Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain

Autophagy

Volumn 3, Issue 3, 2007, Pages 222-229

  Walls, Ken C ^a,b   Klocke, Barbara J ^b   Saftig, Paul ^c   Shibata, Masahiro ^d   Uchiyama, Yasoo ^d   Roth, Kevin A ^a,b   Shacka, John J ^b,e  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF KIEL   (Germany)

^d OSAKA UNIVERSITY   (Japan)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Apoptosis; Autophagy; Cathepsin D; Lysosomal dysfunction; Neurodegeneration; PI3 K

Indexed keywords

BECLIN PROTEIN; CATHEPSIN D; GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE B; PROTEIN P25; PROTEIN P26; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; BRAIN CELL; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; LYSOSOME; MOUSE; NEUROPATHOLOGY; NONHUMAN; SYNTHESIS; WILD TYPE;

MUS;

EID: 34248593481     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.3822     Document Type: Article

References (59)

1. Saftig P, Herman M, Schmahl W, et al. Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J 1995; 14:3599-608.
2. Whitaker JN, Rhodes RH. The distribution of cathepsin D in rat tissues determined by immunocytochemistry. Am J Anat 1983; 166:417-428.
3. Koike M, Nakanishi H, Saftig P, et al. Cathepsin D deficiency induces lysosomal storage wirh ceroid lipofuscin in mouse CNS neurons. J Neurosci 2000; 20:6898-906.
4. Koike M, Shibata M, Waguri S, et al. Participation of aurophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Barren disease). Am J Pathol 2005; 167:1713-28.
5. Halria M. The neuronal ceroid-lipofuscinoses: From past to present. Biochim Biophys Acta 2006; 1762:850-6.
6. Siintola E, Parranen S, Stromme P, et al. Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis. Brain 2006; 129:1438-45-
7. Steinfeld R, Reinhardr K, Schreiber K, et al. Carhepsin D deficiency is associated with a human neurodegenerative disorder. Am J Hum Genet 2006; 78:988-98.
8. Codogno P, Meijer AJ. Autophagy and signaling: Their role in cell survival and cell death. Cell Death Differ 2005; 12:1509-18.
9. Massey AC, Zhang C, Cuervo AM. Chaperone-mediated autophagy in aging and disease. Curr Top Dev Biol 2006; 73:205-35.
10. Chu CT. Autophagic stress in neuronal injury and disease. J Neuropathol Exp Neurol 2006; 65;423-32.
11. Nakanishi H, Zhang J, Koike M, et al. Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. J Neurosci 2001; 21:7526-33.
12. Koike M, Shibata M, Ohsawa Y, et al. Involvement of two diffetent cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci 2003; 22:146-61.
13. Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membtanes aftet processing. EMBO J 2000; 19:5720-8.
14. Boya P, Gonzalez-Polo RA, Casares N, et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25:1025-40.
15. Shacka JJ, Klocke BJ, Shibata M, et al. Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Mol Pharmacol 2006; In press.
16. Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997; 275:661-5.
17. Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000; 275:992-8.
18. Darra SR, Dudek H, Tao X et al. Akr phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91:231-41.
19. Franke TF, Hornik CR Segev L, Shostak GA, Sugimoro C. PI3K/Akt and apoptosis: SIZE matters. Oncogene 2003; 22:8983-98.
20. Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005; 8:179-183.
21. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098-101.
22. Cao Y, Espinola JA, Fossale E, et al. Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem 2006; 281:20483-93.
23. Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumori-genesis by beclin 1. Nature 1999; 402:672-6.
24. Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2001; 2:330-5.
25. Stambolic V, MacPherson D, Sas D, et al. Regulation of PTEN transcription by p53. Mol Cell 2001; 8:317-25.
26. Arico S, Petiot A, Bauvy C, et al. The tumor suppressor PTEN positively regulates macro-autophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2001; 276:35243-6.
27. Saftig P, Hartmann D, Lullmann-Rauch R, et al. Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system. J Biol Chem 1997; 272:18628-35.
28. Zhou H, Li XM, Meinkoth J, Pittman RN. Akt regulates cell survival and apoptosis at a postmitochondrial level. J Cell Biol 2000; 151:483-94.
29. Pap M, Cooper GM. Role of glycogen synthase synase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 1998; 273:19929-32.
30. Amlak M, Uddin S, Mahmud D, et al. Regulation of myeloma cell growth through Akt/ Gsk3/forkhead signaling pathway. Biochem Biophys Res Commun 2002; 297:760-4.
31. Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR pathways in cells. Proc Nad Acad Sci USA 2005; 102:8204-9.
32. Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19:5720-8.
33. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15:1101-11.
34. Yamamoto A, Cremona ML, Rothman JE. Autophagy-mediated clearance of hunringtin aggregates triggered by the insulin-signaling pathway. J Cell Biol 2006; 172:719-31.
35. West JD, Ji C, Marnett LJ. Modulation of DNA fragmentation factor 40 nuclease activity by polyCADP-ribose) polymerase-1. J Biol Chem 2005; 280:15141-7.
36. Gilliams-Francis KL, Quaye AA, Naegele JR. PARP cleavage, DNA fragmentation, and pyknosis during excitotoxin-induced neuronal death. Exp Neurol 2003; 184:359-72.
37. Krupinski J, Ferrer I, Barrachina M, Secades JJ, Mercadal J, Lozano R. CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat. Neuropharmacology 2002; 42:846-54.
38. Cao Y, Espinola JA, Fossale E, et al. Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem 2006; 281:20483-93.
39. Cao Y, Espinola JA, Fossale E, et al. Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem 2006; 281:20483-93.
40. Scarlatti F, Bauvy C, Ventruti A, et al. Ceramide-mediated macroautophagy involves inhibirion of protein kinase B and up-regulation of beclin 1. J Biol Chem 2004; 279:18384-91.
41. Shacka JJ, Roth KA. Cathepsin deficiency as a model for neuronal ceroid lipofuscinoses. Am J Pathol 2005; 167:1473-6.
42. Siintola E, Partanen S, Stromme P, et al. Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis. Brain 2006; 129:1438-45.
43. Pap M, Cooper GM. Role of translation initiation factot 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway. Mol Cell Biol 2002; 22:578-86.
44. Cohen P, Frame S. The renaissance of GSK3. Nat Rev Mol Cell Biol 2001; 2:769-76.
45. Frame S, Cohen P, Biondi RM. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol Cell 2001; 7:1321-7.
46. Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegenerarion in GSK-3beta conditional transgenic mice. EMBO J 2001; 20:27-39.
47. Pelisch F, Blaustein M, Kornblihtt AR, Srebrow A. Cross-ralk between signaling pathways regulares alrernarive splicing: A novel role for JNK. J Biol Chem 2005; 280:25461-9.
48. Song JJ, Lee YJ. Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: A negative feedback loop. J Cell Biol 2005; 170:61-72.
49. Shacka JJ, Sahawneh MA, Gonzalez JD, Ye YZ, D'alessandro TL, Estevez AG. Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells. Cell Death Differ 2006; 13:1506-14.
50. Yue Z, Jin S, Yang C, Levine AJ, Heinrz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100:15077-82.
51. Shibata M, Lu T, Furuya T, et al. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem 2006; 281:14474-85.
52. Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122:927-39.
53. Hoyer-Hansen M, Bastholm L, Mathiasen IS, Elling F, Jaattela M. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ 2005; 12:1297-309.
54. Shacka JJ, Lu J, Xie ZL, Uchiyama Y, Roth KA, Zhang J. Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci Lett 2007, DOI: 101016/j.neulet.2006.12.025.
55. Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol 2007; 170:75-86.
56. Hay N, Sonenberg N. Upstteam and downstteam of mTOR. Genes Dev 2004; 18:1926-45.
57. Li Y, Corradetti MN, Inoki K, Guan KL. TSC2: Filling the GAP in the mTOR signaling pathway. Trends Biochem Sci 2004; 29:32-8.
58. Cao Y, Espinola JA, Fossale E, et al. Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem 2006; 281:20483-93.
59. Bandhyopadhyay U, Cuervo AM. Chaperone-mediated autophagy in aging and neurodegeneration: Lessons from alpha-synuclein. Exp Gerontol 2006.