Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depression

Biological Psychiatry

Volumn 72, Issue 4, 2012, Pages 331-338

  Zarate Jr , Carlos A ^a   Brutsche, Nancy ^a   Laje, Gonzalo ^a   Luckenbaugh, David A ^a   Venkata, Swarajya L Vattem ^b   Ramamoorthy, Anuradha ^b   Moaddel, Ruin ^b   Wainer, Irving W ^b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Bipolar disorder; dehydronorketamine; depression; hydroxynorketamine; norketamine; psychosis; response

Indexed keywords

CYTOCHROME P450; DEHYDRONORKETAMINE; DRUG METABOLITE; HYDROXYKETAMINE; HYDROXYNORKETAMINE; KETAMINE; NORKETAMINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD ANALYSIS; DISSOCIATIVE DISORDER; DNA POLYMORPHISM; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG METABOLISM; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PSYCHOSIS; SYMPTOM; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ADULT; AGED; ANTIDEPRESSIVE AGENTS; BIPOLAR DISORDER; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DEPRESSIVE DISORDER, MAJOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; KETAMINE; MALE; MASS SPECTROMETRY; MIDDLE AGED; PHARMACOGENETICS; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES;

EID: 84864286398     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.03.004     Document Type: Article

References (42)

1. T.R. Insel, E.M. Scolnick Cure therapeutics and strategic prevention: Raising the bar for mental health research Mol Psychiatry 11 2006 11 17 (Pubitemid 43251083)
2. R. Machado-Vieira, G. Salvadore, D.A. Luckenbaugh, H.K. Manji, C.A. Zarate Jr Rapid onset of antidepressant action: A new paradigm in the research and treatment of major depressive disorder J Clin Psychiatry 69 2008 946 958 (Pubitemid 351944948)
3. R. Machado-Vieira, G. Salvadore, N. Diazgranados, C.A. Zarate Jr Ketamine and the next generation of antidepressants with a rapid onset of action Pharmacol Ther 123 2009 143 150
4. C.A. Zarate Jr, J.B. Singh, J.A. Quiroz, G. De Jesus, K.K. Denicoff, D.A. Luckenbaugh A double-blind, placebo-controlled study of memantine in the treatment of major depression Am J Psychiatry 163 2006 153 155 (Pubitemid 43050119)
5. R.M. Berman, A. Cappiello, A. Anand, D.A. Oren, G.R. Heninger, D.S. Charney, J.H. Krystal Antidepressant effects of ketamine in depressed patients Biol Psychiatry 47 2000 351 354 (Pubitemid 30109248)
6. G.W. Valentine, G.F. Mason, R. Gomez, M. Fasula, J. Watzl, B. Pittman The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS Psychiatry Res 191 2011 122 127
7. M. aan het Rot, K.A. Collins, J.W. Murrough, A.M. Perez, D.L. Reich, D.S. Charney, S.J. Mathew Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression Biol Psychiatry 67 2010 139 145
8. C.A. Zarate Jr, J.B. Singh, P.J. Carlson, N.E. Brutsche, R. Ameli, D.A. Luckenbaugh A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression Arch Gen Psychiatry 63 2006 856 864 (Pubitemid 44188478)
9. N. Diazgranados, L. Ibrahim, N.E. Brutsche, A. Newberg, P. Kronstein, S. Khalife A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression Arch Gen Psychiatry 67 2010 793 802
10. C.A. Zarate Jr, N.E. Brutsche, L. Ibrahim, J. Franco-Chaves, N. Diazgranados, A. Cravchik Replication of ketamine's antidepressant efficacy in bipolar depression: A randomized controlled add-on trial [published online ahead of print January 30] Biol Psychiatry 2012
11. N. Li, B. Lee, R.J. Liu, M. Banasr, J.M. Dwyer, M. Iwata mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists Science 329 2010 959 964
12. A.E. Autry, M. Adachi, E. Nosyreva, E.S. Na, M.F. Los, P.F. Cheng NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses Nature 475 2011 91 95
13. G. Salvadore, B.R. Cornwell, F. Sambataro, D. Latov, V. Colon-Rosario, F.W. Carver Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine Neuropsychopharmacology 35 2010 1415 1422
14. G. Salvadore, B.R. Cornwell, V. Colon-Rosario, R. Coppola, C. Grillon, C.A. Zarate Jr, H.K. Manji Increased anterior cingulate cortical activity in response to fearful faces: A neurophysiological biomarker that predicts rapid antidepressant response to ketamine Biol Psychiatry 65 2009 289 295
15. J. Horacek, M. Brunovsky, T. Novak, B. Tislerova, T. Palenicek, V. Bubenikova-Valesova Subanesthetic dose of ketamine decreases prefrontal theta cordance in healthy volunteers: Implications for antidepressant effect Psychol Med 40 2010 1443 1451
16. A.C. Lahti, D. Warfel, T. Michaelidis, M.A. Weiler, K. Frey, C.A. Tamminga Long-term outcome of patients who receive ketamine during research Biol Psychiatry 49 2001 869 875 (Pubitemid 32436391)
17. P.F. White, J. Schuttler, A. Shafer, D.R. Stanski, Y. Horai, A.J. Trevor Comparative pharmacology of the ketamine isomers Studies in volunteers Br J Anaesth 57 1985 197 203 (Pubitemid 15093411)
18. J.W. Newcomer, N.B. Farber, V. Jevtovic-Todorovic, G. Selke, A.K. Melson, T. Hershey Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis Neuropsychopharmacology 20 1999 106 118 (Pubitemid 29010370)
19. S. Porcelli, C. Fabbri, E. Spina, A. Serretti, D. De Ronchi Genetic polymorphisms of cytochrome P450 enzymes and antidepressant metabolism Expert Opin Drug Metab Toxicol 7 2011 1101 1115
20. Y. Hijazi, R. Boulieu Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes Drug Metab Dispos 30 2002 853 858 (Pubitemid 34671099)
21. Y. Yanagihara, S. Kariya, M. Ohtani, K. Uchino, T. Aoyama, Y. Yamamura, T. Iga Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes Drug Metab Dispos 29 2001 887 890 (Pubitemid 32488646)
22. S. Portmann, H.Y. Kwan, R. Theurillat, A. Schmitz, M. Mevissen, W. Thormann Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro J Chromatogr A 1217 2010 7942 7948
23. L.Y. Leung, T.A. Baillie Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine J Med Chem 29 1986 2396 2399 (Pubitemid 17182325)
24. D.W. Herd, B.J. Anderson, N.H. Holford Modeling the norketamine metabolite in children and the implications for analgesia Paediatr Anaesth 17 2007 831 840 (Pubitemid 47221150)
25. J.R. Holtman Jr, P.A. Crooks, J.K. Johnson-Hardy, M. Hojomat, M. Kleven, E.P. Wala Effects of norketamine enantiomers in rodent models of persistent pain Pharmacol Biochem Behav 90 2008 676 685
26. X. Zhao, L.V. Swarajya, R. Moaddel, D.A. Luckenbaugh, N.E. Brutsche, L. Ibrahim Simultaneous population pharmacokinetic modeling of ketamine and three major metabolites in patients with treatment-resistant bipolar depression [published online ahead of print February 1] Br J Clin Pharmacol 2012
27. M. First, R.L. Spitzer, M. Gibbon, J.B.W. Williams Structured Clinical Interview for the DSM-IV-TR Axis I Disorders-Patient Edition 2002 Biometrics Research Department, New York State Psychiatric Institute New York
28. L. Ibrahim, N. DiazGranados, J. Franco-Chaves, N.E. Brutsche, I.D. Henter, P. Kronstein Course of improvement in depressive symtpoms to a single intravenous infusion of ketamine vs add-on riluzole: Results from a four-week, double-blind, placebo-controlled study [published online ahead of print February 1] Neuropsychopharmacology 2012
29. L.E. Phelps, N. Brutsche, J.R. Moral, D.A. Luckenbaugh, H.K. Manji, C.A. Zarate Jr Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist Biol Psychiatry 65 2009 181 184
30. S.A. Montgomery, M. Asberg A new depression scale designed to be sensitive to change Br J Psychiatry 134 1979 382 389 (Pubitemid 9136500)
31. J.E. Overall, D.R. Gorham The Brief Psychiatric Rating Scale Psychol Rep 10 1962 790 812
32. J.D. Bremner, J.H. Krystal, F.W. Putnam, S.M. Southwick, C. Marmar, D.S. Charney, C.M. Mazure Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS) J Trauma Stress 11 1998 125 136 (Pubitemid 28097797)
33. R. Moaddel, S.L. Venkata, M.J. Tanga, J.E. Bupp, C.E. Green, L. Iyer A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome Talanta 82 2010 1892 1904
34. S.C. Sim, M. Ingelman-Sundberg The human cytochrome P450 Allele Nomenclature Committee Web site: submission criteria, procedures, and objectives Methods Mol Biol 320 2006 183 191
35. C.F. Thorn, T.E. Klein, R.B. Altman PharmGKB: the pharmacogenetics and pharmacogenomics knowledge base Methods Mol Biol 311 2005 179 191
36. R.M. Jacob, E.C. Johnstone, M.J. Neville, R.T. Walton Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotyping Clin Chem 50 2004 1372 1377 (Pubitemid 38970644)
37. M. Sigtermans, A. Dahan, R. Mooren, M. Bauer, B. Kest, E. Sarton, E. Olofsen S(+)-ketamine effect on experimental pain and cardiac output: A population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers Anesthesiology 111 2009 892 903
38. X. Wen, J.S. Wang, K.T. Kivisto, P.J. Neuvonen, J.T. Backman In vitro evaluation of valproic acid as an inhibitor of human cytochrome P450 isoforms: Preferential inhibition of cytochrome P450 2C9 (CYP2C9) Br J Clin Pharmacol 52 2001 547 553
39. P.Y. Cheng, E.T. Morgan Hepatic cytochrome P450 regulation in disease states Curr Drug Metab 2 2001 165 183 (Pubitemid 32544553)
40. M.L. Williams, I.W. Wainer Genotype/phenotype comparisons: A probe for the effect of disease progression on drug metabolism Curr Opin Drug Discov Devel 5 2002 144 149 (Pubitemid 34453252)
41. S.I. Shedlofsky, B.C. Israel, C.J. McClain, D.B. Hill, R.A. Blouin Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism J Clin Invest 94 1994 2209 2214
42. K.W. Renton Regulation of drug metabolism and disposition during inflammation and infection Expert Opin Drug Metab Toxicol 1 2005 629 640