Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 26, 2015, Pages 8106-8111

  Fuchikami, Manabu ^a   Thomas, Alexandra ^a   Liu, Rongjian ^a   Wohleb, Eric S ^a   Land, Benjamin B ^a   DiLeone, Ralph J ^a   Aghajanian, George K ^a   Duman, Ronald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antidepressant; Glutamate; Neural depolarization; Prefrontal cortex; Synapse

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMIC ACID; INTERLEUKIN 1; KETAMINE; MUSCIMOL; XYLAZINE; ANTIDEPRESSANT AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ANXIETY DISORDER; ARTICLE; BEHAVIOR ASSESSMENT; BRAIN SLICE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; GENE SILENCING; INFRALIMBIC CORTEX; MALE; NERVE CELL; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; OPTOGENETICS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SINGLE DRUG DOSE; SPINE; TRANQUILIZING ACTIVITY; ANIMAL; ANIMAL BEHAVIOR; DRUG EFFECTS; LIMBIC SYSTEM; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

RODENTIA;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; KETAMINE; LIMBIC SYSTEM; MALE; OPTOGENETICS; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84934306544     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414728112     Document Type: Article

References (43)

1. Berman RM, et al. (2000) Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47(4):351-354.
2. Zarate CA, Jr, et al. (2006) A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63(8):856-864.
3. Diazgranados N, et al. (2010) A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression. Arch Gen Psychiatry 67(8):793-802.
4. Li N, et al. (2010) mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 329(5994):959-964.
5. Långsjö JW, et al. (2003) Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 99(3):614-623.
6. Långsjö JW, et al. (2004) Effects of subanesthetic ketamine on regional cerebral glucose metabolism in humans. Anesthesiology 100(5):1065-1071.
7. Holcomb HH, Lahti AC, Medoff DR, Cullen T, Tamminga CA (2005) Effects of non-competitive NMDA receptor blockade on anterior cingulate cerebral blood flow in volunteers with schizophrenia. Neuropsychopharmacology 30(12):2275-2282.
8. Moghaddam B, Adams B, Verma A, Daly D (1997) Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci 17(8):2921-2927.
9. Homayoun H, Moghaddam B (2007) NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons. J Neurosci 27(43):11496-11500.
10. Price JL, Drevets WC (2010) Neurocircuitry of mood disorders. Neuropsychopharmacology 35(1):192-216.
11. Murrough JW (2012) Ketamine as a novel antidepressant: From synapse to behavior. Clin Pharmacol Ther 91(2):303-309.
12. Bessa JM, et al. (2009) The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Mol Psychiatry 14(8):764-773, 739.
13. Izquierdo A, Wellman CL, Holmes A (2006) Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice. J Neurosci 26(21):5733-5738.
14. Li N, et al. (2011) Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry 69(8):754-761.
15. Holmes A, Wellman CL (2009) Stress-induced prefrontal reorganization and executive dysfunction in rodents. Neurosci Biobehav Rev 33(6):773-783.
16. Seamans JK, Lapish CC, Durstewitz D (2008) Comparing the prefrontal cortex of rats and primates: Insights from electrophysiology. Neurotox Res 14(2-3):249-262.
17. Sotres-Bayon F, Quirk GJ (2010) Prefrontal control of fear: More than just extinction. Curr Opin Neurobiol 20(2):231-235.
18. Senn V, et al. (2014) Long-range connectivity defines behavioral specificity of amygdala neurons. Neuron 81(2):428-437.
19. Laurent V, Westbrook RF (2009) Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction. Learn Mem 16(9):520-529.
20. Sierra-Mercado D, Padilla-Coreano N, Quirk GJ (2011) Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology 36(2):529-538.
21. Ji G, Neugebauer V (2012) Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics. Mol Brain 5:36.
22. Liu RJ, Aghajanian GK (2008) Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy. Proc Natl Acad Sci USA 105(1):359-364.
23. Santarelli L, et al. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301(5634):805-809.
24. Mickley GA, et al. (1998) Ketamine blocks a conditioned taste aversion (CTA) in neonatal rats. Physiol Behav 64(3):381-390.
25. Willner P (2005) Chronic mild stress (CMS) revisited: Consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52(2):90-110.
26. Autry AE, et al. (2011) NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475(7354):91-95.
27. Kavalali ET, Monteggia LM (2015) How does ketamine elicit a rapid antidepressant response? Curr Opin Pharmacol 20:35-39.
28. Liu RJ, et al. (2013) GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine. Neuropsychopharmacology 38(11):2268-2277.
29. Turrigiano GG, Nelson SB (2004) Homeostatic plasticity in the developing nervous system. Nat Rev Neurosci 5(2):97-107.
30. Campanac E, Debanne D (2007) Plasticity of neuronal excitability: Hebbian rules beyond the synapse. Arch Ital Biol 145(3-4):277-287.
31. Haider B, McCormick DA (2009) Rapid neocortical dynamics: Cellular and network mechanisms. Neuron 62(2):171-189.
32. Chaudhury D, et al. (2013) Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 493(7433):532-536.
33. Covington HE, 3rd, et al. (2010) Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci 30(48):16082-16090.
34. Tye KM, Deisseroth K (2012) Optogenetic investigation of neural circuits underlying brain disease in animal models. Nat Rev Neurosci 13(4):251-266.
35. Warden MR, et al. (2012) A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge. Nature 492(7429):428-432.
36. Myers-Schulz B, Koenigs M (2012) Functional anatomy of ventromedial prefrontal cortex: Implications for mood and anxiety disorders. Mol Psychiatry 17(2):132-141.
37. McLaughlin RJ, Hill MN, Gorzalka BB (2014) A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior. Neurosci Biobehav Rev 42:116-131.
38. Russo SJ, Nestler EJ (2013) The brain reward circuitry in mood disorders. Nat Rev Neurosci 14(9):609-625.
39. Tye KM, et al. (2013) Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 493(7433):537-541.
40. Salvadore G, et al. (2010) Anterior cingulate desynchronization and functional connectivity with the amygdala during a working memory task predict rapid antidepressant response to ketamine. Neuropsychopharmacology 35(7):1415-1422.
41. Murrough JW, et al. (2013) Neurocognitive effects of ketamine in treatment-resistant major depression: Association with antidepressant response. Psychopharmacology (Berl).
42. Slattery DA, Neumann ID, Cryan JF (2011) Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat. J Psychopharmacol 25(10):1295-1303.
43. Hamani C, et al. (2010) Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats. Biol Psychiatry 67(2):117-124.