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Volumn 127, Issue 1, 2017, Pages 280-292

TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1; INTERLEUKIN-6, MOUSE; TGFB1 PROTEIN, MOUSE;

EID: 85008313695     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI88647     Document Type: Article
Times cited : (221)

References (65)
  • 1
    • 84862176452 scopus 로고    scopus 로고
    • Update on intracerebral hemorrhage
    • Minneap Minn
    • Manno EM. Update on intracerebral hemorrhage. Continuum (Minneap Minn). 2012;18(3):598-610.
    • (2012) Continuum , vol.18 , Issue.3 , pp. 598-610
    • Manno, E.M.1
  • 2
    • 65449176475 scopus 로고    scopus 로고
    • Intracerebral haemorrhage
    • Qureshi AI, Mendelow AD, Hanley DF. Intracerebral haemorrhage. Lancet. 2009;373(9675):1632-1644.
    • (2009) Lancet , vol.373 , Issue.9675 , pp. 1632-1644
    • Qureshi, A.I.1    Mendelow, A.D.2    Hanley, D.F.3
  • 3
    • 84863863921 scopus 로고    scopus 로고
    • Intracerebral haemorrhage: Mechanisms of injury and therapeutic targets
    • Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012;11(8):720-731.
    • (2012) Lancet Neurol. , vol.11 , Issue.8 , pp. 720-731
    • Keep, R.F.1    Hua, Y.2    Xi, G.3
  • 4
    • 34247560648 scopus 로고    scopus 로고
    • Hematoma resolution as a target for intracerebral hemorrhage treatment: Role for peroxisome proliferator-activated receptor gamma in microglia/macrophages
    • Zhao X, et al. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. Ann Neurol. 2007;61(4):352-362.
    • (2007) Ann Neurol. , vol.61 , Issue.4 , pp. 352-362
    • Zhao, X.1
  • 5
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • Schulz C, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. 2012;336(6077):86-90.
    • (2012) Science , vol.336 , Issue.6077 , pp. 86-90
    • Schulz, C.1
  • 6
    • 84928189502 scopus 로고    scopus 로고
    • C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
    • Hoeffel G, et al. C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity. 2015;42(4):665-678.
    • (2015) Immunity , vol.42 , Issue.4 , pp. 665-678
    • Hoeffel, G.1
  • 7
    • 84875892857 scopus 로고    scopus 로고
    • Microglia emerge from erythromyeloid precursors via Pu.1- And Irf8-dependent pathways
    • Kierdorf K, et al. Microglia emerge from erythromyeloid precursors via Pu.1- And Irf8-dependent pathways. Nat Neurosci. 2013;16(3):273-280.
    • (2013) Nat Neurosci. , vol.16 , Issue.3 , pp. 273-280
    • Kierdorf, K.1
  • 8
    • 84893745524 scopus 로고    scopus 로고
    • Identification of a unique TGF-β-dependent molecular and functional signature in microglia
    • Butovsky O, et al. Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci. 2014;17(1):131-143.
    • (2014) Nat Neurosci. , vol.17 , Issue.1 , pp. 131-143
    • Butovsky, O.1
  • 9
    • 84962250196 scopus 로고    scopus 로고
    • New tools for studying microglia in the mouse and human CNS
    • Bennett ML, et al. New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci U S A. 2016;113(12):E1738-E1746.
    • (2016) Proc Natl Acad Sci U S A , vol.113 , Issue.12 , pp. E1738-E1746
    • Bennett, M.L.1
  • 10
    • 85015352880 scopus 로고    scopus 로고
    • Ontogeny and polarization of macrophages in inflammation: Blood monocytes versus tissue macrophages
    • Dey A, Allen J, Hankey-Giblin PA. Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages. Front Immunol. 2014;5:683.
    • (2014) Front Immunol. , vol.5 , pp. 683
    • Dey, A.1    Allen, J.2    Hankey-Giblin, P.A.3
  • 11
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli RC, et al. Synaptic pruning by microglia is necessary for normal brain development. Science. 2011;333(6048):1456-1458.
    • (2011) Science , vol.333 , Issue.6048 , pp. 1456-1458
    • Paolicelli, R.C.1
  • 12
    • 84871076444 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization in tissue repair and remodelling
    • Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol. 2013;229(2):176-185.
    • (2013) J Pathol. , vol.229 , Issue.2 , pp. 176-185
    • Mantovani, A.1    Biswas, S.K.2    Galdiero, M.R.3    Sica, A.4    Locati, M.5
  • 14
    • 77956545744 scopus 로고    scopus 로고
    • Preclinical and clinical research on inflammation after intracerebral hemorrhage
    • Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol. 2010;92(4):463-477.
    • (2010) Prog Neurobiol. , vol.92 , Issue.4 , pp. 463-477
    • Wang, J.1
  • 15
    • 84865351085 scopus 로고    scopus 로고
    • Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration
    • Starossom SC, et al. Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration. Immunity. 2012;37(2):249-263.
    • (2012) Immunity , vol.37 , Issue.2 , pp. 249-263
    • Starossom, S.C.1
  • 16
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest. 2012;122(3):787-795.
    • (2012) J Clin Invest. , vol.122 , Issue.3 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 17
    • 84902549638 scopus 로고    scopus 로고
    • Neuroinflammation and M2 microglia: The good, the bad, and the inflamed
    • Cherry JD, Olschowka JA, O'Banion MK. Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J Neuroinflammation. 2014;11:98.
    • (2014) J Neuroinflammation. , vol.11 , pp. 98
    • Cherry, J.D.1    Olschowka, J.A.2    O'Banion, M.K.3
  • 18
    • 35148835215 scopus 로고    scopus 로고
    • CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    • Ponomarev ED, Maresz K, Tan Y, Dittel BN. CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J Neurosci. 2007;27(40):10714-10721.
    • (2007) J Neurosci. , vol.27 , Issue.40 , pp. 10714-10721
    • Ponomarev, E.D.1    Maresz, K.2    Tan, Y.3    Dittel, B.N.4
  • 19
    • 84953275134 scopus 로고    scopus 로고
    • Interleukin-4 is essential for microglia/macrophage M2 polarization and longterm recovery after cerebral ischemia
    • Liu X, et al. Interleukin-4 is essential for microglia/macrophage M2 polarization and longterm recovery after cerebral ischemia. Stroke. 2016;47(2):498-504.
    • (2016) Stroke , vol.47 , Issue.2 , pp. 498-504
    • Liu, X.1
  • 20
    • 84960437624 scopus 로고    scopus 로고
    • Macrophages in tissue repair, regeneration, and fibrosis
    • Wynn TA, Vannella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity. 2016;44(3):450-462.
    • (2016) Immunity. , vol.44 , Issue.3 , pp. 450-462
    • Wynn, T.A.1    Vannella, K.M.2
  • 21
    • 33751555746 scopus 로고    scopus 로고
    • IL-10 inhibits lipopolysaccharide- induced CD40 gene expression through induction of suppressor of cytokine signaling-3
    • Qin H, Wilson CA, Roberts KL, Baker BJ, Zhao X, Benveniste EN. IL-10 inhibits lipopolysaccharide- induced CD40 gene expression through induction of suppressor of cytokine signaling-3. J Immunol. 2006;177(11):7761-7771.
    • (2006) J Immunol. , vol.177 , Issue.11 , pp. 7761-7771
    • Qin, H.1    Wilson, C.A.2    Roberts, K.L.3    Baker, B.J.4    Zhao, X.5    Benveniste, E.N.6
  • 22
    • 67449110952 scopus 로고    scopus 로고
    • Vivo over-expression of interleukin- 10 increases resistance to focal brain ischemia in mice
    • de Bilbao F, et al. In vivo over-expression of interleukin- 10 increases resistance to focal brain ischemia in mice. J Neurochem. 2009;110(1):12-22.
    • (2009) J Neurochem. , vol.110 , Issue.1 , pp. 12-22
    • De Bilbao, F.1
  • 23
    • 0023726231 scopus 로고
    • Deactivation of macrophages by transforming growth factor-beta
    • Tsunawaki S, Sporn M, Ding A, Nathan C. Deactivation of macrophages by transforming growth factor-beta. Nature. 1988;334(6179):260-262.
    • (1988) Nature , vol.334 , Issue.6179 , pp. 260-262
    • Tsunawaki, S.1    Sporn, M.2    Ding, A.3    Nathan, C.4
  • 24
    • 3242799550 scopus 로고    scopus 로고
    • Smad3 null mice develop airspace enlargement and are resistant to TGFbeta- mediated pulmonary fibrosis
    • Bonniaud P, et al. Smad3 null mice develop airspace enlargement and are resistant to TGFbeta- mediated pulmonary fibrosis. J Immunol. 2004;173(3):2099-2108.
    • (2004) J Immunol. , vol.173 , Issue.3 , pp. 2099-2108
    • Bonniaud, P.1
  • 25
    • 84878807187 scopus 로고    scopus 로고
    • Microglia: Key elements in neural development, plasticity, and pathology
    • Eyo UB, Dailey ME. Microglia: key elements in neural development, plasticity, and pathology. J Neuroimmune Pharmacol. 2013;8(3):494-509.
    • (2013) J Neuroimmune Pharmacol. , vol.8 , Issue.3 , pp. 494-509
    • Eyo, U.B.1    Dailey, M.E.2
  • 26
    • 84860666662 scopus 로고    scopus 로고
    • TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment
    • Abutbul S, et al. TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment. Glia. 2012;60(7):1160-1171.
    • (2012) Glia , vol.60 , Issue.7 , pp. 1160-1171
    • Abutbul, S.1
  • 27
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • Jung S, et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol. 2000;20(11):4106-4114.
    • (2000) Mol Cell Biol. , vol.20 , Issue.11 , pp. 4106-4114
    • Jung, S.1
  • 28
    • 0345381021 scopus 로고    scopus 로고
    • Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage
    • Chapman GA, Moores K, Harrison D, Campbell CA, Stewart BR, Strijbos PJ. Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage. J Neurosci. 2000;20(15):RC87.
    • (2000) J Neurosci. , vol.20 , Issue.15 , pp. RC87
    • Chapman, G.A.1    Moores, K.2    Harrison, D.3    Campbell, C.A.4    Stewart, B.R.5    Strijbos, P.J.6
  • 29
    • 13144279282 scopus 로고    scopus 로고
    • Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia
    • Harrison JK, et al. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci U S A. 1998;95(18):10896-10901.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.18 , pp. 10896-10901
    • Harrison, J.K.1
  • 30
    • 33745573660 scopus 로고    scopus 로고
    • Control of microglial neurotoxicity by the fractalkine receptor
    • Cardona AE, et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci. 2006;9(7):917-924.
    • (2006) Nat Neurosci. , vol.9 , Issue.7 , pp. 917-924
    • Cardona, A.E.1
  • 31
    • 78650161998 scopus 로고    scopus 로고
    • Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide
    • Corona AW, et al. Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. J Neuroinflammation. 2010;7:93.
    • (2010) J Neuroinflammation , vol.7 , pp. 93
    • Corona, A.W.1
  • 33
    • 80455176830 scopus 로고    scopus 로고
    • Thrombininduced autophagy: A potential role in intracerebral hemorrhage
    • Hu S, Xi G, Jin H, He Y, Keep RF, Hua Y. Thrombininduced autophagy: a potential role in intracerebral hemorrhage. Brain Res. 2011;1424:60-66.
    • (2011) Brain Res. , vol.1424 , pp. 60-66
    • Hu, S.1    Xi, G.2    Jin, H.3    He, Y.4    Keep, R.F.5    Hua, Y.6
  • 34
    • 33846639223 scopus 로고    scopus 로고
    • Brain injury after intracerebral hemorrhage: The role of thrombin and iron
    • Hua Y, Keep RF, Hoff JT, Xi G. Brain injury after intracerebral hemorrhage: the role of thrombin and iron. Stroke. 2007;38(2 Suppl):759-762.
    • (2007) Stroke , vol.38 , Issue.2 , pp. 759-762
    • Hua, Y.1    Keep, R.F.2    Hoff, J.T.3    Xi, G.4
  • 35
    • 33947526659 scopus 로고    scopus 로고
    • Outcomes validity and reliability of the modified Rankin scale: Implications for stroke clinical trials: A literature review and synthesis
    • Banks JL, Marotta CA. Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis. Stroke. 2007;38(3):1091-1096.
    • (2007) Stroke , vol.38 , Issue.3 , pp. 1091-1096
    • Banks, J.L.1    Marotta, C.A.2
  • 36
    • 70449137214 scopus 로고
    • Cerebral vascular accidents in patients over the age of 60. II. Prognosis
    • Rankin J. Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J. 1957;2(5):200-215.
    • (1957) Scott Med J. , vol.2 , Issue.5 , pp. 200-215
    • Rankin, J.1
  • 37
    • 0035071406 scopus 로고    scopus 로고
    • The ICH score: A simple, reliable grading scale for intracerebral hemorrhage
    • Hemphill JC, Bonovich DC, Besmertis L, Manley GT, Johnston SC. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke. 2001;32(4):891-897.
    • (2001) Stroke , vol.32 , Issue.4 , pp. 891-897
    • Hemphill, J.C.1    Bonovich, D.C.2    Besmertis, L.3    Manley, G.T.4    Johnston, S.C.5
  • 38
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330(6005):841-845.
    • (2010) Science , vol.330 , Issue.6005 , pp. 841-845
    • Ginhoux, F.1
  • 39
    • 84960354901 scopus 로고    scopus 로고
    • Tissue-resident macrophage ontogeny and homeostasis
    • Ginhoux F, Guilliams M. Tissue-resident macrophage ontogeny and homeostasis. Immunity. 2016;44(3):439-449.
    • (2016) Immunity , vol.44 , Issue.3 , pp. 439-449
    • Ginhoux, F.1    Guilliams, M.2
  • 40
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sacderived erythro-myeloid progenitors
    • Gomez Perdiguero E, et al. Tissue-resident macrophages originate from yolk-sacderived erythro-myeloid progenitors. Nature. 2015;518(7540):547-551.
    • (2015) Nature , vol.518 , Issue.7540 , pp. 547-551
    • Gomez, P.E.1
  • 41
    • 84905116959 scopus 로고    scopus 로고
    • Differential roles of microglia and monocytes in the inflamed central nervous system
    • Yamasaki R, et al. Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med. 2014;211(8):1533-1549.
    • (2014) J Exp Med. , vol.211 , Issue.8 , pp. 1533-1549
    • Yamasaki, R.1
  • 42
    • 84882920844 scopus 로고    scopus 로고
    • Microglial polarization and plasticity: Evidence from organotypic hippocampal slice cultures
    • Ajmone-Cat MA, Mancini M, De Simone R, Cilli P, Minghetti L. Microglial polarization and plasticity: evidence from organotypic hippocampal slice cultures. Glia. 2013;61(10):1698-1711.
    • (2013) Glia , vol.61 , Issue.10 , pp. 1698-1711
    • Ajmone-Cat, M.A.1    Mancini, M.2    De Simone, R.3    Cilli, P.4    Minghetti, L.5
  • 43
    • 84862180623 scopus 로고    scopus 로고
    • TGFβ signaling plays a critical role in promoting alternative macrophage activation
    • Gong D, Shi W, Yi SJ, Chen H, Groffen J, Heisterkamp N. TGFβ signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol. 2012;13:31.
    • (2012) BMC Immunol. , vol.13 , pp. 31
    • Gong, D.1    Shi, W.2    Yi, S.J.3    Chen, H.4    Groffen, J.5    Heisterkamp, N.6
  • 44
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003;3(1):23-35.
    • (2003) Nat Rev Immunol. , vol.3 , Issue.1 , pp. 23-35
    • Gordon, S.1
  • 45
    • 84898027883 scopus 로고    scopus 로고
    • TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation
    • Norden DM, Fenn AM, Dugan A, Godbout JP. TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation. Glia. 2014;62(6):881-895.
    • (2014) Glia , vol.62 , Issue.6 , pp. 881-895
    • Norden, D.M.1    Fenn, A.M.2    Dugan, A.3    Godbout, J.P.4
  • 46
    • 84939864920 scopus 로고    scopus 로고
    • Transforming growth factor-β1 acts via TβR-I on microglia to protect against MPP(+)-induced dopaminergic neuronal loss
    • Liu Z, Chen HQ, Huang Y, Qiu YH, Peng YP. Transforming growth factor-β1 acts via TβR-I on microglia to protect against MPP(+)-induced dopaminergic neuronal loss. Brain Behav Immun. 2016;51:131-143.
    • (2016) Brain Behav Immun. , vol.51 , pp. 131-143
    • Liu, Z.1    Chen, H.Q.2    Huang, Y.3    Qiu, Y.H.4    Peng, Y.P.5
  • 47
    • 84906996463 scopus 로고    scopus 로고
    • Induction of transforming growth factor beta receptors following focal ischemia in the rat brain
    • Pál G, Lovas G, Dobolyi A. Induction of transforming growth factor beta receptors following focal ischemia in the rat brain. PLoS One. 2014;9(9):e106544.
    • (2014) PLoS One , vol.9 , Issue.9 , pp. e106544
    • Pál, G.1    Lovas, G.2    Dobolyi, A.3
  • 48
    • 84893676729 scopus 로고    scopus 로고
    • Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain
    • Campbell IL, et al. Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain. J Neurosci. 2014;34(7):2503-2513.
    • (2014) J Neurosci. , vol.34 , Issue.7 , pp. 2503-2513
    • Campbell, I.L.1
  • 49
    • 36049051243 scopus 로고    scopus 로고
    • Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis
    • Luo J, et al. Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. J Clin Invest. 2007;117(11):3306-3315.
    • (2007) J Clin Invest. , vol.117 , Issue.11 , pp. 3306-3315
    • Luo, J.1
  • 50
    • 84902345621 scopus 로고    scopus 로고
    • Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice
    • Cekanaviciute E, Fathali N, Doyle KP, Williams AM, Han J, Buckwalter MS. Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia. 2014;62(8):1227-1240.
    • (2014) Glia , vol.62 , Issue.8 , pp. 1227-1240
    • Cekanaviciute, E.1    Fathali, N.2    Doyle, K.P.3    Williams, A.M.4    Han, J.5    Buckwalter, M.S.6
  • 51
    • 84888324248 scopus 로고    scopus 로고
    • The microglial sensome revealed by direct RNA sequencing
    • Hickman SE, et al. The microglial sensome revealed by direct RNA sequencing. Nat Neurosci. 2013;16(12):1896-1905.
    • (2013) Nat Neurosci. , vol.16 , Issue.12 , pp. 1896-1905
    • Hickman, S.E.1
  • 52
    • 0036161092 scopus 로고    scopus 로고
    • Flow cytometric analysis of inflammatory cells in ischemic rat brain
    • Campanella M, Sciorati C, Tarozzo G, Beltramo M. Flow cytometric analysis of inflammatory cells in ischemic rat brain. Stroke. 2002;33(2):586-592.
    • (2002) Stroke , vol.33 , Issue.2 , pp. 586-592
    • Campanella, M.1    Sciorati, C.2    Tarozzo, G.3    Beltramo, M.4
  • 53
    • 34248673126 scopus 로고    scopus 로고
    • Isolation of murine microglial cells for RNA analysis or flow cytometry
    • Cardona AE, Huang D, Sasse ME, Ransohoff RM. Isolation of murine microglial cells for RNA analysis or flow cytometry. Nat Protoc. 2006;1(4):1947-1951.
    • (2006) Nat Protoc. , vol.1 , Issue.4 , pp. 1947-1951
    • Cardona, A.E.1    Huang, D.2    Sasse, M.E.3    Ransohoff, R.M.4
  • 55
    • 84862254691 scopus 로고    scopus 로고
    • Autologous blood injection to model spontaneous intracerebral hemorrhage in mice
    • Sansing L, Kasner S, McCullough L, Agarwal P, Welsh F, Kariko K. Autologous blood injection to model spontaneous intracerebral hemorrhage in mice. J Vis Exp. 2011;(54):e2618.
    • (2011) J Vis Exp. , Issue.54 , pp. e2618
    • Sansing, L.1    Kasner, S.2    McCullough, L.3    Agarwal, P.4    Welsh, F.5    Kariko, K.6
  • 57
    • 84901355983 scopus 로고    scopus 로고
    • Mouse models of intracerebral hemorrhage in ventricle, cortex, and hippocampus by injections of autologous blood or collagenase
    • Zhu W, Gao Y, Chang CF, Wan JR, Zhu SS, Wang J. Mouse models of intracerebral hemorrhage in ventricle, cortex, and hippocampus by injections of autologous blood or collagenase. PLoS One. 2014;9(5):e97423.
    • (2014) PLoS One , vol.9 , Issue.5 , pp. e97423
    • Zhu, W.1    Gao, Y.2    Chang, C.F.3    Wan, J.R.4    Zhu, S.S.5    Wang, J.6
  • 58
    • 1842664163 scopus 로고    scopus 로고
    • Chronic behavioral testing after focal ischemia in the mouse: Functional recovery and the effects of gender
    • Li X, Blizzard KK, Zeng Z, DeVries AC, Hurn PD, McCullough LD. Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp Neurol. 2004;187(1):94-104.
    • (2004) Exp Neurol. , vol.187 , Issue.1 , pp. 94-104
    • Li, X.1    Blizzard, K.K.2    Zeng, Z.3    DeVries, A.C.4    Hurn, P.D.5    McCullough, L.D.6
  • 59
    • 40849142249 scopus 로고    scopus 로고
    • Neurological impairment in rats after subarachnoid hemorrhage-a comparison of functional tests
    • Thal SC, Mebmer K, Schmid-Elsaesser R, Zausinger S. Neurological impairment in rats after subarachnoid hemorrhage-a comparison of functional tests. J Neurol Sci. 2008;268(1-2):150-159.
    • (2008) J Neurol Sci. , vol.268 , Issue.1-2 , pp. 150-159
    • Thal, S.C.1    Mebmer, K.2    Schmid-Elsaesser, R.3    Zausinger, S.4
  • 60
    • 84857405490 scopus 로고    scopus 로고
    • Gait analysis as a method for assessing neurological outcome in a mouse model of stroke
    • Hetze S, Römer C, Teufelhart C, Meisel A, Engel O. Gait analysis as a method for assessing neurological outcome in a mouse model of stroke. J Neurosci Methods. 2012;206(1):7-14.
    • (2012) J Neurosci Methods , vol.206 , Issue.1 , pp. 7-14
    • Hetze, S.1    Römer, C.2    Teufelhart, C.3    Meisel, A.4    Engel, O.5
  • 61
    • 84883149909 scopus 로고    scopus 로고
    • MMP-3 mediates psychosineinduced globoid cell formation: Implications for leukodystrophy pathology
    • Ijichi K, et al. MMP-3 mediates psychosineinduced globoid cell formation: implications for leukodystrophy pathology. Glia. 2013;61(5):765-777.
    • (2013) Glia , vol.61 , Issue.5 , pp. 765-777
    • Ijichi, K.1
  • 63
    • 79957915948 scopus 로고    scopus 로고
    • CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS
    • Regen T, et al. CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS. Brain Behav Immun. 2011;25(5):957-970.
    • (2011) Brain Behav Immun. , vol.25 , Issue.5 , pp. 957-970
    • Regen, T.1
  • 64
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 65
    • 84940919725 scopus 로고    scopus 로고
    • CX3CR1 signaling on monocytes is dispensable after intracerebral hemorrhage
    • Taylor RA, Hammond MD, Ai Y, Sansing LH. CX3CR1 signaling on monocytes is dispensable after intracerebral hemorrhage. PLoS One. 2014;9(12):e114472.
    • (2014) PLoS One , vol.9 , Issue.12 , pp. e114472
    • Taylor, R.A.1    Hammond, M.D.2    Ai, Y.3    Sansing, L.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.