-
3
-
-
0035856021
-
Helicobacter pylori infection and the development of gastric cancer
-
Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001;345:784-9
-
(2001)
N Engl J Med
, vol.345
, pp. 784-789
-
-
Uemura, N.1
Okamoto, S.2
Yamamoto, S.3
-
4
-
-
84912068268
-
Global burden of gastric cancer attributable to Helicobacter pylori
-
Plummer M, Franceschi S, Vignat J, et al. Global burden of gastric cancer attributable to Helicobacter pylori. Int J Cancer 2015;136:487-90
-
(2015)
Int J Cancer
, vol.136
, pp. 487-490
-
-
Plummer, M.1
Franceschi, S.2
Vignat, J.3
-
6
-
-
0033029710
-
Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer
-
Richards FM, McKee SA, Rajpar MH, et al. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum Mol Genet 1999;8:607-10
-
(1999)
Hum Mol Genet
, vol.8
, pp. 607-610
-
-
Richards, F.M.1
McKee, S.A.2
Rajpar, M.H.3
-
7
-
-
19144370998
-
Fundoplication and the risk of esophageal cancer in gastroesophageal reflux disease: a Veterans Affairs cohort study
-
Tran T, Spechler SJ, Richardson P, et al. Fundoplication and the risk of esophageal cancer in gastroesophageal reflux disease: a Veterans Affairs cohort study. Am J Gastroenterol 2005;100:1002-8
-
(2005)
Am J Gastroenterol
, vol.100
, pp. 1002-1008
-
-
Tran, T.1
Spechler, S.J.2
Richardson, P.3
-
8
-
-
67650095398
-
High-temperature beverages and foods and esophageal cancer risk-a systematic review
-
Islami F, Boffetta P, Ren JS, et al. High-temperature beverages and foods and esophageal cancer risk-a systematic review. Int J Cancer 2009;125:491-524
-
(2009)
Int J Cancer
, vol.125
, pp. 491-524
-
-
Islami, F.1
Boffetta, P.2
Ren, J.S.3
-
9
-
-
70449675039
-
Patterns of food and nutrient consumption in northern Iran, a high-risk area for esophageal cancer
-
Islami F, Malekshah AF, Kimiagar M, et al. Patterns of food and nutrient consumption in northern Iran, a high-risk area for esophageal cancer. Nutr Cancer 2009;61:475-83
-
(2009)
Nutr Cancer
, vol.61
, pp. 475-483
-
-
Islami, F.1
Malekshah, A.F.2
Kimiagar, M.3
-
10
-
-
62449159357
-
Green tea drinking, high tea temperature and esophageal cancer in high-and low-risk areas of Jiangsu Province, China: a population-based case-control study
-
Wu M, Liu AM, Kampman E, et al. Green tea drinking, high tea temperature and esophageal cancer in high-and low-risk areas of Jiangsu Province, China: a population-based case-control study. Int J Cancer 2009;124:1907-13
-
(2009)
Int J Cancer
, vol.124
, pp. 1907-1913
-
-
Wu, M.1
Liu, A.M.2
Kampman, E.3
-
11
-
-
84881458405
-
Barrett esophagus and risk of esophageal cancer: a clinical review
-
Spechler SJ
-
Spechler SJ. Barrett esophagus and risk of esophageal cancer: a clinical review. Spechler SJ. JAMA 2013;310:627-36
-
(2013)
JAMA
, vol.310
, pp. 627-636
-
-
Spechler, S.J.1
-
12
-
-
84863409027
-
Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomas
-
Yoon HH, Shi Q, Sukov WR, et al. Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomas. Clin Cancer Res 2012;18:546-54
-
(2012)
Clin Cancer Res
, vol.18
, pp. 546-554
-
-
Yoon, H.H.1
Shi, Q.2
Sukov, W.R.3
-
13
-
-
84892934795
-
HER-2/neu gene amplification in relation to expression of HER2 and HER3 proteins in patients with esophageal adenocarcinoma
-
Yoon HH, Sukov WR, Shi Q, et al. HER-2/neu gene amplification in relation to expression of HER2 and HER3 proteins in patients with esophageal adenocarcinoma. Cancer 2014;120:415-24
-
(2014)
Cancer
, vol.120
, pp. 415-424
-
-
Yoon, H.H.1
Sukov, W.R.2
Shi, Q.3
-
14
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010;376:687-97
-
(2010)
Lancet
, vol.376
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
-
15
-
-
84892852372
-
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial
-
Fuchs CS, Tomasek J, Yong CJ, et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 2014;383:31-9
-
(2014)
Lancet
, vol.383
, pp. 31-39
-
-
Fuchs, C.S.1
Tomasek, J.2
Yong, C.J.3
-
16
-
-
84945587359
-
Subgroup analyses of the safety and efficacy of ramucirumab in Japanese and Western patients in RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer
-
Shitara K, Muro K, Shimada Y, et al. Subgroup analyses of the safety and efficacy of ramucirumab in Japanese and Western patients in RAINBOW: a randomized clinical trial in second-line treatment of gastric cancer. Gastric Cancer 2016;19:927-38
-
(2016)
Gastric Cancer
, vol.19
, pp. 927-938
-
-
Shitara, K.1
Muro, K.2
Shimada, Y.3
-
17
-
-
84908139963
-
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial
-
Wilke H, Muro K, Van Cutsem E, et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. Lancet Oncol 2014;15:1224-35
-
(2014)
Lancet Oncol
, vol.15
, pp. 1224-1235
-
-
Wilke, H.1
Muro, K.2
Van Cutsem, E.3
-
18
-
-
34248193253
-
Immune surveillance of tumors
-
Swann JB, Smyth MJ. Immune surveillance of tumors. J Clin Invest 2007;117:1137-46
-
(2007)
J Clin Invest
, vol.117
, pp. 1137-1146
-
-
Swann, J.B.1
Smyth, M.J.2
-
19
-
-
84880924265
-
The immune microenvironment of human tumors: general significance and clinical impact
-
Fridman WH, Dieu-Nosjean MC, Pagès F, et al. The immune microenvironment of human tumors: general significance and clinical impact. Cancer Microenviron 2013;6:117-22
-
(2013)
Cancer Microenviron
, vol.6
, pp. 117-122
-
-
Fridman, W.H.1
Dieu-Nosjean, M.C.2
Pagès, F.3
-
20
-
-
84886944563
-
The immune microenvironment as a guide for cancer therapies
-
Fridman WH. The immune microenvironment as a guide for cancer therapies. Oncoimmunology 2012;1:261-2
-
(2012)
Oncoimmunology
, vol.1
, pp. 261-262
-
-
Fridman, W.H.1
-
21
-
-
84892575790
-
Bronchoalveolar lavage in lung cancer-diagnostic value and assessment of the anti-cancer immune response
-
Osinska I, Domagala-Kulawik J. Bronchoalveolar lavage in lung cancer-diagnostic value and assessment of the anti-cancer immune response. Postepy Hig Med Dosw (Online) 2013;67:1119-27
-
(2013)
Postepy Hig Med Dosw (Online)
, vol.67
, pp. 1119-1127
-
-
Osinska, I.1
Domagala-Kulawik, J.2
-
23
-
-
84893489025
-
PD-1 as a potential target in cancer therapy
-
McDermott DF, Atkins MB. PD-1 as a potential target in cancer therapy. Cancer Med 2013;2:662-73
-
(2013)
Cancer Med
, vol.2
, pp. 662-673
-
-
McDermott, D.F.1
Atkins, M.B.2
-
25
-
-
70349569569
-
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
-
Ahmadzadeh M, Johnson LA, Heemskerk B, et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009;114:1537-44
-
(2009)
Blood
, vol.114
, pp. 1537-1544
-
-
Ahmadzadeh, M.1
Johnson, L.A.2
Heemskerk, B.3
-
26
-
-
84951790085
-
Novel cancer antigens for personalized immunotherapies: latest evidence and clinical potential
-
Wurz GT, Kao CJ, DeGregorio MW. Novel cancer antigens for personalized immunotherapies: latest evidence and clinical potential. Ther Adv Med Oncol 2016;8:4-31
-
(2016)
Ther Adv Med Oncol
, vol.8
, pp. 4-31
-
-
Wurz, G.T.1
Kao, C.J.2
DeGregorio, M.W.3
-
27
-
-
84966552789
-
PD-L1 is an independent prognostic predictor in gastric cancer of Western patients
-
Böger C, Behrens HM, Mathiak M, et al. PD-L1 is an independent prognostic predictor in gastric cancer of Western patients. Oncotarget 2016;7:24269-83
-
(2016)
Oncotarget
, vol.7
, pp. 24269-24283
-
-
Böger, C.1
Behrens, H.M.2
Mathiak, M.3
-
28
-
-
84977606368
-
Prognostic significance of tumor infiltrating immune cells and PD-L1 expression in gastric carcinoma in Chinese patients
-
Geng R, Dai C, Wong A, et al. Prognostic significance of tumor infiltrating immune cells and PD-L1 expression in gastric carcinoma in Chinese patients. J Clin Oncol 2015;33:abstr 4042
-
(2015)
J Clin Oncol
, vol.33
-
-
Geng, R.1
Dai, C.2
Wong, A.3
-
29
-
-
84962009435
-
Epithelial PD-L2 Expression Marks Barrett's Esophagus and Esophageal Adenocarcinoma
-
Derks S, Nason KS, Liao X, et al. Epithelial PD-L2 Expression Marks Barrett's Esophagus and Esophageal Adenocarcinoma. Cancer Immunol Res 2015;3:1123-9
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 1123-1129
-
-
Derks, S.1
Nason, K.S.2
Liao, X.3
-
30
-
-
85043663660
-
-
Tanaka H, Tamura T, Kimura K, et al. Sakurai K, Toyokawa T, Amano R, et al. Association of the immune checkpoint molecule expression with neutrophil-lymphocyte ratio in patients with gastric cancer: A retrospective study. J Clin Oncol 2016;34:abstr 48
-
(2016)
Association of the immune checkpoint molecule expression with neutrophil-lymphocyte ratio in patients with gastric cancer: A retrospective study. J Clin Oncol
, vol.34
-
-
Tanaka, H.1
Tamura, T.2
Kimura, K.3
Sakurai, K.4
Toyokawa, T.5
Amano, R.6
-
31
-
-
85043657378
-
Comprehensive characterization of PDL-1 and CTLA-4 in gastric cancer
-
Schloesser HA, Drebber U, Thelen M, et al. Comprehensive characterization of PDL-1 and CTLA-4 in gastric cancer. J Clin Oncol 2015;33:abstr 4056
-
(2015)
J Clin Oncol
, vol.33
-
-
Schloesser, H.A.1
Drebber, U.2
Thelen, M.3
-
32
-
-
84898658808
-
Correlation between infiltration of FOXP3+ regulatory T cells and expression of B7-H1 in the tumor tissues of gastric cancer
-
Hou J, Yu Z, Xiang R, et al. Correlation between infiltration of FOXP3+ regulatory T cells and expression of B7-H1 in the tumor tissues of gastric cancer. Exp Mol Pathol 2014;96:284-91
-
(2014)
Exp Mol Pathol
, vol.96
, pp. 284-291
-
-
Hou, J.1
Yu, Z.2
Xiang, R.3
-
33
-
-
33745491116
-
Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance
-
Wu C, Zhu Y, Jiang J, et al. Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem 2006;108:19-24
-
(2006)
Acta Histochem
, vol.108
, pp. 19-24
-
-
Wu, C.1
Zhu, Y.2
Jiang, J.3
-
34
-
-
84989768532
-
Adaptive immune resistance in gastro-esophageal cancer: Correlating tumoral/stromal PDL1 expression with CD8+ cell count
-
Kelly RJ, Thompson E, Zahurak M, et al. Adaptive immune resistance in gastro-esophageal cancer: Correlating tumoral/stromal PDL1 expression with CD8+ cell count. J Clin Oncol 2015;33:abstr 4031
-
(2015)
J Clin Oncol
, vol.33
-
-
Kelly, R.J.1
Thompson, E.2
Zahurak, M.3
-
35
-
-
85014675286
-
Safety, PD-L1 expression, and clinical activity of avelumab (MSB0010718C), an anti-PD-L1 antibody, in Japanese patients with advanced gastric or gastroesophageal junction cancer
-
Nishina T, Shitara K, Iwasa S, et al. Safety, PD-L1 expression, and clinical activity of avelumab (MSB0010718C), an anti-PD-L1 antibody, in Japanese patients with advanced gastric or gastroesophageal junction cancer. J Clin Oncol 2016;34:abstr 168
-
(2016)
J Clin Oncol
, vol.34
-
-
Nishina, T.1
Shitara, K.2
Iwasa, S.3
-
36
-
-
20244384862
-
Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer
-
Ohigashi Y, Sho M, Yamada Y, et al. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res 2005;11:2947-53
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2947-2953
-
-
Ohigashi, Y.1
Sho, M.2
Yamada, Y.3
-
37
-
-
79954639292
-
Clinicopathologic and molecular profiles of microsatellite unstable Barrett Esophagus-associated adenocarcinoma
-
Farris AB 3rd, Demicco EG, Le LP, et al. Clinicopathologic and molecular profiles of microsatellite unstable Barrett Esophagus-associated adenocarcinoma. Am J Surg Pathol 2011;35:647-55
-
(2011)
Am J Surg Pathol
, vol.35
, pp. 647-655
-
-
Farris, A.B.1
Demicco, E.G.2
Le, L.P.3
-
38
-
-
84888027023
-
Distinct genetic aberrations in oesophageal adeno and squamous carcinoma
-
Pandilla R, Kotapalli V, Gowrishankar S, et al. Distinct genetic aberrations in oesophageal adeno and squamous carcinoma. Eur J Clin Invest 2013;43:1233-9
-
(2013)
Eur J Clin Invest
, vol.43
, pp. 1233-1239
-
-
Pandilla, R.1
Kotapalli, V.2
Gowrishankar, S.3
-
39
-
-
0036716699
-
Inflammatory gradient in Barrett's oesophagus: implications for disease complications
-
Fitzgerald RC, Abdalla S, Onwuegbusi BA, et al. Inflammatory gradient in Barrett's oesophagus: implications for disease complications. Gut 2002;51:316-22
-
(2002)
Gut
, vol.51
, pp. 316-322
-
-
Fitzgerald, R.C.1
Abdalla, S.2
Onwuegbusi, B.A.3
-
40
-
-
27644452325
-
Barrett's oesophagus is characterized by a predominantly humoral inflammatory response
-
Moons LM, Kusters JG, Bultman E, et al. Barrett's oesophagus is characterized by a predominantly humoral inflammatory response. J Pathol 2005;207:269-76
-
(2005)
J Pathol
, vol.207
, pp. 269-276
-
-
Moons, L.M.1
Kusters, J.G.2
Bultman, E.3
-
41
-
-
79961016549
-
Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice
-
Lesterhuis WJ, Punt CJ, Hato SV, et al. Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice. J Clin Invest 2011;121:3100-8
-
(2011)
J Clin Invest
, vol.121
, pp. 3100-3108
-
-
Lesterhuis, W.J.1
Punt, C.J.2
Hato, S.V.3
-
42
-
-
0038302927
-
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
-
Loke P, Allison JP. PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci U S A 2003;100:5336-41
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 5336-5341
-
-
Loke, P.1
Allison, J.P.2
-
43
-
-
84929051791
-
Infiltration of alternatively activated macrophages in cancer tissue is associated with MDSC and Th2 polarization in patients with esophageal cancer
-
Gao J, Wu Y, Su Z, et al. Infiltration of alternatively activated macrophages in cancer tissue is associated with MDSC and Th2 polarization in patients with esophageal cancer. PLoS One 2014;9:e104453
-
(2014)
PLoS One
, vol.9
-
-
Gao, J.1
Wu, Y.2
Su, Z.3
-
44
-
-
5844264920
-
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
-
Latchman Y, Wood CR, Chernova T, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001;2:261-8
-
(2001)
Nat Immunol
, vol.2
, pp. 261-268
-
-
Latchman, Y.1
Wood, C.R.2
Chernova, T.3
-
45
-
-
33746854425
-
Regulation of T cell activation and tolerance by PDL2
-
Zhang Y, Chung Y, Bishop C, et al. Regulation of T cell activation and tolerance by PDL2. Proc Natl Acad Sci U S A 2006;103:11695-700
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11695-11700
-
-
Zhang, Y.1
Chung, Y.2
Bishop, C.3
-
46
-
-
0038185203
-
Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction
-
Wang S, Bajorath J, Flies DB, et al. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J Exp Med 2003;197:1083-91
-
(2003)
J Exp Med
, vol.197
, pp. 1083-1091
-
-
Wang, S.1
Bajorath, J.2
Flies, D.B.3
-
47
-
-
84908354848
-
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
-
Robert C, Ribas A, Wolchok JD, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 2014;384:1109-17
-
(2014)
Lancet
, vol.384
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
-
48
-
-
84898973055
-
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
-
Topalian SL, Sznol M, McDermott DF, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014;32:1020-30
-
(2014)
J Clin Oncol
, vol.32
, pp. 1020-1030
-
-
Topalian, S.L.1
Sznol, M.2
McDermott, D.F.3
-
49
-
-
84936791837
-
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer
-
Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med 2015;373:123-35
-
(2015)
N Engl J Med
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
50
-
-
84946607195
-
Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
-
Motzer RJ, Escudier B, McDermott DF, et al. Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med 2015;373:1803-13
-
(2015)
N Engl J Med
, vol.373
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
-
51
-
-
84920031180
-
In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
-
Wang C, Thudium KB, Han M, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res 2014;2:846-56
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 846-856
-
-
Wang, C.1
Thudium, K.B.2
Han, M.3
-
52
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 2015;372:2018-28
-
(2015)
N Engl J Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
-
53
-
-
84929481481
-
Pembrolizumab versus Ipilimumab in Advanced Melanoma
-
Robert C, Schachter J, Long GV, et al. Pembrolizumab versus Ipilimumab in Advanced Melanoma. N Engl J Med 2015;372:2521-32
-
(2015)
N Engl J Med
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
-
54
-
-
84938205998
-
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
-
Ribas A, Puzanov I, Dummer R, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol 2015;16:908-18
-
(2015)
Lancet Oncol
, vol.16
, pp. 908-918
-
-
Ribas, A.1
Puzanov, I.2
Dummer, R.3
-
55
-
-
85043656111
-
-
2016 [cited 2016 04/18/2016]
-
FDA 2016 [cited 2016 04/18/2016]. Available online: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Label_ApprovalHistory#apphist
-
-
-
-
56
-
-
85043656828
-
-
FDA 2016. Available online: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Label_ApprovalHistory
-
-
-
-
57
-
-
84936749833
-
Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer
-
Gettinger SN, Horn L, Gandhi L, et al. Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer. J Clin Oncol 2015;33:2004-12
-
(2015)
J Clin Oncol
, vol.33
, pp. 2004-2012
-
-
Gettinger, S.N.1
Horn, L.2
Gandhi, L.3
-
58
-
-
84931083080
-
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
-
Weber JS, D'Angelo SP, Minor D, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 2015;16:375-84
-
(2015)
Lancet Oncol
, vol.16
, pp. 375-384
-
-
Weber, J.S.1
D'Angelo, S.P.2
Minor, D.3
-
59
-
-
84941783535
-
Clinical response, progression-free survival (PFS), and safety in patients (pts) with advanced melanoma (MEL) receiving nivolumab (NIVO) combined with ipilimumab (IPI) vs IPI monotherapy in CheckMate 069 study
-
Hodi FS, Postow MA, Chesney JA, et al. Clinical response, progression-free survival (PFS), and safety in patients (pts) with advanced melanoma (MEL) receiving nivolumab (NIVO) combined with ipilimumab (IPI) vs IPI monotherapy in CheckMate 069 study. J Clin Oncol 2015;33:abstr 9004
-
(2015)
J Clin Oncol
, vol.33
-
-
Hodi, F.S.1
Postow, M.A.2
Chesney, J.A.3
-
60
-
-
84924901863
-
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
-
Rizvi NA, Mazières J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol 2015;16:257-65
-
(2015)
Lancet Oncol
, vol.16
, pp. 257-265
-
-
Rizvi, N.A.1
Mazières, J.2
Planchard, D.3
-
61
-
-
84944937210
-
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer. N Engl J Med 2015;373:1627-39
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
62
-
-
84942089321
-
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma
-
Larkin J, Hodi FS, Wolchok JD. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N Engl J Med 2015;373:1270-1
-
(2015)
N Engl J Med
, vol.373
, pp. 1270-1271
-
-
Larkin, J.1
Hodi, F.S.2
Wolchok, J.D.3
-
63
-
-
84887262315
-
A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors
-
Herbst RS, Gordon MS, Fine GD, et al. A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors. J Clin Oncol 2013;31:abstr 3000
-
(2013)
J Clin Oncol
, vol.31
-
-
Herbst, R.S.1
Gordon, M.S.2
Fine, G.D.3
-
64
-
-
84937041504
-
Relationship between PD-L1 expression and clinical outcomes in patients with advanced gastric cancer treated with the anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) in KEYNOTE-012
-
Bang YJ, Chung HC, Shankaran V, et al. Relationship between PD-L1 expression and clinical outcomes in patients with advanced gastric cancer treated with the anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) in KEYNOTE-012. J Clin Oncol 2015;33:abstr 4001
-
(2015)
J Clin Oncol
, vol.33
-
-
Bang, Y.J.1
Chung, H.C.2
Shankaran, V.3
-
65
-
-
84985928578
-
Updated results for the advanced esophageal carcinoma cohort of the phase Ib KEYNOTE-028 study of pembrolizumab (MK-3475)
-
Doi T, Piha-Paul SA, Jalal SI, et al. Updated results for the advanced esophageal carcinoma cohort of the phase Ib KEYNOTE-028 study of pembrolizumab (MK-3475). J Clin Oncol 2016;34:abstr 7
-
(2016)
J Clin Oncol
, vol.34
-
-
Doi, T.1
Piha-Paul, S.A.2
Jalal, S.I.3
-
66
-
-
84987603333
-
PD-1 blockade in mismatch repair deficient non-colorectal gastrointestinal cancers
-
Le DT, Uram JN, Wang H, et al. PD-1 blockade in mismatch repair deficient non-colorectal gastrointestinal cancers. J Clin Oncol 2016;34:abstr 195
-
(2016)
J Clin Oncol
, vol.34
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
67
-
-
85014675286
-
Safety, PD-L1 expression, and clinical activity of avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with advanced gastric or gastroesophageal junction cancer
-
Chung HC, Arkenau HT, Wyrwicz L, et al. Safety, PD-L1 expression, and clinical activity of avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with advanced gastric or gastroesophageal junction cancer. J Clin Oncol 2016;34:abstr 167
-
(2016)
J Clin Oncol
, vol.34
-
-
Chung, H.C.1
Arkenau, H.T.2
Wyrwicz, L.3
-
68
-
-
84987784391
-
Phase II study of nivolumab (ONO-4538/BMS-936558) in patients with esophageal cancer: Preliminary report of overall survival
-
Kojima T, Hara H, Yamaguchi K, et al. Phase II study of nivolumab (ONO-4538/BMS-936558) in patients with esophageal cancer: Preliminary report of overall survival. J Clin Oncol 2016;34:abstr TPS175
-
(2016)
J Clin Oncol
, vol.34
-
-
Kojima, T.1
Hara, H.2
Yamaguchi, K.3
-
69
-
-
84951568141
-
INTEGRATE: A randomized phase II double-blind placebo-controlled study of regorafenib in refractory advanced oesophagogastric cancer (AOGC)-A study by the Australasian Gastrointestinal Trials Group (AGITG), first results
-
Pavlakis N, Sjoquist KM, Tsobanis E, et al. INTEGRATE: A randomized phase II double-blind placebo-controlled study of regorafenib in refractory advanced oesophagogastric cancer (AOGC)-A study by the Australasian Gastrointestinal Trials Group (AGITG), first results. J Clin Oncol 2015;33:abstr 9
-
(2015)
J Clin Oncol
, vol.33
-
-
Pavlakis, N.1
Sjoquist, K.M.2
Tsobanis, E.3
-
70
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Horn L, Lawrence DP, Rost S, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014;515:563-7
-
(2014)
Nature
, vol.515
, pp. 563-567
-
-
Horn, L.1
Lawrence, D.P.2
Rost, S.3
-
71
-
-
84907521154
-
Preliminary data from a multi-arm expansion study of MEDI4736, an anti-PD-L1 antibody
-
Segal NH, Antonia SJ, Brahmer JR, et al. Preliminary data from a multi-arm expansion study of MEDI4736, an anti-PD-L1 antibody. J Clin Oncol 2014;32:abstr 3002
-
(2014)
J Clin Oncol
, vol.32
-
-
Segal, N.H.1
Antonia, S.J.2
Brahmer, J.R.3
-
72
-
-
85043662860
-
-
[3/11/2016]
-
ClinicalTrials.gov. Esophageal Cancer PD-1 2016 [3/11/2016]. Available online: https://clinicaltrials.gov/ct2/results?term=esophageal+cancer+PD-1&Search=Search
-
(2016)
Esophageal Cancer PD-1
-
-
-
73
-
-
85043664429
-
-
[3/11/2016]
-
ClinicalTrials.gov. Gastric Cancer PD-1 2016 [3/11/2016]. Available online: https://clinicaltrials.gov/ct2/results?term=gastric+cancer+PD-1&Search=Search
-
(2016)
Gastric Cancer PD-1
-
-
-
74
-
-
84859128199
-
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
-
Taube JM, Anders RA, Young GD, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012;4:127ra37
-
(2012)
Sci Transl Med
, vol.4
-
-
Taube, J.M.1
Anders, R.A.2
Young, G.D.3
-
77
-
-
85043662502
-
-
[4/23/2016]
-
ClinicalTrials.gov 2016 [4/23/2016]. Available online: https://clinicaltrials.gov/ct2/results?term=nivolumab+gastric&Search=Search
-
(2016)
-
-
-
78
-
-
85043659383
-
-
[04/22/2016]
-
ClinicalTrials.gov 2016 [04/22/2016]. Available online: https://clinicaltrials.gov/ct2/results?term=avelumab+gastric&Search=Search
-
(2016)
-
-
-
79
-
-
85043654361
-
-
[4/25/2016]
-
clinicalTrials.gov 2016 [4/25/2016]. Available online: https://clinicaltrials.gov/ct2/results?term=MEDI4736+gastric&Search=Search
-
(2016)
-
-
-
80
-
-
85043657735
-
-
ClinicalTrials.gov 2016. Available online: https://clinicaltrials.gov/ct2/results?term=durvalumab+esophageal&Search=Search
-
(2016)
-
-
-
81
-
-
84978219443
-
Predictive Markers for the Efficacy of Anti-PD-1/PD-L1 Antibodies in Lung Cancer
-
Shukuya T, Carbone DP. Predictive Markers for the Efficacy of Anti-PD-1/PD-L1 Antibodies in Lung Cancer. J Thorac Oncol 2016;11:976-88
-
(2016)
J Thorac Oncol
, vol.11
, pp. 976-988
-
-
Shukuya, T.1
Carbone, D.P.2
-
83
-
-
84944314045
-
Erratum to Assays for predicting and monitoring responses to lung cancer immunotherapy
-
Teixidó C, Karachaliou N, González-Cao M, et al. Erratum to Assays for predicting and monitoring responses to lung cancer immunotherapy. Cancer Biol Med 2015;12:259
-
(2015)
Cancer Biol Med
, vol.12
, pp. 259
-
-
Teixidó, C.1
Karachaliou, N.2
González-Cao, M.3
-
84
-
-
84937544496
-
Assays for predicting and monitoring responses to lung cancer immunotherapy
-
Teixidó C, Karachaliou N, González-Cao M, et al. Assays for predicting and monitoring responses to lung cancer immunotherapy. Cancer Biol Med 2015;12:87-95
-
(2015)
Cancer Biol Med
, vol.12
, pp. 87-95
-
-
Teixidó, C.1
Karachaliou, N.2
González-Cao, M.3
-
85
-
-
80055083189
-
Microsatellite instability and colorectal cancer
-
Geiersbach KB, Samowitz WS. Microsatellite instability and colorectal cancer. Arch Pathol Lab Med 2011;135:1269-77
-
(2011)
Arch Pathol Lab Med
, vol.135
, pp. 1269-1277
-
-
Geiersbach, K.B.1
Samowitz, W.S.2
-
86
-
-
58149144567
-
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1
-
Ligtenberg MJ, Kuiper RP, Chan TL, et al. Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1. Nat Genet 2009;41:112-7
-
(2009)
Nat Genet
, vol.41
, pp. 112-117
-
-
Ligtenberg, M.J.1
Kuiper, R.P.2
Chan, T.L.3
-
88
-
-
0032555020
-
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease
-
Aaltonen LA, Salovaara R, Kristo P, et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 1998;338:1481-7
-
(1998)
N Engl J Med
, vol.338
, pp. 1481-1487
-
-
Aaltonen, L.A.1
Salovaara, R.2
Kristo, P.3
-
89
-
-
17944362664
-
Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer)
-
Hampel H, Frankel WL, Martin E, et al. Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer). N Engl J Med 2005;352:1851-60
-
(2005)
N Engl J Med
, vol.352
, pp. 1851-1860
-
-
Hampel, H.1
Frankel, W.L.2
Martin, E.3
-
90
-
-
40449121314
-
Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers
-
Halvarsson B, Anderson H, Domanska K, et al. Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers. Am J Clin Pathol 2008;129:238-44
-
(2008)
Am J Clin Pathol
, vol.129
, pp. 238-244
-
-
Halvarsson, B.1
Anderson, H.2
Domanska, K.3
-
91
-
-
33746794561
-
Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): a guide for clinicians
-
Hendriks YM, de Jong AE, Morreau H, et al. Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): a guide for clinicians. CA Cancer J Clin 2006;56:213-25
-
(2006)
CA Cancer J Clin
, vol.56
, pp. 213-225
-
-
Hendriks, Y.M.1
de Jong, A.E.2
Morreau, H.3
-
92
-
-
78650966622
-
Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis
-
Timmermann B, Kerick M, Roehr C, et al. Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS One 2010;5:e15661
-
(2010)
PLoS One
, vol.5
-
-
Timmermann, B.1
Kerick, M.2
Roehr, C.3
-
93
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012;487:330-7
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
-
94
-
-
84932628341
-
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
-
Le DT, Uram JN, Wang H, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med 2015;372:2509-20
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
95
-
-
84907814266
-
Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H)
-
Goldstein J, Tran B, Ensor J, et al. Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H). Ann Oncol 2014:1032-8
-
(2014)
Ann Oncol
, pp. 1032-1038
-
-
Goldstein, J.1
Tran, B.2
Ensor, J.3
-
96
-
-
14544300998
-
Systematic review of microsatellite instability and colorectal cancer prognosis
-
Popat S, Hubner R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 2005;23:609-18
-
(2005)
J Clin Oncol
, vol.23
, pp. 609-618
-
-
Popat, S.1
Hubner, R.2
Houlston, R.S.3
-
97
-
-
0038002279
-
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
-
Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003;349:247-57
-
(2003)
N Engl J Med
, vol.349
, pp. 247-257
-
-
Ribic, C.M.1
Sargent, D.J.2
Moore, M.J.3
-
98
-
-
79958828886
-
DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy
-
Sinicrope FA, Foster NR, Thibodeau SN, et al. DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy. J Natl Cancer Inst 2011;103:863-75
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 863-875
-
-
Sinicrope, F.A.1
Foster, N.R.2
Thibodeau, S.N.3
-
99
-
-
84925678885
-
Systematic review of the predictive effect of MSI status in colorectal cancer patients undergoing 5FU-based chemotherapy
-
Webber EM, Kauffman TL, O'Connor E, et al. Systematic review of the predictive effect of MSI status in colorectal cancer patients undergoing 5FU-based chemotherapy. BMC Cancer 2015;15:156
-
(2015)
BMC Cancer
, vol.15
, pp. 156
-
-
Webber, E.M.1
Kauffman, T.L.2
O'Connor, E.3
-
100
-
-
41349097776
-
Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers
-
Schwitalle Y, Kloor M, Eiermann S, et al. Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers. Gastroenterology 2008;134:988-97
-
(2008)
Gastroenterology
, vol.134
, pp. 988-997
-
-
Schwitalle, Y.1
Kloor, M.2
Eiermann, S.3
-
101
-
-
84864692605
-
Prognostic impact of FoxP3+ regulatory T cells in relation to CD8+ T lymphocyte density in human colon carcinomas
-
Yoon HH, Orrock JM, Foster NR, et al. Prognostic impact of FoxP3+ regulatory T cells in relation to CD8+ T lymphocyte density in human colon carcinomas. PLoS One 2012;7:e42274
-
(2012)
PLoS One
, vol.7
-
-
Yoon, H.H.1
Orrock, J.M.2
Foster, N.R.3
-
102
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006;313:1960-4
-
(2006)
Science
, vol.313
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
-
103
-
-
0001119305
-
hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
-
Leung SY, Yuen ST, Chung LP, et al. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res 1999;59:159-64
-
(1999)
Cancer Res
, vol.59
, pp. 159-164
-
-
Leung, S.Y.1
Yuen, S.T.2
Chung, L.P.3
-
104
-
-
0030061373
-
Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis
-
dos Santos NR, Seruca R, Constância M, et al. Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. Gastroenterology 1996;110:38-44
-
(1996)
Gastroenterology
, vol.110
, pp. 38-44
-
-
dos Santos, N.R.1
Seruca, R.2
Constância, M.3
-
105
-
-
84861613037
-
Microsatellite instability in sporadic gastric cancer: its prognostic role and guidance for 5-FU based chemotherapy after R0 resection
-
An JY, Kim H, Cheong JH, et al. Microsatellite instability in sporadic gastric cancer: its prognostic role and guidance for 5-FU based chemotherapy after R0 resection. Int J Cancer 2012;131:505-11
-
(2012)
Int J Cancer
, vol.131
, pp. 505-511
-
-
An, J.Y.1
Kim, H.2
Cheong, J.H.3
-
106
-
-
79951593439
-
High microsatellite instability predicts good prognosis in intestinal-type gastric cancers
-
Kim H, An JY, Noh SH, et al. High microsatellite instability predicts good prognosis in intestinal-type gastric cancers. J Gastroenterol Hepatol 2011;26:585-92
-
(2011)
J Gastroenterol Hepatol
, vol.26
, pp. 585-592
-
-
Kim, H.1
An, J.Y.2
Noh, S.H.3
-
107
-
-
33644998539
-
Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers
-
Beghelli S, de Manzoni G, Barbi S, et al. Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers. Surgery 2006;139:347-56
-
(2006)
Surgery
, vol.139
, pp. 347-356
-
-
Beghelli, S.1
de Manzoni, G.2
Barbi, S.3
-
108
-
-
85006595371
-
Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization
-
[Epub ahead of print]
-
Mathiak M, Warneke VS, Behrens HM, et al. Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization. Appl Immunohistochem Mol Morphol 2015. [Epub ahead of print]
-
(2015)
Appl Immunohistochem Mol Morphol
-
-
Mathiak, M.1
Warneke, V.S.2
Behrens, H.M.3
-
109
-
-
84866535863
-
Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes
-
Bernal M, Ruiz-Cabello F, Concha A, et al. Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes. Cancer Immunol Immunother 2012;61:1359-71
-
(2012)
Cancer Immunol Immunother
, vol.61
, pp. 1359-1371
-
-
Bernal, M.1
Ruiz-Cabello, F.2
Concha, A.3
-
110
-
-
0030069269
-
Genetic alterations on chromosomes 3 and 9 of esophageal cancer tissues from China
-
Wang L, Li W, Wang X, et al. Genetic alterations on chromosomes 3 and 9 of esophageal cancer tissues from China. Oncogene 1996;12:699-703
-
(1996)
Oncogene
, vol.12
, pp. 699-703
-
-
Wang, L.1
Li, W.2
Wang, X.3
-
111
-
-
0034027697
-
Microsatellite instability in squamous cell carcinomas and dysplasias of the esophagus
-
Kagawa Y, Yoshida K, Hirai T, et al. Microsatellite instability in squamous cell carcinomas and dysplasias of the esophagus. Anticancer Res 2000;20:213-7
-
(2000)
Anticancer Res
, vol.20
, pp. 213-217
-
-
Kagawa, Y.1
Yoshida, K.2
Hirai, T.3
-
112
-
-
15044363628
-
Aberrations in the mismatch repair genes and the clinical impact on oesophageal squamous carcinomas from a high incidence area in South Africa
-
Naidoo R, Ramburan A, Reddi A, et al. Aberrations in the mismatch repair genes and the clinical impact on oesophageal squamous carcinomas from a high incidence area in South Africa. J Clin Pathol 2005;58:281-4
-
(2005)
J Clin Pathol
, vol.58
, pp. 281-284
-
-
Naidoo, R.1
Ramburan, A.2
Reddi, A.3
-
113
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Signatures of mutational processes in human cancer. Nature 2013;500:415-21
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
-
114
-
-
84873186179
-
Deciphering signatures of mutational processes operative in human cancer
-
Alexandrov LB, Nik-Zainal S, Wedge DC, et al. Deciphering signatures of mutational processes operative in human cancer. Cell Rep 2013;3:246-59
-
(2013)
Cell Rep
, vol.3
, pp. 246-259
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
-
115
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 2014;371:2189-99
-
(2014)
N Engl J Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
-
116
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015;348:124-8
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
117
-
-
68149155982
-
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
-
Peggs KS, Quezada SA, Chambers CA, et al. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 2009;206:1717-25
-
(2009)
J Exp Med
, vol.206
, pp. 1717-1725
-
-
Peggs, K.S.1
Quezada, S.A.2
Chambers, C.A.3
-
118
-
-
33749038866
-
Reversal of the TCR stop signal by CTLA-4
-
Schneider H, Downey J, Smith A, et al. Reversal of the TCR stop signal by CTLA-4. Science 2006;313:1972-5
-
(2006)
Science
, vol.313
, pp. 1972-1975
-
-
Schneider, H.1
Downey, J.2
Smith, A.3
-
119
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
Postow MA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med 2015;372:2006-17
-
(2015)
N Engl J Med
, vol.372
, pp. 2006-2017
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
-
120
-
-
0032741283
-
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
-
Gabrilovich DI, Ishida T, Nadaf S, et al. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin Cancer Res 1999;5:2963-70
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2963-2970
-
-
Gabrilovich, D.I.1
Ishida, T.2
Nadaf, S.3
-
121
-
-
77952300540
-
Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival
-
Escudier B, Bellmunt J, Négrier S, et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol 2010;28:2144-50
-
(2010)
J Clin Oncol
, vol.28
, pp. 2144-2150
-
-
Escudier, B.1
Bellmunt, J.2
Négrier, S.3
-
122
-
-
84893502903
-
Sensitizing protective tumor microenvironments to antibody-mediated therapy
-
Pallasch CP, Leskov I, Braun CJ, et al. Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell 2014;156:590-602
-
(2014)
Cell
, vol.156
, pp. 590-602
-
-
Pallasch, C.P.1
Leskov, I.2
Braun, C.J.3
-
123
-
-
18344375283
-
Immunotherapy and chemotherapy-a practical partnership
-
Lake RA, Robinson BW. Immunotherapy and chemotherapy-a practical partnership. Nat Rev Cancer 2005;5:397-405
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 397-405
-
-
Lake, R.A.1
Robinson, B.W.2
-
124
-
-
33846429184
-
Induced sensitization of tumor stroma leads to eradication of established cancer by T cells
-
Zhang B, Bowerman NA, Salama JK, et al. Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. J Exp Med 2007;204:49-55
-
(2007)
J Exp Med
, vol.204
, pp. 49-55
-
-
Zhang, B.1
Bowerman, N.A.2
Salama, J.K.3
-
125
-
-
84893876109
-
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
-
Deng L, Liang H, Burnette B, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest 2014;124:687-95
-
(2014)
J Clin Invest
, vol.124
, pp. 687-695
-
-
Deng, L.1
Liang, H.2
Burnette, B.3
|