Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 30, 2016, Pages E4387-E4396

  Doucet Beaupré, Hélène ^a,b   Gilbert, Catherine ^a,b   Profes, Marcos Schaan ^a,b   Chabrat, Audrey ^a,b   Pacelli, Consiglia ^c   Giguère, Nicolas ^c   Rioux, Véronique ^a,b   Charest, Julien ^a,b   Deng, Qiaolin ^d   Laguna, Ariadna ^d,e   Ericson, Johan ^d   Perlmann, Thomas ^a,e   Angg, Siew Lan ^f   Cicchetti, Francesca ^a,g   Parent, Martin ^a,b   Trudeau, Louis Eric ^c   Lévesque, Martin ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE MONTRÉAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d KAROLINSKA INSTITUTE   (Sweden)

^e LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^f THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^g LAVAL UNIVERSITY   (Canada)

Author keywords

Dopamine neurons; Mitochondrial dysfunctions; Parkinson's disease; Protein aggregates; Transcription factors

Indexed keywords

ALPHA SYNUCLEIN; LIM HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR LMX1A; TRANSCRIPTION FACTOR LMX1B; UNCLASSIFIED DRUG; LIM HOMEOBOX TRANSCRIPTION FACTOR 1 BETA; LMX1A PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DOPAMINERGIC NERVE CELL; IN VITRO STUDY; MESENCEPHALON; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NERVE CELL DEGENERATION; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY CHAIN; STABLE EXPRESSION; ANIMAL; C57BL MOUSE; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM; PROTEINOSIS; TRANSGENIC MOUSE;

ALPHA-SYNUCLEIN; ANIMALS; CELL SURVIVAL; DNA DAMAGE; DOPAMINERGIC NEURONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEK293 CELLS; HUMANS; LIM-HOMEODOMAIN PROTEINS; MESENCEPHALON; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA; OXIDATIVE STRESS; PROTEIN AGGREGATION, PATHOLOGICAL; TRANSCRIPTION FACTORS;

EID: 84979581714     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1520387113     Document Type: Article

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