Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders

Cell Stem Cell

Volumn 20, Issue 5, 2017, Pages 659-674.e9

  Lorenz, Carmen ^a,b   Lesimple, Pierre ^c,d   Bukowiecki, Raul ^a   Zink, Annika ^a,e   Inak, Gizem ^a   Mlody, Barbara ^a   Singh, Manvendra ^a   Semtner, Marcus ^a   Mah, Nancy ^e   Auré, Karine ^c,d   Leong, Megan ^a   Zabiegalov, Oleksandr ^a   Lyras, Ekaterini Maria ^e   Pfiffer, Vanessa ^a   Fauler, Beatrix ^f   Eichhorst, Jenny ^h   Wiesner, Burkhard ^h   Huebner, Norbert ^a   Priller, Josef ^b,e,g   Mielke, Thorsten ^f   Meierhofer, David ^f   Izsvák, Zsuzsanna ^a   Meier, Jochen C ^a,i   Bouillaud, Frédéric ^c,d   Adjaye, James ^j   Schuelke, Markus ^e   Wanker, Erich E ^a   Lombès, Anne ^c,d   Prigione, Alessandro ^a   more..

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b BERLIN INSTITUTE OF HEALTH   (Germany)

^c INSTITUT COCHIN   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^g GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^h LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

ⁱ TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^j Department of Orthopedic Surgery   (Germany)

more..

Author keywords

calcium; drug discovery; induced pluripotent stem cells; iPSCs; metabolism; mitochondria; mitochondrial disorders; mtDNA mutations; neural progenitors; NPCs

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AVANAFIL; MITOCHONDRIAL DNA; CALCIUM;

ARTICLE; ASTROCYTE; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CELL MATURATION; DNA SEQUENCE; DOPAMINERGIC NERVE CELL; DRUG SCREENING; EMBRYO; ENERGY METABOLISM; FUNCTIONAL ASSESSMENT; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; HYPERPOLARIZATION; INDUCED PLURIPOTENT STEM CELL; MITOCHONDRIAL DNA DISORDER; NEURAL STEM CELL; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; WHOLE CELL PATCH CLAMP; CELL LINE; CYTOLOGY; DRUG DEVELOPMENT; GENETICS; METABOLISM; MITOCHONDRION; MUTATION; PROCEDURES;

CALCIUM; CELL LINE; DNA, MITOCHONDRIAL; DRUG DISCOVERY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MITOCHONDRIA; MUTATION; NEURAL STEM CELLS;

EID: 85010918121     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.12.013     Document Type: Article

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