Ketamine accelerates fear extinction via mTORC1 signaling

Neurobiology of Disease

Volumn 100, Issue , 2017, Pages 1-8

  Girgenti, Matthew J ^a   Ghosal, Sriparna ^a   LoPresto, Dora ^a   Taylor, Jane R ^a   Duman, Ronald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fear extinction; Ketamine; Medial prefrontal cortex; mTOR; PTSD

Indexed keywords

KETAMINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSOCIATION; BRAIN TISSUE; CONDITIONED REFLEX; CONNECTOME; CONTROLLED STUDY; FEAR; FEAR CONDITIONING TEST; MALE; MEDIAL PREFRONTAL CORTEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RAT; REGULATORY MECHANISM; REINFORCEMENT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; MEMORY; METABOLISM; PHYSIOLOGY; POSTTRAUMATIC STRESS DISORDER; PREFRONTAL CORTEX; SPRAGUE DAWLEY RAT;

ANIMALS; CONDITIONING, CLASSICAL; EXTINCTION, PSYCHOLOGICAL; FEAR; KETAMINE; MALE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MEMORY; PREFRONTAL CORTEX; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; STRESS DISORDERS, POST-TRAUMATIC;

EID: 85008319415     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2016.12.026     Document Type: Article

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