Dehydroandrographolide inhibits oral cancer cell migration and invasion through NF-κB-, AP-1-, and SP-1-modulated matrix metalloproteinase-2 inhibition

Biochemical Pharmacology

Volumn 130, Issue , 2017, Pages 10-20

  Hsieh, Ming Ju ^a,b,c   Chen, Jui Chieh ^d   Yang, Wei En ^b,e   Chien, Su Yu ^a,f,g   Chen, Mu Kuan ^a   Lo, Yu Sheng ^a   Hsi, Yi Ting ^a   Chuang, Yi Ching ^a   Lin, Chia Chieh ^a   Yang, Shun Fa ^b,e  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^g MINGDAO UNIVERSITY   (Taiwan)

Author keywords

Dehydroandrographolide; Invasion; Matrix metalloproteinase 2; Migration; Oral cancer

Indexed keywords

ANDROGRAPHOLIDE; ANTINEOPLASTIC AGENT; DEHYDROANDROGRAPHOLIDE; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE 1; SYNAPTOPHYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANS ACTING FACTOR; TRANS ACTING TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; DITERPENE; PROTEINASE INHIBITOR; TRANSCRIPTION FACTOR SP1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL INVASION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; METASTASIS; MIGRATION INHIBITION; MOUSE; MOUTH CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING; ZYMOGRAPHY; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; ENZYMOLOGY; MALE; METABOLISM; MOUTH TUMOR; NEOPLASM METASTASIS; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DITERPENES; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED BALB C; MOUTH NEOPLASMS; NEOPLASM METASTASIS; NF-KAPPA B; PROTEASE INHIBITORS; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP-1;

EID: 85011307933     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2017.01.011     Document Type: Article

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