Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

Molecular Cell

Volumn 65, Issue 2, 2017, Pages 323-335

  Zhang, Yang W ^a   Wang, Zhihong ^b   Xie, Wenbing ^a   Cai, Yi ^a   Xia, Limin ^a   Easwaran, Hariharan ^a   Luo, Jianjun ^a   Yen, Ray Whay Chiu ^a   Li, Yana ^c   Baylin, Stephen B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF THE SCIENCES   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5hmC; acetylation; cancer; DNA demethylation; DNA methylation; oxidative stress; TET2

Indexed keywords

DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; PROTEIN; TET2 PROTEIN; UNCLASSIFIED DRUG; 5 METHYLCYTOSINE; 5-HYDROXYMETHYLCYTOSINE; CHROMATIN; DNA; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; DNA BINDING PROTEIN; E1A ASSOCIATED P300 PROTEIN; EP300 PROTEIN, HUMAN; HDAC1 PROTEIN, HUMAN; HDAC2 PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN BINDING; TET2 PROTEIN, HUMAN;

A2780 CELL LINE; ARTICLE; CHROMATIN; CONTROLLED STUDY; DEACETYLATION; DNA DAMAGE; DNA METHYLATION; ENHANCER REGION; ENZYME ACTIVITY; HCT 116 CELL LINE; HUMAN; HUMAN CELL; MALIGNANT NEOPLASM; OVARIAN CANCER CELL LINE; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN ACETYLATION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STABILITY; REGULATORY MECHANISM; UBIQUITINATION; ACETYLATION; ANALOGS AND DERIVATIVES; GENETIC TRANSFECTION; GENETICS; METABOLISM; NEOPLASM; PROTEIN PROCESSING; RNA INTERFERENCE; TIME FACTOR;

5-METHYLCYTOSINE; ACETYLATION; CHROMATIN; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA, NEOPLASM; DNA-BINDING PROTEINS; E1A-ASSOCIATED P300 PROTEIN; HCT116 CELLS; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HUMANS; NEOPLASMS; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE; TIME FACTORS; TRANSFECTION; UBIQUITINATION;

EID: 85010285194     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.12.013     Document Type: Article

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