Gut barrier function in malnourished patients

Gut

Volumn 42, Issue 3, 1998, Pages 396-401

  Welsh, F K S ^a   Farmery, S M ^a   MacLennan, K ^a   Sheridan, M B ^a   Barclay, G R ^b   Guillou, P J ^a   Reynolds, J V ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b Blood Transfusion Centre   (United Kingdom)

Author keywords

Cytokine; Endotoxin; Intestinal permeability; Protein energy malnutrition

Indexed keywords

ADULT; AGED; ANTIBODY RESPONSE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOSPITAL PATIENT; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA PERMEABILITY; MALE; MALNUTRITION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0031969046     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.42.3.396     Document Type: Article

References (39)

1. McWhirter JP, Pennington CR. Incidence and recognition of malnutrition in hospital. BMJ 1994;308:945-8.
2. Bistrian HR, Blackburn G, Vitale J, et al. Prevalence of malnutrition in general medical patients. JAMA 1976;253: 1567-70.
3. Windsor TA, Hill GL. Protein depletion and surgical risk. Aust N Z J Surg 1988;58:711-15.
4. Meguid MM, Debonis O, Meguid V, et al. Complications of abdominal operations for malignant disease. Am J Surg 1988;156:341-5.
5. Chandra RK. Nutrition, immunity and infection: present knowledge and future directions. Lancet 1983;1:688-91.
6. Reynolds JV, Redmond HP, Ueno N, et al. Impairment of macrophage activation by protein malnutrition. Cell Immunol 1992;139:493-504.
7. Deitch EA. Multiple organ failure. Pathophysiology and potential future therapy. Ann Surg 1992;216:117-34.
8. Carrico CJ, Meakins JL, Marshall JC, Fry D, Maier RV. Multiple organ failure syndrome: the gastrointestinal tract: the motor of MOF? Arch. Surg 1986;121:197-201.
9. Chandra RK, Wadhwa M. Nutritional modulation of intestinal mucosal immunity. Immunol Invest 1989;18:119-26.
10. Steiner M, Bourges HR, Freedman LS, Gray SJ. Effect of starvation on the tissue composition of the small intestine in the rat. Am J Physiol 1968;215:75-7.
11. Worthington BS, Boatman ES, Kenny GH. Intestinal absorption of intact proteins in normal and protein-deficient rats. Am J Clin Nutr 1974;27:276-86.
12. Sherman P, Forsteer J, Roomi N, et al. Mucin depletion in the intestine of malnourished rats. Am J Physiol 1485;248: G418-23.
13. Sullivan DA, Vaerman JP, Soo C. Influence of severe protein malnutrition on rat lacrimal, salivary and gastrointestinal immune expression during development, adulthood and ageing. Immunology 1993;78:308-17.
14. Barry WS, Pierce NF. Protein deprivation causes reversible impairment of mucosal immune response to cholera toxoid/ toxin in rat gut. Nature 1979;281:64-5.
15. Heyman M, Boudraa G, Sarrut S, et al. Macromolecular transport in jejunal mucosa of children with severe malnutrition. J Pediatr Gastroenterol Nutr 1984;3:357-67.
16. Chandra RK. Nutrition and immunity: lessons from the past and new insights into the future. Am J Clin Nutr 1991; 53: 1087-101.
17. Reynolds JV, O'Farrelly C, Feighery C, et al. Impaired gut barrier function in protein malnourished patients. Br J Surg 1996;83:1288-91.
18. Baker JP, Detsky AS, Weeson DE, et al. Nutritional assessment. A comparison of clinical judgement and objective measures. N Engl J Med 1982;306:969-72.
19. The Veterans Affairs Total Parenteral Nutrition Cooperative Study Group. Perioperative total parenteral nutrition in surgical patients. N Engl J Med 1991;325:525-32.
20. Juby LD, Rothwell J, Axon ATR. Lactulose/mannitol test: an ideal screen for coeliac disease. Gastroenterology 1989;96:79-85.
21. Laker MF, Menzies IS. Increase in human intestinal permeability following ingestion of hypertonic solutions. J Physiol 1977;265:881-94.
22. Cobden I, Hamilton I, Rothwell J, Axon ATR. Cellobiose mannitol test: physiological properties of probe molecules and influence of extraneous factors. Clin Chim Acta 1985;148:53-62.
23. Menzies IS. Quantitative estimation of sugars in blood and urine by paper chromatography using direct densitometry. J Chromatogr 1973;81:109-27.
24. Macfarlane DE, Dahle CE. Isolating RNA from whole blood: the dawn of RNA-based diagnosis? Nature 1993; 362:186-8.
25. Chen D, Klebe RJ. Controls for validation of relative reverse transcription-polymerase chain reaction assays. PCR Methods and Applications 1993;3:127-9.
26. Scott BB, Barclay GR. Endotoxin-polymyxin complexes in an improved enzyme-linked immunosorbant assay for IgG antibodies in blood donor sera to Gram-negative endotoxin core glycolipid. Vox Sang 1987;52:272-80.
27. Deitch EA, Winterton J, Ma L, Berg RD. Gut as a portal of entry for bacteraemia; the role of protein malnutrition. Ann Surg 1987;205:681-92.
28. Deitch EA, Ma JA, Ma L, Berg RD, Specian RD. Protein malnutrition predisposes to inflammatory induced gut-origin septic states. Ann Surg 1990;211:500-8.
29. Chandra RK, Gupta SP. Increased bacterial adherence to respiratory and buccal epithelial cells in protein-energy malnutrition. Immunol Infect 1991;1:55-7.
30. Maxton DG, Menzies IS, Slavin B, Thompson RP. Small intestinal function during enterai feeding and starvation in man. Clin Sci 1989;77:401-6.
31. Elia M, Goren A, Behrens R, et al. Effect of total starvation and very low calorie diets on intestinal permeability in man. Clin Sci 1987;73:205-10.
32. Ziegler TR, Smith RJ, O'Dwyer ST, et al. Increased intestinal permeability associated with infection in burn patients. Arch Surg 1988;123:1313-19.
33. Pape HC, Dwenger A, Regel G, et al. Increased gut permeability after multiple trauma. Br J Surg 1994;81:850-2.
34. Sedman PC, MacFie J, Palmer MD, et al. Preoperative total parenteral nutrition is not associated with mucosal atrophy or bacterial translocation in humans. Br J Surg 1995;82: 1663-7.
35. Mayer L, Eisenhardt D, Salomon P, et al. Expression of Class II molecules on intestinal epithelial cells in humans. Gastroenterology 1991;100:3-12.
36. Bland PW, Warren LG. Antigen presentation by epithelial cells of the rat small intestine. 1. Kinetics, antigen specificity and blocking by Ia antisera. Immunology 1986;58:1-7.
37. Sanderson IR, Walker WA. Uptake and transport of macromolecules by the intestine: possible role in clinical disorders. (An update). Gastroenterology 1993;104:622-39.
38. Barclay GR. Endogenous endotoxin-core antibody (Endo-CAb) as a marker of endotoxin exposure and a prognostic indicator: a review. Prog Clin Biol Res 1995;392:263-72.
39. Nohr CW, Tchervenkov JI, Meakins JL, Christou NV. Malnutrition and humoral immunity: short-term acute nutritional deprivation. Surgery 1995;98:769-76.