Adult conditional knockout of PGC-1α leads to loss of dopamine neurons

eNeuro

Volumn 3, Issue 4, 2016, Pages

  Jiang, Haisong ^a,b,c   Kang, Sung Ung ^a,b,c   Zhang, Shuran ^a   Karuppagounder, Senthilkumar ^a,b,c   Xu, Jinchong ^a   Lee, Yong Kyu ^a   Kang, Bong Gu ^a   Lee, Yunjong ^a,b,c,d   Zhang, Jianmin ^a,e   Pletnikova, Olga ^a   Troncoso, Juan C ^a   Pirooznia, Shelia ^a,b,c   Andrabi, Shaida A ^a   Dawson, Valina L ^a,b,c   Dawson, Ted M ^a,b,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ADRIENNE HELIS MALVIN MEDICAL RESEARCH FOUNDATION   (United States)

^c Diana Helis Henry Medical Research Foundation   (United States)

^d Sungkyunkwan University School of Medicine   (South Korea)

^e INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Dopamine neuron; Mitochondria; Neurodegeneration; PGC 1 ; Substantia nigra

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; AMPHETAMINE; DOPAMINE; MITOCHONDRIAL PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; CENTRAL STIMULANT AGENT; ISOPROTEIN; PPARGC1A PROTEIN, HUMAN; PPARGC1A PROTEIN, MOUSE;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; GENE DELETION; GENE INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBSTANTIA NIGRA PARS COMPACTA; WESTERN BLOTTING; AGED; ANIMAL; CELL DEATH; DRUG EFFECTS; FEMALE; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MITOCHONDRION; MOTOR ACTIVITY; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AMPHETAMINE; ANIMALS; CELL DEATH; CENTRAL NERVOUS SYSTEM STIMULANTS; CORPUS STRIATUM; DOPAMINERGIC NEURONS; FEMALE; GENE KNOCKOUT TECHNIQUES; HUMANS; MALE; MICE, KNOCKOUT; MITOCHONDRIA; MOTOR ACTIVITY; PARKINSON DISEASE; PARS COMPACTA; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PROTEIN ISOFORMS; RANDOM ALLOCATION;

EID: 85010285616     PISSN: None     EISSN: 23732822     Source Type: Journal    
DOI: 10.1523/ENEURO.0183-16.2016     Document Type: Article

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