Comorbidity of Allergic and Autoimmune Diseases Among Patients With ADHD: A Nationwide Population-Based Study

Journal of Attention Disorders

Volumn 21, Issue 3, 2017, Pages 219-227

  Chen, Mu Hong ^a   Su, Tung Ping ^a,b   Chen, Ying Sheue ^a   Hsu, Ju Wei ^a   Huang, Kai Lin ^a,b   Chang, Wen Han ^a   Chen, Tzeng Ji ^a,b   Bai, Ya Mei ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

ADHD; allergy; autoimmune diseases; comorbidity

Indexed keywords

ADOLESCENT; ATTENTION DEFICIT DISORDER; AUTOIMMUNE DISEASE; CHILD; COMORBIDITY; COMPLICATION; FEMALE; HUMAN; HYPERSENSITIVITY; MALE; ODDS RATIO; PRESCHOOL CHILD; PREVALENCE; RISK FACTOR; TAIWAN;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; AUTOIMMUNE DISEASES; CHILD; CHILD, PRESCHOOL; COMORBIDITY; FEMALE; HUMANS; HYPERSENSITIVITY; MALE; ODDS RATIO; PREVALENCE; RISK FACTORS; TAIWAN;

EID: 85008700520     PISSN: 10870547     EISSN: 15571246     Source Type: Journal    
DOI: 10.1177/1087054712474686     Document Type: Article

References (68)

1. Agrawal D. K., Bharadwaj A., (2005). Allergic airway inflammation. Current Allergy & Asthma Reports, 5, 142-148.
2. Atreya R., Neurath M. F., (2005). Involvement of IL-6 in the pathogenesis of inflammatory bowel disease and colon cancer. Clinical Reviews in Allergy & Immunology, 28, 187-196.
3. Aureli A., Sebastiani P., Del Beato T., Marimpietri A., Melillo V., Sechi E., Di Loreto S., (2008). Investigation on the possible relationship existing between the HLA-DR gene and attention deficit hyperactivity disorder and/or mental retardation. International Journal of Immunopathology and Pharmacology, 21, 985-991.
4. Banerjee J., Bhojani S., Emcy N., (2011). Co-existence of ADHD, autoimmune hypothyroidism and pituitary macroadenoma presenting in a behaviour clinic: A case report and brief review of the literature. Journal of Pediatric Endocrinology and Metabolism, 24, 229-231.
5. Belfer M. L., (2008). Child and adolescent mental disorders: The magnitude of the problem across the globe. Journal of Child Psychology and Psychiatry and Allied Disciplines, 49, 226-236.
6. Bieber T., (2008). Atopic dermatitis. New England Journal of Medicine, 358, 1483-1494.
7. Biederman J., Milberger S., Faraone S. V., Guite J., Warburton R., (1994). Associations between childhood asthma and ADHD: Issues of psychiatric comorbidity and familiality. Journal of the American Academy of Child & Adolescent Psychiatry, 33, 842-848.
8. Bilenberg N., Hougaard D., Norgaard-Pedersen B., Nordenbæk C. M., Olsen J., (2011). Twin study on transplacental-acquired antibodies and attention deficit/hyperactivity disorder: A pilot study. Journal of Neuroimmunology, 236, 72-75.
9. Blackman J. A., Gurka M. J., (2007). Developmental and behavioral comorbidities of asthma in children. Journal of Developmental & Behavioral Pediatrics, 28, 92-99.
10. Brawley A., Silverman B., Kearney S., Guanzon D., Owens M., Bennett H., Schneider A., (2004). Allergic rhinitis in children with attention-deficit/hyperactivity disorder. Annals of Allergy, Asthma & Immunology, 92, 663-667.
11. Brent G. A., (2008). Clinical practice. Graves’ disease. New England Journal of Medicine, 358, 2594-2605.
12. Bujanover S., Levy Y., Katz M., Leitner Y., Vinograd I., Shoenfeld Y., (2003). Lack of association between anti-phospholipid antibodies (APLA) and attention deficit/hyperactivity disorder (ADHD) in children. Clinical and Developmental Immunology, 10, 105-109.
13. Cakaloz B., Akay A. P., Bober E., Yulug B., (2011). Thyroid function and oppositional defiant disorder: More than a coincidence in prepubertal boys with attention-deficit hyperactivity disorder? Journal of Neuropsychiatry and Clinical Neurosciences, 23, E9-E10.
14. Christakou A., Murphy C. M., Chantiluke K., Cubillo A. I., Smith A. B., Giampietro V., Rubia K., (2013). Disorder-specific functional abnormalities during sustained attention in youth with attention deficit hyperactivity disorder (ADHD) and with autism. Molecular Psychiatry, 18, 236-244. doi: 10.1038/mp.2011.185.
15. Drtilkova I., Sery O., Theiner P., Uhrova A., Zackova M., Balastikova B., Znojil V., (2008). Clinical and molecular-genetic markers of ADHD in children. Neuroendocrinology Letters, 29, 320-327.
16. Fasmer O. B., Halmoy A., Eagan T. M., Oedegaard K. J., Haavik J., (2011). Adult attention deficit hyperactivity disorder is associated with asthma. BMC Psychiatry, 11, 128.
17. Gabbay M. A., Sato M. N., Duarte A. J., Dib S. A., (2012). Serum titres of anti-glutamic acid decarboxylase-65 and anti-IA-2 autoantibodies are associated with different immunoregulatory milieu in newly diagnosed type 1 diabetes patients. Clinical & Experimental Immunology, 168, 60-67.
18. Gaitens T., Kaplan B. J., Freigang B., (1998). Absence of an association between IgE-mediated atopic responsiveness and ADHD symptomatology. Journal of Child Psychology and Psychiatry, 39, 427-431.
19. Ghassabian A., Bongers-Schokking J. J., de Rijke Y. B., van Mil N., Jaddoe V. W., de Muinck Keizer-Schrama S. M., Tiemeier H., (2012). Maternal thyroid autoimmunity during pregnancy and the risk of attention deficit/hyperactivity problems in children: The Generation R Study. Thyroid, 22, 178-186.
20. Huang F. Y., Chang T. Y., Chen M. R., Hsu C. H., Lee H. C., Lin S. P., Lee Y. J., (2007). Genetic variations of HLA-DRB1 and susceptibility to Kawasaki disease in Taiwanese children. Human Immunology, 68, 69-74.
21. IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. (2005). Inflammatory bowel disease in children and adolescents: Recommendations for diagnosis: The Porto criteria. Journal of Pediatric Gastroenterology and Nutrition, 41, 1-7.
22. Ishiuji Y., Coghill R. C., Patel T. S., Oshiro Y., Kraft R. A., Yosipovitch G., (2009). Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis. British Journal of Dermatology, 161, 1072-1080.
23. Kira J., (2002). Atopy and neural damage. Internal Medicine, 41, 169-174.
24. Lemiere J., Danckaerts M., Van Hecke W., Mehta M. A., Peeters R., Sunaert S., Sonuga-Barke E., (2012). Brain activation to cues predicting inescapable delay in adolescent attention deficit/hyperactivity disorder: An fMRI pilot study. Brain Research, 1450, 57-66.
25. Lin G. M., Chen Y. J., Kuo D. J., Jaiteh L. E., Wu Y. C., Lo T. S., Li Y. H., (2013). Cancer incidence in patients with schizophrenia or bipolar disorder: A nationwide population-based study in Taiwan, 1997-2009. Schizophrenia Bulletin, 39, 407-416. doi: 10.1093/schbul/sbr162.
26. Mansour M., Cheema G. S., Naguwa S. M., Greenspan A., Borchers A. T., Keen C. L., Gershwin M. E., (2007). Ankylosing spondylitis: A contemporary perspective on diagnosis and treatment. Seminars in Arthritis and Rheumatism, 36, 210-223.
27. Marshall P., (1989). Attention deficit disorder and allergy: A neurochemical model of the relation between the illnesses. Psychological Bulletin, 106, 434-446.
28. Masuda H., Iwai S., Tanaka T., Hayakawa S., (1995). Expression of IL-8, TNF-alpha and IFN-gamma m-RNA in ulcerative colitis, particularly in patients with inactive phase. Journal of Clinical & Laboratory Immunology, 46, 111-123.
29. Matsubara T., (1991). Interleukin 6 activities and tumor necrosis factor-alpha levels in serum of patients with Kawasaki disease. Arerugi, 40, 147-154.
30. Matsushita S., Fujisao S., Nishimura Y., (1996). Molecular mechanisms underlying HLA-DR-associated susceptibility to autoimmunity. International Journal of Cardiology, 54, S81-S90.
31. Mittleman B. B., Castellanos F. X., Jacobsen L. K., Rapoport J. L., Swedo S. E., Shearer G. M., (1997). Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease. Journal of Immunology, 159, 2994-2999.
32. Mogensen N., Larsson H., Lundholm C., Almqvist C., (2011). Association between childhood asthma and ADHD symptoms in adolescence: A prospective population-based twin study. Allergy, 66, 1224-1230.
33. Niederhofer H., (2011). Association of attention-deficit/hyperactivity disorder and celiac disease: A brief report. Primary Care Companion for CNS Disorders, 13, 3.
34. Noble J. A., Valdes A. M., (2011). Genetics of the HLA region in the prediction of type 1 diabetes. Current Diabetes Reports, 11, 533-542.
35. Oades R. D., Dauvermann M. R., Schimmelmann B. G., Schwarz M. J., Myint A. M., (2010). Attention-deficit hyperactivity disorder (ADHD) and glial integrity: S100B, cytokines and kynurenine metabolism—Effects of medication. Behavioral and Brain Functions, 6, 29.
36. Odell J. D., Warren R. P., Warren W. L., Burger R. A., Maciulis A., (1997). Association of genes within the major histocompatibility complex with attention deficit hyperactivity disorder. Neuropsychobiology, 35, 181-186.
37. Ogdie M. N., Macphie I. L., Minassian S. L., Yang M., Fisher S. E., Francks C., (2003). A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: Suggestive linkage on 17p11. American Journal of Human Genetics, 72, 1268-1279.
38. Onouchi Y., Ozaki K., Burns J. C., Shimizu C., Terai M., Hamada H., U.S. Kawasaki Disease Genetics Consortium. (2012). A genome-wide association study identifies three new risk loci for Kawasaki disease. Nature genetics, 44, 517-521.
39. Pearce E. N., Farwell A. P., Braverman L. E., (2003). Thyroiditis. New England Journal of Medicine, 348, 2646-2655.
40. Peterson B. S., Leckman J. F., Tucker D., Scahill L., Staib L., Zhang H., Lombroso P., (2000). Preliminary findings of antistreptococcal antibody titers and basal ganglia volumes in tic, obsessive-compulsive, and attention deficit/hyperactivity disorders. Archives of General Psychiatry, 57, 364-372.
41. Poupon R., (2003). Autoimmune overlapping syndromes. Clinical Liver Disease, 7, 865-878.
42. Raison C. L., Capuron L., Miller A. H., (2006). Cytokines sing the blues: Inflammation and the pathogenesis of depression. Trends in Immunology, 27, 24-31.
43. Rappley M. D., (2005). Clinical practice. Attention deficit-hyperactivity disorder. New England Journal of Medicine, 352, 165-173.
44. Ravikumara M., Sandhu B. K., (2006). Epidemiology of inflammatory bowel diseases in childhood. Indian Journal of Pediatrics, 73, 717-721.
45. Ribasés M., Hervás A., Ramos-Quiroga J. A., Bosch R., Bielsa A., Gastaminza X., Bayés M., (2008). Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. Biological Psychiatry, 63, 935-945.
46. Romanos M., Gerlach M., Warnke A., Schmitt J., (2010). Association of attention-deficit/hyperactivity disorder and atopic eczema modified by sleep disturbance in a large population-based sample. Journal of Epidemiology & Community Health, 64, 269-273.
47. Rosenkranz M. A., Busse W. W., Johnstone T., Swenson C. A., Crisafi G. M., Jackson M. M., Davidson R. J., (2005). Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation. Proceedings of the National Academy of Sciences of the United States of America, 102, 13319-13324.
48. Rout U. K., Mungan N. K., Dhossche D. M., (2012). Presence of GAD65 autoantibodies in the serum of children with autism or ADHD. European Child & Adolescent Psychiatry, 21, 141-147.
49. Sanchez-Carpintero R., Albesa S. A., Crespo N., Villoslada P., Narbona J., (2009). A preliminary study of the frequency of anti-basal ganglia antibodies and streptococcal infection in attention deficit/hyperactivity disorder. Journal of Neurology, 256, 1103-1108.
50. Sawczenko A., Sandhu B. K., (2003). Presenting features of inflammatory bowel disease in Great Britain and Ireland. Archives of Disease in Childhood, 88, 995-1000.
51. Schmitt J., Buske-Kirschbaum A., Roessner V., (2010). Is atopic disease a risk factor for attention-deficit/hyperactivity disorder? A systematic review. Allergy, 65, 1506-1524.
52. Schmitt J., Romanos M., Schmitt N. M., Meurer M., Kirch W., (2009). Atopic eczema and attention-deficit/hyperactivity disorder in a population-based sample of children and adolescents. Journal of the American Medical Association, 301, 724-726.
53. Secnik K., Swensen A., Lage M. J., (2005). Comorbidities and costs of adult patients diagnosed with attention-deficit hyperactivity disorder. Pharmacoeconomics, 23, 93-102.
54. Skanes V. M., Barnard J., Farid N., Marshall W. H., Murphy L., Rideout D., Larsen B., (1986). Class III alleles and high-risk MHC haplotypes in type I diabetes mellitus, Graves’ disease and Hashimoto’s thyroiditis. Molecular Biology & Medicine, 3, 143-157.
55. Smalley S. L., McGough J. J., Moilanen I. K., Loo S. K., Taanila A., Ebeling H., Järvelin M. R., (2007). Prevalence and psychiatric comorbidity of attention-deficit/hyperactivity disorder in an adolescent Finnish population. Journal of the American Academy of Child & Adolescent Psychiatry, 46, 1575-1583.
56. Stein M. A., Weiss R. E., (2003). Thyroid function tests and neurocognitive functioning in children referred for attention deficit/hyperactivity disorder. Psychoneuroendocrinology, 28, 304-316.
57. Sun L., Cao Q., Long X., Sui M., Cao X., Zhu C., Wang Y., (2012). Abnormal functional connectivity between the anterior cingulate and the default mode network in drug-naive boys with attention deficit hyperactivity disorder. Psychiatry Research, 201, 120-127.
58. Swanson J. M., Sergeant J. A., Taylor E., Sonuga-Barke E. J., Jensen P. S., Cantwell D. P., (1998). Attention-deficit hyperactivity disorder and hyperkinetic disorder. Lancet, 351, 429-433.
59. Tacke C. E., Haverman L., Berk B. M., van Rossum M. A., Kuipers I. M., Grootenhuis M. A., Kuijpers T. W., (2012). Quality of life and behavioral functioning in Dutch children with a history of Kawasaki disease. Journal of Pediatrics, 161, 314-319.e1.
60. Taurines R., Schmitt J., Renner T., Conner A. C., Warnke A., Romanos M., (2010). Developmental comorbidity in attention-deficit/hyperactivity disorder. Attention Deficit and Hyperactivity Disorder, 2, 267-289.
61. Umehara Y., Kudo M., Nakaoka R., Kawasaki T., Shiomi M., (2006). Serum proinflammatory cytokines and adhesion molecules in ulcerative colitis. Hepatogastroenterology, 53, 879-882.
62. Valentine J., Rossi E., O’Leary P., Parry T. S., Kurinczuk J. J., Sly P., (1997). Thyroid function in a population of children with attention deficit hyperactivity disorder. Journal of Paediatrics and Child Health, 33, 117-120.
63. Van Jaarsveld C. H., Otten H. G., Jacobs J. W., Kruize A. A., Brus H. L., Bijlsma J. W., (1998). Association of HLA-DR with susceptibility to and clinical expression of rheumatoid arthritis: Re-evaluation by means of genomic tissue typing. British Journal of Rheumatology, 37, 411-416.
64. Wittchen H. U., Jacobi F., (2005). Size and burden of mental disorders in Europe: A critical review and appraisal of 27 studies. European Neuropsychopharmacology, 15, 357-376.
65. Wu C. S., Wang S. C., Cheng Y. C., Gau S. S., (2011). Association of cerebrovascular events with antidepressant use: A case-crossover study. American Journal of Psychiatry, 168, 511-521.
66. Yamashita H., Awata T., Kawasaki E., Ikegami H., Tanaka S., Maruyama T., Japanese Study Group on Type 1 Diabetes Genetics. (2011). Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes. Diabetes/Metabolism Research and Reviews, 27, 844-848.
67. Yarlagadda A., Alfson E., Clayton A. H., (2009). The blood brain barrier and the role of cytokines in neuropsychiatry. Psychiatry (Edgmont), 6, 18-22.
68. Ziporen L., Shoenfeld Y., Levy Y., Korczyn A. D., (1997). Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies. A mouse model. Journal of Clinical Investigation, 100, 613-619.