A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions

Biochemical and Biophysical Research Communications

Volumn 413, Issue 2, 2011, Pages 224-229

  Akashi, Masaya ^a   Higashi, Tomohito ^a   Masuda, Sayuri ^a   Komori, Takahide ^a   Furuse, Mikio ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell cell junction; Coronary artery disease; Endothelial cell; VE cadherin

Indexed keywords

GENE PRODUCT; JUNCTIONAL PROTEIN ASSOCIATED WITH CORONARY ARTERY DISEASE; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL JUNCTION; CONTROLLED STUDY; ENDOTHELIUM CELL; EPITHELIUM CELL; IMMUNOLOCALIZATION; L CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ANTIGENS, CD; CADHERINS; CELL ADHESION MOLECULES; CELL LINE; CORONARY ARTERY DISEASE; DOGS; ENDOTHELIUM, VASCULAR; HUMANS; INTERCELLULAR JUNCTIONS; MICE; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING;

EID: 80053126353     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.08.073     Document Type: Article

References (32)

1. Dejana E., Tournier-Lasserve E., Weinstein B.M. The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. Dev. Cell 2009, 16:209-221.
2. Leach L., Clark P., Lampugnani M.G., Arroyo A.G., Dejana E., Firth J.A. Immunoelectron characterisation of the inter-endothelial junctions of human term placenta. J. Cell Sci. 1993, 104(Pt 4):1073-1081.
3. Morita K., Sasaki H., Furuse M., Tsukita S. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J. Cell Biol. 1999, 147:185-194.
4. Itoh M., Furuse M., Morita K., Kubota K., Saitou M., Tsukita S. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J. Cell Biol. 1999, 147:1351-1363.
5. Itoh M., Morita K., Tsukita S. Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J. Biol. Chem. 1999, 274:5981-5986.
6. Umeda K., Ikenouchi J., Katahira-Tayama S., Furuse K., Sasaki H., Nakayama M., Matsui T., Tsukita S., Furuse M. ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell 2006, 126:741-754.
7. Vestweber D. VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler. Thromb. Vasc. Biol. 2008, 28:223-232.
8. Corada M., Mariotti M., Thurston G., Smith K., Kunkel R., Brockhaus M., Lampugnani M.G., Martin-Padura I., Stoppacciaro A., Ruco L., McDonald D.M., Ward P.A., Dejana E. Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc. Natl. Acad. Sci. USA 1999, 96:9815-9820.
9. Vittet D., Buchou T., Schweitzer A., Dejana E., Huber P. Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Proc. Natl. Acad. Sci. USA 1997, 94:6273-6278.
10. S. Yonemura, Cadherin-actin interactions at adherens junctions. Curr. Opin. Cell Biol. (2011) in press.
11. Yamada S., Pokutta S., Drees F., Weis W.I., Nelson W.J. Deconstructing the cadherin-catenin-actin complex. Cell 2005, 123:889-901.
12. Drees F., Pokutta S., Yamada S., Nelson W.J., Weis W.I. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell 2005, 123:903-915.
13. Abraham S., Yeo M., Montero-Balaguer M., Paterson H., Dejana E., Marshall C.J., Mavria G. VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphorylation. Curr. Biol. 2009, 19:668-674.
14. Nelson C.M., Pirone D.M., Tan J.L., Chen C.S. Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol. Biol. Cell 2004, 15:2943-2953.
15. Lampugnani M.G., Zanetti A., Breviario F., Balconi G., Orsenigo F., Corada M., Spagnuolo R., Betson M., Braga V., Dejana E. VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol. Biol. Cell 2002, 13:1175-1189.
16. Grazia Lampugnani M., Zanetti A., Corada M., Takahashi T., Balconi G., Breviario F., Orsenigo F., Cattelino A., Kemler R., Daniel T.O., Dejana E. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J. Cell Biol. 2003, 161:793-804.
17. Sui X.F., Kiser T.D., Hyun S.W., Angelini D.J., Del Vecchio R.L., Young B.A., Hasday J.D., Romer L.H., Passaniti A., Tonks N.K., Goldblum S.E. Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia. Am. J. Pathol. 2005, 166:1247-1258.
18. Iden S., Rehder D., August B., Suzuki A., Wolburg-Buchholz K., Wolburg H., Ohno S., Behrens J., Vestweber D., Ebnet K. A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep. 2006, 7:1239-1246.
19. Tzima E., Irani-Tehrani M., Kiosses W.B., Dejana E., Schultz D.A., Engelhardt B., Cao G., DeLisser H., Schwartz M.A. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 2005, 437:426-431.
20. Bradfield P.F., Nourshargh S., Aurrand-Lions M., Imhof B.A. JAM family and related proteins in leukocyte migration (Vestweber series). Arterioscler. Thromb. Vasc. Biol. 2007, 27:2104-2112.
21. Erdmann J., Willenborg C., Nahrstaedt J., Preuss M., Konig I.R., Baumert J., Linsel-Nitschke P., Gieger C., Tennstedt S., Belcredi P., Aherrahrou Z., Klopp N., Loley C., Stark K., Hengstenberg C., Bruse P., Freyer J., Wagner A.K., Medack A., Lieb W., Grosshennig A., Sager H.B., Reinhardt A., Schafer A., Schreiber S., El Mokhtari N.E., Raaz-Schrauder D., Illig T., Garlichs C.D., Ekici A.B., Reis A., Schrezenmeir J., Rubin D., Ziegler A., Wichmann H.E., Doering A., Meisinger C., Meitinger T., Peters A., Schunkert H. Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Eur. Heart J. 2011, 32:158-168.
22. The Coronary Artery Disease (C4D) Genetics Cosortium, A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat. Genet. (2011).
23. Toda K., Tsujioka K., Maruguchi Y., Ishii K., Miyachi Y., Kuribayashi K., Imamura S. Establishment and characterization of a tumorigenic murine vascular endothelial cell line (F-2). Cancer Res. 1990, 50:5526-5530.
24. Lawson N.D., Weinstein B.M. In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev. Biol 2002, 248:307-318.
25. Itoh M., Yonemura S., Nagafuchi A., Tsukita S. A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites. J. Cell Biol. 1991, 115:1449-1462.
26. Misawa K., Nosaka T., Morita S., Kaneko A., Nakahata T., Asano S., Kitamura T. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc. Natl. Acad. Sci. USA 2000, 97:3062-3066.
27. Matsuda M., Kobayashi Y., Masuda S., Adachi M., Watanabe T., Yamashita J.K., Nishi E., Tsukita S., Furuse M. Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning. Exp. Cell Res. 2008, 314:939-949.
28. Niwa H., Yamamura K., Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991, 108:193-199.
29. Riento K., Ridley A.J. Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell Biol. 2003, 4:446-456.
30. Gosser Y.Q., Nomanbhoy T.K., Aghazadeh B., Manor D., Combs C., Cerione R.A., Rosen M.K. C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases. Nature 1997, 387:814-819.
31. Knezevic N., Roy A., Timblin B., Konstantoulaki M., Sharma T., Malik A.B., Mehta D. GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability. Mol. Cell Biol. 2007, 27:6323-6333.
32. Hahn C., Schwartz M.A. Mechanotransduction in vascular physiology and atherogenesis. Nat. Rev. Mol. Cell Biol. 2009, 10:53-62.