Food matters: how the microbiome and gut–brain interaction might impact the development and course of anorexia nervosa

European Child and Adolescent Psychiatry

Volumn 26, Issue 9, 2017, Pages 1031-1041

  Herpertz Dahlmann, Beate ^a   Seitz, Jochen ^a   Baines, John ^b  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b MAX PLANCK INSTITUTE FOR EVOLUTIONARY BIOLOGY   (Germany)

Author keywords

Anorexia nervosa; Autoimmune disease; Gut brain interaction; Microbiome; Starvation

Indexed keywords

PREBIOTIC AGENT; PROBIOTIC AGENT; SHORT CHAIN FATTY ACID;

ADOLESCENCE; ANOREXIA NERVOSA; DIET; FOOD; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INTESTINE; INTESTINE MUCOSA PERMEABILITY; MICROBIOME; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NEUROTRANSMISSION; REFEEDING; REVIEW; STARVATION; WEIGHT; WEIGHT GAIN; ADOLESCENT; ANIMAL; BRAIN; CENTRAL NERVOUS SYSTEM DISEASE; DISEASE MODEL; FEMALE; IMMUNOLOGY; INTESTINE FLORA; MICROBIOLOGY; MICROFLORA; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOLOGY;

ADOLESCENT; ANIMALS; ANOREXIA NERVOSA; BRAIN; CENTRAL NERVOUS SYSTEM DISEASES; DIET; DISEASE MODELS, ANIMAL; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; MICE; MICROBIOTA;

EID: 85011296370     PISSN: 10188827     EISSN: 1435165X     Source Type: Journal    
DOI: 10.1007/s00787-017-0945-7     Document Type: Review

References (102)

1. Simopoulos AP (2001) The Hippocratic concept of positive health in the fifth century BC and in the new millennium. World Rev Nutr Diet 89:1–4
2. American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders (DSM-5). American Psychiatric Press
3. Minuchin S, Baker L, Rosman BL, Liebman R, Milman L, Todd TC (1975) A conceptual model of psychosomatic illness in children. Family organization and family therapy. Arch Gen Psychiatry 32:1031–1038
4. Herpertz-Dahlmann B, Seitz J, Konrad K (2011) Aetiology of anorexia nervosa: from a “psychosomatic family model” to a neuropsychiatric disorder? Eur Arch Psychiatry Clin Neurosci 261(Suppl 2):S177–S181. doi:10.1007/s00406-011-0246-y
5. Kaplan AS, Walsh BT, Olmsted M, Attia E, Carter JC, Devlin MJ, Pike KM, Woodside B, Rockert W, Roberto CA, Parides M (2009) The slippery slope: prediction of successful weight maintenance in anorexia nervosa. Psychol Med 39:1037–1045. doi:10.1017/s003329170800442x
6. Misra M, Golden NH, Katzman DK (2016) State of the art systematic review of bone disease in anorexia nervosa. Int J Eat Disord 49:276–292. doi:10.1002/eat.22451
7. Misra M, Klibanski A (2016) Anorexia nervosa and its associated endocrinopathy in young people. Horm Res Paediatr 85:147–157. doi:10.1159/000443735
8. Pollice C, Kaye WH, Greeno CG, Weltzin TE (1997) Relationship of depression, anxiety, and obsessionality to state of illness in anorexia nervosa. Int J Eat Disord 21:367–376
9. Meehan KG, Loeb KL, Roberto CA, Attia E (2006) Mood change during weight restoration in patients with anorexia nervosa. Int J Eat Disord 39:587–589. doi:10.1002/eat.20337
10. Chen J, Papies EK, Barsalou LW (2016) A core eating network and its modulations underlie diverse eating phenomena. Brain Cogn. doi:10.1016/j.bandc.2016.04.004
11. Sherwin E, Rea K, Dinan TG, Cryan JF (2016) A gut (microbiome) feeling about the brain. Curr Opin Gastroenterol 32:96–102. doi:10.1097/mog.0000000000000244
12. Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G, Hyland NP (2015) Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci 9:392. doi:10.3389/fncel.2015.00392
13. Backhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI (2005) Host-bacterial mutualism in the human intestine. Science 307:1915–1920. doi:10.1126/science.1104816
14. Derrien M, van Hylckama Vlieg JE (2015) Fate, activity, and impact of ingested bacteria within the human gut microbiota. Trends Microbiol 23:354–366. doi:10.1016/j.tim.2015.03.002
15. Petra AI, Panagiotidou S, Hatziagelaki E, Stewart JM, Conti P, Theoharides TC (2015) Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation. Clin Ther 37:984–995. doi:10.1016/j.clinthera.2015.04.002
16. Carr J, Kleiman SC, Bulik CM, Bulik-Sullivan EC, Carroll IM (2016) Can attention to the intestinal microbiota improve understanding and treatment of anorexia nervosa? Expert Rev Gastroenterol Hepatol 10:565–569. doi:10.1586/17474124.2016.1166953
17. Steinhausen HC (2002) The outcome of anorexia nervosa in the 20th century. Am J Psychiatry 159:1284–1293
18. Arcelus J, Mitchell AJ, Wales J, Nielsen S (2011) Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies. Arch Gen Psychiatry 68:724–731. doi:10.1001/archgenpsychiatry.2011.74
19. Herpertz-Dahlmann B, van Elburg A, Castro-Fornieles J, Schmidt U (2015) ESCAP Expert Paper: new developments in the diagnosis and treatment of adolescent anorexia nervosa–a European perspective. Eur Child Adolesc Psychiatry 24:1153–1167. doi:10.1007/s00787-015-0748-7
20. Schmidt U, Campbell IC (2013) Treatment of eating disorders can not remain ‘brainless’: the case for brain-directed treatments. Eur Eat Disord Rev 21:425–427. doi:10.1002/erv.2257
21. Staubach F, Kunzel S, Baines AC, Yee A, McGee BM, Backhed F, Baines JF, Johnsen JM (2012) Expression of the blood-group-related glycosyltransferase B4galnt2 influences the intestinal microbiota in mice. ISME J 6:1345–1355. doi:10.1038/ismej.2011.204
22. Kelly JR, Clarke G, Cryan JF, Dinan TG (2016) Brain-gut-microbiota axis: challenges for translation in psychiatry. Ann Epidemiol 26:366–372. doi:10.1016/j.annepidem.2016.02.008
23. Vanuytsel T, van Wanrooy S, Vanheel H, Vanormelingen C, Verschueren S, Houben E, Salim Rasoel S, Tomicronth J, Holvoet L, Farre R, Van Oudenhove L, Boeckxstaens G, Verbeke K, Tack J (2014) Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut 63:1293–1299. doi:10.1136/gutjnl-2013-305690
24. Monteleone AM, Monteleone P, Serino I, Amodio R, Monaco F, Maj M (2016) Underweight subjects with anorexia nervosa have an enhanced salivary cortisol response not seen in weight restored subjects with anorexia nervosa. Psychoneuroendocrinology 70:118–121. doi:10.1016/j.psyneuen.2016.05.004
25. Schorr M, Lawson EA, Dichtel LE, Klibanski A, Miller KK (2015) Cortisol measures across the weight spectrum. J Clin Endocrinol Metab 100:3313–3321. doi:10.1210/jc.2015-2078
26. Jesus P, Ouelaa W, Francois M, Riachy L, Guerin C, Aziz M, Do Rego JC, Dechelotte P, Fetissov SO, Coeffier M (2014) Alteration of intestinal barrier function during activity-based anorexia in mice. Clin Nutr 33:1046–1053. doi:10.1016/j.clnu.2013.11.006
27. Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY (2015) Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 161:264–276. doi:10.1016/j.cell.2015.02.047
28. Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, Siuzdak G (2009) Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci 106:3698–3703. doi:10.1073/pnas.0812874106
29. Ridaura V, Belkaid Y (2015) Gut microbiota: the link to your second brain. Cell 161:193–194. doi:10.1016/j.cell.2015.03.033
30. Jenkins TA, Nguyen JC, Polglaze KE, Bertrand PP (2016) Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut–brain axis. Nutrients. doi:10.3390/nu8010056
31. Neufeld KM, Kang N, Bienenstock J, Foster JA (2011) Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 23(255–264):e119. doi:10.1111/j.1365-2982.2010.01620.x
32. Duman RS (2011) Neurochemical theories of depression: preclinical studies. In: Charney DS, Nestler EJ (eds) Neurobiology of mental illness. Oxford Press, pp 414–444
33. Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, Dinan TG, Cryan JF (2013) The microbiome–gut–brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 18:666–673. doi:10.1038/mp.2012.77
34. Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, Wang W, Tang W, Tan Z, Shi J, Li L, Ruan B (2015) Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun 48:186–194. doi:10.1016/j.bbi.2015.03.016
35. Lurie I, Yang YX, Haynes K, Mamtani R, Boursi B (2015) Antibiotic exposure and the risk for depression, anxiety, or psychosis: a nested case-control study. J Clin Psychiatry 76:1522–1528. doi:10.4088/JCP.15m09961
36. Kaye WH, Fudge JL, Paulus M (2009) New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci 10:573–584. doi:10.1038/nrn2682
37. Kaye WH, Wierenga CE, Bailer UF, Simmons AN, Bischoff-Grethe A (2013) Nothing tastes as good as skinny feels: the neurobiology of anorexia nervosa. Trends Neurosci 36:110–120. doi:10.1016/j.tins.2013.01.003
38. Herpertz-Dahlmann B, Wewetzer C (2014) Eating disorders. In: Gerlach M, Warnke A, Greenhill L (eds) Psychiatric drugs in children and adolescents. Springer, Heidelberg, pp 429–437
39. Harrisberger F, Smieskova R, Schmidt A, Lenz C, Walter A, Wittfeld K, Grabe HJ, Lang UE, Fusar-Poli P, Borgwardt S (2015) BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: a systematic review and meta-analysis. Neurosci Biobehav Rev 55:107–118. doi:10.1016/j.neubiorev.2015.04.017
40. Desbonnet L, Clarke G, Traplin A, O’Sullivan O, Crispie F, Moloney RD, Cotter PD, Dinan TG, Cryan JF (2015) Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour. Brain Behav Immun 48:165–173. doi:10.1016/j.bbi.2015.04.004
41. Savignac HM, Corona G, Mills H, Chen L, Spencer JP, Tzortzis G, Burnet PW (2013) Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine. Neurochem Int 63:756–764. doi:10.1016/j.neuint.2013.10.006
42. Liang S, Wang T, Hu X, Luo J, Li W, Wu X, Duan Y, Jin F (2015) Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress. Neuroscience 310:561–577. doi:10.1016/j.neuroscience.2015.09.033
43. Savignac HM, Tramullas M, Kiely B, Dinan TG, Cryan JF (2015) Bifidobacteria modulate cognitive processes in an anxious mouse strain. Behav Brain Res 287:59–72. doi:10.1016/j.bbr.2015.02.044
44. Monteleone P, Fabrazzo M, Martiadis V, Serritella C, Pannuto M, Maj M (2005) Circulating brain-derived neurotrophic factor is decreased in women with anorexia and bulimia nervosa but not in women with binge-eating disorder: relationships to co-morbid depression, psychopathology and hormonal variables. Psychol Med 35:897–905
45. Zwipp J, Hass J, Schober I, Geisler D, Ritschel F, Seidel M, Weiss J, Roessner V, Hellweg R, Ehrlich S (2014) Serum brain-derived neurotrophic factor and cognitive functioning in underweight, weight-recovered and partially weight-recovered females with anorexia nervosa. Prog Neuropsychopharmacol Biol Psychiatry 54:163–169. doi:10.1016/j.pnpbp.2014.05.006
46. Mohle L, Mattei D, Heimesaat MM, Bereswill S, Fischer A, Alutis M, French T, Hambardzumyan D, Matzinger P, Dunay IR, Wolf SA (2016) Ly6C(hi) monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis. Cell Rep 15:1945–1956. doi:10.1016/j.celrep.2016.04.074
47. Martin-Subero M, Anderson G, Kanchanatawan B, Berk M, Maes M (2016) Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut–brain pathways. CNS Spectr 21:184–198. doi:10.1017/s1092852915000449
48. Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M (2011) Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun 25:397–407. doi:10.1016/j.bbi.2010.10.023
49. Maes M, Kubera M, Leunis JC, Berk M (2012) Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut. J Affect Disord 141:55–62. doi:10.1016/j.jad.2012.02.023
50. Raevuori A, Haukka J, Vaarala O, Suvisaari JM, Gissler M, Grainger M, Linna MS, Suokas JT (2014) The increased risk for autoimmune diseases in patients with eating disorders. PLoS One 9:e104845. doi:10.1371/journal.pone.0104845
51. Frost GS, Walton GE, Swann JR, Psichas A, Costabile A, Johnson LP, Sponheimer M, Gibson GR, Barraclough TG (2014) Impacts of plant-based foods in ancestral hominin diets on the metabolism and function of gut microbiota in vitro. MBio 5:e00853–e00814. doi:10.1128/mBio.00853-14
52. den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM (2013) The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res 54:2325–2340. doi:10.1194/jlr.R036012
53. Stilling RM, Bordenstein SR, Dinan TG, Cryan JF (2014) Friends with social benefits: host-microbe interactions as a driver of brain evolution and development? Front Cell Infect Microbiol 4:147. doi:10.3389/fcimb.2014.00147
54. Stilling RM, Dinan TG, Cryan JF (2014) Microbial genes, brain & behaviour—epigenetic regulation of the gut–brain axis. Genes Brain Behav 13:69–86. doi:10.1111/gbb.12109
55. De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, Backhed F, Mithieux G (2014) Microbiota-generated metabolites promote metabolic benefits via gut–brain neural circuits. Cell 156:84–96. doi:10.1016/j.cell.2013.12.016
56. Byrne CS, Chambers ES, Morrison DJ, Frost G (2015) The role of short chain fatty acids in appetite regulation and energy homeostasis. Int J Obes (Lond) 39:1331–1338. doi:10.1038/ijo.2015.84
57. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027–1031. doi:10.1038/nature05414
58. Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, Lyle BJ, Martini MC, Ursell LK, Clemente JC, Van Treuren W, Walters WA, Knight R, Newgard CB, Heath AC, Gordon JI (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214. doi:10.1126/science.1241214
59. Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J, Kau AL, Rich SS, Concannon P, Mychaleckyj JC, Liu J, Houpt E, Li JV, Holmes E, Nicholson J, Knights D, Ursell LK, Knight R, Gordon JI (2013) Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science 339:548–554. doi:10.1126/science.1229000
60. Adan RA, Hillebrand JJ, De Rijke C, Nijenhuis W, Vink T, Garner KM, Kas MJ (2003) Melanocortin system and eating disorders. Ann N Y Acad Sci 994:267–274
61. Monteleone P, Carratu R, Carteni M, Generoso M, Lamberti M, Magistris LD, Brambilla F, Colurcio B, Secondulfo M, Maj M (2004) Intestinal permeability is decreased in anorexia nervosa. Mol Psychiatry 9:76–80. doi:10.1038/sj.mp.4001374
62. Uil JJ, van Elburg RM, van Overbeek FM, Mulder CJ, VanBerge-Henegouwen GP, Heymans HS (1997) Clinical implications of the sugar absorption test: intestinal permeability test to assess mucosal barrier function. Scand J Gastroenterol Suppl 223:70–78
63. Pals KL, Chang RT, Ryan AJ, Gisolfi CV (1997) Effect of running intensity on intestinal permeability. J Appl Physiol (1985) 82:571–576
64. Elia M, Behrens R, Northrop C, Wraight P, Neale G (1987) Evaluation of mannitol, lactulose and 51Cr-labelled ethylenediaminetetra-acetate as markers of intestinal permeability in man. Clin Sci (Lond) 73:197–204
65. Welsh FK, Farmery SM, MacLennan K, Sheridan MB, Barclay GR, Guillou PJ, Reynolds JV (1998) Gut barrier function in malnourished patients. Gut 42:396–401
66. Pfleiderer A, Lagier JC, Armougom F, Robert C, Vialettes B, Raoult D (2013) Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample. Eur J Clin Microbiol Infect Dis 32:1471–1481. doi:10.1007/s10096-013-1900-2
67. Morita H, Obata K, Abe C, Shiba D, Shirakawa M, Kudo T, Takahashi S (2015) Feasibility of a short-arm centrifuge for mouse hypergravity experiments. PLoS One 10:e0133981. doi:10.1371/journal.pone.0133981
68. Armougom F, Henry M, Vialettes B, Raccah D, Raoult D (2009) Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and methanogens in anorexic patients. PLoS One 4:e7125. doi:10.1371/journal.pone.0007125
69. Kleiman SC, Watson HJ, Bulik-Sullivan EC, Huh EY, Tarantino LM, Bulik CM, Carroll IM (2015) The intestinal microbiota in acute anorexia nervosa and during renourishment: relationship to depression, anxiety, and eating disorder psychopathology. Psychosom Med 77:969–981. doi:10.1097/psy.0000000000000247
70. Mack I, Cuntz U, Gramer C, Niedermaier S, Pohl C, Schwiertz A, Zimmermann K, Zipfel S, Enck P, Penders J (2016) Weight gain in anorexia nervosa does not ameliorate the faecal microbiota, branched chain fatty acid profiles, and gastrointestinal complaints. Sci Rep 6:26752. doi:10.1038/srep26752
71. Holzer P, Farzi A (2014) Neuropeptides and the microbiota-gut–brain axis. Adv Exp Med Biol 817:195–219. doi:10.1007/978-1-4939-0897-4_9
72. Smink FR, van Hoeken D, Hoek HW (2013) Epidemiology, course, and outcome of eating disorders. Curr Opin Psychiatry 26:543–548. doi:10.1097/YCO.0b013e328365a24f
73. Neuman H, Debelius JW, Knight R, Koren O (2015) Microbial endocrinology: the interplay between the microbiota and the endocrine system. FEMS Microbiol Rev 39:509–521. doi:10.1093/femsre/fuu010
74. Terashi M, Asakawa A, Harada T, Ushikai M, Coquerel Q, Sinno MH, Dechelotte P, Inui A, Fetissov SO (2011) Ghrelin reactive autoantibodies in restrictive anorexia nervosa. Nutrition 27:407–413. doi:10.1016/j.nut.2011.01.002
75. Fetissov SO, Crook MA (2011) What increased consumption of licorice may reveal in anorexia nervosa. Nutrition 27:853–854. doi:10.1016/j.nut.2011.05.004
76. Corcos M, Guilbaud O, Paterniti S, Moussa M, Chambry J, Chaouat G, Consoli SM, Jeammet P (2003) Involvement of cytokines in eating disorders: a critical review of the human literature. Psychoneuroendocrinology 28:229–249
77. Solmi M, Veronese N, Favaro A, Santonastaso P, Manzato E, Sergi G, Correll CU (2015) Inflammatory cytokines and anorexia nervosa: a meta-analysis of cross-sectional and longitudinal studies. Psychoneuroendocrinology 51:237–252. doi:10.1016/j.psyneuen.2014.09.031
78. Solmi M, Santonastaso P, Caccaro R, Favaro A (2013) A case of anorexia nervosa with comorbid Crohn’s disease: beneficial effects of anti-TNF-alpha therapy? Int J Eat Disord 46:639–641. doi:10.1002/eat.22153
79. Lee KN, Lee OY (2014) Intestinal microbiota in pathophysiology and management of irritable bowel syndrome. World J Gastroenterol 20:8886–8897. doi:10.3748/wjg.v20.i27.8886
80. Rajilic-Stojanovic M, Jonkers DM, Salonen A, Hanevik K, Raes J, Jalanka J, de Vos WM, Manichanh C, Golic N, Enck P, Philippou E, Iraqi FA, Clarke G, Spiller RC, Penders J (2015) Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena? Am J Gastroenterol 110:278–287. doi:10.1038/ajg.2014.427
81. Herpertz-Dahlmann B (2015) Adolescent eating disorders: update on definitions, symptomatology, epidemiology, and comorbidity. Child Adolesc Psychiatr Clin N Am 24:177–196. doi:10.1016/j.chc.2014.08.003
82. Million M, Angelakis E, Maraninchi M, Henry M, Giorgi R, Valero R, Vialettes B, Raoult D (2013) Correlation between body mass index and gut concentrations of Lactobacillus reuteri, Bifidobacterium animalis, Methanobrevibacter smithii and Escherichia coli. Int J Obes (Lond) 37:1460–1466. doi:10.1038/ijo.2013.20
83. Marzola E, Panepinto C, Delsedime N, Amianto F, Fassino S, Abbate-Daga G (2016) A factor analysis of the meanings of anorexia nervosa: intrapsychic, relational, and avoidant dimensions and their clinical correlates. BMC Psychiatry 16:190. doi:10.1186/s12888-016-0894-6
84. Kleiman SC, Carroll IM, Tarantino LM, Bulik CM (2015) Gut feelings: a role for the intestinal microbiota in anorexia nervosa? Int J Eat Disord 48:449–451. doi:10.1002/eat.22394
85. Goffredo M, Mass K, Parks EJ, Wagner DA, McClure EA, Graf J, Savoye M, Pierpont B, Cline G, Santoro N (2016) Role of gut microbiota and short chain fatty acids in modulating energy harvest and fat partitioning in youth. J Clin Endocrinol Metab 101:4367–4376. doi:10.1210/jc.2016-1797
86. Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI, Krakoff J (2011) Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr 94:58–65. doi:10.3945/ajcn.110.010132
87. Martinez KB, Pierre JF, Chang EB (2016) The gut microbiota: the gateway to improved metabolism. Gastroenterol Clin N Am 45:601–614. doi:10.1016/j.gtc.2016.07.001
88. Salonen A, de Vos WM (2014) Impact of diet on human intestinal microbiota and health. Annu Rev Food Sci Technol 5:239–262. doi:10.1146/annurev-food-030212-182554
89. Walker AW, Ince J, Duncan SH, Webster LM, Holtrop G, Ze X, Brown D, Stares MD, Scott P, Bergerat A, Louis P, McIntosh F, Johnstone AM, Lobley GE, Parkhill J, Flint HJ (2011) Dominant and diet-responsive groups of bacteria within the human colonic microbiota. ISME J 5:220–230. doi:10.1038/ismej.2010.118
90. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ (2014) Diet rapidly and reproducibly alters the human gut microbiome. Nature 505:559–563. doi:10.1038/nature12820
91. Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, Nadimpalli A, Antonopoulos DA, Jabri B, Chang EB (2012) Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice. Nature 487:104–108. doi:10.1038/nature11225
92. Misra M, Tsai P, Anderson EJ, Hubbard JL, Gallagher K, Soyka LA, Miller KK, Herzog DB, Klibanski A (2006) Nutrient intake in community-dwelling adolescent girls with anorexia nervosa and in healthy adolescents. Am J Clin Nutr 84:698–706
93. Gibson GR, Roberfroid MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125:1401–1412
94. https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Wikipedia/Assessment
95. Hutkins RW, Krumbeck JA, Bindels LB, Cani PD, Fahey G Jr, Goh YJ, Hamaker B, Martens EC, Mills DA, Rastal RA, Vaughan E, Sanders ME (2016) Prebiotics: why definitions matter. Curr Opin Biotechnol 37:1–7. doi:10.1016/j.copbio.2015.09.001
96. Zhong Y, Cai D, Cai W, Geng S, Chen L, Han T (2009) Protective effect of galactooligosaccharide-supplemented enteral nutrition on intestinal barrier function in rats with severe acute pancreatitis. Clin Nutr 28:575–580. doi:10.1016/j.clnu.2009.04.026
97. Mika A, Greenwood B N, Chichlowski M, Borchert D, Hulen K A, Berg B et al (2014) Dietary prebiotics increase Bifidobacterium spp. and Lactobacillus spp. in the gut and promote stress resistance. Brain Behav Immun 40(Supplement). doi:10.1016/j.bbi.2014.06.175
98. Schmidt K, Cowen PJ, Harmer CJ, Tzortzis G, Errington S, Burnet PW (2015) Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology 232:1793–1801. doi:10.1007/s00213-014-3810-0
99. Savignac HM, Kiely B, Dinan TG, Cryan JF (2014) Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice. Neurogastroenterol Motil 26:1615–1627. doi:10.1111/nmo.12427
100. Mazurak N, Broelz E, Storr M, Enck P (2015) Probiotic therapy of the irritable bowel syndrome: why is the evidence still poor and what can be done about It? J Neurogastroenterol Motil 21:471–485. doi:10.5056/jnm15071
101. Kristensen NB, Bryrup T, Allin KH, Nielsen T, Hansen TH, Pedersen O (2016) Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials. Genome Med 8:52. doi:10.1186/s13073-016-0300-5
102. Sheridan PO, Bindels LB, Saulnier DM, Reid G, Nova E, Holmgren K, O’Toole PW, Bunn J, Delzenne N, Scott KP (2014) Can prebiotics and probiotics improve therapeutic outcomes for undernourished individuals? Gut Microbes 5:74–82. doi:10.4161/gmic.27252