Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Nature Genetics

Volumn 47, Issue 11, 2015, Pages 1282-1293

  Kato, Norihiro ^a   Loh, Marie ^b,c,d   Takeuchi, Fumihiko ^a   Verweij, Niek ^e   Wang, Xu ^f   Zhang, Weihua ^c,g   NKelly, Tanika ^h   Saleheen, Danish ^i,j,k   Lehne, Benjamin ^c   Leach, Irene Mateo ^e   Drong, Alexander W ^l   Abbott, James ^c   Wahl, Simone ^m,n   Tan, Sian Tsung ^g,o   Scott, William R ^c,o   Campanella, Gianluca ^c   Chadeau Hyam, Marc ^c   Afzal, Uzma ^c,g   Ahluwalia, Tarunveer S ^p,q,r   Bonder, Marc Jan ^e   Chen, Peng ^f   Dehghan, Abbas ^s   Edwards, Todd L ^t   Esko, Tõnu ^u,v,w,x   Go, Min Jin ^y   Harris, Sarah E ^z   Hartiala, Jaana ^aa   Kasela, Silva ^u   Kasturiratne, Anuradhani ^ab   Khor, Chiea Chuen ^f,ac,ad   Kleber, Marcus E ^ae   Li, Huaixing ^af   Mok, Zuan Yu ^ag   Nakatochi, Masahiro ^ah   Sapari, Nur Sabrina ^ag   Saxena, Richa ^ai   Stewart, Alexandre F R ^aj,ak   Stolk, Lisette ^s   Tabara, Yasuharu ^al   Teh, Ai Ling ^am   Wu, Ying ^an   Wu, Jer Yuarn ^ao,ap   Zhang, Yi ^aq,ar   Aits, Imke ^as   Da Silva Couto Alves, Alexessander ^c   Das, Shikta ^c   Dorajoo, Rajkumar ^ac   CHopewell, Jemma ^at   Kim, Yun Kyoung ^y   WKoivula, Robert ^au   Luan, Jian'An ^av   Lyytikäinen, Leo Pekka ^aw,ax   NNguyen, Quang ^ay   Pereira, Mark A ^az   Postmus, Iris ^ba,bb   TRaitakari, Olli ^bc,bd   Scannell Bryan, Molly ^be   Scott, Robert A ^av   Sorice, Rossella ^bf   Tragante, Vinicius ^bg   Traglia, Michela ^bh,bi   White, Jon ^bj   Yamamoto, Ken ^bk   Zhang, Yonghong ^bl   Adair, Linda S ^bm   Ahmed, Alauddin ^bn   Akiyama, Koichi ^a   Asif, Rasheed ⁱ   Aung, Tin ^bo   Barroso, Inês ^av,bp,bq   Bjonnes, Andrew ^ai   Braun, Timothy R ^br   Cai, Hui ^bs,bt   Chang, Li Ching ^ao   Chen, Chien Hsiun ^ao,ap   Cheng, Ching Yu ^f,ad,bo   Chong, Yap Seng ^am,bu   Collins, Rory ^at   Courtney, Regina ^bs,bt   Davies, Gail ^z   Delgado, Graciela ^ae   Do, Loi D ^ay   Doevendans, Pieter A ^bg   Gansevoort, Ron T ^e   Gao, Yu Tang ^bv   Grammer, Tanja B ^ae   Grarup, Niels ^p   Grewal, Jagvir ^c,g   Gu, Dongfeng ^bw   SWander, Gurpreet ^bx   Hartikainen, Anna Liisa ^b,by   Hazen, Stanley L ^bz   He, Jing ^bs   Heng, Chew Kiat ^bu   Hixso, E James Ames ^ca   Hofman, Albert ^s   Hsu, Chris ^aa   Huang, Wei ^cb   Husemoen, Lise L N ^cc   Hwang, Joo Yeon ^y   Ichihara, Sahoko ^cd   Igase, Michiya ^ce   Isono, Masato ^a   Justesen, Johanne M ^p   Katsuya, Tomohiro ^cf   GKibriya, Muhammad ^be   Kim, Young Jin ^y   Kishimoto, Miyako ^a   Koh, Woon Puay ^f,ad   Kohara, Katsuhiko ^ce   Kumari, Meena ^bj   Kwek, Kenneth ^cg   Lee, Nanette R ^ch   Lee, Jeannette ^f   Liao, Jiemin ^ad,bo   Lieb, Wolfgang ^as   Liewald, David C M ^z   Matsubara, Tatsuaki ^ci   Matsushita, Yumi ^a   Meitinger, Thomas ^m,cj   Mihailov, Evelin ^u   Milani, Lili ^u   Mills, Rebecca ^g   Mononen, Nina ^aw,ax   Müller Nurasyid, Martina ^m,ck,cl   Nabika, Toru ^cm   Nakashima, Eitaro ^cn,co   Ng, Hong Kiat ^ag   Nikus, Kjell ^cp   Nutile, Teresa ^bf   Ohkubo, Takayoshi ^cq   Ohnaka, Keizo ^cr   Parish, Sarah ^at   Paternoster, Lavinia ^cs   Peng, Hao ^bl   Peters, Annette ^m,cl   TPham, Son ^ay   Pinidiyapathirage, Mohitha J ^ab   Rahman, Mahfuzar ^bn,ct   Rakugi, Hiromi ^cf   Rolandsson, Olov ^cu   Rozario, Michelle Ann ^ag   Ruggiero, Daniela ^bf   Sala, Cinzia F ^bh   Sarju, Ralhan ^bx   Shimokawa, Kazuro ^a   Snieder, Harold ^e   SparsØ, Thomas ^p   Spiering, Wilko ^bg   Starr, John M ^z   Stott, David J ^cv   OStram, Daniel ^aa   Sugiyama, Takao ^cw   Szymczak, Silke ^as   Tang, W H Wilson ^bz   Tong, Lin ^be   Trompet, Stella ^ba   Turjanmaa, Väinö ^ax,cp   Ueshima, Hirotsugu ^cx   Uitterlinden, André G ^s   Umemura, Satoshi ^cy   Vaarasmaki, Marja ^b,by   Dam, Rob Mvan ^f   Van Gilst, Wiek H ^e   Van Veldhuisen, Dirk J ^e   Viikari, Jorma S ^bc,cz   Waldenberger, Melanie ^m   Wang, Yiqin ^af   Wang, Aili ^bl   Wilson, Rory ^m   Wong, Tien Yin ^ad,bo   Xiang, Yong Bing ^bv   Yamaguchi, Shuhei ^cm   Ye, Xingwang ^af   Young, Robin D ^j   Young, Terri L ^ad,da   Yuan, Jian Min ^db   Zhou, Xueya ^dc,dd   Asselbergs, Folkert W ^bg,bj,de   Ciullo, Marina ^bf   Clarke, Robert ^at   Deloukas, Panos ^df,dg   Franke, Andre ^as   Paul, W Frank ^au,cu,dh   Franks, Steve ^di   Friedlander, Yechiel ^dj   Gross, Myron D ^dk   Guo, Zhirong ^bl   Hansen, Torben ^p   Jarvelin, Marjo Riitta ^b,c,by,dl   JØrgensen, Torben ^cc   Jukema, J Wouter ^ba,de,dm   Kähönen, Mika ^ax,cp   Kajio, Hiroshi ^a   Kivimaki, Mika ^bj   Lee, Jong Young ^dn,do   Lehtimäki, Terho ^aw,ax   Linneberg, Allan ^cc,dp,dq   Miki, Tetsuro ^ce   Pedersen, Oluf ^p   Samani, Nilesh J ^dr,ds   SØrensen, Thorkild I A ^p,cs,dt   Takayanagi, Ryoichi ^cr   Toniolo, Daniela ^bf,bh   Ahsan, Habibul ^be   Allayee, Hooman ^aa   Chen, Yuan Tsong ^ao   Danesh, John ^j,bp   Deary, Ian J ^z   Franco, Oscar H ^s   Franke, Lude ^e   THeijman, Bastiaan ^ba   Holbrook, Joanna D ^am   Isaacs, Aaron ^s   Kim, Bong Jo ^y   Lin, Xu ^af   Liu, Jianjun ^f,ac   März, Winfried ^ae,du,dv   Metspalu, Andres ^u   Mohlke, Karen L ^an   Sangher, K ^br   Harambir, Dharambir ^br   Shu, Xiao Ou ^bs,bt   Van Meurs, Joyce B J ^s   Vithana, Eranga ^ad,bo   Wickremasinghe, Ananda R ^ab   Wijmenga, Cisca ^e   Wolffenbuttel, Bruce H W ^e   Yokota, Mitsuhiro ^ci   Zheng, Wei ^bs,bt   Zhu, Dingliang ^aq,ar   Vineis, Paolo ^c   Kyrtopoulos, Soterios A ^dw   Kleinjans, Jos C S ^dx   McCarthy, Mark I ^l,at   Soong, Richie ^ad,ag   Gieger, Christian ^m   Scott, James ^o   Teo, Yik Ying ^f,ac,ad,bo   He, Jiang ^h   Elliott, Paul ^c   Tai, E Shyong ^f,cf,dy   Van Der Harst, Pim ^e,de   Kooner, Jaspal S ^g,o,dz   Chambers, John C ^c,g,dz   more..

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b UNIVERSITY OF OULU   (Finland)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d AGENCY FOR SCIENCE   (Singapore)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^g EALING HOSPITAL NHS TRUST   (United Kingdom)

^h TULANE UNIVERSITY   (United States)

ⁱ Center for Non Communicable Diseases   (Pakistan)

^j UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^k UNIVERSITY OF PENNSYLVANIA   (United States)

^l UNIVERSITY OF OXFORD   (United Kingdom)

^m INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁿ GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^o NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^p Capital Region   (Denmark)

^q UNIVERSITY OF COPENHAGEN   (Denmark)

^r STENO DIABETES CENTER   (Denmark)

^s ERASMUS MEDICAL CENTER   (Netherlands)

^t VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^u UNIVERSITY OF TARTU   (Estonia)

^v BOSTON CHILDREN S HOSPITAL   (United States)

^w HARVARD MEDICAL SCHOOL   (United States)

^x BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^y Korea National Institute of Health   (South Korea)

^z UNIVERSITY OF EDINBURGH   (United Kingdom)

^aa UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^ab UNIVERSITY OF KELANIYA   (Sri Lanka)

^ac GENOME INSTITUTE OF SINGAPORE   (Singapore)

^ad NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^ae UNIVERSITY OF HEIDELBERG   (Germany)

^af INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^ag NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^ah NAGOYA UNIVERSITY HOSPITAL   (Japan)

^ai MASSACHUSETTS GENERAL HOSPITAL   (United States)

^aj UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^ak Ruddy Canadian Cardiovascular Genetics Centre   (Canada)

^al KYOTO UNIVERSITY   (Japan)

^am AGENCY FOR SCIENCE   (Singapore)

^an UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^ao INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^ap CHINA MEDICAL UNIVERSITY   (Taiwan)

^aq SHANGHAI JIAO TONG UNIVERSITY   (China)

^ar Shanghai Institute of Hypertension   (China)

^as UNIVERSITY OF KIEL   (Germany)

^at UNIVERSITY OF OXFORD   (United Kingdom)

^au LUND UNIVERSITY HOSPITAL   (Sweden)

^av UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^aw FIMLAB LABORATORIES   (Finland)

^ax TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^ay BACH MAI HOSPITAL   (Viet Nam)

^az UNIVERSITY OF MINNESOTA   (United States)

^ba LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^bb Netherlands Consortium for Healthy Ageing   (Netherlands)

^bc TURKU UNIVERSITY HOSPITAL   (Finland)

^bd UNIVERSITY OF TURKU   (Finland)

^be UNIVERSITY OF CHICAGO   (United States)

^bf CNR   (Italy)

^bg UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^bh SAN RAFFAELE HOSPITAL   (Italy)

^bi INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^bj UNIVERSITY COLLEGE LONDON   (United Kingdom)

^bk KYUSHU UNIVERSITY   (Japan)

^bl MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^bm IL   (United States)

^bn U Chicago Research Bangladesh Ltd   (Bangladesh)

^bo SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^bp WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^bq ADDENBROOKE S HOSPITAL   (United Kingdom)

^br UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^bs VANDERBILT UNIVERSITY   (United States)

^bt VANDERBILT INGRAM CANCER CENTER   (United States)

^bu NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^bv SHANGHAI CANCER INSTITUTE   (China)

^bw FUWAI HOSPITAL   (China)

^bx DAYANAND MEDICAL COLLEGE AND HOSPITAL   (India)

^by OULU UNIVERSITY HOSPITAL   (Finland)

^bz LERNER RESEARCH INSTITUTE   (United States)

^ca UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^cb CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

^cc GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^cd MIE UNIVERSITY   (Japan)

^ce EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^cf OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^cg Women's and Children's Hospital   (Singapore)

^ch UNIVERSITY OF SAN CARLOS   (Philippines)

^ci AICHI GAKUIN UNIVERSITY   (Japan)

^cj TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^ck UNIVERSITY OF MUNICH   (Germany)

^cl DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^cm SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^cn NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^co CHUBU ROSAI HOSPITAL   (Japan)

^cp TAMPERE UNIVERSITY HOSPITAL   (Finland)

^cq TEIKYO UNIVERSITY   (Japan)

^cr KYUSHU UNIVERSITY   (Japan)

^cs UNIVERSITY OF BRISTOL   (United Kingdom)

^ct RESEARCH AND EVALUATION DIVISION   (Bangladesh)

^cu UMEÅ UNIVERSITY   (Sweden)

^cv UNIVERSITY OF GLASGOW   (United Kingdom)

^cw INSTITUTE FOR ADULT DISEASES   (Japan)

^cx SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^cy YOKOHAMA CITY UNIVERSITY   (Japan)

^cz UNIVERSITY OF TURKU   (Finland)

^da DUKE UNIVERSITY MEDICAL CENTER   (United States)

^db UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^dc TSINGHUA UNIVERSITY   (China)

^dd UNIVERSITY OF HONG KONG   (Hong Kong)

^de ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^df QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^dg KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^dh HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^di HAMMERSMITH HOSPITAL   (United Kingdom)

^dj HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^dk UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^dl UNIVERSITY OF OULU   (Finland)

^dm INTERUNIVERSITY CARDIOLOGY INSTITUTE OF THE NETHERLANDS   (Netherlands)

^dn Ministry of Health and Welfare   (South Korea)

^do Theragen ETEX Bio Institute   (South Korea)

^dp Rigshospitalet   (Denmark)

^dq UNIVERSITY OF COPENHAGEN   (Denmark)

^dr UNIVERSITY OF LEICESTER   (United Kingdom)

^ds GLENFIELD HOSPITAL   (United Kingdom)

^dt The Capital Region   (Denmark)

^du MEDICAL UNIVERSITY OF GRAZ   (Austria)

^dv SYNLAB ACADEMY   (Germany)

^dw INSTITUTE OF BIOLOGY   (Greece)

^dx MAASTRICHT UNIVERSITY   (Netherlands)

^dy Dept Medicine Endocrinol Diabet   (Singapore)

^dz IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARHGAP24 GENE; ARTICLE; BLOOD PRESSURE REGULATION; CPG ISLAND; DIASTOLIC BLOOD PRESSURE; DNA METHYLATION; EAST ASIAN; EUROPEAN; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HEART LEFT VENTRICLE MASS; HUMAN; HUMAN EXPERIMENT; IGFBP3 GENE; KCNK3 GENE; MORTALITY; NORMAL HUMAN; OSR1 GENE; PDE3A GENE; PHENOTYPE; PRDM6 GENE; PRIORITY JOURNAL; REPLICATION STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; SLC22A7 GENE; SOUTH ASIAN; SYSTOLIC BLOOD PRESSURE; TBX2 GENE; VASCULAR SMOOTH MUSCLE; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CAUCASIAN; ETHNOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; MALE; MIDDLE AGED; PROCEDURES; REGRESSION ANALYSIS; RISK FACTOR; VERY ELDERLY;

BRAIN NATRIURETIC PEPTIDE; PEPTIDE FRAGMENT; PRO-BRAIN NATRIURETIC PEPTIDE (1-76);

ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; DNA METHYLATION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS; RISK FACTORS;

EID: 84965118964     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3405     Document Type: Article

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