-
1
-
-
80052236883
-
The global obesity pandemic: Shaped by global drivers and local environments
-
Swinburn BA, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378(9793):804-814.
-
(2011)
Lancet
, vol.378
, Issue.9793
, pp. 804-814
-
-
Swinburn, B.A.1
-
2
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860-867.
-
(2006)
Nature
, vol.444
, Issue.7121
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
3
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011;121(6):2111-2117.
-
(2011)
J Clin Invest
, vol.121
, Issue.6
, pp. 2111-2117
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
4
-
-
84949627236
-
Regulation of metabolism by the innate immune system
-
Lackey DE, Olefsky JM. Regulation of metabolism by the innate immune system. Nat Rev Endocrinol. 2016;12(1):15-28.
-
(2016)
Nat Rev Endocrinol
, vol.12
, Issue.1
, pp. 15-28
-
-
Lackey, D.E.1
Olefsky, J.M.2
-
5
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007;117(1):175-184.
-
(2007)
J Clin Invest
, vol.117
, Issue.1
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
6
-
-
85008352591
-
Role of innate and adaptive immunity in obesity- Associated metabolic disease
-
McLaughlin T, Ackerman SE, Shen L, Engleman E. Role of innate and adaptive immunity in obesity- Associated metabolic disease. J Clin Invest. 2017;127(1):5-13.
-
(2017)
J Clin Invest
, vol.127
, Issue.1
, pp. 5-13
-
-
McLaughlin, T.1
Ackerman, S.E.2
Shen, L.3
Engleman, E.4
-
7
-
-
85008319832
-
Islet inflammation in type 2 diabetes and physiology
-
Eguchi K, Nagia R. Islet inflammation in type 2 diabetes and physiology. J Clin Invest. 2017;127(1):14-23.
-
(2017)
J Clin Invest
, vol.127
, Issue.1
, pp. 14-23
-
-
Eguchi, K.1
Nagia, R.2
-
8
-
-
73549090090
-
Kupffer cell activation is a causal factor for hepatic insulin resistance
-
Lanthier N, Molendi-Coste O, Horsmans Y, van Rooijen N, Cani PD, Leclercq IA. Kupffer cell activation is a causal factor for hepatic insulin resistance. Am J Physiol Gastrointest Liver Physiol. 2010;298(1):G107-G116.
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
, Issue.1
, pp. G107-G116
-
-
Lanthier, N.1
Molendi-Coste, O.2
Horsmans, Y.3
Van, R.N.4
Cani, P.D.5
Leclercq, I.A.6
-
9
-
-
77951146612
-
C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
-
Obstfeld AE, et al. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes. 2010;59(4):916-925.
-
(2010)
Diabetes
, vol.59
, Issue.4
, pp. 916-925
-
-
Obstfeld, A.E.1
-
10
-
-
85008400938
-
Liver inflammation and fibrosis
-
Koyama Y, Brenner DA. Liver inflammation and fibrosis. J Clin Invest. 2017;127(1):55-64.
-
(2017)
J Clin Invest
, vol.127
, Issue.1
, pp. 55-64
-
-
Koyama, Y.1
Brenner, D.A.2
-
11
-
-
85008311773
-
The initiation of metabolic inflammation in childhood obesity
-
Singer K, Lumeng CN. The initiation of metabolic inflammation in childhood obesity. J Clin Invest. 2017;127(1):65-73.
-
(2017)
J Clin Invest
, vol.127
, Issue.1
, pp. 65-73
-
-
Singer, K.1
Lumeng, C.N.2
-
12
-
-
84878785347
-
Immunological goings-on in visceral adipose tissue
-
Mathis D. Immunological goings-on in visceral adipose tissue. Cell Metab. 2013;17(6):851-859.
-
(2013)
Cell Metab
, vol.17
, Issue.6
, pp. 851-859
-
-
Mathis, D.1
-
13
-
-
33846821855
-
Postprandial variations of plasma inflammatory markers in abdominally obese men
-
Blackburn P, et al. Postprandial variations of plasma inflammatory markers in abdominally obese men. Obesity (Silver Spring). 2006;14(10):1747-1754.
-
(2006)
Obesity (Silver Spring)
, vol.14
, Issue.10
, pp. 1747-1754
-
-
Blackburn, P.1
-
14
-
-
80052278497
-
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: Molecular mechanisms and probiotic treatment
-
Amar J, et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med. 2011;3(9):559-572.
-
(2011)
EMBO Mol Med.
, vol.3
, Issue.9
, pp. 559-572
-
-
Amar, J.1
-
15
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116(11):3015-3025.
-
(2006)
J Clin Invest
, vol.116
, Issue.11
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
16
-
-
85008354535
-
Immunologic impact of the intestine in metabolic disease
-
Winer DA, Winer S, Dranse HJ, Lam TKT. Immunologic impact of the intestine in metabolic disease. J Clin Invest. 2017;127(1):33-42.
-
(2017)
J Clin Invest
, vol.127
, Issue.1
, pp. 33-42
-
-
Winer, D.A.1
Winer, S.2
Dranse, H.J.3
Lam, T.K.T.4
-
17
-
-
84860476011
-
Omega 3 fatty acids and GPR120
-
Oh DY, Olefsky JM. Omega 3 fatty acids and GPR120. Cell Metab. 2012;15(5):564-565.
-
(2012)
Cell Metab
, vol.15
, Issue.5
, pp. 564-565
-
-
Oh, D.Y.1
Olefsky, J.M.2
-
18
-
-
84902075318
-
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity
-
Lee YS, et al. Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell. 2014;157(6):1339-1352.
-
(2014)
Cell
, vol.157
, Issue.6
, pp. 1339-1352
-
-
Lee, Y.S.1
-
19
-
-
84872290190
-
Hypoxia and adipose tissue function and dysfunction in obesity
-
Trayhurn P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev. 2013;93(1):1-21.
-
(2013)
Physiol Rev.
, vol.93
, Issue.1
, pp. 1-21
-
-
Trayhurn, P.1
-
21
-
-
62849107819
-
Metabolic dysregulation and adipose tissue fibrosis: Role of collagen VI
-
Khan T, et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol. 2009;29(6):1575-1591.
-
(2009)
Mol Cell Biol.
, vol.29
, Issue.6
, pp. 1575-1591
-
-
Khan, T.1
-
22
-
-
33646139156
-
A pericellular collagenase directs the 3-dimensional development of white adipose tissue
-
Chun TH, Hotary KB, Sabeh F, Saltiel AR, Allen ED, Weiss SJ. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell. 2006;125(3):577-591.
-
(2006)
Cell
, vol.125
, Issue.3
, pp. 577-591
-
-
Chun, T.H.1
Hotary, K.B.2
Sabeh, F.3
Saltiel, A.R.4
Allen, E.D.5
Weiss, S.J.6
-
23
-
-
85008319765
-
Hypothalamic inflammation in obesity and metabolic disease
-
Jais A, Brüning JC. Hypothalamic inflammation in obesity and metabolic disease. J Clin Invest. 2017;127(1):24-32.
-
(2017)
J Clin Invest.
, vol.127
, Issue.1
, pp. 24-32
-
-
Jais, A.1
Brüning, J.C.2
-
24
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005;11(2):191-198.
-
(2005)
Nat Med.
, vol.11
, Issue.2
, pp. 191-198
-
-
Arkan, M.C.1
-
25
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420(6913):333-336.
-
(2002)
Nature
, vol.420
, Issue.6913
, pp. 333-336
-
-
Hirosumi, J.1
-
26
-
-
75749108288
-
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
-
Nakamura T, et al. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell. 2010;140(3):338-348.
-
(2010)
Cell
, vol.140
, Issue.3
, pp. 338-348
-
-
Nakamura, T.1
-
27
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010;140(6):900-917.
-
(2010)
Cell
, vol.140
, Issue.6
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
28
-
-
77957348390
-
Sphingolipids and insulin resistance: The five Ws
-
Summers SA. Sphingolipids and insulin resistance: the five Ws. Curr Opin Lipidol. 2010;21(2):128-135.
-
(2010)
Curr Opin Lipidol
, vol.21
, Issue.2
, pp. 128-135
-
-
Summers, S.A.1
-
29
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar B, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. 2011;17(2):179-188.
-
(2011)
Nat Med
, vol.17
, Issue.2
, pp. 179-188
-
-
Vandanmagsar, B.1
-
30
-
-
70350389389
-
Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fatfed mice
-
Saberi M, et al. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fatfed mice. Cell Metab. 2009;10(5):419-429.
-
(2009)
Cell Metab
, vol.10
, Issue.5
, pp. 419-429
-
-
Saberi, M.1
-
31
-
-
34247511496
-
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis
-
Wellen KE, et al. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell. 2007;129(3):537-548.
-
(2007)
Cell
, vol.129
, Issue.3
, pp. 537-548
-
-
Wellen, K.E.1
-
32
-
-
34147122535
-
Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance
-
Lesniewski LA, et al. Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007;13(4):455-462.
-
(2007)
Nat Med
, vol.13
, Issue.4
, pp. 455-462
-
-
Lesniewski, L.A.1
-
33
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
Holland WL, et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 2007;5(3):167-179.
-
(2007)
Cell Metab
, vol.5
, Issue.3
, pp. 167-179
-
-
Holland, W.L.1
-
34
-
-
84925485114
-
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
-
Li P, et al. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015;21(3):239-247.
-
(2015)
Nat Med
, vol.21
, Issue.3
, pp. 239-247
-
-
Li, P.1
-
35
-
-
84995554134
-
Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance
-
Li P, et al. Hematopoietic-derived galectin-3 causes cellular and systemic insulin resistance. Cell. 2016;167(4):973-984.
-
(2016)
Cell
, vol.167
, Issue.4
, pp. 973-984
-
-
Li, P.1
-
36
-
-
80053087484
-
Inflammasome is a central player in the induction of obesity and insulin resistance
-
Stienstra R, et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A. 2011;108(37):15324-15329.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.37
, pp. 15324-15329
-
-
Stienstra, R.1
-
37
-
-
85008343699
-
Skeletal muscle inflammation and insulin resistance in obesity
-
Wu H, Ballantyne CM. Skeletal muscle inflammation and insulin resistance in obesity. J Clin Invest. 2017;127(1):43-54.
-
(2017)
J Clin Invest
, vol.127
, Issue.1
, pp. 43-54
-
-
Wu, H.1
Ballantyne, C.M.2
-
38
-
-
33244481462
-
Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance
-
Zick Y. Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE. 2005;2005(268):4.
-
(2005)
Sci STKE. 2005
, Issue.268
, pp. 4
-
-
Zick, Y.1
-
39
-
-
77950525966
-
Endoplasmic reticulum stress and atherosclerosis
-
Hotamisligil GS. Endoplasmic reticulum stress and atherosclerosis. Nat Med. 2010;16(4):396-399.
-
(2010)
Nat Med
, vol.16
, Issue.4
, pp. 396-399
-
-
Hotamisligil, G.S.1
-
40
-
-
85008323159
-
Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk
-
Goldfine AB, Shoelson SE. Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. J Clin Invest. 2017;127(1):83-93.
-
(2017)
J Clin Invest
, vol.127
, Issue.1
, pp. 83-93
-
-
Goldfine, A.B.1
Shoelson, S.E.2
-
41
-
-
85008411846
-
The ominous triad of adipose tissue dysfunction: Inflammation, fibrosis, and impaired angiogenesis
-
Crewe C, An YA, Scherer PE. The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. J Clin Invest. 2017;127(1):74-82.
-
(2017)
J Clin Invest
, vol.127
, Issue.1
, pp. 74-82
-
-
Crewe, C.1
An, Y.A.2
Scherer, P.E.3
|