Functional intestinal bile acid 7α-dehydroxylation by Clostridium scindens associated with protection from Clostridium difficile infection in a gnotobiotic mouse model

Frontiers in Cellular and Infection Microbiology

Volumn 6, Issue DEC, 2016, Pages

  Studer, Nicolas ^a   Desharnais, Lyne ^b   Beutler, Markus ^c   Brugiroux, Sandrine ^c   Terrazos, Miguel A ^a   Menin, Laure ^b   Schürch, Christian M ^a   McCoy, Kathy D ^d   Kuehne, Sarah A ^e   Minton, Nigel P ^e   Stecher, Bärbel ^c   Bernier Latmani, Rizlan ^b   Hapfelmeier, Siegfried ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b EPFL   (Switzerland)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF BERN   (Switzerland)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

7 dehydroxylation; Clostridium difficile; Clostridium difficile infection (CDI); Clostridium scindens; Gnotobiotic mouse model; Gut microbiota; Intestinal infection; Secondary bile acids

Indexed keywords

7ALPHA HYDROXYCHOLESTEROL; CALGRANULIN; CEFOXITIN; CYCLOSERINE; DEOXYCHOLIC ACID; ERYTHROMYCIN; LITHOCHOLIC ACID; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; TAUROCHOLIC ACID; BILE ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; BILE ACID METABOLISM; CLOSTRIDIUM; CLOSTRIDIUM DIFFICILE INFECTION; CLOSTRIDIUM SCINDENS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GERMINATION; GNOTOBIOTICS; HISTOPATHOLOGY; INTESTINE FLORA; LIPID ABSORPTION; MICROBIAL COLONIZATION; MOUSE; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; PHYLOGENETIC TREE; PHYSIOLOGICAL PROCESS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VEGETATIVE GROWTH; ANIMAL; BIOTRANSFORMATION; CLOSTRIDIUM INFECTIONS; DISEASE MODEL; GERMFREE ANIMAL; INTESTINE; METABOLISM; MICROBIOLOGY;

ANIMALS; BILE ACIDS AND SALTS; BIOTRANSFORMATION; CLOSTRIDIUM; CLOSTRIDIUM INFECTIONS; DISEASE MODELS, ANIMAL; GERM-FREE LIFE; INTESTINES; MICE;

EID: 85009754141     PISSN: None     EISSN: 22352988     Source Type: Journal    
DOI: 10.3389/fcimb.2016.00191     Document Type: Article

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