: 85011665440     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.4494     Document Type: Article
Times cited : (175)

References (57)
  • 1
    • 36849154193 scopus 로고
    • Memory and molecular turnover
    • Crick, F. Memory and molecular turnover. Nature 312, 101 (1984).
    • (1984) Nature , vol.312 , pp. 101
    • Crick, F.1
  • 2
    • 79955622702 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression in physiological and pathological brain processes
    • Gräff, J., Kim, D., Dobbin, M.M. & Tsai, L.H. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol. Rev. 91, 603-649 (2011).
    • (2011) Physiol. Rev. , vol.91 , pp. 603-649
    • Gräff, J.1    Kim, D.2    Dobbin, M.M.3    Tsai, L.H.4
  • 3
    • 80054793380 scopus 로고    scopus 로고
    • Neuronal activity-regulated gene transcription in synapse development and cognitive function
    • West, A.E. & Greenberg, M.E. Neuronal activity-regulated gene transcription in synapse development and cognitive function. Cold Spring Harb. Perspect. Biol. http://dx.doi.org/10.1101/cshperspect.a005744 (2011).
    • (2011) Cold Spring Harb. Perspect. Biol.
    • West, A.E.1    Greenberg, M.E.2
  • 4
    • 84887009499 scopus 로고    scopus 로고
    • The emerging field of neuroepigenetics
    • Sweatt, J.D. The emerging field of neuroepigenetics. Neuron 80, 624-632 (2013).
    • (2013) Neuron , vol.80 , pp. 624-632
    • Sweatt, J.D.1
  • 5
    • 84926103731 scopus 로고    scopus 로고
    • Epigenetic mechanisms of chronic pain
    • Descalzi, G. et al. Epigenetic mechanisms of chronic pain. Trends Neurosci. 38, 237-246 (2015).
    • (2015) Trends Neurosci. , vol.38 , pp. 237-246
    • Descalzi, G.1
  • 6
    • 84873823667 scopus 로고    scopus 로고
    • Epigenetics and persistent memory: Implications for reconsolidation and silent extinction beyond the zero
    • Lattal, K.M. & Wood, M.A. Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero. Nat. Neurosci. 16, 124-129 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 124-129
    • Lattal, K.M.1    Wood, M.A.2
  • 7
    • 77958526499 scopus 로고    scopus 로고
    • Epigenetic regulation of the neural transcriptome: The meaning of the marks
    • Meaney, M.J. & Ferguson-Smith, A.C. Epigenetic regulation of the neural transcriptome: the meaning of the marks. Nat. Neurosci. 13, 1313-1318 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 1313-1318
    • Meaney, M.J.1    Ferguson-Smith, A.C.2
  • 8
    • 57649239938 scopus 로고    scopus 로고
    • Decoding the epigenetic language of neuronal plasticity
    • Borrelli, E., Nestler, E.J., Allis, C.D. & Sassone-Corsi, P. Decoding the epigenetic language of neuronal plasticity. Neuron 60, 961-974 (2008).
    • (2008) Neuron , vol.60 , pp. 961-974
    • Borrelli, E.1    Nestler, E.J.2    Allis, C.D.3    Sassone-Corsi, P.4
  • 9
    • 80051712275 scopus 로고    scopus 로고
    • Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond
    • Guo, J.U., Su, Y., Zhong, C., Ming, G.L. & Song, H. Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond. Cell Cycle 10, 2662-2668 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 2662-2668
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 10
    • 84994713348 scopus 로고    scopus 로고
    • The role of epigenetic mechanisms in the regulation of gene expression in the nervous system
    • Cholewa-Waclaw, J. et al. The role of epigenetic mechanisms in the regulation of gene expression in the nervous system. J. Neurosci. 36, 11427-11434 (2016).
    • (2016) J. Neurosci. , vol.36 , pp. 11427-11434
    • Cholewa-Waclaw, J.1
  • 12
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch, R. & Bird, A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33 (Suppl.), 245-254 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 13
    • 84911939594 scopus 로고    scopus 로고
    • Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution
    • Vierstra, J. et al. Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science 346, 1007-1012 (2014).
    • (2014) Science , vol.346 , pp. 1007-1012
    • Vierstra, J.1
  • 14
    • 84977478852 scopus 로고    scopus 로고
    • Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide
    • Schmid, R.S. et al. Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide. Neuro-oncol. 18, 962-973 (2016).
    • (2016) Neuro-oncol. , vol.18 , pp. 962-973
    • Schmid, R.S.1
  • 15
    • 84931066427 scopus 로고    scopus 로고
    • Epigenomic signatures of neuronal diversity in the mammalian brain
    • Mo, A. et al. Epigenomic signatures of neuronal diversity in the mammalian brain. Neuron 86, 1369-1384 (2015).
    • (2015) Neuron , vol.86 , pp. 1369-1384
    • Mo, A.1
  • 16
    • 84908542111 scopus 로고    scopus 로고
    • Decoding neural transcriptomes and epigenomes via high-throughput sequencing
    • Shin, J., Ming, G.L. & Song, H. Decoding neural transcriptomes and epigenomes via high-throughput sequencing. Nat. Neurosci. 17, 1463-1475 (2014).
    • (2014) Nat. Neurosci. , vol.17 , pp. 1463-1475
    • Shin, J.1    Ming, G.L.2    Song, H.3
  • 17
    • 84888877924 scopus 로고    scopus 로고
    • Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
    • Buenrostro, J.D., Giresi, P.G., Zaba, L.C., Chang, H.Y. & Greenleaf, W.J. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat. Methods 10, 1213-1218 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 1213-1218
    • Buenrostro, J.D.1    Giresi, P.G.2    Zaba, L.C.3    Chang, H.Y.4    Greenleaf, W.J.5
  • 18
    • 60749094831 scopus 로고    scopus 로고
    • Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
    • Ma, D.K. et al. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323, 1074-1077 (2009).
    • (2009) Science , vol.323 , pp. 1074-1077
    • Ma, D.K.1
  • 19
    • 80053270332 scopus 로고    scopus 로고
    • Neuronal activity modifies the DNA methylation landscape in the adult brain
    • Guo, J.U. et al. Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat. Neurosci. 14, 1345-1351 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 1345-1351
    • Guo, J.U.1
  • 20
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • Guo, J.U., Su, Y., Zhong, C., Ming, G.L. & Song, H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145, 423-434 (2011).
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 21
    • 35848964343 scopus 로고    scopus 로고
    • Electroconvulsive therapy for depression
    • Lisanby, S.H. Electroconvulsive therapy for depression. N. Engl. J. Med. 357, 1939-1945 (2007).
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1939-1945
    • Lisanby, S.H.1
  • 22
    • 84858062797 scopus 로고    scopus 로고
    • Spatial firing correlates of physiologically distinct cell types of the rat dentate gyrus
    • Neunuebel, J.P. & Knierim, J.J. Spatial firing correlates of physiologically distinct cell types of the rat dentate gyrus. J. Neurosci. 32, 3848-3858 (2012).
    • (2012) J. Neurosci. , vol.32 , pp. 3848-3858
    • Neunuebel, J.P.1    Knierim, J.J.2
  • 23
    • 84865755978 scopus 로고    scopus 로고
    • The accessible chromatin landscape of the human genome
    • Thurman, R.E. et al. The accessible chromatin landscape of the human genome. Nature 489, 75-82 (2012).
    • (2012) Nature , vol.489 , pp. 75-82
    • Thurman, R.E.1
  • 24
    • 84928699628 scopus 로고    scopus 로고
    • Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum
    • Frank, C.L. et al. Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum. Nat. Neurosci. 18, 647-656 (2015).
    • (2015) Nat. Neurosci. , vol.18 , pp. 647-656
    • Frank, C.L.1
  • 25
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589 (2010).
    • (2010) Mol. Cell , vol.38 , pp. 576-589
    • Heinz, S.1
  • 26
    • 84924346202 scopus 로고    scopus 로고
    • Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling
    • Davie, K. et al. Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling. PLoS Genet. 11, e1004994 (2015).
    • (2015) PLoS Genet. , vol.11 , pp. e1004994
    • Davie, K.1
  • 27
    • 84923377359 scopus 로고    scopus 로고
    • Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease
    • Gjoneska, E. et al. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature 518, 365-369 (2015).
    • (2015) Nature , vol.518 , pp. 365-369
    • Gjoneska, E.1
  • 28
    • 84864462544 scopus 로고    scopus 로고
    • A map of the cis-regulatory sequences in the mouse genome
    • Shen, Y. et al. A map of the cis-regulatory sequences in the mouse genome. Nature 488, 116-120 (2012).
    • (2012) Nature , vol.488 , pp. 116-120
    • Shen, Y.1
  • 29
    • 59649099253 scopus 로고    scopus 로고
    • The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons
    • Pintchovski, S.A., Peebles, C.L., Kim, H.J., Verdin, E. & Finkbeiner, S. The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. J. Neurosci. 29, 1525-1537 (2009).
    • (2009) J. Neurosci. , vol.29 , pp. 1525-1537
    • Pintchovski, S.A.1    Peebles, C.L.2    Kim, H.J.3    Verdin, E.4    Finkbeiner, S.5
  • 30
    • 77952367798 scopus 로고    scopus 로고
    • Widespread transcription at neuronal activity-regulated enhancers
    • Kim, T.K. et al. Widespread transcription at neuronal activity-regulated enhancers. Nature 465, 182-187 (2010).
    • (2010) Nature , vol.465 , pp. 182-187
    • Kim, T.K.1
  • 31
    • 58549092132 scopus 로고    scopus 로고
    • Synaptic activity-responsive element in the Arc/Arg3. 1 promoter essential for synapse-to-nucleus signaling in activated neurons
    • Kawashima, T. et al. Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons. Proc. Natl. Acad. Sci. USA 106, 316-321 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 316-321
    • Kawashima, T.1
  • 32
    • 84917732422 scopus 로고    scopus 로고
    • Genome-wide identification and characterization of functional neuronal activity-dependent enhancers
    • Malik, A.N. et al. Genome-wide identification and characterization of functional neuronal activity-dependent enhancers. Nat. Neurosci. 17, 1330-1339 (2014).
    • (2014) Nat. Neurosci. , vol.17 , pp. 1330-1339
    • Malik, A.N.1
  • 33
    • 84899450857 scopus 로고    scopus 로고
    • Transcriptional enhancers: From properties to genome-wide predictions
    • Shlyueva, D., Stampfel, G. & Stark, A. Transcriptional enhancers: from properties to genome-wide predictions. Nat. Rev. Genet. 15, 272-286 (2014).
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 272-286
    • Shlyueva, D.1    Stampfel, G.2    Stark, A.3
  • 34
    • 80053217575 scopus 로고    scopus 로고
    • ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity
    • Young, M.D. et al. ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity. Nucleic Acids Res. 39, 7415-7427 (2011).
    • (2011) Nucleic Acids Res. , vol.39 , pp. 7415-7427
    • Young, M.D.1
  • 35
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • Barski, A. et al. High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837 (2007).
    • (2007) Cell , vol.129 , pp. 823-837
    • Barski, A.1
  • 36
    • 78650747491 scopus 로고    scopus 로고
    • Discovery and characterization of chromatin states for systematic annotation of the human genome
    • Ernst, J. & Kellis, M. Discovery and characterization of chromatin states for systematic annotation of the human genome. Nat. Biotechnol. 28, 817-825 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 817-825
    • Ernst, J.1    Kellis, M.2
  • 37
    • 79958117256 scopus 로고    scopus 로고
    • MEME-ChIP: Motif analysis of large DNA datasets
    • Machanick, P. & Bailey, T.L. MEME-ChIP: motif analysis of large DNA datasets. Bioinformatics 27, 1696-1697 (2011).
    • (2011) Bioinformatics , vol.27 , pp. 1696-1697
    • Machanick, P.1    Bailey, T.L.2
  • 38
    • 0028860249 scopus 로고
    • Fos: An immediate-early transcription factor in neurons
    • Curran, T. & Morgan, J.I. Fos: an immediate-early transcription factor in neurons. J. Neurobiol. 26, 403-412 (1995).
    • (1995) J. Neurobiol. , vol.26 , pp. 403-412
    • Curran, T.1    Morgan, J.I.2
  • 39
    • 0027183404 scopus 로고
    • Numerous candidate plasticity-related genes revealed by differential cDNA cloning
    • Nedivi, E., Hevroni, D., Naot, D., Israeli, D. & Citri, Y. Numerous candidate plasticity-related genes revealed by differential cDNA cloning. Nature 363, 718-722 (1993).
    • (1993) Nature , vol.363 , pp. 718-722
    • Nedivi, E.1    Hevroni, D.2    Naot, D.3    Israeli, D.4    Citri, Y.5
  • 40
    • 84873577692 scopus 로고    scopus 로고
    • Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis
    • Jang, M.H. et al. Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis. Cell Stem Cell 12, 215-223 (2013).
    • (2013) Cell Stem Cell , vol.12 , pp. 215-223
    • Jang, M.H.1
  • 41
    • 84912144889 scopus 로고    scopus 로고
    • Synaptic, transcriptional and chromatin genes disrupted in autism
    • De Rubeis, S. et al. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515, 209-215 (2014).
    • (2014) Nature , vol.515 , pp. 209-215
    • De Rubeis, S.1
  • 42
    • 84939895629 scopus 로고    scopus 로고
    • Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery
    • Felling, R.J. & Song, H. Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery. Exp. Neurol. 268, 37-45 (2015).
    • (2015) Exp. Neurol. , vol.268 , pp. 37-45
    • Felling, R.J.1    Song, H.2
  • 43
    • 84901830680 scopus 로고    scopus 로고
    • Motif-based analysis of large nucleotide data sets using MEME-ChIP
    • Ma, W., Noble, W.S. & Bailey, T.L. Motif-based analysis of large nucleotide data sets using MEME-ChIP. Nat. Protoc. 9, 1428-1450 (2014).
    • (2014) Nat. Protoc. , vol.9 , pp. 1428-1450
    • Ma, W.1    Noble, W.S.2    Bailey, T.L.3
  • 44
    • 31844447757 scopus 로고    scopus 로고
    • GABA regulates synaptic integration of newly generated neurons in the adult brain
    • Ge, S. et al. GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature 439, 589-593 (2006).
    • (2006) Nature , vol.439 , pp. 589-593
    • Ge, S.1
  • 45
    • 34548806900 scopus 로고    scopus 로고
    • Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain
    • Duan, X. et al. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell 130, 1146-1158 (2007).
    • (2007) Cell , vol.130 , pp. 1146-1158
    • Duan, X.1
  • 46
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • Langmead, B. & Salzberg, S.L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357-359 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 47
    • 53849146020 scopus 로고    scopus 로고
    • Model-based analysis of ChIP-Seq (MACS)
    • Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008).
    • (2008) Genome Biol. , vol.9 , pp. R137
    • Zhang, Y.1
  • 48
    • 84878834064 scopus 로고    scopus 로고
    • DiffReps: Detecting differential chromatin modification sites from ChIP-seq data with biological replicates
    • Shen, L. et al. diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates. PLoS One 8, e65598 (2013).
    • (2013) PLoS One , vol.8 , pp. e65598
    • Shen, L.1
  • 49
    • 84880968176 scopus 로고    scopus 로고
    • GAT: A simulation framework for testing the association of genomic intervals
    • Heger, A., Webber, C., Goodson, M., Ponting, C.P. & Lunter, G. GAT: a simulation framework for testing the association of genomic intervals. Bioinformatics 29, 2046-2048 (2013).
    • (2013) Bioinformatics , vol.29 , pp. 2046-2048
    • Heger, A.1    Webber, C.2    Goodson, M.3    Ponting, C.P.4    Lunter, G.5
  • 50
    • 78651271733 scopus 로고    scopus 로고
    • Integrative genomics viewer
    • Robinson, J.T. et al. Integrative genomics viewer. Nat. Biotechnol. 29, 24-26 (2011).
    • (2011) Nat. Biotechnol. , vol.29 , pp. 24-26
    • Robinson, J.T.1
  • 51
    • 84899493057 scopus 로고    scopus 로고
    • Ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases
    • Shen, L., Shao, N., Liu, X. & Nestler, E. ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases. BMC Genomics 15, 284 (2014).
    • (2014) BMC Genomics , vol.15 , pp. 284
    • Shen, L.1    Shao, N.2    Liu, X.3    Nestler, E.4
  • 52
    • 65449136284 scopus 로고    scopus 로고
    • TopHat: Discovering splice junctions with RNA-Seq
    • Trapnell, C., Pachter, L. & Salzberg, S.L. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25, 1105-1111 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 53
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
    • Trapnell, C. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28, 511-515 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 511-515
    • Trapnell, C.1
  • 54
    • 84893740377 scopus 로고    scopus 로고
    • Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain
    • Guo, J.U. et al. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat. Neurosci. 17, 215-222 (2014).
    • (2014) Nat. Neurosci. , vol.17 , pp. 215-222
    • Guo, J.U.1
  • 55
    • 67649524640 scopus 로고    scopus 로고
    • Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (formaldehyde assisted isolation of regulatory elements)
    • Giresi, P.G. & Lieb, J.D. Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (formaldehyde assisted isolation of regulatory elements). Methods 48, 233-239 (2009).
    • (2009) Methods , vol.48 , pp. 233-239
    • Giresi, P.G.1    Lieb, J.D.2
  • 56
    • 84861733509 scopus 로고    scopus 로고
    • Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA
    • Simon, J.M., Giresi, P.G., Davis, I.J. & Lieb, J.D. Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA. Nat. Protoc. 7, 256-267 (2012).
    • (2012) Nat. Protoc. , vol.7 , pp. 256-267
    • Simon, J.M.1    Giresi, P.G.2    Davis, I.J.3    Lieb, J.D.4
  • 57
    • 84857707318 scopus 로고    scopus 로고
    • ChromHMM: Automating chromatin-state discovery and characterization
    • Ernst, J. & Kellis, M. ChromHMM: automating chromatin-state discovery and characterization. Nat. Methods 9, 215-216 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 215-216
    • Ernst, J.1    Kellis, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.