Randomized placebo-controlled d-cycloserine with cognitive behavior therapy for pediatric posttraumatic stress

Journal of Child and Adolescent Psychopharmacology

Volumn 24, Issue 2, 2014, Pages 69-77

  Scheeringa, Michael S ^a   Weems, Carl F ^b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW ORLEANS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSERINE; PLACEBO; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANXIETY; ANXIETY DISORDER; ARTICLE; ATTENTION; BEHAVIOR DISORDER; CHILD; CLINICAL ARTICLE; COGNITIVE THERAPY; COMORBIDITY; CONTROLLED STUDY; DEPRESSION; DEPRESSION INVENTORY; FEMALE; HUMAN; INJURY; MALE; MEMORY; POSTTRAUMATIC STRESS DISORDER; PSYCHOTHERAPY; RANDOMIZED CONTROLLED TRIAL; SYMPTOM; TREATMENT RESPONSE; ADOLESCENT; AGONISTS; DOUBLE BLIND PROCEDURE; MULTIMODALITY CANCER THERAPY; PROCEDURES; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; STRESS DISORDERS, POST-TRAUMATIC; TIME FACTOR; TREATMENT OUTCOME;

ADOLESCENT; CHILD; COGNITIVE THERAPY; COMBINED MODALITY THERAPY; CYCLOSERINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, N-METHYL-D-ASPARTATE; STRESS DISORDERS, POST-TRAUMATIC; TIME FACTORS; TREATMENT OUTCOME;

EID: 84897441592     PISSN: 10445463     EISSN: 15578992     Source Type: Journal    
DOI: 10.1089/cap.2013.0106     Document Type: Article

References (33)

1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Association; 1994.
2. Birmaher B, Khetarpal S, Cully M, Brent DA, McKenzie S: Screen for Child Anxiety Related Disorders (SCARED)-Parent form and child form (8 years and older). In: Innovations in Clinical Practice: Focus on Children & Adolescents, edited by L. VandeCreek and T.L. Jackson. Sarasota, FL: Professional Resource Press/Professional Resource Exchange, 99-104, 2003.
3. Carle AC, Millsap RE, Cole DA: Measurement bias across gender on the Children's Depression Inventory. Educ Psychol Meas 68, 281-303, 2008.
4. Chavira DA, Stein MB, Bailey K, and Stein MT: Parental opinions regarding treatment for social anxiety disorder in youth. J Dev Behav Pediatr 24, 315-322, 2003.
5. Cohen J, Mannarino A: A treatment outcome study for sexually abused preschool children: Initial findings. J Am Acad Child Adolesc Psychiatry 35, 42-50, 1996.
6. Cohen JA, Deblinger E, Mannarino AP, Steer RA: A multisite, randomized controlled trial for children with sexual abuse-related PTSD symptoms. J Am Acad Child Adolesc Psychiatry 43, 393-402, 2004.
7. Cohen JA, Mannarino AP: Interventions for sexually abused children: Initial treatment outcome findings. Child Maltreat 3, 17-26, 1998.
8. Crane GE: The psychotropic effects of cycloserine: A new use for an antibiotic. Compr Psychiatry 2, 51-59, 1961.
9. de Kleine RA, Hendriks G, Kusters WJC, Broekman TG, van Minnen A: A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder. Biol Psychiatry 71, 962-968, 2012.
10. Deblinger E, Stauffer L, Steer R: Comparative efficacies of supportive and cognitive behavioral group therapies for young children who have been sexually abused and their nonoffending mothers. Child Maltreat 6, 332-343, 2001.
11. Farrell LJ, Waters AM, Boschen MJ, Hattingh L, McConnell H, Milliner EL, Collings N, Zimmer-Gembeck M, Shelton D, Ollen-dick TH, Testa C, Storch EA: Difficult-to-treat pediatric obsessive-compulsive disorder: Feasibility and preliminary results of a randomized pilot trial of D-cycloserine-augmented behavior therapy. Depress Anxiety 30, 721-731, 2013.
12. Foa EB, Johnson KM, Feeny NC, Treadwell KR: The Child PTSD Symptom Scale: A preliminary examination of its psychometric properties. J Clin Child Psychol 30, 376-384, 2001.
13. Gau S, Shur-Fen Shang C, Liu S, Lin CH, Swanson JM, Liu YC, Tu CL: Psychometric properties of the Chinese version of the Swan-son, Nolan, and Pelham, version IV scale-parent form. Int J Methods Psychiatr Res 17, 35-44, 2008.
14. Gilboa-Schechtman E, Foa EB, Shafran N, Aderka IM, Powers MB, Rachamim L, Rosenbach L, Yadin E, Apter A.: Prolonged exposure versus dynamic therapy for adolescent PTSD: A pilot randomized controlled trial. J Am Acad Child Adolesc Psychiatry 49, 1034-1042, 2010.
15. Heresco-Levy U, Kremer I, Javitt DC, Goichman R, Reshef A, Bla-naru M, Cohen T: Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder. Int J Neuropsycho-pharmacol 5, 301-307, 2002.
16. Jaycox LH, Cohen JA, Mannarino AP, Walker DW, Langley AK, Gegenheimer KL, Scott M, Schonlau M: Children's mental health care following Hurricane Katrina: A field trial of trauma-focused psychotherapies. J Trauma Stress 23, 223-231, 2010.
17. Kataoka SH, Stein BD, Jaycox LH, Wong M, Escudero P, Tu W, Zaragoza C, Fink A: A school-based mental health program for traumatized Latino immigrant children. J Am Acad Child Adolesc Psychiatry 42, 311-318, 2003.
18. Kazdin AE: Research Design in Clinical Psychology, 4th ed. Need-ham Heights, MA: Allyn & Bacon, 2003.
19. King N, Tonge B, Mullen P: Treating sexually abused children with posttraumatic stress symptoms: A randomized clinical trial. J Am Acad Child Adolesc Psychiatry 39, 1347-1355, 2000.
20. Kovacs M: The Children's Depression Inventory Manual. Toronto: Multi-Health Systems, 1992.
21. Lenth RV (2006-9) Java Applets for Power and Sample Size (computer software).
22. Litz BT, Salters-Pedneault K, Steenkamp MM, Hermos JA, Bryant RA, Otto MW, Hofmann SG: A randomized placebo-controlled trial of D-cycloserine and exposure therapy for posttraumatic stress disorder. J Psychiatr Res 46, 1194-1190, 2012.
23. Norberg MM, Krystal JH, Tolin DF: A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biol Psychiatry 63, 1118-1126, 2008.
24. Scheeringa MS, Weems CF, Cohen JA, Amaya-Jackson L, Guthrie D: Trauma-focused cognitive-behavioral therapy for posttrau-matic stress disorder in three through six year-old children: A randomized clinical trial. J Child Psychol Psychiatry 52, 853-860, 2011.
25. Scheeringa MS, Wright MJ, Hunt JP, Zeanah CH: Factors affecting the diagnosis and prediction of PTSD symptomatology in children and adolescents. Am J Psychiatry 163, 644-651, 2006.
26. Shaffer D, Fisher P, Lucas C: NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): Description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39, 28-38, 2000.
27. Silverman WK, Ortiz CD, Viswesvaran C, Burns BJ, Kolko DJ, Putnam FW, Amaya-Jackson L: Evidence-based psychosocial treatments for children and adolescents exposed to traumatic events. J Clin Child Adolesc Psychol 37, 156-183, 2008.
28. Smith P, Yule W, Perrin S, Tranah T, Dalgleish T, Clark DM: Cognitive-behavioral therapy for PTSD in children and adolescents: A preliminary randomized controlled trial. J Am Acad Child Adolesc Psychiatry 46, 1051-1061, 2007.
29. Stein B, Jaycox L, Kataoka S: A mental health intervention for schoolchildren exposed to violence: A randomized controlled trial. JAMA 290, 603-611, 2003.
30. Storch EA, Murphy TK, Goodman WK, Geffken GR, Lewin AB, Henin A, Micco JA, Sprich S, Wilhelm S, Bengtson M, Geller DA: A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Biol Psychiatry 68, 1073-1076, 2010.
31. van Berckel BN, Lipsch C, Timp S, Gispen-de Wied C, Wynne H, van Ree JM, Kahn RS: Behavioral and neuroendocrine effects of the partial NMDA agonist D-cycloserine in healthy subjects. Neu-ropsychopharmacology 16, 317-324, 1997.
32. Walker DL, Ressler KJ, Lu KT, Davis M: Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J Neurosci 22, 2343-2351, 2002.
33. Waters AM, Pittaway M, Mogg K, Bradley BP, Pine DS: Attention training towards positive stimuli in clinically anxious children. Dev Cogn Neurosci 4, 77-84, 2013.