Disorder-specific functional abnormalities during sustained attention in youth with Attention Deficit Hyperactivity Disorder (ADHD) and with Autism

Molecular Psychiatry

Volumn 18, Issue 2, 2013, Pages 236-244

  Christakou, A ^a,b   Murphy, C M ^a   Chantiluke, K ^a   Cubillo, A I ^a   Smith, A B ^a   Giampietro, V ^a   Daly, E ^a   Ecker, C ^a   Robertson, D ^a   Murphy, D G ^a   Rubia, K ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

ADHD; ASD; attention; dorsolateral prefrontal cortex; fMRI

Indexed keywords

ADOLESCENT; ARTICLE; ATTENTION; ATTENTION DEFICIT DISORDER; AUTISM; BRAIN FUNCTION; BRAIN REGION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INTELLIGENCE QUOTIENT; MALE; PARIETAL CORTEX; PRECUNEUS; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHOOL CHILD; STRIATE CORTEX; TASK PERFORMANCE; THALAMUS;

ANALYSIS OF VARIANCE; ATTENTION; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; AUTISTIC DISORDER; BRAIN MAPPING; CASE-CONTROL STUDIES; CEREBRAL CORTEX; CHILD; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MOVEMENT; NEUROPSYCHOLOGICAL TESTS; OXYGEN; PHOTIC STIMULATION; PSYCHOMOTOR PERFORMANCE; QUESTIONNAIRES; REACTION TIME;

EID: 84873055806     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2011.185     Document Type: Article

References (69)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington DC, 2000.
2. World Health Organisation. The ICD-10 classification of mental and behavioural disorders. In: World Health Organisation (ed): Clinical Descriptions and Diagnostic Guidelines. World Health Organisation: Geneva, 1994.
3. Leyfer OT, Folstein SE, Bacalman S, Davis NO, Dinh E, Morgan J et al. Comorbid psychiatric disorders in children with autism: Interview development and rates of disorders. J Autism Dev Disord 2006; 36: 849-861.
4. Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G. Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a populationderived sample. J Am Acad Child Adolesc Psychiatry 2008; 47: 921-929.
5. Sturm H, Fernell E, Gillberg C. Autism spectrum disorders in children with normal intellectual levels: Associated impairments and subgroup. Dev Med Child Neurol 2004; 46: 444-447.
6. Willcutt EG, Doyle AE, Nigg JT, Faraone SV, Pennington BF. Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review. Biol Psychiatry 2005; 57: 1336-1346.
7. Rubia K. 'Cool' inferior fronto-striatal dysfunction in Attention Deficit Hyperactivity Disorder (ADHD) versus 'hot' ventromedial orbitofronto-limbic dysfunction in conduct disorder: A review. Biol Psychiatry 2011; 69: E69-e87.
8. Corbett BA, Constantine LJ. Autism and attention deficit hyperactivity disorder: Assessing attention and response control with the Integrated Visual and Auditory Continuous Performance Test. Child Neuropsychol 2006; 12: 335-348.
9. Corbett BA, Constantine LJ, Hendren R, Rocke D, Ozonoff S. Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Res 2009; 166: 210-222.
10. Garretson HB, Fein D, Waterhouse L. Sustained attention in children with autism. J Autism Dev Disord 1990; 20: 101-114.
11. Schatz AM, Weimer AK, Trauner DA. Brief report Attention differences in Asperger syndrome. J Autism Dev Disord 2002; 32: 333-336.
12. Johnson KA, Robertson IH, Kelly SP, Silk TJ, Barry E, Dáibhis A et al. Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention. Neuropsychologia 2007; 45: 2234-2245.
13. Parasuraman R, Warm JS, See JE. Brain systems of vigilance. In: Parasuraman R (ed). The Attentive Brain. MIT Press: Cambridge, MA, 1998, pp 221-256.
14. Warm JS. An introduction to vigilance. In:Warm JS (ed). Sustained Attention in Human Performance. Wiley: Chichester, 1984, pp 1-14.
15. Sergeant JA. A theory of attention: An information processing perspective. Attention, memory, and executive function. In: Reid LG, Krasnegor NA (eds). Attention, Memory, and Executive function. Paul H Brookes Publishing: Baltimore, MD, 1996, pp 57-69.
16. Rubia K, Halari R, Cubillo A, Mohammad M, Taylor E. Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-nai?ve children with ADHD during a Rewarded Continuous Performance Task. Neuropharmacology 2009; 57: 640-652.
17. Rubia K, Smith A, Halari R, Matukura F, Mohammad M, Taylor E et al. Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure Conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure Attention-Deficit/Hyperactivity Disorder during sustained attention. Am J Psychiatry 2009; 166: 83-94.
18. Cubillo A, Halari R, Smith A, Giampietro V, Taylor E, Rubia K. Fronto-cortical and fronto-subcortical brain abnormalities in children and adults with ADHD: A review and evidence for fronto-striatal dysfunctions in adults with ADHD followed up from childhood during motivation and attention. Cortex 2012 (in press); doi:10.1016/j.cortex.2011.04.007.
19. Allen G, Courchesne E. Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: An fMRI study of autism. Am J Psychiatry 2003; 160: 262-273.
20. Belmonte MK, Yurgelun-Todd DA. Functional anatomy of impaired selective attention and compensatory processing in autism. Brain res Cogn brain res 2003; 2003-17: 651-664.
21. Gomot M, Bernard FA, Davis MH, Belmonte MK, Ashwin C, Bullmore ET et al. Change detection in children with autism: An auditory event-related fMRI study. Neuroimage 2006; 29: 475-484.
22. Shafritz KM, Dichter GS, Baranek GT, Belger A. The neural circuitry mediating shifts in behavioral response and cognitive set in autism. Biol Psychiatry 2008; 63: 974-980.
23. Schmitz N, Rubia K, Daly E, Smith A, Williams S, Murphy D. Neural correlates of executive function in Autistic Spectrum Disorders. Biol Psychiatry 2006; 59: 7-16.
24. Silk TJ, Rinehart N, Bradshaw JL, Tonge B, Egan G, O'Boyle MW et al. Visuospatial processing and the function of prefrontalparietal networks in autism spectrum disorders: A functional MRI study. Am J Psychiatry 2006; 163: 1440-U1443.
25. Brieber S, Neufang S, Bruning N, Kamp-Becker I, Remschmidt H, Herpertz-Dahlmann B et al. Structural brain abnormalities in adolescents with autism spectrum disorder and patients with attention deficit/hyperactivity disorder. J Child Psychol Psychiatry 2007; 48: 1251-1258.
26. Voisin J, Bidet-Caulet A, Bertrand O, Fonlupt P. Listening in silence activates auditory areas: A functional magnetic resonance imaging study. J Neuroscience 2006; 26: 273-278.
27. Smith A, Halari R, Giampietro V, Brammer M, Rubia K. Developmental effects of reward on sustained attention networks. Neuroimage 2011; 56: 1693-1704.
28. Rubia K, Cubillo A, Smith AB, Woolley J, Heyman I, Brammer MJ. Disorder-specific dysfunction in right inferior prefrontal cortex during two inhibition tasks in boys with attention-deficit hyperactivity disorder compared to boys with obsessive-compulsive disorder. Hum Brain Mapp 2010; 31: 287-299.
29. Rubia K, Cubillo A, Woolley J, Brammer MJ, Smith AB. Disorderspecific dysfunctions in patients with Attention-Deficit/Hyperactivity Disorder compared to patients with Obsessive-compulsive disorder during interference inhibition and attention allocation. Hum Brain Mapp 2011; 32: 601-611.
30. Rubia K, Halari R, Smith AB, Mohammad M, Scott S, Brammer MJ. Shared and disorder-specific prefrontal abnormalities in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure CD during interference inhibition and attention allocation. J Child Psychol Psychiatry 2009; 50: 669-678.
31. Oldfield RC. The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 1971; 9: 97-113.
32. Goodman R. The strengths and difficulties questionnaire: A research note. J Child Psychol Psychiatry Allied Disciplines 1997; 38: 581-586.
33. Conners CK, Sitarenios G, Parker JDA, Epstein JN. Revision and restandardization of the Conners Teacher Rating Scale (CTRS-R): Factor structure, reliability, and criterion validity. J Abnormal Child Psychol 1998; 26: 279-291.
34. Lord C, Rutter M, Lecouteur A. Autism diagnostic interviewrevised - a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994; 24: 659-685.
35. Lord C, Rutter M, Goode S, Heemsbergen J, Jordan H, Mawhood L et al. Autism diagnostic observation schedule - a standardized observation of communicative and social-behavior. J Autism Dev Disord 1989; 19: 185-212.
36. Rutter M, Bailey L, Lord C (eds) Social Communication Question. Western Psychological Services: Los Angeles, USA, 2003.
37. Wechsler D. Wechsler Abbreviated Scale of Intelligence. The Psychological Corporation: San Antonio Texas, 1999.
38. Drummond SP, Bischoff-Grethe A, Dinges DF, Ayalon L, Mednick SC, Meloy MJ. The neural basis of the psychomotor vigilance task. Sleep 2005; 28: 1059-1068.
39. Rubia K, Overmeyer S, Taylor E, Brammer M, Williams S, Simmons A et al. Prefrontal involvement in 00temporal bridging00 and timing movement. Neuropsychologia 1998; 36: 1283-1293.
40. Miyake Y, Onishi Y, Poppel E. Two types of anticipation in synchronization tapping. Acta Neurobiol Experimentalis 2004; 64: 415-426.
41. Brammer MJ, Bullmore ET, Simmons A, Williams SC, Grasby PM, Howard RJ et al. Generic brain activation mapping in functional magnetic resonance imaging: A nonparametric approach. Magn Reson Imaging 1997; 15: 763-770.
42. Bullmore ET, Suckling J, Overmeyer S, Rabe-Hesketh S, Taylor E, Brammer MJ. Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. IEEE Trans Med Imaging 1999; 18: 32-42.
43. Bullmore E, Long C, Suckling J, Fadili J, Calvert G, Zelaya F et al. Colored noise and computational inference in neurophysiological (fMRI) time series analysis: Resampling methods in time and wavelet domains. Hum Brain Mapp 2001; 12: 61-78.
44. Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Brain. Thieme: New York, 1988.
45. Rubia K, Smith A, Brammer M, Taylor E. Performance of children with Attention Deficit Hyperactivity Disorder (ADHD) on a test battery for impulsiveness. Child Neuropsychol 2007; 30: 659-695.
46. Klein C, Wendling K, Huettner P, Ruder H, Peper M. Intra-subject variability in attention-deficit hyperactivity disorder. Biol Psychiatry 2006; 60: 1088-1097.
47. Rubia K, Halari R, Christakou A, Taylor E. Impulsiveness as a timing disturbance: Neurocognitive abnormalities in attentiondeficit hyperactivity disorder during temporal processes and normalization with methylphenidate. Philos Trans R Soc Lond B Biol Sci 2009; 364: 1919-1931.
48. Rubia K, Noorloos J, Smith A, Gunning B, Sergeant J. Motor timing deficits in community and clinical boys with hyperactive behavior: The effect of methylphenidate on motor timing. J Abnormal Child Psychol 2003; 31: 301-313.
49. Rommelse NNJ, Franke B, Geurts HM, Hartman CA, Buitelaar JK. Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. European Child Adoles Psychiatry 2010; 19: 281-295.
50. Rommelse NNJ, Geurts HM, Franke B, Buitelaar JK, Hartman CA. A review on cognitive and brain endophenotypes that may be common in autism spectrum disorder and attention-deficit/hyperactivity disorder and facilitate the search for pleiotropic genes. Neurosci Biobehav Rev 2011; 35: 1363-1396.
51. Cubillo A, Halari R, Giampietro V, Taylor E, Rubia K. Frontostriatal hypo-activation during interference inhibition and attention allocation in a group of grown up children with ADHD with persistent hyperactive/inattentive behaviours in adulthood. Hum Brain Mapp 2011; 193: 17-27.
52. Stevens MC, Pearlson GD, Kiehl KA. An FMRI auditory oddball study of combined-subtype attention deficit hyperactivity disorder. Am J Psychiatry 2007; 164: 1737-1749.
53. Dickstein SG, Bannon K, Castellanos FX, Milham MP. The neural correlates of attention deficit hyperactivity disorder: An ALE metaanalysis. J Child Psychol Psychiatry 2006; 47: 1051-1062.
54. Stigler KA, McDonald BC, Anand A, Saykin AJ, McDougle CJ. Structural and functional magnetic resonance imaging of autism spectrum disorders. Brain Res 2011; 1380: 146-161.
55. Hallahan B, Daly EM, McAlonan G, Loth E, Toal F, O'Brien F et al. Brain morphometry volume in autistic spectrum disorder: A magnetic resonance imaging study of adults. Psychol Med 2009; 39: 337-346.
56. Toal F, Daly EM, Page L, Deeley Q, Hallahan B, Bloemen O. Clinical and anatomical heterogeneity in autistic spectrum disorder: A structural MRI study. Psychol Med 2010; 40: 1171-1181.
57. Deeley Q, Daly E, Surguladze S, Tunstall N, Mezey G, Beer D et al. Facial emotion processing in criminal psychopathy - Preliminary functional magnetic resonance imaging study. Br J Psychiatry 2006; 189: 533-539.
58. Hazlett HC, Poe MD, Gerig G, Smith RG, Piven J. Cortical Gray and White Brain Tissue Volume in Adolescents and Adults with Autism. Biol Psychiatry 2006; 59: 1-6.
59. Minshew NJ, Williams DL. The new neurobiology of autism. Archives Neurol 2007; 64: 945-950.
60. Weissman DH, Roberts KC, Visscher KM, Woldorff MG. The neural bases of momentary lapses in attention. Nat Neurosci 2006; 9: 971-978.
61. Broyd SJ, Demanuele C, Debener S, Helps SK, James CJ, Sonuga-Barke EJS. Default-mode brain dysfunction in mental disorders: A systematic review. Neurosci Biobehav Rev 2009; 33: 279-296.
62. Cherkassky VL, Kana RK, Keller TA, Just MA. Functional connectivity in a baseline resting-state network in autism. Neuroreport 2006; 17: 1687-1690.
63. Konrad K, Eickhoff SB. Is the ADHD Brain Wired Differently? A Review on Structural and Functional Connectivity in Attention Deficit Hyperactivity Disorder. Hum Brain Mapp 2010; 31: 904-916.
64. Sonuga-Barke EJS, Castellanos FX. Spontaneous attentional fluctuations in impaired states and pathological conditions: A neurobiological hypothesis. Neurosci and Biobehav Rev 2007; 31: 977-986.
65. Tamm L, Menon V, Reiss AL. Parietal attentional system aberrations during target detection in adolescents with attention deficit hyperactivity disorder: Event-related fMRI evidence. Am J Psychiatry 2006; 163: 1033-1043.
66. Geurts HM, Vertie S, Oosterlaan J, Roeyers H, Sergeant JA. How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? J Child Psychol Psychiatry 2004; 45: 836-854.
67. Yeo BTT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M et al. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol 2011; 106: 1125-1165.
68. Nakao T, Radua J, Rubia K, Mataix-Cols D. Gray matter volume abnormalities in ADHD and the effects of stimulant medication: Voxel-based meta-analysis. Am J Psychiatry 2011; 168: 1154-1163.
69. Murphy SE. Using Functional Neuroimaging to Investigate the Mechanisms of Action of Selective Serotonin Reuptake Inhibitors (SSRIs). Curr Pharm Des 2010; 16: 1990-1997.