Clinicopathologic factors identify sporadic mismatch repair-defective colon cancers

American Journal of Clinical Pathology

Volumn 129, Issue 2, 2008, Pages 238-244

  Halvarsson, Britta ^a   Anderson, Harald ^b   Domanska, Katarina ^b   Lindmark, Gudrun ^a   Nilhert, Mef ^b,c  

^a HELSINGBORG HOSPITAL   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Histopathology; Microsatellite instability; Mismatch repair; Morphology; Tumor infiltrating lymphocyte

Indexed keywords

B RAF KINASE; MISMATCH REPAIR PROTEIN; BRAF PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; CANCER GROWTH; CLINICAL FEATURE; COLON CANCER; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MISMATCH REPAIR; MORPHOLOGICAL TRAIT; MUCINOUS CARCINOMA; NECROSIS; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEX; TUMOR ASSOCIATED LEUKOCYTE; TUMOR DIFFERENTIATION; TUMOR LOCALIZATION; COLON TUMOR; EVALUATION; GENETICS; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY; PREDICTION AND FORECASTING; PROGNOSIS; SEX DIFFERENCE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; COLONIC NEOPLASMS; DNA MISMATCH REPAIR; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTO-ONCOGENE PROTEINS B-RAF; SEX FACTORS;

EID: 40449121314     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/0PP5GDRTXUDVKAWJ     Document Type: Article

References (36)

1. Lengauer C, Kinzler K W, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998;396:643-649.
2. Sjoblom T, Jones S, Wood LD, et al. The consensus coding sequences of human breast and colorectal cancers. Science. 2006;314:268-274.
3. Aaltonen LA, Salovaara R, Kristo P, et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med. 1998;338:1481-1487.
4. Kerber RA, Neklason DW, Samowitz WS, et al. Frequency of familial colon cancer and hereditary nonpolyposis colorectal cancer (Lynch syndrome) in a large population database. Fam Cancer. 2005;4:239-244.
5. Cunningham JM, Christensen ER, Tester DJ, et al. Hypermethylation of the Hmlh1 promoter in colon cancer with microsatellite instability. Cancer Res. 1998;58:3455-3460.
6. Thibodeau SN, French AJ, Cunningham JM, et al. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of Hmlh1. Cancer Res. 1998;58:1713-1718.
7. Lindor NM, Burgart LJ, Leontovich O, et al. Immunohisto-chemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol. 2002;20:1043-1048.
8. Ruszkiewicz A, Bennett G, Moore J, et al. Correlation of mismatch repair genes immunohistochemistry and microsatellite instability status in HNPCC-associated tumours. Pathology. 2002;34:541-547.
9. Domingo E, Laiho P, Ollikainen M, et al. Braf screening as a low-cost effective strategy for simplifying HNPCC genetic testing. J Med Genet. 2004;41:664-668.
10. Renkonen-Sinisalo L, Aarnio M, Mecklin J P, et al. Surveillance improves survival of colorectal cancer in patients with hereditary nonpolyposis colorectal cancer. Cancer Detect Prev. 2000;24:137-142.
11. Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003;349:247-257.
12. Popat S, Hubner R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol. 2005;23:609-618.
13. Benatti P, Gafa R, Barana D, et al. Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res. 2005;11:8332-8340.
14. Lanza G, Gafa R, Santini A, et al. Immunohistochemical test for Mlh1 and Msh2 expression predicts clinical outcome in stage Ii and Iii colorectal cancer patients. J Clin Oncol. 2006;24:2359-2367.
15. Sinicrope FA, Rego RL, Foster N, et al. Microsatellite instability accounts for tumor site-related differences in clinicopathological variables and prognosis in human colon cancers. Am J Gastroenterol. 2006;101:2818-2825.
16. Smyrk TC, Watson P, Kaul K, et al. Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma. Cancer. 2001;91:2417-2422.
17. Ward R, Meagher A, Tomlinson I, et al. Microsatellite instability and the clinicopathological features of sporadic colorectal cancer. Gut. 2001;48:821-829.
18. Young J, Simms LA, Biden KG, et al. Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. Am J Pathol. 2001;159:2107-2116.
19. Greenson JK, Bonner JD, Ben-Yzhak O, et al. Phenotype of microsatellite unstable colorectal carcinomas: well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability. Am J Surg Pathol. 2003;27:563-570.
20. Jass JR. Role of the pathologist in the diagnosis of hereditary non-polyposis colorectal cancer. Dis Markers. 2004;20:215-224.
21. Yearsley M, Hampel H, Lehman A, et al. Histologic features distinguish microsatellite-high from microsatellite-low and microsatellite-stable colorectal carcinomas, but do not differentiate germline mutations from methylation of the Mlh1 promoter. Hum Pathol. 2006;37:831-838.
22. Hamilton SR, Aaltonen LA, eds. Pathology and Genetics of Tumours of the Digestive System. Lyon, France: IARC Press; 2001. World Health Organization Classification of Tumours.
23. Jass JR, Do KA, Simms LA, et al. Morphology of sporadic colorectal cancer with DNA replication errors. Gut. 1998;42:673-679.
24. Jass JR, Ajioka Y, Allen J P, et al. Assessment of invasive growth pattern and lymphocytic infiltration in colorectal cancer. Histopathology. 1996;28:543-548.
25. Alexander J, Watanabe T, Wu TT, et al. Histopathological identification of colon cancer with microsatellite instability. Am J Pathol. 2001;158:527-535.
26. Graham DM, Appelman HD. Crohn's-like lymphocytic reaction and colorectal carcinoma: a potential histologic prognosticator. Mod Pathol. 1990;3:332-335.
27. Shia J, Ellis NA, Paty PB, et al. Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer. Am J Surg Pathol. 2003;27:1407-1417.
28. Halvarsson B, Lindblom A, Rambech E, et al. Microsatellite instability analysis and/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer? Virchows Arch. 2004;444:135-141.
29. Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417:949-954.
30. Rothman K. Modern Epidemiology. Boston, MA: Little, Brown; 1986.
31. Kakar S, Burgart LJ, Thibodeau SN, et al. Frequency of loss of Hmlh1 expression in colorectal carcinoma increases with advancing age. Cancer. 2003;97:1421-1427.
32. Dykes SL, Qui H, Rothenberger DA, et al. Evidence of a preferred molecular pathway in patients with synchronous colorectal cancer. Cancer. 2003;98:48-54.
33. Velayos FS, Lee SH, Qiu H, et al. The mechanism of microsatellite instability is different in synchronous and metachronous colorectal cancer. J Gastrointest Surg. 2005;9:329-335.
34. Michael-Robinson JM, Biemer-Huttmann A, Purdie DM, et al. Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status. Gut. 2001;48:360-366.
35. Kakar S, Aksoy S, Burgart LJ, et al. Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival. Mod Pathol. 2004;17:696-700.
36. Wright CM, Stewart ID. Histopathology and mismatch repair status of 458 consecutive colorectal carcinomas. Am J Surg Pathol. 2003;27:1393-1406.