-
1
-
-
0032816549
-
The substantia nigra of the human brain. II. patterns of loss of dopamine-containing neurons in Parkinson's disease
-
[1] Damier, P., Hirsch, E.C., Agid, Y., Graybiel, A.M., The substantia nigra of the human brain. II. patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain: J. Neurol. 122 (1999), 1437–1448.
-
(1999)
Brain: J. Neurol.
, vol.122
, pp. 1437-1448
-
-
Damier, P.1
Hirsch, E.C.2
Agid, Y.3
Graybiel, A.M.4
-
2
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
[2] Spillantini, M.G., Schmidt, M.L., Lee, V.M., Trojanowski, J.Q., Jakes, R., Goedert, M., Alpha-synuclein in Lewy bodies. Nature 388:6645 (1997), 839–840.
-
(1997)
Nature
, vol.388
, Issue.6645
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
3
-
-
0031941058
-
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
-
[3] Baba, M., Nakajo, S., Tu, P.H., Tomita, T., Nakaya, K., Lee, V.M., Trojanowski, J.Q., Iwatsubo, T., Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152:4 (1998), 879–884.
-
(1998)
Am. J. Pathol.
, vol.152
, Issue.4
, pp. 879-884
-
-
Baba, M.1
Nakajo, S.2
Tu, P.H.3
Tomita, T.4
Nakaya, K.5
Lee, V.M.6
Trojanowski, J.Q.7
Iwatsubo, T.8
-
4
-
-
0032584686
-
Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
-
[4] Spillantini, M.G., Crowther, R.A., Jakes, R., Cairns, N.J., Lantos, P.L., Goedert, M., Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett. 251:3 (1998), 205–208.
-
(1998)
Neurosci. Lett.
, vol.251
, Issue.3
, pp. 205-208
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Cairns, N.J.4
Lantos, P.L.5
Goedert, M.6
-
5
-
-
84881147729
-
Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein
-
[5] Lee, H.J., Cho, E.D., Lee, K.W., Kim, J.H., Cho, S.G., Lee, S.J., Autophagic failure promotes the exocytosis and intercellular transfer of alpha-synuclein. Exp. Mol. Med., 45, 2013, e22.
-
(2013)
Exp. Mol. Med.
, vol.45
, pp. e22
-
-
Lee, H.J.1
Cho, E.D.2
Lee, K.W.3
Kim, J.H.4
Cho, S.G.5
Lee, S.J.6
-
6
-
-
80053613574
-
Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
-
[6] Volpicelli-Daley, L.A., Luk, K.C., Patel, T.P., Tanik, S.A., Riddle, D.M., Stieber, A., Meaney, D.F., Trojanowski, J.Q., Lee, V.M., Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72:1 (2011), 57–71.
-
(2011)
Neuron
, vol.72
, Issue.1
, pp. 57-71
-
-
Volpicelli-Daley, L.A.1
Luk, K.C.2
Patel, T.P.3
Tanik, S.A.4
Riddle, D.M.5
Stieber, A.6
Meaney, D.F.7
Trojanowski, J.Q.8
Lee, V.M.9
-
7
-
-
84869109864
-
Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
-
[7] Luk, K.C., Kehm, V., Carroll, J., Zhang, B., O'Brien, P., Trojanowski, J.Q., Lee, V.M., Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338:6109 (2012), 949–953.
-
(2012)
Science
, vol.338
, Issue.6109
, pp. 949-953
-
-
Luk, K.C.1
Kehm, V.2
Carroll, J.3
Zhang, B.4
O'Brien, P.5
Trojanowski, J.Q.6
Lee, V.M.7
-
8
-
-
33745026738
-
Autophagy and aging: the importance of maintaining “clean” cells
-
[8] Cuervo, A.M., Bergamini, E., Brunk, U.T., Droge, W., Ffrench, M., Terman, A., Autophagy and aging: the importance of maintaining “clean” cells. Autophagy 1:3 (2005), 131–140.
-
(2005)
Autophagy
, vol.1
, Issue.3
, pp. 131-140
-
-
Cuervo, A.M.1
Bergamini, E.2
Brunk, U.T.3
Droge, W.4
Ffrench, M.5
Terman, A.6
-
9
-
-
84877615360
-
Therapeutic induction of autophagy to modulate neurodegenerative disease progression
-
[9] Hochfeld, W.E., Lee, S., Rubinsztein, D.C., Therapeutic induction of autophagy to modulate neurodegenerative disease progression. Acta Pharmacol. Sin. 34:5 (2013), 600–604.
-
(2013)
Acta Pharmacol. Sin.
, vol.34
, Issue.5
, pp. 600-604
-
-
Hochfeld, W.E.1
Lee, S.2
Rubinsztein, D.C.3
-
10
-
-
65549150407
-
Management of side effects of sirolimus therapy
-
[10] Stallone, G., Infante, B., Grandaliano, G., Gesualdo, L., Management of side effects of sirolimus therapy. Transplantation 87:8 Suppl (2009), S23–S26.
-
(2009)
Transplantation
, vol.87
, Issue.8
, pp. S23-S26
-
-
Stallone, G.1
Infante, B.2
Grandaliano, G.3
Gesualdo, L.4
-
11
-
-
84866737855
-
Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant alpha-synuclein
-
[11] Lan, D.M., Liu, F.T., Zhao, J., Chen, Y., Wu, J.J., Ding, Z.T., Yue, Z.Y., Ren, H.M., Jiang, Y.P., Wang, J., Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant alpha-synuclein. Neurochem. Res. 37:9 (2012), 2025–2032.
-
(2012)
Neurochem. Res.
, vol.37
, Issue.9
, pp. 2025-2032
-
-
Lan, D.M.1
Liu, F.T.2
Zhao, J.3
Chen, Y.4
Wu, J.J.5
Ding, Z.T.6
Yue, Z.Y.7
Ren, H.M.8
Jiang, Y.P.9
Wang, J.10
-
12
-
-
77956855813
-
Pathogenic lysosomal depletion in Parkinson's disease
-
[12] Dehay, B., Bove, J., Rodriguez-Muela, N., Perier, C., Recasens, A., Boya, P., Vila, M., Pathogenic lysosomal depletion in Parkinson's disease. J. Neurosci. 30:37 (2010), 12535–12544.
-
(2010)
J. Neurosci.
, vol.30
, Issue.37
, pp. 12535-12544
-
-
Dehay, B.1
Bove, J.2
Rodriguez-Muela, N.3
Perier, C.4
Recasens, A.5
Boya, P.6
Vila, M.7
-
13
-
-
80955177196
-
TFEB links autophagy to lysosomal biogenesis
-
[13] Settembre, C., Di Malta, C., Polito, V.A., Garcia Arencibia, M., Vetrini, F., Erdin, S., Erdin, S.U., Huynh, T., Medina, D., Colella, P., et al. TFEB links autophagy to lysosomal biogenesis. Science 332:6036 (2011), 1429–1433.
-
(2011)
Science
, vol.332
, Issue.6036
, pp. 1429-1433
-
-
Settembre, C.1
Di Malta, C.2
Polito, V.A.3
Garcia Arencibia, M.4
Vetrini, F.5
Erdin, S.6
Erdin, S.U.7
Huynh, T.8
Medina, D.9
Colella, P.10
-
14
-
-
67749122634
-
A gene network regulating lysosomal biogenesis and function
-
[14] Sardiello, M., Palmieri, M., di Ronza, A., Medina, D.L., Valenza, M., Gennarino, V.A., Di Malta, C., Donaudy, F., Embrione, V., Polishchuk, R.S., et al. A gene network regulating lysosomal biogenesis and function. Science 325:5939 (2009), 473–477.
-
(2009)
Science
, vol.325
, Issue.5939
, pp. 473-477
-
-
Sardiello, M.1
Palmieri, M.2
di Ronza, A.3
Medina, D.L.4
Valenza, M.5
Gennarino, V.A.6
Di Malta, C.7
Donaudy, F.8
Embrione, V.9
Polishchuk, R.S.10
-
15
-
-
0014305619
-
Trehalase and the transport of glucose in the mammalian kidney and intestine
-
[15] Sacktor, B., Trehalase and the transport of glucose in the mammalian kidney and intestine. Proc. Natl. Acad. Sci. USA 60:3 (1968), 1007–1014.
-
(1968)
Proc. Natl. Acad. Sci. USA
, vol.60
, Issue.3
, pp. 1007-1014
-
-
Sacktor, B.1
-
16
-
-
0036282324
-
Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies
-
[16] Richards, A.B., Krakowka, S., Dexter, L.B., Schmid, H., Wolterbeek, A.P., Waalkens-Berendsen, D.H., Shigoyuki, A., Kurimoto, M., Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies. Food Chem. Toxicol.: Int. J. Publ. Br. Ind. Biol. Res. Assoc. 40:7 (2002), 871–898.
-
(2002)
Food Chem. Toxicol.: Int. J. Publ. Br. Ind. Biol. Res. Assoc.
, vol.40
, Issue.7
, pp. 871-898
-
-
Richards, A.B.1
Krakowka, S.2
Dexter, L.B.3
Schmid, H.4
Wolterbeek, A.P.5
Waalkens-Berendsen, D.H.6
Shigoyuki, A.7
Kurimoto, M.8
-
17
-
-
77954955573
-
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
-
[17] Rodriguez-Navarro, J.A., Rodriguez, L., Casarejos, M.J., Solano, R.M., Gomez, A., Perucho, J., Cuervo, A.M., Garcia de Yebenes, J., Mena, M.A., Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiol. Dis. 39:3 (2010), 423–438.
-
(2010)
Neurobiol. Dis.
, vol.39
, Issue.3
, pp. 423-438
-
-
Rodriguez-Navarro, J.A.1
Rodriguez, L.2
Casarejos, M.J.3
Solano, R.M.4
Gomez, A.5
Perucho, J.6
Cuervo, A.M.7
Garcia de Yebenes, J.8
Mena, M.A.9
-
18
-
-
84884294596
-
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
-
[18] Castillo, K., Nassif, M., Valenzuela, V., Rojas, F., Matus, S., Mercado, G., Court, F.A., van Zundert, B., Hetz, C., Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy 9:9 (2013), 1308–1320.
-
(2013)
Autophagy
, vol.9
, Issue.9
, pp. 1308-1320
-
-
Castillo, K.1
Nassif, M.2
Valenzuela, V.3
Rojas, F.4
Matus, S.5
Mercado, G.6
Court, F.A.7
van Zundert, B.8
Hetz, C.9
-
19
-
-
1642633757
-
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
-
[19] Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N.R., Doi, H., Kurosawa, M., Nekooki, M., Nukina, N., Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease. Nat. Med. 10:2 (2004), 148–154.
-
(2004)
Nat. Med.
, vol.10
, Issue.2
, pp. 148-154
-
-
Tanaka, M.1
Machida, Y.2
Niu, S.3
Ikeda, T.4
Jana, N.R.5
Doi, H.6
Kurosawa, M.7
Nekooki, M.8
Nukina, N.9
-
20
-
-
24044483249
-
Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42
-
[20] Liu, R., Barkhordarian, H., Emadi, S., Park, C.B., Sierks, M.R., Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42. Neurobiol. Dis. 20:1 (2005), 74–81.
-
(2005)
Neurobiol. Dis.
, vol.20
, Issue.1
, pp. 74-81
-
-
Liu, R.1
Barkhordarian, H.2
Emadi, S.3
Park, C.B.4
Sierks, M.R.5
-
21
-
-
79955694568
-
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
-
[21] Qiao, L., Hamamichi, S., Caldwell, K.A., Caldwell, G.A., Yacoubian, T.A., Wilson, S., Xie, Z.L., Speake, L.D., Parks, R., Crabtree, D., et al. Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol. Brain, 1, 2008, 17.
-
(2008)
Mol. Brain
, vol.1
, pp. 17
-
-
Qiao, L.1
Hamamichi, S.2
Caldwell, K.A.3
Caldwell, G.A.4
Yacoubian, T.A.5
Wilson, S.6
Xie, Z.L.7
Speake, L.D.8
Parks, R.9
Crabtree, D.10
-
22
-
-
33847215777
-
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis
-
[22] Shacka, J.J., Klocke, B.J., Young, C., Shibata, M., Olney, J.W., Uchiyama, Y., Saftig, P., Roth, K.A., Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. J. Neurosci. 27:8 (2007), 2081–2090.
-
(2007)
J. Neurosci.
, vol.27
, Issue.8
, pp. 2081-2090
-
-
Shacka, J.J.1
Klocke, B.J.2
Young, C.3
Shibata, M.4
Olney, J.W.5
Uchiyama, Y.6
Saftig, P.7
Roth, K.A.8
-
23
-
-
34248593481
-
Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain
-
[23] Walls, K.C., Klocke, B.J., Saftig, P., Shibata, M., Uchiyama, Y., Roth, K.A., Shacka, J.J., Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain. Autophagy 3:3 (2007), 222–229.
-
(2007)
Autophagy
, vol.3
, Issue.3
, pp. 222-229
-
-
Walls, K.C.1
Klocke, B.J.2
Saftig, P.3
Shibata, M.4
Uchiyama, Y.5
Roth, K.A.6
Shacka, J.J.7
-
24
-
-
0034077041
-
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
-
[24] Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W.H., Castillo, P.E., Shinsky, N., Verdugo, J.M., Armanini, M., Ryan, A., et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25:1 (2000), 239–252.
-
(2000)
Neuron
, vol.25
, Issue.1
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
-
25
-
-
84907033533
-
Addition of exogenous alpha-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous alpha-synuclein to Lewy body and Lewy neurite-like aggregates
-
[25] Volpicelli-Daley, L.A., Luk, K.C., Lee, V.M., Addition of exogenous alpha-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous alpha-synuclein to Lewy body and Lewy neurite-like aggregates. Nat. Protoc. 9:9 (2014), 2135–2146.
-
(2014)
Nat. Protoc.
, vol.9
, Issue.9
, pp. 2135-2146
-
-
Volpicelli-Daley, L.A.1
Luk, K.C.2
Lee, V.M.3
-
26
-
-
84878230429
-
Lewy body-like alpha-synuclein aggregates resist degradation and impair macroautophagy
-
[26] Tanik, S.A., Schultheiss, C.E., Volpicelli-Daley, L.A., Brunden, K.R., Lee, V.M., Lewy body-like alpha-synuclein aggregates resist degradation and impair macroautophagy. J. Biol. Chem. 288:21 (2013), 15194–15210.
-
(2013)
J. Biol. Chem.
, vol.288
, Issue.21
, pp. 15194-15210
-
-
Tanik, S.A.1
Schultheiss, C.E.2
Volpicelli-Daley, L.A.3
Brunden, K.R.4
Lee, V.M.5
-
27
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson's disease
-
[27] Braak, H., Del Tredici, K., Rub, U., de Vos, R.A., Jansen Steur, E.N., Braak, E., Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24:2 (2003), 197–211.
-
(2003)
Neurobiol. Aging
, vol.24
, Issue.2
, pp. 197-211
-
-
Braak, H.1
Del Tredici, K.2
Rub, U.3
de Vos, R.A.4
Jansen Steur, E.N.5
Braak, E.6
-
28
-
-
34247161367
-
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
-
[28] Sarkar, S., Davies, J.E., Huang, Z., Tunnacliffe, A., Rubinsztein, D.C., Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J. Biol. Chem. 282:8 (2007), 5641–5652.
-
(2007)
J. Biol. Chem.
, vol.282
, Issue.8
, pp. 5641-5652
-
-
Sarkar, S.1
Davies, J.E.2
Huang, Z.3
Tunnacliffe, A.4
Rubinsztein, D.C.5
-
29
-
-
84862285881
-
Autophagic degradation of tau in primary neurons and its enhancement by trehalose
-
[29] Kruger, U., Wang, Y., Kumar, S., Mandelkow, E.M., Autophagic degradation of tau in primary neurons and its enhancement by trehalose. Neurobiol. Aging 33:10 (2012), 2291–2305.
-
(2012)
Neurobiol. Aging
, vol.33
, Issue.10
, pp. 2291-2305
-
-
Kruger, U.1
Wang, Y.2
Kumar, S.3
Mandelkow, E.M.4
-
30
-
-
29644437591
-
Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy
-
[30] Davies, J.E., Sarkar, S., Rubinsztein, D.C., Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy. Hum. Mol. Genet. 15:1 (2006), 23–31.
-
(2006)
Hum. Mol. Genet.
, vol.15
, Issue.1
, pp. 23-31
-
-
Davies, J.E.1
Sarkar, S.2
Rubinsztein, D.C.3
-
31
-
-
84861899099
-
Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils
-
[31] Yu, W.B., Jiang, T., Lan, D.M., Lu, J.H., Yue, Z.Y., Wang, J., Zhou, P., Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils. Arch. Biochem. Biophys. 523:2 (2012), 144–150.
-
(2012)
Arch. Biochem. Biophys.
, vol.523
, Issue.2
, pp. 144-150
-
-
Yu, W.B.1
Jiang, T.2
Lan, D.M.3
Lu, J.H.4
Yue, Z.Y.5
Wang, J.6
Zhou, P.7
-
32
-
-
84919624038
-
Trehalose is a versatile and long-lived chaperone for desiccation tolerance
-
[32] Tapia, H., Koshland, D.E., Trehalose is a versatile and long-lived chaperone for desiccation tolerance. Curr. Biol.: Cb. 24:23 (2014), 2758–2766.
-
(2014)
Curr. Biol.: Cb.
, vol.24
, Issue.23
, pp. 2758-2766
-
-
Tapia, H.1
Koshland, D.E.2
-
33
-
-
0034992527
-
Influence of trehalose on the molecular chaperone activity of p26, a small heat shock/alpha-crystallin protein
-
[33] Viner, R.I., Clegg, J.S., Influence of trehalose on the molecular chaperone activity of p26, a small heat shock/alpha-crystallin protein. Cell Stress Chaperones 6:2 (2001), 126–135.
-
(2001)
Cell Stress Chaperones
, vol.6
, Issue.2
, pp. 126-135
-
-
Viner, R.I.1
Clegg, J.S.2
-
34
-
-
84929448327
-
Treatment with Trehalose prevents behavioral and neurochemical deficits produced in an AAV alpha-synuclein rat model of Parkinson's disease
-
[34] He, Q., Koprich, J.B., Wang, Y., Yu, W.B., Xiao, B.G., Brotchie, J.M., Wang, J., Treatment with Trehalose prevents behavioral and neurochemical deficits produced in an AAV alpha-synuclein rat model of Parkinson's disease. Mol. Neurobiol. 53:4 (2016), 2258–2268.
-
(2016)
Mol. Neurobiol.
, vol.53
, Issue.4
, pp. 2258-2268
-
-
He, Q.1
Koprich, J.B.2
Wang, Y.3
Yu, W.B.4
Xiao, B.G.5
Brotchie, J.M.6
Wang, J.7
|