Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability

EMBO Journal

Volumn 35, Issue 18, 2016, Pages 1979-1990

  Perales Clemente, Ester ^a   Cook, Alexandra N ^a   Evans, Jared M ^a   Roellinger, Samantha ^a   Secreto, Frank ^a   Emmanuele, Valentina ^b   Oglesbee, Devin ^a   Mootha, Vamsi K ^c   Hirano, Michio ^d   Schon, Eric A ^d   Terzic, Andre ^a   Nelson, Timothy J ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF MESSINA   (Italy)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Department of Medicine   (United States)

Author keywords

global private mutation; human iPSC; intra person variability; mitochondrial DNA; quality control; universal heteroplasmy

Indexed keywords

MITOCHONDRIAL DNA; TRANSFER RNA;

AEROBIC METABOLISM; AMINO ACID SUBSTITUTION; ARTICLE; CELL CLONE; CELL DIFFERENTIATION; CLASSIFICATION; CLINICAL TRIAL; CONTROLLED STUDY; FIBROBLAST; GENETIC VARIABILITY; GENOTYPE; GLYCOLYSIS; HETEROPLASMY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; KARYOTYPE; MELAS SYNDROME; MITOCHONDRIAL GENOME; MITOCHONDRIAL HAPLOGROUP; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MUTATIONAL LOAD; NEXT GENERATION SEQUENCING; NUCLEAR REPROGRAMMING; OXYGEN CONSUMPTION; POINT MUTATION; PRIORITY JOURNAL; PROGENY; PROTEIN FUNCTION; REGENERATIVE MEDICINE; SEQUENCE ANALYSIS; SKIN FIBROBLAST; STEM CELL SELF-RENEWAL; WILD TYPE; CARDIAC MUSCLE CELL; CELL RESPIRATION; CHEMISTRY; GENETIC VARIATION; GENETICS; HIGH THROUGHPUT SEQUENCING; MUTATION; PHENOTYPE; PHYSIOLOGY;

CELL DIFFERENTIATION; CELL RESPIRATION; DNA, MITOCHONDRIAL; GENETIC VARIATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MUTATION; MYOCYTES, CARDIAC; PHENOTYPE;

EID: 84978646252     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201694892     Document Type: Article

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