Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies a mouse model

Journal of Clinical Investigation

Volumn 100, Issue 3, 1997, Pages 613-619

  Ziporen, Lea ^a,b   Shoenfeld, Yehuda ^a   Levy, Yair ^a   Korczyn, Amos D ^b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Anticardiolipin antibodies; Antiphospholipid syndrome; Autoimmune experimental model; Autoimmunity; Behavioral defects

Indexed keywords

AUTOANTIBODY; CARDIOLIPIN ANTIBODY; PHOSPHOLIPID ANTIBODY;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; BEHAVIOR DISORDER; CONTROLLED STUDY; ETIOLOGY; EXPERIMENTAL MODEL; HYPERACTIVITY; MOTOR DYSFUNCTION; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL;

EID: 0030818836     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119572     Document Type: Article

References (53)

1. Hughes, G.R.V. 1993. The antiphospholipid syndrome: ten years on. Lancet. 342:341-344.
2. Asherson, R.A., R. Cerrera, J.C. Piette, and Y. Shoenfeld. 1996. The Antiphospholipid Syndrome. CRC Press, Inc., Boca Raton, FL. 331 pp.
3. Alarcon Segovia, D., M. Delez, C.V. Oria, J. Sanchez-Guerrero, L. Gomez-Pacheco, J. Cabiedes, L. Fernandez, and S.P. De Leon. 1990. Antiphospholipid antibodies and antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients. Medicine (Baltimore). 68:353-365.
4. Hojnik, M., J. George, L. Ziporen, and Y. Shoenfeld. 1996. Heart valve involvement (Libman-Sack endocarditis) in the antiphospholipid syndrome. Circulation. 93:1579-1587.
5. Harris, E.N., A.E. Gharavi, R.A. Asherson, M.L. Boey, and G.R. Huges. 1984. Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. Clin. Exp. Rheumatol. 2:47-51.
6. Asherson, R.A., D. Merchey, G. Phillips, N. Sheehan, A.E. Gharavi, E.N. Harris, and G.R.V. Hughes. 1987. Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann. Rheum. Dis. 46:605-611.
7. Levine, S.R., M.J. Deegan, N. Futreu, and K.M.A. Welch. 1990. Cerebrovascular and neurologic disease associated with antiphospholipid antibodies: 48 cases. Neurology. 40:1181-1189.
8. Brey, R.L., A.E. Gharavi, and M.D. Lockshin. 1993. Neurologic complications of antiphospholipid antibodies. Rheum. Dis. Clin. North Am. 19:833-850.
9. Toubi, E., M.A. Khamashta, A. Panarra, and G.R.V. Hughes. 1995. Association of antiphospholipid antibodies with central nervous system disease in systemic lupus erythematosus. Am. J. Med. 99:397-401.
10. Ginsburg, K.S., H.M. Liang, L. Newcomer, S.Z. Goldhaber, P.H. Schur, C.H. Hennekans, and M.J. Stampfer. 1992. Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. Ann. Intern. Med. 117:997-1002.
11. Inzelberg, R., and A.D. Korczyn. 1989. Lupus anticoagulant and late onset seizures. Acta Neurol. Scand. 79:114-118.
12. Herranz, M.T., G. Rivier, M.A. Khamashta, K.U. Blaser, and G.R.V. Hughes. 1994. Association between antiphospholipid antibodies and epilepsy in patients with SLE. Arthritis Rheum. 37:569-571.
13. Digre, K.B., F.J. Durcan, D.W. Branch, D.M. Jacobson, M.W. Varner, and J.R. Baringer. 1989. Amaurosis fugax associated with antiphospholipid antibodies. Ann. Neurol. 25:228-232.
14. Inzelberg, R., N.M. Bornstein, I. Reider, and A.D. Korczyn. 1992. The lupus anticoagulant and dementia in non-SLE patients. Dementia. 3:140-145.
15. Westerman, E.M., J.M. Miles, M. Backonja, and W.R. Sundstrom. 1992. Neuropathologic findings in multi-infarct dementia associated with anticardiolipin antibody. Arthritis Rheum. 35:1038-1041.
16. Khamashta, M.A., A. Gil, B. Anciones, P. Lavilla, M.E. Valencia. V. Pintado, and J.J. Vazquez. 1988. Chorea in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann. Rheum. Dis. 67:681-683.
17. Robbins, L. 1991. Migraine and anticardiolipin antibodies - case reports of 13 patients, and the prevalence of antiphospholipid antibodies in migraineurs. Headache. 31:537-539.
18. Montalban, J., R. Cervera, J. Font, J. Ordi, J. Vianna, H.J. Haga, M. Tintore, M.A. Khamashta, and G.R.V. Hughes. 1992. Lack of association between anticardiolipin antibodies and migraine in systemic lupus erythematosus. Neurology. 42:681-682.
19. Lavalle, C., S. Pizzaro, C. Drenkard, J. Sanchez-Guerrero, and D. Alarcon Segovia. 1990. Transverse myelitis: a manifestation of systemic lupus erythematosus strongly associated with antiphospholipid antibodies. J. Rheumatol. 17:34-37.
20. Gilburd, B., M. Stein, Y. Tomer, D. Tanne, O. Abramski, Y. Chapman, A. Ahiron, M. Blank, and Y. Shoenfeld. 1993. Autoantibodies to phospholipids and brain extract in patients with the Guillain-Barre syndrome: cross-reactive or pathogenic? Autoimmunity. 16:23-27.
21. Pierangeli, S., J.H. Barker, D. Stikovac, D. Ackerman, G. Anderson, J. Barquinero, R. Acland, and E.N. Harris. 1995. Effect of human IgG antiphospholipid antibodies on an in vivo thrombosis model in mice. Thromb. Haemostasis. 71:670-674.
22. Kornberg, A., M. Blank, S. Hafman, and Y. Shoenfeld. 1994. Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J. Immunol. 153:1328-1332.
23. Sun, K.H., W.T. Liu, C.Y. Tsai, T.S. Liao, W.M. Lin, and C.L. Yu. 1992. Inhibition of astrocyte proliferation and binding to brain tissue of anticardiolipin antibodies purified from lupus serum. Ann. Rheum. Dis. 51:707-712.
24. Smith, H.R., C.L. Hansen, R. Rose, and R.T. Canoso. 1990. Autoimmune MRL-lpr/lpr mice are an animal model for the secondary antiphospholipid syndrome. J. Rheumatol. 17:911-915.
25. Hashimoto, Y., M. Kawamura, K. Ichikawa, T. Suzuki, T. Sumida, S. Yoshida, E. Matsuura, S. Ikehara, and T. Koike. 1992. Anticardiolipin antibodies in NZW × BxSB F1 mice. J. Immunol. 149:1063-1068.
26. Hess, D.C., M. Taormina, J. Thompson, K.D. Sethi, B. Diamond, R. Rao, C.R. Chamberlain, and D.S. Feldman. 1993. Cognitive and neurologic deficits in the MRL/lpr mouse: a clinicopathologic study. J. Rheumatol. 20:610-617.
27. Brey, R.L., S. Cote, R. Barohn, C. Jackson, R. Crawley, and J.M. Teale. 1995. Model for the neuromuscular complications of systemic lupus erythematosus. Lupus. 4:209-212.
28. Galli, M., P. Confurius, H.C Hemker, M.H. Debaets, P.J.C. van Breda-Vriesman, T. Barbui, R.F.A. Zwaal, and E.M. Bevers. 1990. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to plasma protein cofactor. Lancet. 335:1544-1547.
29. Brey, R.L., S.A. Cote, and J.M. Teale. 1994. Autoimmune disease is accelerated in MRL/++ mice after apolipoprotein H immunization. Neurology. 44(Suppl. 2):A316. (Abstr.)
30. Shoenfeld, Y. 1994. Idiotypic induction of autoimmunity: a new aspect of the idiotypic network. FASEB (Fed. Am. Soc. Exp. Biol.) J. 8:1296-1301.
31. Bakimer, R., P. Fishman, M. Blank, B. Srendi, M. Djaldetti, and Y. Shoenfeld. 1992. Induction of primary antiphospholipid syndrome in mice by immunizing with a human monoclonal anticardiolipin antibody (H3). J. Clin. Invest. 89:1558-1563.
32. Blank, M., J. Cohen, V. Toder, and Y. Shoenfeld. 1991. Induction of antiphospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc. Natl. Acad. Sci. USA. 88: 3069-3073.
33. Sutjita, M., A. Hohmann, R. Comacchio, and J. Bradley. 1988. Polyspecific human and murine antibodies to diphtheria and tetanus toxoids and phospholipids. Clin. Exp. Immunol. 73:191-197.
34. Damianovich, M., B. Guilburd, J. George, N. Del Papa, A. Afek, I. Goldberg, Y. Kopolovic, D. Roth, G. Barkai, P.L. Meroni, and Y. Shoenfeld. 1996. Pathogenic role of antiendothelial cell antibodies (AECA) in vasculitis: an idiotypic experimental model. J. Immunol. 156:4946-4951.
35. Del Papa, N., L. Guidali, L. Spatola, P. Bonara, M.O. Borghi, A. Tincani, G. Balestrieri, and P.L. Meroni. 1995. Relationship between anti-phospholipid and anti-endothelial cell antibodies III: beta-2 glycoprotein I mediates the antibody binding to endothelial membranes and induces the expression of adhesion molecules. Clin. Exp. Rheumatol. 13:179-185.
36. Garlanda, C., C. Parravicini, M. Sironi, M. De Rossi, R. Wainstok de Calmanovici, F. Carozz, F. Bussolino, F. Colotta, A. Mantovani, and A. Vecchi. 1994. Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cell transformed by polyoma middle sized T antigen: implication for the pathogenesis of opportunistic vascular tumors. Proc. Natl. Acad. Sci. USA. 91:7291-7295.
37. Ziporen, L., I. Goldberg, M. Arad, M. Hojnik, J. Ordi-Ros, A. Afek, M. Blank, Y. Sandbank, M. Vilardell-Tarres, I. de Torres, et al. 1996. Libman-Sacks endocarditis in the antiphospholipid syndrome: immunopathological findings in deformed heart valves. Lupus. 5:196-205.
38. Tupper, D.E., and R.B. Wallace. 1980. Utility of the neurological examination in rats. Acta Neurobiol. Exp. (Wars.). 40:999-1003.
39. Eilam, D., H. Szechtman, M. Faigon, V. Dubovik, J. Feldon, and D.M. Michaelson. 1993. Disintegration of the spatial organization of behavior in experimental autoimmune dementia. Neuroscience. 56:83-91.
40. Eilam, D., and I. Golani. 1989. Home base behavior of rats (Rattus norvegicus) exploring a novel environment. Behav. Brain Res. 34:199-211.
41. Dar, S.M., and W.R. Wooles. 1986. Effects of chronically administered methyxantine on ethanol-induced motor incoordination in mice. Life Sci. 39: 1429-1437.
42. Drenkard, C., J. Sanchez-Guerrero, and D. Alarcon-Segovia. 1989. Fall in antiphospholipid antibody at time of thrombooclusive episodes in systemic lupus erythematosus. J. Rheumatol. 16:614-617.
43. Furie, R., T. Ishikawa, V. Dhawan, and D. Eidelberg. 1994. Alternating hemichorea in primary antiphospholipid syndrome: evidence for contralateral striatal hypermetabolism. Neurology. 44:2197-2199.
44. Husby, G., I. van de Rijn, J.B. Zabriskie, Z.H. Abdin, and R.C. Williams. 1976. Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. J. Exp. Med. 144:1094-1110.
45. Eilam, D., and I. Goiani. 1994. Amphetamine-induced stereotypy in rats: its morphogenesis in locale space from normal exploration. In Ethology and Psychopharmacology. S.J. Cooper and C.A. Hendrie, editors. John Wiley & Sons Inc., New York.
46. Konard, C.R., M.J. Forster, and H. Lal. 1988. Behavioral approach to probe altered neurotransmission in autoimmune NZB/BINJ mice: implications for investigations of cognitive dysfunction. Drug Dev. Res. 15:275-295.
47. McCrae, K.R., A. DeMichele, P. Samuels, D. Roth, A. Kuo, Q.H. Meng, J. Rauch, and D.B. Cines. 1991. Detection of endothelial cell reactive immunoglobulin in patients with antiphospholipid antibodies. Br. J. Haematol. 79:595-605.
48. Cines, D.B., and K.R. McCrae. 1995. The antiphospholipid-protein syndrome. J. Clin. Immunol. 15:86-100.
49. Hess, D.C., J.C. Sheppard, and R.J. Adams. 1993. Increased immunoglobulin binding to cerebral endothelium in patients with antiphospholipid antibodies. Stroke. 24:994-999.
50. Simantov, R., J.M. LaSala, S.K. Lo, A.E. Gharavi, L.R. Sammaritano, J.E. Salmon, and R.L. Silverstein. 1995. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J. Clin. Invest. 96:211-221.
51. Silver, R.K., T.A. Mullen, M.S. Caplan, P.D. O'Connell, and A. Ragin. 1995. Inducible platelet adherence to human umbilical vein endothelium by anticardiolipin antibody-positive sera. Am. J. Obstet. Gynecol. 173:702-707.
52. Brey, R.L., A. Escalante, and S. Cote. 1995. Soluble adhesion proteins, anticardiolipin antibodies and neurological disease in SLE. Arthritis Rheum. Suppl. 314. (Abstr.)
53. 2GPI than with anti-phospholipid antibodies. J. Rheumatol. 22:1899-1906.